| Q0010 protein network | https://string-db.org/network/4932.Q0010 | Putative uncharacterized protein Q0010, mitochondrial; Dubious open reading frame; unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| Q0017 protein network | https://string-db.org/network/4932.Q0017 | Putative uncharacterized protein Q0017, mitochondrial; Dubious open reading frame; unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| Q0032 protein network | https://string-db.org/network/4932.Q0032 | Putative uncharacterized protein Q0032, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| COX1 protein network | https://string-db.org/network/4932.Q0045 | Subunit I of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; Belo [...] |
| AI1 protein network | https://string-db.org/network/4932.Q0050 | Putative COX1/OXI3 intron 1 protein; Reverse transcriptase required for splicing of the COX1 pre-mRNA; encoded by a mobile group II intron within the mitochondrial COX1 gene. |
| AI2 protein network | https://string-db.org/network/4932.Q0055 | Putative COX1/OXI3 intron 2 protein; Reverse transcriptase required for splicing of the COX1 pre-mRNA; encoded by a mobile group II intron within the mitochondrial COX1 gene. |
| AI3 protein network | https://string-db.org/network/4932.Q0060 | Truncated non-functional cytochrome oxidase 1; Endonuclease I-SceIII; encoded by a mobile group I intron within the mitochondrial COX1 gene. |
| AI4 protein network | https://string-db.org/network/4932.Q0065 | Truncated non-functional cytochrome oxidase 1; Endonuclease I-SceII; encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4 [...] |
| AI5_ALPHA protein network | https://string-db.org/network/4932.Q0070 | Truncated non-functional cytochrome oxidase 1; Endonuclease I-SceIV; involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene; In the N-terminal section; [...] |
| AI5_BETA protein network | https://string-db.org/network/4932.Q0075 | Intron-encoded DNA endonuclease aI5 beta; Protein of unknown function; encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than A [...] |
| ATP8 protein network | https://string-db.org/network/4932.Q0080 | ATP synthase protein 8; Subunit 8 of the F0 sector of mitochondrial F1F0 ATP synthase; encoded on the mitochondrial genome; ATP8 and ATP6 mRNAs are not translated in the absence of the F1 sector [...] |
| ATP6 protein network | https://string-db.org/network/4932.Q0085 | Subunit a of the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrially encoded; translation is specifically activated by Atp22p; ATP6 and ATP8 mRNAs are not translated in the absence of t [...] |
| Q0092 protein network | https://string-db.org/network/4932.Q0092 | Putative uncharacterized protein Q0092, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| COB protein network | https://string-db.org/network/4932.Q0105 | Cytochrome b; mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p. |
| BI2 protein network | https://string-db.org/network/4932.Q0110 | Cytochrome b mRNA maturase bI2; Mitochondrial mRNA maturase with a role in splicing; encoded by both exon and intron sequences of partially processed COB mRNA; In the N-terminal section; belongs [...] |
| BI3 protein network | https://string-db.org/network/4932.Q0115 | Cytochrome b mRNA maturase bI3; Mitochondrial mRNA maturase; forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partial [...] |
| BI4 protein network | https://string-db.org/network/4932.Q0120 | Truncated, nonfunctional cytochrome b; Mitochondrial mRNA maturase; forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of [...] |
| OLI1 protein network | https://string-db.org/network/4932.Q0130 | F0-ATP synthase subunit c (ATPase-associated proteolipid); encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes A [...] |
| VAR1 protein network | https://string-db.org/network/4932.Q0140 | Mitochondrial ribosomal protein of the small subunit; mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochon [...] |
| Q0142 protein network | https://string-db.org/network/4932.Q0142 | Putative uncharacterized protein Q0142, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partiall [...] |
| Q0143 protein network | https://string-db.org/network/4932.Q0143 | Putative uncharacterized protein Q0143, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| Q0144 protein network | https://string-db.org/network/4932.Q0144 | Putative uncharacterized protein Q0144, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| SCEI protein network | https://string-db.org/network/4932.Q0160 | I-SceI DNA endonuclease; encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene. |
| Q0182 protein network | https://string-db.org/network/4932.Q0182 | Putative uncharacterized protein Q0182, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| COX2 protein network | https://string-db.org/network/4932.Q0250 | Subunit II of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits. |
| Q0255 protein network | https://string-db.org/network/4932.Q0255 | Uncharacterized mitochondrial protein RF1; Maturase-like protein. |
| COX3 protein network | https://string-db.org/network/4932.Q0275 | Subunit III of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits. |
| Q0297 protein network | https://string-db.org/network/4932.Q0297 | Putative uncharacterized protein Q0297, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partiall [...] |
| TFC3 protein network | https://string-db.org/network/4932.YAL001C | Subunit of RNA polymerase III transcription initiation factor complex; part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p [...] |
| VPS8 protein network | https://string-db.org/network/4932.YAL002W | Vacuolar protein sorting-associated protein 8; Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pa [...] |
| EFB1 protein network | https://string-db.org/network/4932.YAL003W | Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-t [...] |
| YAL004W protein network | https://string-db.org/network/4932.YAL004W | Putative uncharacterized protein YAL004W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps v [...] |
| SSA1 protein network | https://string-db.org/network/4932.YAL005C | Heat shock protein SSA1; ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; required for ubiquitin-dependent degradation of short-lived proteins; forms [...] |
| ERP2 protein network | https://string-db.org/network/4932.YAL007C | Protein ERP2; Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1p, Emp24 [...] |
| FUN14 protein network | https://string-db.org/network/4932.YAL008W | Protein FUN14; Integral mitochondrial outer membrane (MOM) protein; dosage suppressor of an MDM10 null that reduces ERMES-related phenotypes, such as alterations in mitochondrial morphology, prot [...] |
