Organism Overview: Buchnera aphidicola Sg


 
gidA protein networkhttps://string-db.org/network/198804.BUsg_001Glucose inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s( [...]
atpB protein networkhttps://string-db.org/network/198804.BUsg_002ATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
atpE protein networkhttps://string-db.org/network/198804.BUsg_003ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembra [...]
atpF protein networkhttps://string-db.org/network/198804.BUsg_004ATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembra [...]
atpH protein networkhttps://string-db.org/network/198804.BUsg_005ATP synthase delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extrame [...]
atpA protein networkhttps://string-db.org/network/198804.BUsg_006ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit; Belongs to the ATPase alpha/beta chains family.
atpG protein networkhttps://string-db.org/network/198804.BUsg_007ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of [...]
atpD protein networkhttps://string-db.org/network/198804.BUsg_008ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha [...]
atpC protein networkhttps://string-db.org/network/198804.BUsg_009ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane.
gyrB protein networkhttps://string-db.org/network/198804.BUsg_010DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in a [...]
dnaN protein networkhttps://string-db.org/network/198804.BUsg_011DNA polymerase III beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading [...]
dnaA protein networkhttps://string-db.org/network/198804.BUsg_012Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-st [...]
rpmH protein networkhttps://string-db.org/network/198804.BUsg_01350S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family.
rnpA protein networkhttps://string-db.org/network/198804.BUsg_014Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. [...]
yidD protein networkhttps://string-db.org/network/198804.BUsg_015Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.
yidC protein networkhttps://string-db.org/network/198804.BUsg_016Inner membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins tha [...]
thdF protein networkhttps://string-db.org/network/198804.BUsg_017Thiophene and furan oxidation protein; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of c [...]
mopB protein networkhttps://string-db.org/network/198804.BUsg_01810 kd chaperonin (GroES); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
mopA protein networkhttps://string-db.org/network/198804.BUsg_01960 kd chaperonin (protein cpn60); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
yjeK protein networkhttps://string-db.org/network/198804.BUsg_020Hypothetical 38.7 kDa protein; With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P) on 'Lys-34'. EpmB appears to act [...]
efp protein networkhttps://string-db.org/network/198804.BUsg_021Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by [...]
dnaC protein networkhttps://string-db.org/network/198804.BUsg_022DNA replication protein DnaC; This protein is required for chromosomal replication. It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein comp [...]
dnaT protein networkhttps://string-db.org/network/198804.BUsg_023Primosomal protein I; This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert wit [...]
ftsY protein networkhttps://string-db.org/network/198804.BUsg_025Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition par [...]
rpoH protein networkhttps://string-db.org/network/198804.BUsg_026RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involve [...]
glmS protein networkhttps://string-db.org/network/198804.BUsg_027Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
glmU protein networkhttps://string-db.org/network/198804.BUsg_028UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyz [...]
yigL protein networkhttps://string-db.org/network/198804.BUsg_029Hypothetical 29.8 kDa protein; Protein in pldB-metR.
metR protein networkhttps://string-db.org/network/198804.BUsg_030Transcriptional activator protein MetR; Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes; Belongs to the LysR transcriptional reg [...]
metE protein networkhttps://string-db.org/network/198804.BUsg_0315-methyltetrahydropteroyltriglutamate-- homocystein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vita [...]
purH protein networkhttps://string-db.org/network/198804.BUsg_032Bifunctional purine biosynthesis protein.
hupA protein networkhttps://string-db.org/network/198804.BUsg_033DNA-binding protein hu-alpha; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belon [...]
rpoC protein networkhttps://string-db.org/network/198804.BUsg_034DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
rpoB protein networkhttps://string-db.org/network/198804.BUsg_035DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
rplL protein networkhttps://string-db.org/network/198804.BUsg_03650S ribosomal protein L7/l12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the ba [...]
rplJ protein networkhttps://string-db.org/network/198804.BUsg_03750S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal prot [...]
rplA protein networkhttps://string-db.org/network/198804.BUsg_03850S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
rplK protein networkhttps://string-db.org/network/198804.BUsg_03950S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
nusG protein networkhttps://string-db.org/network/198804.BUsg_040Transcription antitermination protein NusG; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the [...]
secE protein networkhttps://string-db.org/network/198804.BUsg_041Preprotein translocase SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
murB protein networkhttps://string-db.org/network/198804.BUsg_042UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.
metF protein networkhttps://string-db.org/network/198804.BUsg_0435,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
argE protein networkhttps://string-db.org/network/198804.BUsg_044Acetylornithine deacetylase; Belongs to the peptidase M20A family. ArgE subfamily.
argC protein networkhttps://string-db.org/network/198804.BUsg_045N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydroge [...]
argB protein networkhttps://string-db.org/network/198804.BUsg_046Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate.
argG protein networkhttps://string-db.org/network/198804.BUsg_047Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
argH protein networkhttps://string-db.org/network/198804.BUsg_048Argininosuccinate lyase.
yibN protein networkhttps://string-db.org/network/198804.BUsg_049Hypothetical 15.6 kDa protein; Protein in secB-tdh.
secB protein networkhttps://string-db.org/network/198804.BUsg_050Protein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, [...]
cysE protein networkhttps://string-db.org/network/198804.BUsg_051Serine acetyltransferase.
rpoD protein networkhttps://string-db.org/network/198804.BUsg_052RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the p [...]
dnaG protein networkhttps://string-db.org/network/198804.BUsg_053DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
rpsU protein networkhttps://string-db.org/network/198804.BUsg_05430S ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family.
gcp protein networkhttps://string-db.org/network/198804.BUsg_055Probable O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is invo [...]
ribB protein networkhttps://string-db.org/network/198804.BUsg_0563,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
rfaE protein networkhttps://string-db.org/network/198804.BUsg_057ADP-heptose synthas; Belongs to the carbohydrate kinase PfkB family.
cca protein networkhttps://string-db.org/network/198804.BUsg_058tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order [...]
bacA protein networkhttps://string-db.org/network/198804.BUsg_059Bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family.
crr protein networkhttps://string-db.org/network/198804.BUsg_060Pts system, glucose-specific IIa component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylat [...]
ptsI protein networkhttps://string-db.org/network/198804.BUsg_061Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate ac [...]
ptsH protein networkhttps://string-db.org/network/198804.BUsg_062Phosphocarrier protein H PR; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport syst [...]
cysK protein networkhttps://string-db.org/network/198804.BUsg_063Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family.
gltX protein networkhttps://string-db.org/network/198804.BUsg_065glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end [...]
fliE protein networkhttps://string-db.org/network/198804.BUsg_066Flagellar hook-basal body complex protein FliE.
fliF protein networkhttps://string-db.org/network/198804.BUsg_067Flagellar M-ring protein; The M ring may be actively involved in energy transduction.
fliG protein networkhttps://string-db.org/network/198804.BUsg_068Flagellar motor switch protein FliG; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex int [...]
fliH protein networkhttps://string-db.org/network/198804.BUsg_069Flagellar assembly protein FliH; Needed for flagellar regrowth and assembly; Belongs to the FliH family.
fliI protein networkhttps://string-db.org/network/198804.BUsg_070Flagellum-specific ATP synthase; Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be inv [...]
fliJ protein networkhttps://string-db.org/network/198804.BUsg_071Flagellar FliJ protein; Flagellar protein that affects chemotactic events. Belongs to the FliJ family.
fliK protein networkhttps://string-db.org/network/198804.BUsg_072Flagellar hook-length control protein; Controls the length of the flagellar hook; Belongs to the FliK family.