| SPO7 protein network | https://string-db.org/network/4932.YAL009W | Sporulation-specific protein SPO7; Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclea [...] |
| MDM10 protein network | https://string-db.org/network/4932.YAL010C | Mitochondrial distribution and morphology protein 10; Subunit of both the ERMES and the SAM complex; component of ERMES complex which acts as a molecular tether between the mitochondria and the E [...] |
| SWC3 protein network | https://string-db.org/network/4932.YAL011W | SWR1-complex protein 3; Protein of unknown function; component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear [...] |
| CYS3 protein network | https://string-db.org/network/4932.YAL012W | Cystathionine gamma-lyase; catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; pro [...] |
| DEP1 protein network | https://string-db.org/network/4932.YAL013W | Transcriptional regulatory protein DEP1; Component of the Rpd3L histone deacetylase complex; required for diauxic shift-induced histone H2B deposition onto rDNA genes; transcriptional modulator i [...] |
| SYN8 protein network | https://string-db.org/network/4932.YAL014C | Syntaxin-8; Endosomal SNARE related to mammalian syntaxin 8; Belongs to the syntaxin family. |
| NTG1 protein network | https://string-db.org/network/4932.YAL015C | Endonuclease III homolog 1; DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDN [...] |
| YAL016C-A protein network | https://string-db.org/network/4932.YAL016C-A | Putative uncharacterized membrane protein YAL016C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially [...] |
| YAL016C-B protein network | https://string-db.org/network/4932.YAL016C-B | Putative uncharacterized protein YAL016C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| TPD3 protein network | https://string-db.org/network/4932.YAL016W | Regulatory subunit A of the heterotrimeric PP2A complex; the heterotrimeric protein phosphatase 2A (PP2A) complex also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pp [...] |
| PSK1 protein network | https://string-db.org/network/4932.YAL017W | Serine/threonine-protein kinase PSK1; PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unkn [...] |
| LDS1 protein network | https://string-db.org/network/4932.YAL018C | Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds2p and Rrt8p, and a strain mutant for all 3 genes exhi [...] |
| FUN30 protein network | https://string-db.org/network/4932.YAL019W | ATP-dependent helicase FUN30; Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centro [...] |
| ATS1 protein network | https://string-db.org/network/4932.YAL020C | Protein required for modification of wobble nucleosides in tRNA; acts with Elongator complex, Kti11p, and Kti12p; has a potential role in regulatory interactions between microtubules and the cell [...] |
| CCR4 protein network | https://string-db.org/network/4932.YAL021C | Glucose-repressible alcohol dehydrogenase transcriptional effector; Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the majo [...] |
| FUN26 protein network | https://string-db.org/network/4932.YAL022C | Nucleoside transporter FUN26; High affinity, broad selectivity, nucleoside/nucleobase transporter; vacuolar membrane localized transporter which may regulate the balance of nicotinamide riboside [...] |
| PMT2 protein network | https://string-db.org/network/4932.YAL023C | Dolichyl-phosphate-mannose--protein mannosyltransferase 2; Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threoni [...] |
| LTE1 protein network | https://string-db.org/network/4932.YAL024C | Guanine nucleotide exchange factor LTE1; Protein similar to GDP/GTP exchange factors; without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle p [...] |
| MAK16 protein network | https://string-db.org/network/4932.YAL025C | Essential nuclear protein; constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus [...] |
| DRS2 protein network | https://string-db.org/network/4932.YAL026C | Probable phospholipid-transporting ATPase DRS2; Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to c [...] |
| SAW1 protein network | https://string-db.org/network/4932.YAL027W | 5'- and 3'-flap DNA binding protein; recruits Rad1p-Rad10p to single-strand annealing intermediates with 3' non-homologous tails for removal during double-strand break repair; complexes with Rad1 [...] |
| FRT2 protein network | https://string-db.org/network/4932.YAL028W | Protein HPH2; Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role [...] |
| MYO4 protein network | https://string-db.org/network/4932.YAL029C | Myosin-4; Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growin [...] |
| SNC1 protein network | https://string-db.org/network/4932.YAL030W | Synaptobrevin homolog 1; Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocyto [...] |
| GIP4 protein network | https://string-db.org/network/4932.YAL031C | GLC7-interacting protein 4; Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; protein overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potentia [...] |
| PRP45 protein network | https://string-db.org/network/4932.YAL032C | Pre-mRNA-processing protein 45; Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional [...] |
| POP5 protein network | https://string-db.org/network/4932.YAL033W | Ribonuclease P/MRP protein subunit POP5; Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and fa [...] |
| FUN19 protein network | https://string-db.org/network/4932.YAL034C | SWIRM domain-containing protein FUN19; Non-essential protein of unknown function; expression induced in response to heat stress; FUN19 has a paralog, YOR338W, that arose from the whole genome dup [...] |
| MTW1 protein network | https://string-db.org/network/4932.YAL034W-A | Kinetochore-associated protein MTW1; Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assem [...] |
| FUN12 protein network | https://string-db.org/network/4932.YAL035W | Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundanc [...] |
| RBG1 protein network | https://string-db.org/network/4932.YAL036C | Ribosome-interacting GTPase 1; Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid; Belongs to [...] |
| YAL037C-A protein network | https://string-db.org/network/4932.YAL037C-A | Putative protein of unknown function. |
| CDC19 protein network | https://string-db.org/network/4932.YAL038W | Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated [...] |
| CYC3 protein network | https://string-db.org/network/4932.YAL039C | Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in mitochondrial intermembrane space; human homolog HCCS implicated in microphthalmia with [...] |
| CLN3 protein network | https://string-db.org/network/4932.YAL040C | G1/S-specific cyclin CLN3; G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, [...] |