fliM protein networkhttps://string-db.org/network/198804.BUsg_073Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex int [...]
fliN protein networkhttps://string-db.org/network/198804.BUsg_074Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex inte [...]
fliP protein networkhttps://string-db.org/network/198804.BUsg_075Flagellar biosynthetic protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family.
fliQ protein networkhttps://string-db.org/network/198804.BUsg_076Flagellar biosynthetic protein FliQ; Role in flagellar biosynthesis; Belongs to the FliQ/MopD/SpaQ family.
fliR protein networkhttps://string-db.org/network/198804.BUsg_077Flagellar biosynthetic protein FliR; Role in flagellar biosynthesis; Belongs to the FliR/MopE/SpaR family.
rpmG protein networkhttps://string-db.org/network/198804.BUsg_07850S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.
rpmB protein networkhttps://string-db.org/network/198804.BUsg_07950S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.
ytfN protein networkhttps://string-db.org/network/198804.BUsg_080Hypothetical 136.8 kDa protein; Protein in msrA-chpB.
ppa protein networkhttps://string-db.org/network/198804.BUsg_081Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
pmbA protein networkhttps://string-db.org/network/198804.BUsg_082PmbA; Probable metalloprotease; Belongs to the peptidase U62 family.
yraL protein networkhttps://string-db.org/network/198804.BUsg_083Hypothetical 31.3 kDa protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
fabB protein networkhttps://string-db.org/network/198804.BUsg_0843-oxoacyl-[acyl-carrier-protein] synthase I; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongati [...]
tal protein networkhttps://string-db.org/network/198804.BUsg_085Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
tkt protein networkhttps://string-db.org/network/198804.BUsg_086Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
dapE protein networkhttps://string-db.org/network/198804.BUsg_087Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in [...]
dapA protein networkhttps://string-db.org/network/198804.BUsg_088Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
bcp protein networkhttps://string-db.org/network/198804.BUsg_089Bacterioferritin comigratory protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in c [...]
aroC protein networkhttps://string-db.org/network/198804.BUsg_090Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch poin [...]
BUsg_091 protein networkhttps://string-db.org/network/198804.BUsg_091Hypothetical 21.2 kDa protein; Y098; Belongs to the UPF0115 family.
hisG protein networkhttps://string-db.org/network/198804.BUsg_092ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate [...]
hisD protein networkhttps://string-db.org/network/198804.BUsg_093Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
hisC protein networkhttps://string-db.org/network/198804.BUsg_094Histidinolphosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
hisB protein networkhttps://string-db.org/network/198804.BUsg_095Histidine biosynthesis bifunctional protein; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
hisH protein networkhttps://string-db.org/network/198804.BUsg_096Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the [...]
hisA protein networkhttps://string-db.org/network/198804.BUsg_097Phosphoribosylformimino-5-aminoimidazole carboxamid.
hisF protein networkhttps://string-db.org/network/198804.BUsg_098Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the amm [...]
hisI protein networkhttps://string-db.org/network/198804.BUsg_099Histidine biosynthesis bifunctional protein; In the C-terminal section; belongs to the PRA-PH family.
gnd protein networkhttps://string-db.org/network/198804.BUsg_1006-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
dcd protein networkhttps://string-db.org/network/198804.BUsg_101Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP.
metG protein networkhttps://string-db.org/network/198804.BUsg_102methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
mesJ protein networkhttps://string-db.org/network/198804.BUsg_103Putative cell cycle protein MesJ; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine [...]
ribE protein networkhttps://string-db.org/network/198804.BUsg_104Riboflavin synthase alpha chain; Catalyzes the dismutation of two molecules of 6,7-dimethyl-8- ribityllumazine, resulting in the formation of riboflavin and 5-amino- 6-(D-ribitylamino)uracil.
rnfA protein networkhttps://string-db.org/network/198804.BUsg_105Putative membrane protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
ydgM protein networkhttps://string-db.org/network/198804.BUsg_106Putative ferredoxin-like protein in add-nth; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type fe [...]
ydgO protein networkhttps://string-db.org/network/198804.BUsg_108Hypothetical 38.1 kDa protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family.
ydgP protein networkhttps://string-db.org/network/198804.BUsg_109Hypothetical 21.9 kDa protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.
ydgQ protein networkhttps://string-db.org/network/198804.BUsg_110Hypothetical 24.5 kDa protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
nth protein networkhttps://string-db.org/network/198804.BUsg_111Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- [...]
priA protein networkhttps://string-db.org/network/198804.BUsg_112Primosomal protein n; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its h [...]
tyrS protein networkhttps://string-db.org/network/198804.BUsg_113tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of [...]
ydiC protein networkhttps://string-db.org/network/198804.BUsg_114Hypothetical 13.3 kDa protein; Protein in lpp-aroD; Belongs to the HesB/IscA family.
ydiK protein networkhttps://string-db.org/network/198804.BUsg_115Hypothetical 39.8 kDa protein; Protein in lpp-aroD.
aroH protein networkhttps://string-db.org/network/198804.BUsg_116Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate [...]
thrS protein networkhttps://string-db.org/network/198804.BUsg_117threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor en [...]
rpmI protein networkhttps://string-db.org/network/198804.BUsg_11950S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family.
rplT protein networkhttps://string-db.org/network/198804.BUsg_12050S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing func [...]
pheS protein networkhttps://string-db.org/network/198804.BUsg_121phenylalanyl-tRNA synthetase alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
pheT protein networkhttps://string-db.org/network/198804.BUsg_122phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
himA protein networkhttps://string-db.org/network/198804.BUsg_123Integration host factor Alpha-subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in tra [...]
queA protein networkhttps://string-db.org/network/198804.BUsg_124S-adenosylmethionine:tRNA ribosyltransferase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
tgt protein networkhttps://string-db.org/network/198804.BUsg_125Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in [...]
yajC protein networkhttps://string-db.org/network/198804.BUsg_126Hypothetical 11.9 kDa protein; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, [...]
glyS protein networkhttps://string-db.org/network/198804.BUsg_127glycyl-tRNA synthetase beta chain.
glyQ protein networkhttps://string-db.org/network/198804.BUsg_128glycyl-tRNA synthetase alpha chain.
folE protein networkhttps://string-db.org/network/198804.BUsg_129GTP cyclohydrolase I.
nfo protein networkhttps://string-db.org/network/198804.BUsg_130Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phospha [...]
rplY protein networkhttps://string-db.org/network/198804.BUsg_13150S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 fa [...]
yabI protein networkhttps://string-db.org/network/198804.BUsg_132Hypothetical 26.3 kDa protein; Protein in araC-tbpA.
surA protein networkhttps://string-db.org/network/198804.BUsg_133Survival protein SurA precursor; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their [...]
ksgA protein networkhttps://string-db.org/network/198804.BUsg_134Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a c [...]
apaH protein networkhttps://string-db.org/network/198804.BUsg_135Bis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family.
folA protein networkhttps://string-db.org/network/198804.BUsg_136Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
carB protein networkhttps://string-db.org/network/198804.BUsg_137Carbamoyl-phosphate synthase large chain.
carA protein networkhttps://string-db.org/network/198804.BUsg_138Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.
dapB protein networkhttps://string-db.org/network/198804.BUsg_139Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family.
lytB protein networkhttps://string-db.org/network/198804.BUsg_140LytB; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the termina [...]
lspA protein networkhttps://string-db.org/network/198804.BUsg_141Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
ileS protein networkhttps://string-db.org/network/198804.BUsg_142isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such e [...]