| CDC24 protein network | https://string-db.org/network/4932.YAL041W | Cell division control protein 24; Guanine nucleotide exchange factor (GEF) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation [...] |
| ERV46 protein network | https://string-db.org/network/4932.YAL042W | Protein localized to COPII-coated vesicles; forms a complex with Erv41p; involved in the membrane fusion stage of transport; Belongs to the ERGIC family. |
| PTA1 protein network | https://string-db.org/network/4932.YAL043C | Pre-tRNA-processing protein PTA1; Subunit of holo-CPF; holo-CPF is a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRN [...] |
| GCV3 protein network | https://string-db.org/network/4932.YAL044C | H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; exp [...] |
| BOL1 protein network | https://string-db.org/network/4932.YAL044W-A | BolA-like protein 1; Mitochondrial matrix protein involved in Fe-S cluster biogenesis; facilitates [4Fe-2S] cluster inception into mitochondrial proteins such as lipoate synthase and succinate de [...] |
| BOL3 protein network | https://string-db.org/network/4932.YAL046C | BolA-like protein 3; Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress by acting along with Nfu1p at a late step i [...] |
| SPC72 protein network | https://string-db.org/network/4932.YAL047C | Spindle pole component SPC72; Gamma-tubulin small complex (gamma-TuSC) receptor; recruits the gamma-TuSC complex to the cytoplasmic side of the SPB, connecting nuclear microtubules to the SPB; in [...] |
| GEM1 protein network | https://string-db.org/network/4932.YAL048C | Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and [...] |
| AIM2 protein network | https://string-db.org/network/4932.YAL049C | Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor; Belongs to the AIM2 famil [...] |
| OAF1 protein network | https://string-db.org/network/4932.YAL051W | Oleate-activated transcription factor; subunit of a heterodimeric complex with Pip2p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty ac [...] |
| FLC2 protein network | https://string-db.org/network/4932.YAL053W | Flavin carrier protein 2; Putative calcium channel involved in calcium release under hypotonic stress; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FL [...] |
| ACS1 protein network | https://string-db.org/network/4932.YAL054C | Acetyl-coA synthetase isoform; along with Acs2p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon source [...] |
| PEX22 protein network | https://string-db.org/network/4932.YAL055W | Peroxisome assembly protein 22; Putative peroxisomal membrane protein; required for import of peroxisomal proteins; functionally complements a Pichia pastoris pex22 mutation; Belongs to the perox [...] |
| YAL056C-A protein network | https://string-db.org/network/4932.YAL056C-A | Putative uncharacterized protein YAL056C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| GPB2 protein network | https://string-db.org/network/4932.YAL056W | Guanine nucleotide-binding protein subunit beta 2; Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity [...] |
| CNE1 protein network | https://string-db.org/network/4932.YAL058W | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian [...] |
| YAL059C-A protein network | https://string-db.org/network/4932.YAL059C-A | Putative uncharacterized membrane protein YAL059C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially [...] |
| ECM1 protein network | https://string-db.org/network/4932.YAL059W | Shuttling pre-60S factor ECM1; Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm; Belongs to [...] |
| BDH1 protein network | https://string-db.org/network/4932.YAL060W | NAD-dependent (R,R)-butanediol dehydrogenase; catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of [...] |
| BDH2 protein network | https://string-db.org/network/4932.YAL061W | Probable diacetyl reductase [(R)-acetoin forming] 2; Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; Belongs to [...] |
| GDH3 protein network | https://string-db.org/network/4932.YAL062W | NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen [...] |
| FLO9 protein network | https://string-db.org/network/4932.YAL063C | Flocculation protein FLO9; Lectin-like protein with similarity to Flo1p; thought to be expressed and involved in flocculation; Belongs to the flocculin family. |
| TDA8 protein network | https://string-db.org/network/4932.YAL064C-A | Topoisomerase I damage affected protein 8; Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene. |
| YAL064W-B protein network | https://string-db.org/network/4932.YAL064W-B | Uncharacterized membrane protein YAL064W-B; Fungal-specific protein of unknown function. |
| YAL065C protein network | https://string-db.org/network/4932.YAL065C | Uncharacterized protein YAL065C; Putative protein of unknown function; shows sequence similarity to FLO1 and other flocculins. |
| YAL066W protein network | https://string-db.org/network/4932.YAL066W | Putative uncharacterized protein YAL066W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| SEO1 protein network | https://string-db.org/network/4932.YAL067C | Probable transporter SEO1; Putative permease; member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide. |
| PAU8 protein network | https://string-db.org/network/4932.YAL068C | Seripauperin-11; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; Belongs to the SRP1/TIP1 family. Seripauperin subfamily. |
| YAL068W-A protein network | https://string-db.org/network/4932.YAL068W-A | Putative UPF0320 protein YAL068W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping [...] |
| YAL069W protein network | https://string-db.org/network/4932.YAL069W | Putative uncharacterized protein YAL069W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| ERP1 protein network | https://string-db.org/network/4932.YAR002C-A | Protein ERP1; Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPI [...] |
| NUP60 protein network | https://string-db.org/network/4932.YAR002W | FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier an [...] |
| SWD1 protein network | https://string-db.org/network/4932.YAR003W | COMPASS component SWD1; Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfam [...] |
| RFA1 protein network | https://string-db.org/network/4932.YAR007C | Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against i [...] |
| SEN34 protein network | https://string-db.org/network/4932.YAR008W | Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial s [...] |
| BUD14 protein network | https://string-db.org/network/4932.YAR014C | Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; forms a complex with Kel1p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, [...] |
| ADE1 protein network | https://string-db.org/network/4932.YAR015W | Phosphoribosylaminoimidazole-succinocarboxamide synthase; N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumul [...] |