ribF protein networkhttps://string-db.org/network/198804.BUsg_143Riboflavin biosynthesis protein RibF; Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
rpsT protein networkhttps://string-db.org/network/198804.BUsg_14430S ribosomal protein S20; Binds directly to 16S ribosomal RNA.
dnaJ protein networkhttps://string-db.org/network/198804.BUsg_145DNAJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous [...]
dnaK protein networkhttps://string-db.org/network/198804.BUsg_146DNAK protein (heat shock protein 70); Acts as a chaperone; Belongs to the heat shock protein 70 family.
nuoA protein networkhttps://string-db.org/network/198804.BUsg_147NADH dehydrogenase I chain A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in t [...]
nuoB protein networkhttps://string-db.org/network/198804.BUsg_148NADH dehydrogenase I chain B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation [...]
nuoCD protein networkhttps://string-db.org/network/198804.BUsg_149NADH dehydrogenase I chain C, chain D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the en [...]
nuoE protein networkhttps://string-db.org/network/198804.BUsg_150NADH dehydrogenase I chain E; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation [...]
nuoF protein networkhttps://string-db.org/network/198804.BUsg_151NADH dehydrogenase I chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation [...]
nuoG protein networkhttps://string-db.org/network/198804.BUsg_152NADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation [...]
nuoH protein networkhttps://string-db.org/network/198804.BUsg_153NADH dehydrogenase I chain H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in t [...]
nuoI protein networkhttps://string-db.org/network/198804.BUsg_154NADH dehydrogenase I chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in t [...]
nuoJ protein networkhttps://string-db.org/network/198804.BUsg_155NADH dehydrogenase I chain J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation [...]
nuoK protein networkhttps://string-db.org/network/198804.BUsg_156NADH dehydrogenase I chain K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in t [...]
nuoL protein networkhttps://string-db.org/network/198804.BUsg_157NADH dehydrogenase I chain L; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation [...]
nuoM protein networkhttps://string-db.org/network/198804.BUsg_158NADH dehydrogenase I chain M; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation [...]
nuoN protein networkhttps://string-db.org/network/198804.BUsg_159NADH dehydrogenase I chain N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in t [...]
ygjT protein networkhttps://string-db.org/network/198804.BUsg_160Hypothetical 35.8 kDa protein; Protein in ebgC-uxaA.
folC protein networkhttps://string-db.org/network/198804.BUsg_161FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or [...]
prsA protein networkhttps://string-db.org/network/198804.BUsg_163Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hy [...]
ipk protein networkhttps://string-db.org/network/198804.BUsg_164Isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily.
prfA protein networkhttps://string-db.org/network/198804.BUsg_165Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
hemK protein networkhttps://string-db.org/network/198804.BUsg_166HemK; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine met [...]
ychA protein networkhttps://string-db.org/network/198804.BUsg_167Transcriptional regulator; Belongs to the UPF0162 family.
nadE protein networkhttps://string-db.org/network/198804.BUsg_168NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
ackA protein networkhttps://string-db.org/network/198804.BUsg_169Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
pta protein networkhttps://string-db.org/network/198804.BUsg_170Phosphate acetyltransferase; Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family.
nrdB protein networkhttps://string-db.org/network/198804.BUsg_172Ribonucleoside-diphosphate reductase 1 beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides ( [...]
nrdA protein networkhttps://string-db.org/network/198804.BUsg_173Ribonucleoside-diphosphate reductase 1 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [...]
gyrA protein networkhttps://string-db.org/network/198804.BUsg_174DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in a [...]
yba2 protein networkhttps://string-db.org/network/198804.BUsg_175Hypothetical protein.
ahpC protein networkhttps://string-db.org/network/198804.BUsg_176Alkyl hydroperoxide reductase subunit C; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role i [...]
grpE protein networkhttps://string-db.org/network/198804.BUsg_178GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exch [...]
yfjB protein networkhttps://string-db.org/network/198804.BUsg_179Hypothetical 32.6 kDa protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation [...]
smpA protein networkhttps://string-db.org/network/198804.BUsg_180Small protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
ydhD protein networkhttps://string-db.org/network/198804.BUsg_18112.9 kDa protein; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters.
rnt protein networkhttps://string-db.org/network/198804.BUsg_182Ribonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP [...]
sodA protein networkhttps://string-db.org/network/198804.BUsg_183Superoxide dismutase (MN); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dism [...]
pth protein networkhttps://string-db.org/network/198804.BUsg_184peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
ychF protein networkhttps://string-db.org/network/198804.BUsg_185Probable GTP-binding protein In trea-pth; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. Belongs to the TRAFAC class OBG-HflX-like GT [...]
thrC protein networkhttps://string-db.org/network/198804.BUsg_186Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
thrB protein networkhttps://string-db.org/network/198804.BUsg_187Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
thrA protein networkhttps://string-db.org/network/198804.BUsg_188Bifunctional aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family.
hpt protein networkhttps://string-db.org/network/198804.BUsg_189Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine (By similarity).
panC protein networkhttps://string-db.org/network/198804.BUsg_190Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase f [...]
panB protein networkhttps://string-db.org/network/198804.BUsg_1913-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to [...]
dksA protein networkhttps://string-db.org/network/198804.BUsg_192DNAK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several am [...]
truA protein networkhttps://string-db.org/network/198804.BUsg_193tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
secA protein networkhttps://string-db.org/network/198804.BUsg_195Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to [...]
mutT protein networkhttps://string-db.org/network/198804.BUsg_196Mutator MutT; Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposit [...]
yacE protein networkhttps://string-db.org/network/198804.BUsg_197Hypothetical 22.6 kDa protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
guaC protein networkhttps://string-db.org/network/198804.BUsg_198GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and [...]
aceE protein networkhttps://string-db.org/network/198804.BUsg_199Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
aceF protein networkhttps://string-db.org/network/198804.BUsg_200Dihydrolipoamide acetyltransferase component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymat [...]
lpdA protein networkhttps://string-db.org/network/198804.BUsg_201Dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
speD protein networkhttps://string-db.org/network/198804.BUsg_202S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of th [...]
speE protein networkhttps://string-db.org/network/198804.BUsg_203Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermid [...]
pfs protein networkhttps://string-db.org/network/198804.BUsg_204MTA/SAH nucleosidase (p46); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the correspondin [...]
yadR protein networkhttps://string-db.org/network/198804.BUsg_205Hypothetical 12.1 kDa protein; Required for insertion of 4Fe-4S clusters for at least IspG.
ftsZ protein networkhttps://string-db.org/network/198804.BUsg_206Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the tim [...]
ftsA protein networkhttps://string-db.org/network/198804.BUsg_207Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
ddlB protein networkhttps://string-db.org/network/198804.BUsg_208D-alanine--D-alanine ligase; Cell wall formation.
murG protein networkhttps://string-db.org/network/198804.BUsg_210Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid interme [...]
ftsW protein networkhttps://string-db.org/network/198804.BUsg_211Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily.
murD protein networkhttps://string-db.org/network/198804.BUsg_212UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF [...]
ftsI protein networkhttps://string-db.org/network/198804.BUsg_216Penicillin binding protein 3 precursor; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily.
ftsL protein networkhttps://string-db.org/network/198804.BUsg_217Cell division protein; Essential cell division protein; Belongs to the FtsL family.
yabC protein networkhttps://string-db.org/network/198804.BUsg_218Hypothetical 36.0 kDa protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
ilvH protein networkhttps://string-db.org/network/198804.BUsg_219Acetolactate synthase small subunit.