| KIN3 protein network | https://string-db.org/network/4932.YAR018C | Serine/threonine-protein kinase KIN3; Nonessential serine/threonine protein kinase; possible role in DNA damage response; influences tolerance to high levels of ethanol. |
| CDC15 protein network | https://string-db.org/network/4932.YAR019C | Cell division control protein 15; Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase acti [...] |
| PAU7 protein network | https://string-db.org/network/4932.YAR020C | Seripauperin-7; Member of the seripauperin multigene family; active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme; Belongs to the SRP1/TIP1 fami [...] |
| YAR023C protein network | https://string-db.org/network/4932.YAR023C | Putative integral membrane protein; member of DUP240 gene family; Belongs to the DUP/COS family. |
| UIP3 protein network | https://string-db.org/network/4932.YAR027W | ULP1-interacting protein 3; Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family; Belongs to the DUP/COS family. |
| YAR028W protein network | https://string-db.org/network/4932.YAR028W | DUP240 protein YAR028W; Putative integral membrane protein; member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS. |
| YAR029W protein network | https://string-db.org/network/4932.YAR029W | DUP240 protein YAR029W; Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; Belong [...] |
| YAR030C protein network | https://string-db.org/network/4932.YAR030C | Putative uncharacterized protein YAR030C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| PRM9 protein network | https://string-db.org/network/4932.YAR031W | Pheromone-regulated protein; contains 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family; PRM9 has a paralog, PRM8, that arose [...] |
| MST28 protein network | https://string-db.org/network/4932.YAR033W | Multicopy suppressor of SEC21 protein 28; Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles [...] |
| YAR035C-A protein network | https://string-db.org/network/4932.YAR035C-A | Uncharacterized protein YAR035C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a [...] |
| YAT1 protein network | https://string-db.org/network/4932.YAR035W | Outer mitochondrial carnitine acetyltransferase; minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated. |
| SWH1 protein network | https://string-db.org/network/4932.YAR042W | Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats and FFAT motif; interacts with ER anchor Scs2p at the nucleus-vacuole junction; regulated by sterol binding; SWH1 [...] |
| YAR047C protein network | https://string-db.org/network/4932.YAR047C | Putative uncharacterized membrane protein YAR047C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| FLO1 protein network | https://string-db.org/network/4932.YAR050W | Lectin-like protein involved in flocculation; cell wall protein that binds mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resis [...] |
| YAR053W protein network | https://string-db.org/network/4932.YAR053W | Putative uncharacterized protein YA5053W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YAR060C protein network | https://string-db.org/network/4932.YAR060C | Putative uncharacterized protein YAR060C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YAR060C has a paralog [...] |
| YAR064W protein network | https://string-db.org/network/4932.YAR064W | Uncharacterized protein YAR064W; Pseudogenic fragment with similarity to flocculins; YAR064W has a paralog, YHR213W-B, that arose from a segmental duplication. |
| YAR066W protein network | https://string-db.org/network/4932.YAR066W | Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YAR066W has a paralog, YHR214W, that arose from a segmental duplication. |
| YAR068W protein network | https://string-db.org/network/4932.YAR068W | Uncharacterized protein YAR068W; Fungal-specific protein of unknown function; induced in respiratory-deficient cells; YAR068W has a paralog, YHR214W-A, that arose from a segmental duplication. |
| YAR069C protein network | https://string-db.org/network/4932.YAR069C | Putative uncharacterized protein YAR069C; Dubious open reading frame; unlikely to encode a protein, based on available experimental and comparative sequence data; YAR069C has a paralog, YHR214C-D [...] |
| YAR070C protein network | https://string-db.org/network/4932.YAR070C | Putative uncharacterized protein YAR070C; Dubious open reading frame; unlikely to encode a protein, based on available experimental and comparative sequence data; YAR070C has a paralog, YHR214C-B [...] |
| PHO11 protein network | https://string-db.org/network/4932.YAR071W | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and P [...] |
| IMD1 protein network | https://string-db.org/network/4932.YAR073W | Putative inosine-5'-monophosphate dehydrogenase 1; Nonfunctional protein with homology to IMP dehydrogenase; blocked reading frame, located close to the telomere; not expressed at detectable leve [...] |
| YAR075W protein network | https://string-db.org/network/4932.YAR075W | Putative inosine-5'-monophosphate dehydrogenase-like protein YAR075W; Non-functional protein with homology IMP dehydrogenase; YAR073W/IMD1 and YAR075W comprise a continuous reading frame in most [...] |
| ECM15 protein network | https://string-db.org/network/4932.YBL001C | UPF0045 protein ECM15; Non-essential protein of unknown function; likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in [...] |
| HTB2 protein network | https://string-db.org/network/4932.YBL002W | Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA repli [...] |
| HTA2 protein network | https://string-db.org/network/4932.YBL003C | Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p faci [...] |
| UTP20 protein network | https://string-db.org/network/4932.YBL004W | U3 small nucleolar RNA-associated protein 20; Component of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA; Belongs to the UTP20 family. |
| PDR3 protein network | https://string-db.org/network/4932.YBL005W | Transcription factor PDR3; Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting PDRE [...] |
| LDB7 protein network | https://string-db.org/network/4932.YBL006C | Chromatin structure-remodeling complex protein RSC14; Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad rang [...] |
| YBL006W-A protein network | https://string-db.org/network/4932.YBL006W-A | Putative uncharacterized protein YBL006W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| SLA1 protein network | https://string-db.org/network/4932.YBL007C | Actin cytoskeleton-regulatory complex protein SLA1; Cytoskeletal protein binding protein; required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynami [...] |
| HIR1 protein network | https://string-db.org/network/4932.YBL008W | Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene sile [...] |
| YBL008W-A protein network | https://string-db.org/network/4932.YBL008W-A | Uncharacterized protein YBL008W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| ALK2 protein network | https://string-db.org/network/4932.YBL009W | Serine/threonine-protein kinase Haspin homolog ALK2; Protein kinase; along with its paralog, ALK1, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper [...] |
| YBL010C protein network | https://string-db.org/network/4932.YBL010C | Uncharacterized protein YBL010C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles; Belongs to the bZIP family. |
| SCT1 protein network | https://string-db.org/network/4932.YBL011W | Glycerol-3-phosphate O-acyltransferase 1; Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; p [...] |
| YBL012C protein network | https://string-db.org/network/4932.YBL012C | Putative uncharacterized protein YBL012C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| FMT1 protein network | https://string-db.org/network/4932.YBL013W | Methionyl-tRNA formyltransferase, mitochondrial; Methionyl-tRNA formyltransferase; catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate. |
| RRN6 protein network | https://string-db.org/network/4932.YBL014C | RNA polymerase I-specific transcription initiation factor RRN6; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA poly [...] |
| ACH1 protein network | https://string-db.org/network/4932.YBL015W | Acetyl-CoA hydrolase; Protein with CoA transferase activity; particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for ac [...] |
| FUS3 protein network | https://string-db.org/network/4932.YBL016W | Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphor [...] |
| PEP1 protein network | https://string-db.org/network/4932.YBL017C | Vacuolar protein sorting/targeting protein VPS10; Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; [...] |
| POP8 protein network | https://string-db.org/network/4932.YBL018C | Ribonucleases P/MRP protein subunit POP8; Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and f [...] |
| APN2 protein network | https://string-db.org/network/4932.YBL019W | DNA-(apurinic or apyrimidinic site) lyase 2; Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII. |
| RFT1 protein network | https://string-db.org/network/4932.YBL020W | Membrane protein required for translocation of Man5GlcNac2-PP-Dol; required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the [...] |
| HAP3 protein network | https://string-db.org/network/4932.YBL021C | Transcriptional activator HAP3; Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator o [...] |
| PIM1 protein network | https://string-db.org/network/4932.YBL022C | ATP-dependent Lon protease; involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria; Belongs to the peptidase S16 family. |
| MCM2 protein network | https://string-db.org/network/4932.YBL023C | Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increas [...] |
| NCL1 protein network | https://string-db.org/network/4932.YBL024W | Multisite-specific tRNA:(cytosine-C(5))-methyltransferase; S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-conta [...] |
| RRN10 protein network | https://string-db.org/network/4932.YBL025W | Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I. |
| LSM2 protein network | https://string-db.org/network/4932.YBL026W | U6 snRNA-associated Sm-like protein LSm2; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Ls [...] |
| RPL19B protein network | https://string-db.org/network/4932.YBL027W | Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bact [...] |
| YBL028C protein network | https://string-db.org/network/4932.YBL028C | UPF0642 protein YBL028C; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribos [...] |
| YBL029C-A protein network | https://string-db.org/network/4932.YBL029C-A | UPF0768 protein YBL029C-A; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication [...] |
| YBL029W protein network | https://string-db.org/network/4932.YBL029W | Uncharacterized protein YBL029W; Non-essential protein of unknown function. |
| PET9 protein network | https://string-db.org/network/4932.YBL030C | ADP,ATP carrier protein 2; Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; required for viabilit [...] |
| SHE1 protein network | https://string-db.org/network/4932.YBL031W | Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud [...] |
| HEK2 protein network | https://string-db.org/network/4932.YBL032W | Heterogeneous nuclear rnp K-like protein 2; RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phospho [...] |
| RIB1 protein network | https://string-db.org/network/4932.YBL033C | GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway. |
| STU1 protein network | https://string-db.org/network/4932.YBL034C | Protein STU1; Component of the mitotic spindle; binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on [...] |
| POL12 protein network | https://string-db.org/network/4932.YBL035C | B subunit of DNA polymerase alpha-primase complex; required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation [...] |
| YBL036C protein network | https://string-db.org/network/4932.YBL036C | Pyridoxal phosphate homeostasis protein; Putative non-specific single-domain racemase; based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in re [...] |
| APL3 protein network | https://string-db.org/network/4932.YBL037W | Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport. |
| MRPL16 protein network | https://string-db.org/network/4932.YBL038W | Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L16 ribosomal protein; synthetic lethality with hac1 mutation suggests a possible role in synthesis of precursors for [...] |
| URA7 protein network | https://string-db.org/network/4932.YBL039C | Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; i [...] |
| YBL039C-A protein network | https://string-db.org/network/4932.YBL039C-A | Uncharacterized protein YBL039C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the veri [...] |
| YBL039W-B protein network | https://string-db.org/network/4932.YBL039W-B | Uncharacterized protein YBL039W-B; Putative protein of unknown function; mCherry fusion protein localizes to the vacuole. |
| ERD2 protein network | https://string-db.org/network/4932.YBL040C | ER lumen protein-retaining receptor; HDEL receptor; an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in mainte [...] |
| PRE7 protein network | https://string-db.org/network/4932.YBL041W | Beta 6 subunit of the 20S proteasome. |
| FUI1 protein network | https://string-db.org/network/4932.YBL042C | High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; [...] |
| ECM13 protein network | https://string-db.org/network/4932.YBL043W | Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication. |