ilvI protein networkhttps://string-db.org/network/198804.BUsg_220Acetolactate synthase large subunit.
htrA protein networkhttps://string-db.org/network/198804.BUsg_222Periplasmic serine protease; Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.
dapD protein networkhttps://string-db.org/network/198804.BUsg_2232,3,4,5-tetrahydropyridine-2-carboxylate n-succinyltransferase; Belongs to the transferase hexapeptide repeat family.
map protein networkhttps://string-db.org/network/198804.BUsg_224Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharg [...]
rpsB protein networkhttps://string-db.org/network/198804.BUsg_22530S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.
tsf protein networkhttps://string-db.org/network/198804.BUsg_226Elongation factor TS (EF-TS); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stag [...]
pyrH protein networkhttps://string-db.org/network/198804.BUsg_227Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
frr protein networkhttps://string-db.org/network/198804.BUsg_228Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosome [...]
dxr protein networkhttps://string-db.org/network/198804.BUsg_2291-deoxy-d-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP).
uppS protein networkhttps://string-db.org/network/198804.BUsg_230Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,3 [...]
yaeT protein networkhttps://string-db.org/network/198804.BUsg_231Unknown protein from 2d-page spots m62/m63/; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
fabZ protein networkhttps://string-db.org/network/198804.BUsg_232(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated [...]
dnaE protein networkhttps://string-db.org/network/198804.BUsg_233DNA polymerase III alpha chain; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuc [...]
proS protein networkhttps://string-db.org/network/198804.BUsg_234prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRN [...]
flhB protein networkhttps://string-db.org/network/198804.BUsg_235Flagellar biosynthetic protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of [...]
flhA protein networkhttps://string-db.org/network/198804.BUsg_236Flagellar protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin (By similarity); Belo [...]
argS protein networkhttps://string-db.org/network/198804.BUsg_237arginyl-tRNA synthetase.
gloB protein networkhttps://string-db.org/network/198804.BUsg_238Probable hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.
rnhA protein networkhttps://string-db.org/network/198804.BUsg_239Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
dnaQ protein networkhttps://string-db.org/network/198804.BUsg_240DNA polymerase III epsilon chain; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing functio [...]
lpcA protein networkhttps://string-db.org/network/198804.BUsg_241Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
gpt protein networkhttps://string-db.org/network/198804.BUsg_242Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
grpE1 protein networkhttps://string-db.org/network/198804.BUsg_243GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exch [...]
yfjF protein networkhttps://string-db.org/network/198804.BUsg_244Hypothetical protein; Belongs to the UPF0125 (RnfH) family.
smpB protein networkhttps://string-db.org/network/198804.BUsg_245Small protein B; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA a [...]
yfhC protein networkhttps://string-db.org/network/198804.BUsg_246Hypothetical 20.0 kDa protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
acpS protein networkhttps://string-db.org/network/198804.BUsg_247Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.
era protein networkhttps://string-db.org/network/198804.BUsg_248GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly als [...]
rnc protein networkhttps://string-db.org/network/198804.BUsg_249Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some m [...]
lepB protein networkhttps://string-db.org/network/198804.BUsg_250Signal peptidase I; Belongs to the peptidase S26 family.
lepA protein networkhttps://string-db.org/network/198804.BUsg_251GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codo [...]
trmU protein networkhttps://string-db.org/network/198804.BUsg_252tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of [...]
purB protein networkhttps://string-db.org/network/198804.BUsg_253Adenylosuccinate lyase.
fabI protein networkhttps://string-db.org/network/198804.BUsg_255Enoyl-[acyl-carrier-protein] reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elong [...]
rnb protein networkhttps://string-db.org/network/198804.BUsg_256Exoribonuclease II; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity).
ychE protein networkhttps://string-db.org/network/198804.BUsg_257Hypothetical 23.5 kDa protein; Protein in adhE-oppA.
lipB protein networkhttps://string-db.org/network/198804.BUsg_258Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can al [...]
lipA protein networkhttps://string-db.org/network/198804.BUsg_259Lipoic acid synthetase (lip-syn); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-depende [...]
pyrF protein networkhttps://string-db.org/network/198804.BUsg_260Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamil [...]
ribA protein networkhttps://string-db.org/network/198804.BUsg_261GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
cls protein networkhttps://string-db.org/network/198804.BUsg_262Cardiolipin synthetase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
yciA protein networkhttps://string-db.org/network/198804.BUsg_263Protein in trpA 3' region; Belongs to the acyl coenzyme A hydrolase family.
ispZ protein networkhttps://string-db.org/network/198804.BUsg_264Probable intracellular septation protein; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family.
yciC protein networkhttps://string-db.org/network/198804.BUsg_265Hypothetical 28.8 kDa protein; Protein in trpA 3' region.
trpA protein networkhttps://string-db.org/network/198804.BUsg_266Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
trpB protein networkhttps://string-db.org/network/198804.BUsg_267Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
trpC protein networkhttps://string-db.org/network/198804.BUsg_268Tryptophan biosynthesis protein TrpCF; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the T [...]
trpD protein networkhttps://string-db.org/network/198804.BUsg_269Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranila [...]
BUsg_270 protein networkhttps://string-db.org/network/198804.BUsg_270Hypothetical 34.4 kDa protein; Protein in trpA 3' region; Y281.
yciL protein networkhttps://string-db.org/network/198804.BUsg_271Hypothetical 30.2 kDa protein; Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family.
sohB protein networkhttps://string-db.org/network/198804.BUsg_272Possible protease SohB; Possible protease; Belongs to the peptidase S49 family.
topA protein networkhttps://string-db.org/network/198804.BUsg_273DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of [...]
suhB protein networkhttps://string-db.org/network/198804.BUsg_274Extragenic suppressor protein SuhB; Belongs to the inositol monophosphatase superfamily.
yfgB protein networkhttps://string-db.org/network/198804.BUsg_275Hypothetical 43.1 kDa protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proof [...]
gcpE protein networkhttps://string-db.org/network/198804.BUsg_276GcpE (protein e); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
hisS protein networkhttps://string-db.org/network/198804.BUsg_277histidyl-tRNA synthetase.
glyA protein networkhttps://string-db.org/network/198804.BUsg_278Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major so [...]
bioB protein networkhttps://string-db.org/network/198804.BUsg_280Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily [...]
bioA protein networkhttps://string-db.org/network/198804.BUsg_281Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8 [...]
ybhE protein networkhttps://string-db.org/network/198804.BUsg_282Hypothetical 36.3 kDa protein; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate.
ycfU protein networkhttps://string-db.org/network/198804.BUsg_284Hypothetical 43.3 kDa protein; Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is depe [...]
ycfV protein networkhttps://string-db.org/network/198804.BUsg_285Hypothetical ABC transporter ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane [...]
ycfW protein networkhttps://string-db.org/network/198804.BUsg_286Hypothetical 45.3 kDa protein; Protein in mfd-cobB.
gapA protein networkhttps://string-db.org/network/198804.BUsg_287Glyceraldehyde 3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction [...]
yqcD protein networkhttps://string-db.org/network/198804.BUsg_288Hypothetical 29.0 kDa protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
fldA protein networkhttps://string-db.org/network/198804.BUsg_289Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family.
ybgI protein networkhttps://string-db.org/network/198804.BUsg_291Hypothetical 26.9 kDaprotein; Protein in phrB-nei.
sucA protein networkhttps://string-db.org/network/198804.BUsg_2922-oxoglutarate dehydrogenase E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion [...]
sucB protein networkhttps://string-db.org/network/198804.BUsg_293Dihydrolipoamide succinyltransferase component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-Co [...]
gpmA protein networkhttps://string-db.org/network/198804.BUsg_294Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
pfkA protein networkhttps://string-db.org/network/198804.BUsg_2956-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
glpF protein networkhttps://string-db.org/network/198804.BUsg_296Glycerol uptake facilitator protein; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic mem [...]
tpiA protein networkhttps://string-db.org/network/198804.BUsg_297Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the [...]
himD protein networkhttps://string-db.org/network/198804.BUsg_298Integration host factor beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in tran [...]
rpsA protein networkhttps://string-db.org/network/198804.BUsg_29930S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).
aroA protein networkhttps://string-db.org/network/198804.BUsg_3013-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl [...]
serC protein networkhttps://string-db.org/network/198804.BUsg_302Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belon [...]
serS protein networkhttps://string-db.org/network/198804.BUsg_303seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further [...]
trxB protein networkhttps://string-db.org/network/198804.BUsg_304Thioredoxin reductase.
infA protein networkhttps://string-db.org/network/198804.BUsg_305Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl- [...]
aspS protein networkhttps://string-db.org/network/198804.BUsg_306aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor [...]
znuB protein networkhttps://string-db.org/network/198804.BUsg_307High-affinity zinc uptake system membrane protein; Involved in the high-affinity zinc uptake transport system. Belongs to the ABC-3 integral membrane protein family.
znuC protein networkhttps://string-db.org/network/198804.BUsg_308High-affinity zinc uptake system ATP-binding protein; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the A [...]
znuA protein networkhttps://string-db.org/network/198804.BUsg_309High-affinity zinc uptake system protein ZnuA; Involved in the high-affinity zinc uptake transport system.
yebA protein networkhttps://string-db.org/network/198804.BUsg_310Hypothetical 46.7 kDa protein; Protein in msbB-ruvB; Belongs to the peptidase M23B family.
pykA protein networkhttps://string-db.org/network/198804.BUsg_311Pyruvate kinase; Belongs to the pyruvate kinase family.
zwf protein networkhttps://string-db.org/network/198804.BUsg_312Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
htpX protein networkhttps://string-db.org/network/198804.BUsg_313Probable protease HtpX; Belongs to the peptidase M48B family.
yoaE protein networkhttps://string-db.org/network/198804.BUsg_314Hypothetical 56.5 kDa protein; Protein in sdaA-manX.
yeaZ protein networkhttps://string-db.org/network/198804.BUsg_315Hypothetical 25.2 kDa protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the t [...]
minE protein networkhttps://string-db.org/network/198804.BUsg_316Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures c [...]
minD protein networkhttps://string-db.org/network/198804.BUsg_317Septum site-determining protein MinD; ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blockin [...]
minC protein networkhttps://string-db.org/network/198804.BUsg_318Cell division inhibitor MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have f [...]
yjjT protein networkhttps://string-db.org/network/198804.BUsg_319Hypothetical 37.6 kDa protein; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family.
ompA protein networkhttps://string-db.org/network/198804.BUsg_320Outer membrane protein A precursor; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows [...]
mviN protein networkhttps://string-db.org/network/198804.BUsg_321Virulence factor MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
pyrC protein networkhttps://string-db.org/network/198804.BUsg_322Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
flgN protein networkhttps://string-db.org/network/198804.BUsg_323Flagella synthesis protein FlgN; Required for the efficient initiation of filament assembly. Belongs to the FlgN family.
flgA protein networkhttps://string-db.org/network/198804.BUsg_324Flagella basal body P-ring formation protein; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring ass [...]
flgB protein networkhttps://string-db.org/network/198804.BUsg_325Flagellar basal-body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity).
flgC protein networkhttps://string-db.org/network/198804.BUsg_326Flagellar basal-body rod protein FlgC; Belongs to the flagella basal body rod proteins family.
flgD protein networkhttps://string-db.org/network/198804.BUsg_327Basal-body rod modification protein FlgD; Required for flagellar hook formation. May act as a scaffolding protein (By similarity).
flgE protein networkhttps://string-db.org/network/198804.BUsg_328Flagellar hook protein FlgE.
flgF protein networkhttps://string-db.org/network/198804.BUsg_329Flagellar basal-body rod protein FlgF; Belongs to the flagella basal body rod proteins family.
flgG protein networkhttps://string-db.org/network/198804.BUsg_330Flagellar basal-body rod protein FlgG; Belongs to the flagella basal body rod proteins family.
flgH protein networkhttps://string-db.org/network/198804.BUsg_331Flagellar L-ring protein precursor; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
flgI protein networkhttps://string-db.org/network/198804.BUsg_332Flagellar P-ring protein precursor; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
flgJ protein networkhttps://string-db.org/network/198804.BUsg_333Flagellar protein flgJ.
flgK protein networkhttps://string-db.org/network/198804.BUsg_334Flagellar hook-associated protein 1.
rne protein networkhttps://string-db.org/network/198804.BUsg_335Ribonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation [...]
rluC protein networkhttps://string-db.org/network/198804.BUsg_336Ribosomal large subunit pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA; Belongs to the pseudouridine synthase [...]
rpmF protein networkhttps://string-db.org/network/198804.BUsg_337Ribosomal protein l32; Belongs to the bacterial ribosomal protein bL32 family.
fabD protein networkhttps://string-db.org/network/198804.BUsg_338Malonyl coa-acyl carrier protein transacylase; Belongs to the FabD family.
fabG protein networkhttps://string-db.org/network/198804.BUsg_3393-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cy [...]
acpP protein networkhttps://string-db.org/network/198804.BUsg_340Acyl-carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
tmk protein networkhttps://string-db.org/network/198804.BUsg_341Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
holB protein networkhttps://string-db.org/network/198804.BUsg_342DNA polymerase III delta' subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exo [...]
ycfH protein networkhttps://string-db.org/network/198804.BUsg_343Hypothetical 29.8 kDa protein; Protein in holB-ptsG.
ptsG protein networkhttps://string-db.org/network/198804.BUsg_344Pts system, glucose-specific IIbc component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphoryla [...]
ycfF protein networkhttps://string-db.org/network/198804.BUsg_345Hypothetical 13.2 kDa protein hit-like protein.
ompF protein networkhttps://string-db.org/network/198804.BUsg_347Outer membrane protein F precursor; Forms pores that allow passive diffusion of small molecules across the membrane.
asnS protein networkhttps://string-db.org/network/198804.BUsg_348asparaginyl-tRNA synthetase.
pncB protein networkhttps://string-db.org/network/198804.BUsg_349Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase [...]
pyrD protein networkhttps://string-db.org/network/198804.BUsg_350Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
ycbY protein networkhttps://string-db.org/network/198804.BUsg_351Hypothetical 78.9 kDa protein; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. [...]
uup protein networkhttps://string-db.org/network/198804.BUsg_352ABC transporter ATP-binding protein Uup; Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in [...]
yceA protein networkhttps://string-db.org/network/198804.BUsg_353Hypothetical 40.0 kDa protein; Protein in htrB-dinI; Belongs to the UPF0176 family.
valS protein networkhttps://string-db.org/network/198804.BUsg_354valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors [...]
pepA protein networkhttps://string-db.org/network/198804.BUsg_355Aminopeptidase A/I; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
argF protein networkhttps://string-db.org/network/198804.BUsg_356Ornithine carbamoyltransferase chain F; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; B [...]