| YBL044W protein network | https://string-db.org/network/4932.YBL044W | Putative protein of unknown function; YBL044W is not an essential protein. |
| COR1 protein network | https://string-db.org/network/4932.YBL045C | Core subunit of the ubiquinol-cytochrome c reductase complex; the ubiquinol-cytochrome c reductase complex (bc1 complex) is a component of the mitochondrial inner membrane electron transport chai [...] |
| PSY4 protein network | https://string-db.org/network/4932.YBL046W | Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, b [...] |
| EDE1 protein network | https://string-db.org/network/4932.YBL047C | EH domain-containing and endocytosis protein 1; Scaffold protein involved in the formation of early endocytic sites; putative regulator of cytokinesis; homo-oligomerization is required for locali [...] |
| RRT1 protein network | https://string-db.org/network/4932.YBL048W | Regulator of rDNA transcription protein 1; Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to enco [...] |
| MOH1 protein network | https://string-db.org/network/4932.YBL049W | Protein yippee-like MOH1; Protein of unknown function, essential for stationary phase survival; not required for growth on nonfermentable carbon sources; possibly linked with vacuolar transport; [...] |
| SEC17 protein network | https://string-db.org/network/4932.YBL050W | Alpha-soluble NSF attachment protein; Alpha-SNAP cochaperone; SNARE-complex adaptor for Sec18 (NSF) during the disassembly of postfusion cis-SNARE complexes; stimulates the ATPase activity of Sec [...] |
| PIN4 protein network | https://string-db.org/network/4932.YBL051C | RNA-binding protein PIN4; Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and sever [...] |
| SAS3 protein network | https://string-db.org/network/4932.YBL052C | Histone acetyltransferase catalytic subunit of NuA3 complex; acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy toler [...] |
| TOD6 protein network | https://string-db.org/network/4932.YBL054W | Transcriptional regulatory protein TOD6; PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; h [...] |
| YBL055C protein network | https://string-db.org/network/4932.YBL055C | Deoxyribonuclease Tat-D; 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases. |
| PTC3 protein network | https://string-db.org/network/4932.YBL056W | Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p [...] |
| PTH2 protein network | https://string-db.org/network/4932.YBL057C | Peptidyl-tRNA hydrolase 2; One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-asso [...] |
| SHP1 protein network | https://string-db.org/network/4932.YBL058W | UBX domain-containing substrate adaptor for Cdc48p; ubiquitin regulatory X domain-containing protein that acts as a substrate recruiting cofactor for Cdc48p; positively regulates Glc7p PPase acti [...] |
| CMC2 protein network | https://string-db.org/network/4932.YBL059C-A | COX assembly mitochondrial protein 2; Protein involved in respiratory chain complex assembly or maintenance; protein of the mitochondrial intermembrane space; contains twin Cx9C motifs that can f [...] |
| YBL059W protein network | https://string-db.org/network/4932.YBL059W | Uncharacterized protein YBL059W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a para [...] |
| YEL1 protein network | https://string-db.org/network/4932.YBL060W | Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip; Belongs to the YEL1 family. |
| SKT5 protein network | https://string-db.org/network/4932.YBL061C | Protein SKT5; Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole gen [...] |
| YBL062W protein network | https://string-db.org/network/4932.YBL062W | Putative uncharacterized membrane protein YBL062W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| KIP1 protein network | https://string-db.org/network/4932.YBL063W | Kinesin-like protein KIP1; Kinesin-related motor protein; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for c [...] |
| PRX1 protein network | https://string-db.org/network/4932.YBL064C | Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxi [...] |
| YBL065W protein network | https://string-db.org/network/4932.YBL065W | Putative uncharacterized protein YBL065W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ve [...] |
| SEF1 protein network | https://string-db.org/network/4932.YBL066C | Putative transcription factor; has homolog in Kluyveromyces lactis. |
| UBP13 protein network | https://string-db.org/network/4932.YBL067C | Ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication; Belongs to the peptidase C19 family. |
| PRS4 protein network | https://string-db.org/network/4932.YBL068W | Ribose-phosphate pyrophosphokinase 4; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five [...] |
| YBL068W-A protein network | https://string-db.org/network/4932.YBL068W-A | Putative uncharacterized protein YBL068W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by funga [...] |
| AST1 protein network | https://string-db.org/network/4932.YBL069W | Protein AST1; Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid raf [...] |
| YBL070C protein network | https://string-db.org/network/4932.YBL070C | Putative uncharacterized protein YBL070C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YBL071C protein network | https://string-db.org/network/4932.YBL071C | Uncharacterized protein YBL071C; Putative protein of unknown function; conserved among S. cerevisiae strains; YBL071C is not an essential gene. |
| YBL071C-B protein network | https://string-db.org/network/4932.YBL071C-B | Uncharacterized protein YBL071C-B; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| KTI11 protein network | https://string-db.org/network/4932.YBL071W-A | Diphthamide biosynthesis protein 3; Zn-ribbon protein that co-purifies with Dph1 and Dph2; in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunit [...] |
| RPS8A protein network | https://string-db.org/network/4932.YBL072C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplicatio [...] |
| AAR2 protein network | https://string-db.org/network/4932.YBL074C | A1 cistron-splicing factor AAR2; Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA o [...] |
| SSA3 protein network | https://string-db.org/network/4932.YBL075C | Heat shock protein SSA3; ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the h [...] |
| ILS1 protein network | https://string-db.org/network/4932.YBL076C | Isoleucine--tRNA ligase, cytoplasmic; Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A. |
| YBL077W protein network | https://string-db.org/network/4932.YBL077W | Putative uncharacterized protein YBL077W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| ATG8 protein network | https://string-db.org/network/4932.YBL078C | Autophagy-related protein 8; Component of autophagosomes and Cvt vesicles; regulator of Atg1p, targets it to autophagosomes; binds the Atg1p-Atg13p complex, triggering its vacuolar degradation; u [...] |