pyrB protein networkhttps://string-db.org/network/198804.BUsg_357Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
pyrI protein networkhttps://string-db.org/network/198804.BUsg_358Aspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase.
yhaR protein networkhttps://string-db.org/network/198804.BUsg_359Hypothetical protein; Belongs to the RutC family.
deaD protein networkhttps://string-db.org/network/198804.BUsg_360ATP-dependent RNA helicase DEAD; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.
pnp protein networkhttps://string-db.org/network/198804.BUsg_361Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
rpsO protein networkhttps://string-db.org/network/198804.BUsg_362Ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several [...]
truB protein networkhttps://string-db.org/network/198804.BUsg_363tRNA pseudouridine synthase b; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
rbfA protein networkhttps://string-db.org/network/198804.BUsg_364Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but n [...]
infB protein networkhttps://string-db.org/network/198804.BUsg_365Initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribo [...]
nusA protein networkhttps://string-db.org/network/198804.BUsg_366N utilization substance protein A; Participates in both transcription termination and antitermination.
secG protein networkhttps://string-db.org/network/198804.BUsg_367Protein-export membrane protein SecG; Involved in protein export. Participates in an early event of protein translocation (By similarity).
ftsH protein networkhttps://string-db.org/network/198804.BUsg_369Cell division; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the cent [...]
ftsJ protein networkhttps://string-db.org/network/198804.BUsg_370Cell division protein FtsJ; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
greA protein networkhttps://string-db.org/network/198804.BUsg_371Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trappi [...]
yrbA protein networkhttps://string-db.org/network/198804.BUsg_372Hypothetical protein; Belongs to the BolA/IbaG family.
murA protein networkhttps://string-db.org/network/198804.BUsg_373UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
rplU protein networkhttps://string-db.org/network/198804.BUsg_37450S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
rpmA protein networkhttps://string-db.org/network/198804.BUsg_375Ribosomal protein l27; Belongs to the bacterial ribosomal protein bL27 family.
yhbZ protein networkhttps://string-db.org/network/198804.BUsg_376Hypothetical 43.3 kd GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysi [...]
rpsI protein networkhttps://string-db.org/network/198804.BUsg_37730S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.
rplM protein networkhttps://string-db.org/network/198804.BUsg_37850S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages [...]
pheA protein networkhttps://string-db.org/network/198804.BUsg_379P-protein; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
ffh protein networkhttps://string-db.org/network/198804.BUsg_380Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nasce [...]
rpsP protein networkhttps://string-db.org/network/198804.BUsg_381Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.
rimM protein networkhttps://string-db.org/network/198804.BUsg_38216S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19 [...]
trmD protein networkhttps://string-db.org/network/198804.BUsg_383tRNA (guanine-n1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.
rplS protein networkhttps://string-db.org/network/198804.BUsg_38450S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
tldD protein networkhttps://string-db.org/network/198804.BUsg_385Tldd protein; Probable metalloprotease.
aroD protein networkhttps://string-db.org/network/198804.BUsg_3863-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
fis protein networkhttps://string-db.org/network/198804.BUsg_387Factor-for-inversion stimulation protein; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family [...]
rluD protein networkhttps://string-db.org/network/198804.BUsg_388Ribosomal large subunit pseudouridine synthase d; Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; Belongs to the pseudouridine syntha [...]
yfiO protein networkhttps://string-db.org/network/198804.BUsg_389Hypothetical 27.8 kDa lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
alaS protein networkhttps://string-db.org/network/198804.BUsg_390alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRN [...]
csrA protein networkhttps://string-db.org/network/198804.BUsg_391Carbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid g [...]
gshA protein networkhttps://string-db.org/network/198804.BUsg_392Glutamate--cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
metK protein networkhttps://string-db.org/network/198804.BUsg_393S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet forma [...]
yggJ protein networkhttps://string-db.org/network/198804.BUsg_395Hypothetical 26.9 kDa protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity); [...]
ygfA protein networkhttps://string-db.org/network/198804.BUsg_396Hypothetical 21.1 kDa protein; Protein in ssr-serA; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
rpiA protein networkhttps://string-db.org/network/198804.BUsg_397Ribose 5-phosphate isomerase a; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
glnS protein networkhttps://string-db.org/network/198804.BUsg_398glutaminyl-tRNA synthetase.
pyrG protein networkhttps://string-db.org/network/198804.BUsg_399CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the fo [...]
eno protein networkhttps://string-db.org/network/198804.BUsg_400Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
ygcF protein networkhttps://string-db.org/network/198804.BUsg_401Hypothetical 25.0 kDa protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the [...]
ygcM protein networkhttps://string-db.org/network/198804.BUsg_402Putative 6-pyruvoyl tetrahydrobiopterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
ygbB protein networkhttps://string-db.org/network/198804.BUsg_404Hypothetical 16.9 kDa protein; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes th [...]
ygbP protein networkhttps://string-db.org/network/198804.BUsg_405Hypothetical 25.7 kDa protein; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltra [...]
ygbQ protein networkhttps://string-db.org/network/198804.BUsg_406Hypothetical protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, whic [...]
cysC protein networkhttps://string-db.org/network/198804.BUsg_407Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate.
cysJ protein networkhttps://string-db.org/network/198804.BUsg_413Sulfite reductase [NADPH] flavoprotein alpha; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required [...]
mutS protein networkhttps://string-db.org/network/198804.BUsg_414DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase act [...]
dsbA protein networkhttps://string-db.org/network/198804.BUsg_415Thiol:disulfide interchange protein DsbA precursor; Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins (By similarity).
pol protein networkhttps://string-db.org/network/198804.BUsg_416DNA polymerase I 3'-5' exo domain; 5'-3' exonuclease acting preferentially on double-stranded DNA.
yihA protein networkhttps://string-db.org/network/198804.BUsg_417Hypothetical GTP-binding protein in polA-hemN; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase su [...]
typA protein networkhttps://string-db.org/network/198804.BUsg_418GTP-binding protein typa/bipa; A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP [...]
gmk protein networkhttps://string-db.org/network/198804.BUsg_419Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
ygfZ protein networkhttps://string-db.org/network/198804.BUsg_420Unknown protein from 2d-page (spot pr51); Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory netw [...]
lysS protein networkhttps://string-db.org/network/198804.BUsg_422lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
lysA protein networkhttps://string-db.org/network/198804.BUsg_423Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
thyA protein networkhttps://string-db.org/network/198804.BUsg_425Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate ( [...]
yleA protein networkhttps://string-db.org/network/198804.BUsg_426Hypothetical 53.7 kDa protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at positio [...]
ybeY protein networkhttps://string-db.org/network/198804.BUsg_427Hypothetical 17.5 kDa protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
ybeX protein networkhttps://string-db.org/network/198804.BUsg_428Hypothetical 33.3 kDa protein; Plays a role in the transport of magnesium and cobalt ions.
leuS protein networkhttps://string-db.org/network/198804.BUsg_429leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
holA protein networkhttps://string-db.org/network/198804.BUsg_430DNA polymerase III delta subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exon [...]
ybeN protein networkhttps://string-db.org/network/198804.BUsg_431Hypothetical 24.5 kDa protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
yhhP protein networkhttps://string-db.org/network/198804.BUsg_432Hypothetical protein; Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified [...]
asd protein networkhttps://string-db.org/network/198804.BUsg_433Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the as [...]
yhgN protein networkhttps://string-db.org/network/198804.BUsg_434Hypothetical 21.5 kDa protein; Protein in asd-gntU.
pgk protein networkhttps://string-db.org/network/198804.BUsg_435Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
fba protein networkhttps://string-db.org/network/198804.BUsg_436Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphat [...]
yggB protein networkhttps://string-db.org/network/198804.BUsg_437Hypothetical 30.9 kDa protein; Protein in sbm-fba.
recC protein networkhttps://string-db.org/network/198804.BUsg_438Exodeoxyribonuclease V 125 kD polypeptide; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP [...]
recB protein networkhttps://string-db.org/network/198804.BUsg_439Exodeoxyribonuclease V 135 kD polypeptide; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP [...]
recD protein networkhttps://string-db.org/network/198804.BUsg_440Exodeoxyribonuclease V 67 kD polypeptide; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP- [...]
argA protein networkhttps://string-db.org/network/198804.BUsg_441Amino-acid acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily.
mltA protein networkhttps://string-db.org/network/198804.BUsg_442Membrane-bound lytic murein transglycosylase; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity).
ribH protein networkhttps://string-db.org/network/198804.BUsg_4436,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. [...]
thiL protein networkhttps://string-db.org/network/198804.BUsg_444Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thi [...]
ribD1 protein networkhttps://string-db.org/network/198804.BUsg_445Riboflavin biosynthesis protein RibD.
ribD2 protein networkhttps://string-db.org/network/198804.BUsg_446Riboflavin biosynthesis protein RibD; Belongs to the HTP reductase family.
nusB protein networkhttps://string-db.org/network/198804.BUsg_447N utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of t [...]
dxs protein networkhttps://string-db.org/network/198804.BUsg_4481-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP) [...]
ispA protein networkhttps://string-db.org/network/198804.BUsg_449Geranyltranstransferase.
yajR protein networkhttps://string-db.org/network/198804.BUsg_450Hypothetical 49.0 kDa protein; Protein in abpA-cyoE.
yccK protein networkhttps://string-db.org/network/198804.BUsg_451Hypothetical 12.4 kDa protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD [...]
cyoE protein networkhttps://string-db.org/network/198804.BUsg_452Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
cyoD protein networkhttps://string-db.org/network/198804.BUsg_453Cytochrome o ubiquinol oxidase D; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. [...]
cyoC protein networkhttps://string-db.org/network/198804.BUsg_454Cytochrome o ubiquinol oxidase C; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. [...]
cyoB protein networkhttps://string-db.org/network/198804.BUsg_455Cytochrome o ubiquinol oxidase B; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. [...]
cyoA protein networkhttps://string-db.org/network/198804.BUsg_456Cytochrome o ubiquinol oxidase A; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. [...]
bolA protein networkhttps://string-db.org/network/198804.BUsg_457Bola protein; Belongs to the BolA/IbaG family.
tig protein networkhttps://string-db.org/network/198804.BUsg_458Trigger factor (TF); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belo [...]
clpP protein networkhttps://string-db.org/network/198804.BUsg_459ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degrada [...]
clpX protein networkhttps://string-db.org/network/198804.BUsg_460ATP-dependent Clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the abs [...]
lon protein networkhttps://string-db.org/network/198804.BUsg_461ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for [...]
ppiD protein networkhttps://string-db.org/network/198804.BUsg_462Peptidyl-prolyl cis-trans isomerase D; PPIases accelerate the folding of proteins.
ybaX protein networkhttps://string-db.org/network/198804.BUsg_463Hypothetical 25.5 kDa protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
mdlA protein networkhttps://string-db.org/network/198804.BUsg_464Multidrug resistance-like ATP-binding protein; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family.
mdlB protein networkhttps://string-db.org/network/198804.BUsg_465Multidrug resistance-like ATP-binding protein; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family.
dnaX protein networkhttps://string-db.org/network/198804.BUsg_466DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuc [...]
ybaB protein networkhttps://string-db.org/network/198804.BUsg_467Hypothetical 12.0 kDa protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
htpG protein networkhttps://string-db.org/network/198804.BUsg_468Heat shock protein HtpG; Molecular chaperone. Has ATPase activity.
adk protein networkhttps://string-db.org/network/198804.BUsg_469Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolis [...]
folD protein networkhttps://string-db.org/network/198804.BUsg_470FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahy [...]
cysS protein networkhttps://string-db.org/network/198804.BUsg_471cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
ybeD protein networkhttps://string-db.org/network/198804.BUsg_472Hypothetical protein; Belongs to the UPF0250 family.
cspE protein networkhttps://string-db.org/network/198804.BUsg_473Cold shock like protein CspE.
aroE protein networkhttps://string-db.org/network/198804.BUsg_474Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshi [...]
yrdC protein networkhttps://string-db.org/network/198804.BUsg_475Hypothetical 20.8 kDa protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conver [...]
smg protein networkhttps://string-db.org/network/198804.BUsg_476Smg; Belongs to the Smg family.
def protein networkhttps://string-db.org/network/198804.BUsg_477Polypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine i [...]
fmt protein networkhttps://string-db.org/network/198804.BUsg_478methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethi [...]
rplQ protein networkhttps://string-db.org/network/198804.BUsg_47950S ribosomal protein L17.
rpoA protein networkhttps://string-db.org/network/198804.BUsg_480DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
rpsD protein networkhttps://string-db.org/network/198804.BUsg_48130S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
rpsK protein networkhttps://string-db.org/network/198804.BUsg_48230S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belon [...]
rpsM protein networkhttps://string-db.org/network/198804.BUsg_48330S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 [...]
rpmJ protein networkhttps://string-db.org/network/198804.BUsg_48450S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.
secY protein networkhttps://string-db.org/network/198804.BUsg_485Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at t [...]
rplO protein networkhttps://string-db.org/network/198804.BUsg_48650S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
rpmD protein networkhttps://string-db.org/network/198804.BUsg_48750S ribosomal protein L30.
rpsE protein networkhttps://string-db.org/network/198804.BUsg_48830S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family.
rplR protein networkhttps://string-db.org/network/198804.BUsg_48950S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protubera [...]
rplF protein networkhttps://string-db.org/network/198804.BUsg_49050S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the t [...]
rpsH protein networkhttps://string-db.org/network/198804.BUsg_49130S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to [...]
rpsN protein networkhttps://string-db.org/network/198804.BUsg_49230S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the un [...]
rplE protein networkhttps://string-db.org/network/198804.BUsg_49350S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance [...]
rplX protein networkhttps://string-db.org/network/198804.BUsg_49450S ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
rplN protein networkhttps://string-db.org/network/198804.BUsg_49550S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
rpsQ protein networkhttps://string-db.org/network/198804.BUsg_49630S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
rpmC protein networkhttps://string-db.org/network/198804.BUsg_49750S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family.
rplP protein networkhttps://string-db.org/network/198804.BUsg_49850S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.
rpsC protein networkhttps://string-db.org/network/198804.BUsg_49930S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.
rplV protein networkhttps://string-db.org/network/198804.BUsg_50050S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50 [...]
rpsS protein networkhttps://string-db.org/network/198804.BUsg_50130S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
rplB protein networkhttps://string-db.org/network/198804.BUsg_50250S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It [...]
rplW protein networkhttps://string-db.org/network/198804.BUsg_50350S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main dock [...]
rplD protein networkhttps://string-db.org/network/198804.BUsg_50450S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes [...]
rplC protein networkhttps://string-db.org/network/198804.BUsg_50550S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
rpsJ protein networkhttps://string-db.org/network/198804.BUsg_50630S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.