| NUP170 protein network | https://string-db.org/network/4932.YBL079W | Nucleoporin NUP170; Subunit of inner ring of nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; interacts with genomic regions that contain ribosomal protein [...] |
| PET112 protein network | https://string-db.org/network/4932.YBL080C | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally compleme [...] |
| YBL081W protein network | https://string-db.org/network/4932.YBL081W | Uncharacterized protein YBL081W; Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport. |
| ALG3 protein network | https://string-db.org/network/4932.YBL082C | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; involved in synthesis of dolichol-linked oligosaccharide donor for N-linke [...] |
| YBL083C protein network | https://string-db.org/network/4932.YBL083C | Putative uncharacterized protein YBL083C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified ORF [...] |
| CDC27 protein network | https://string-db.org/network/4932.YBL084C | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/a [...] |
| BOI1 protein network | https://string-db.org/network/4932.YBL085W | Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; r [...] |
| YBL086C protein network | https://string-db.org/network/4932.YBL086C | Uncharacterized protein YBL086C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery. |
| RPL23A protein network | https://string-db.org/network/4932.YBL087C | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication. |
| TEL1 protein network | https://string-db.org/network/4932.YBL088C | Serine/threonine-protein kinase TEL1; Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; acts with Red1p and [...] |
| AVT5 protein network | https://string-db.org/network/4932.YBL089W | Vacuolar amino acid transporter 5; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that ar [...] |
| MRP21 protein network | https://string-db.org/network/4932.YBL090W | Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences. |
| MAP2 protein network | https://string-db.org/network/4932.YBL091C | Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p; Belongs to the peptidase M [...] |
| SCS22 protein network | https://string-db.org/network/4932.YBL091C-A | Vesicle-associated membrane protein-associated protein SCS22; Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect [...] |
| RPL32 protein network | https://string-db.org/network/4932.YBL092W | Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog. |
| ROX3 protein network | https://string-db.org/network/4932.YBL093C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme. |
| YBL094C protein network | https://string-db.org/network/4932.YBL094C | Putative uncharacterized protein YBL094C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps un [...] |
| MRX3 protein network | https://string-db.org/network/4932.YBL095W | MIOREX complex component 3; Protein that associates with mitochondrial ribosome; likely functions in cristae junction formation; the authentic, non-tagged protein is detected in highly purified m [...] |
| YBL096C protein network | https://string-db.org/network/4932.YBL096C | Putative uncharacterized protein YBL096C; Non-essential protein of unknown function. |
| BRN1 protein network | https://string-db.org/network/4932.YBL097W | Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission. |
| BNA4 protein network | https://string-db.org/network/4932.YBL098W | Kynurenine 3-monooxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease. |
| ATP1 protein network | https://string-db.org/network/4932.YBL099W | Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 [...] |
| YBL100W-C protein network | https://string-db.org/network/4932.YBL100W-C | Uncharacterized protein YBL100W-C; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| ECM21 protein network | https://string-db.org/network/4932.YBL101C | Protein involved in regulating endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p bindin [...] |
| SFT2 protein network | https://string-db.org/network/4932.YBL102W | Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to [...] |
| RTG3 protein network | https://string-db.org/network/4932.YBL103C | Retrograde regulation protein 3; bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways; forms a complex with another bHLH/Zip protein, Rtg1p, to activate the pathways; target of Hog [...] |
| SEA4 protein network | https://string-db.org/network/4932.YBL104C | SEH-associated protein 4; Subunit of SEACAT, a subcomplex of the SEA complex; Sea4p, along with Rtc1p and Mtc5p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr [...] |
| PKC1 protein network | https://string-db.org/network/4932.YBL105C | Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma i [...] |
| SRO77 protein network | https://string-db.org/network/4932.YBL106C | Lethal(2) giant larvae protein homolog SRO77; Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell [...] |
| MIX23 protein network | https://string-db.org/network/4932.YBL107C | Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C). |
| YBL107W-A protein network | https://string-db.org/network/4932.YBL107W-A | Putative uncharacterized protein YBL107W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| PAU9 protein network | https://string-db.org/network/4932.YBL108C-A | Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vac [...] |
| YBL108W protein network | https://string-db.org/network/4932.YBL108W | Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family [...] |
| YBL109W protein network | https://string-db.org/network/4932.YBL109W | Putative uncharacterized protein YBL109W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YBL111C protein network | https://string-db.org/network/4932.YBL111C | Helicase-like protein encoded within the telomeric Y' element; relocalizes from mitochondrion to cytoplasm upon DNA replication stress. |
| YBL112C protein network | https://string-db.org/network/4932.YBL112C | Putative protein of unknown function; YBL112C is contained within TEL02L. |
| YBL113C protein network | https://string-db.org/network/4932.YBL113C | Uncharacterized protein YBL113C; Helicase-like protein encoded within the telomeric Y' element. |
| YBL113W-A protein network | https://string-db.org/network/4932.YBL113W-A | Putative UPF0479 protein YBL113W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping [...] |
| NTH2 protein network | https://string-db.org/network/4932.YBR001C | Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication; Belongs to the [...] |