tufB protein networkhttps://string-db.org/network/198804.BUsg_507Elongation factor Tu (EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
fusA protein networkhttps://string-db.org/network/198804.BUsg_508Elongation factor g (ef-g); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to th [...]
rpsG protein networkhttps://string-db.org/network/198804.BUsg_50930S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit inte [...]
rpsL protein networkhttps://string-db.org/network/198804.BUsg_51030S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy.
yheL protein networkhttps://string-db.org/network/198804.BUsg_511Hypothetical protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
yheM protein networkhttps://string-db.org/network/198804.BUsg_512Hypothetical 13.0 kDa protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
yheN protein networkhttps://string-db.org/network/198804.BUsg_513Hypothetical 13.6 kDa protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and t [...]
fkpA protein networkhttps://string-db.org/network/198804.BUsg_514FKBP-type peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to th [...]
argD protein networkhttps://string-db.org/network/198804.BUsg_515Acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
yhfC protein networkhttps://string-db.org/network/198804.BUsg_516Hypothetical 43.2 kDa protein; Protein in ppiA-nirB.
trpS protein networkhttps://string-db.org/network/198804.BUsg_517tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.
rpe protein networkhttps://string-db.org/network/198804.BUsg_518Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family.
aroB protein networkhttps://string-db.org/network/198804.BUsg_5193-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquin [...]
aroK protein networkhttps://string-db.org/network/198804.BUsg_520Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
deoD protein networkhttps://string-db.org/network/198804.BUsg_521Purine nucleoside phosphorylase.
deoB protein networkhttps://string-db.org/network/198804.BUsg_522Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.
prfC protein networkhttps://string-db.org/network/198804.BUsg_523Peptide chain release factor 3 (RF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preferenc [...]
yhgI protein networkhttps://string-db.org/network/198804.BUsg_525Hypothetical 21.0 kDa protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S prote [...]
ssb protein networkhttps://string-db.org/network/198804.BUsg_527Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action du [...]
dnaB protein networkhttps://string-db.org/network/198804.BUsg_528Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DN [...]
gshB protein networkhttps://string-db.org/network/198804.BUsg_529Glutathione synthetase.
yqgF protein networkhttps://string-db.org/network/198804.BUsg_530Hypothetical 15.2 kDa protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.
yggS protein networkhttps://string-db.org/network/198804.BUsg_531Hypothetical 25.8 kDa protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
yggW protein networkhttps://string-db.org/network/198804.BUsg_532Hypothetical 42.6 kDa protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently (By similarity). Binds 1 [4 [...]
yggH protein networkhttps://string-db.org/network/198804.BUsg_533Hypothetical 27.3 kDa protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
mutY protein networkhttps://string-db.org/network/198804.BUsg_534A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine [...]
yggX protein networkhttps://string-db.org/network/198804.BUsg_535Hypothetical protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Bel [...]
murI protein networkhttps://string-db.org/network/198804.BUsg_536Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
sbcB protein networkhttps://string-db.org/network/198804.BUsg_537Exodeoxyribonuclease I; Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties followi [...]
yeeX protein networkhttps://string-db.org/network/198804.BUsg_538Hypothetical 12.8 kDa protein; Protein in flu-sbmC; Belongs to the UPF0265 family.
dut protein networkhttps://string-db.org/network/198804.BUsg_540Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intrace [...]
rplI protein networkhttps://string-db.org/network/198804.BUsg_54250S ribosomal protein L9; Binds to the 23S rRNA.
rpsR protein networkhttps://string-db.org/network/198804.BUsg_54330S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosom [...]
rpsF protein networkhttps://string-db.org/network/198804.BUsg_54430S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.
rnr protein networkhttps://string-db.org/network/198804.BUsg_545Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily.
purA protein networkhttps://string-db.org/network/198804.BUsg_546Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to t [...]
hflC protein networkhttps://string-db.org/network/198804.BUsg_547HflC; HflC and HflK could regulate a protease.
hflK protein networkhttps://string-db.org/network/198804.BUsg_548HflK; HflC and HflK could encode or regulate a protease.
mutL protein networkhttps://string-db.org/network/198804.BUsg_550DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchm [...]
mtlD protein networkhttps://string-db.org/network/198804.BUsg_551Mannitol-1-phosphate 5-dehydrogenase.
mtlA protein networkhttps://string-db.org/network/198804.BUsg_552Pts system, mannitol-specific IIabc component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphory [...]
pgi protein networkhttps://string-db.org/network/198804.BUsg_553Glucose-6-phosphate isomerase.
orn protein networkhttps://string-db.org/network/198804.BUsg_554Hypothetical oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family.
amiB protein networkhttps://string-db.org/network/198804.BUsg_555N-acetylmuramoyl-L-alanine amidase AmiB; Cell-wall hydrolase involved in septum cleavage during cell division.
rpmE protein networkhttps://string-db.org/network/198804.BUsg_55650S ribosomal protein L31; Binds the 23S rRNA.
hslV protein networkhttps://string-db.org/network/198804.BUsg_557Heat shock protein HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
hslU protein networkhttps://string-db.org/network/198804.BUsg_558Heat shock protein HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for u [...]
ibp protein networkhttps://string-db.org/network/198804.BUsg_559Heat inducible protein Ibp; Belongs to the small heat shock protein (HSP20) family.
fpr protein networkhttps://string-db.org/network/198804.BUsg_560Ferridoxin NADP reductase; Transports electrons between flavodoxin or ferredoxin and NADPH.
kdtB protein networkhttps://string-db.org/network/198804.BUsg_562Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD [...]
yba4 protein networkhttps://string-db.org/network/198804.BUsg_564Hypothetical protein; To Buchnera BU585.
yhiQ protein networkhttps://string-db.org/network/198804.BUsg_565Hypothetical 26.9 kDa protein; Specifically methylates the guanosine in position 1516 of 16S rRNA.
pitA protein networkhttps://string-db.org/network/198804.BUsg_566Low-affinity inorganic phosphate transporter 1; Low-affinity inorganic phosphate transport; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily.
ynfM protein networkhttps://string-db.org/network/198804.BUsg_567Hypothetical 45.3 kDa protein; Protein in mlc-asr.
dapF protein networkhttps://string-db.org/network/198804.BUsg_568Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of t [...]
cyaY protein networkhttps://string-db.org/network/198804.BUsg_569CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
rho protein networkhttps://string-db.org/network/198804.BUsg_572Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and re [...]
trxA protein networkhttps://string-db.org/network/198804.BUsg_573Thioredoxin (trx); Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
rep protein networkhttps://string-db.org/network/198804.BUsg_574ATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded [...]
ilvC protein networkhttps://string-db.org/network/198804.BUsg_575Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yie [...]
ilvD protein networkhttps://string-db.org/network/198804.BUsg_576Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
nifS protein networkhttps://string-db.org/network/198804.BUsg_577NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms fro [...]
nifU protein networkhttps://string-db.org/network/198804.BUsg_578NifU; A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this compl [...]
hscB protein networkhttps://string-db.org/network/198804.BUsg_579Chaperone protein HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity); Belongs to t [...]
hscA protein networkhttps://string-db.org/network/198804.BUsg_580Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the [...]
fdx protein networkhttps://string-db.org/network/198804.BUsg_581Ferredoxin, 2Fe-2S; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.
engA protein networkhttps://string-db.org/network/198804.BUsg_582Probable GPT-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Eng [...]
yfgM protein networkhttps://string-db.org/network/198804.BUsg_583Hypothetical 22.2 kDa protein; Protein in xseA-hisS.