| RER2 protein network | https://string-db.org/network/4932.YBR002C | Forms the dehydrodolichyl diphosphate syntase (DDS) complex with NUS1; major enzyme of polyprenol synthesis in both the endoplasmic reticulum (ER) and in lipid droplets; participates in ER protei [...] |
| COQ1 protein network | https://string-db.org/network/4932.YBR003W | Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis; Belongs to the FPP/GGPP synthase family. |
| GPI18 protein network | https://string-db.org/network/4932.YBR004C | GPI mannosyltransferase 2; Functional ortholog of human PIG-V; PIG-V is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-ta [...] |
| RCR1 protein network | https://string-db.org/network/4932.YBR005W | Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or [...] |
| UGA2 protein network | https://string-db.org/network/4932.YBR006W | Succinate-semialdehyde dehydrogenase [NADP(+)]; Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate a [...] |
| DSF2 protein network | https://string-db.org/network/4932.YBR007C | Protein DSF2; Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress. |
| FLR1 protein network | https://string-db.org/network/4932.YBR008C | Fluconazole resistance protein 1; Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, d [...] |
| HHF1 protein network | https://string-db.org/network/4932.YBR009C | Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal dom [...] |
| HHT1 protein network | https://string-db.org/network/4932.YBR010W | Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by ac [...] |
| IPP1 protein network | https://string-db.org/network/4932.YBR011C | Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show i [...] |
| YBR012C protein network | https://string-db.org/network/4932.YBR012C | Putative uncharacterized protein YBR012C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by [...] |
| YBR013C protein network | https://string-db.org/network/4932.YBR013C | Putative protein of unknown function; haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein; SWAT-GFP fusion protein localizes to the endoplasmic reticulum while mCherry fusio [...] |
| GRX7 protein network | https://string-db.org/network/4932.YBR014C | Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a [...] |
| MNN2 protein network | https://string-db.org/network/4932.YBR015C | Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartm [...] |
| YBR016W protein network | https://string-db.org/network/4932.YBR016W | Uncharacterized protein YBR016W; Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adap [...] |
| KAP104 protein network | https://string-db.org/network/4932.YBR017C | Importin subunit beta-2; Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; re [...] |
| GAL7 protein network | https://string-db.org/network/4932.YBR018C | Galactose-1-phosphate uridyl transferase; synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; human [...] |
| GAL10 protein network | https://string-db.org/network/4932.YBR019C | Bifunctional protein GAL10; UDP-glucose-4-epimerase; catalyzes interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes conversion of alpha-D-glucose or alpha-D- [...] |
| GAL1 protein network | https://string-db.org/network/4932.YBR020W | Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; human homolog GALK2 complements yeast nu [...] |
| FUR4 protein network | https://string-db.org/network/4932.YBR021W | Uracil permease; Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate b [...] |
| POA1 protein network | https://string-db.org/network/4932.YBR022W | Phosphatase that is highly specific for ADP-ribose 1''-phosphate; a tRNA splicing metabolite; may have a role in regulation of tRNA splicing; Belongs to the POA1 family. |
| CHS3 protein network | https://string-db.org/network/4932.YBR023C | Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore [...] |
| SCO2 protein network | https://string-db.org/network/4932.YBR024W | Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that aros [...] |
| OLA1 protein network | https://string-db.org/network/4932.YBR025C | Obg-like ATPase 1; P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; null mutant displays increased translation rate and [...] |
| ETR1 protein network | https://string-db.org/network/4932.YBR026C | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; 2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to mitochondria, where it has a probable r [...] |
| YBR027C protein network | https://string-db.org/network/4932.YBR027C | Uncharacterized protein YBR027C; Putative protein of unknown function; conserved among S. cerevisiae strains; YBR027C is not an essential gene. |
| YPK3 protein network | https://string-db.org/network/4932.YBR028C | Serine/threonine-protein kinase YPK3; AGC kinase; phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner; directly phosphorylated by TORC1; phosphorylates ribosomal pro [...] |
| CDS1 protein network | https://string-db.org/network/4932.YBR029C | Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis [...] |
| RKM3 protein network | https://string-db.org/network/4932.YBR030W | Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia. |
| RPL4A protein network | https://string-db.org/network/4932.YBR031W | Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication [...] |
| YBR032W protein network | https://string-db.org/network/4932.YBR032W | Uncharacterized protein YBR032W; Putative protein of unknown function; conserved among S. cerevisiae strains; YBR032W is not an essential gene. |
| EDS1 protein network | https://string-db.org/network/4932.YBR033W | Transcriptional regulatory protein EDS1; Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome d [...] |
| HMT1 protein network | https://string-db.org/network/4932.YBR034C | Protein arginine N-methyltransferase 1; Nuclear SAM-dependent mono- and asymmetric methyltransferase; modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; meth [...] |
| PDX3 protein network | https://string-db.org/network/4932.YBR035C | Pyridoxine (pyridoxamine) phosphate oxidase; has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism; Belongs to the pyridoxamine 5'-phos [...] |
| CSG2 protein network | https://string-db.org/network/4932.YBR036C | Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2; Endoplasmic reticulum membrane protein; required for mannosylation of inositolphosphorylceramide and for growth at high calc [...] |
| SCO1 protein network | https://string-db.org/network/4932.YBR037C | Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins [...] |
| CHS2 protein network | https://string-db.org/network/4932.YBR038W | Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localiz [...] |
| ATP3 protein network | https://string-db.org/network/4932.YBR039W | Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis. |
| FIG1 protein network | https://string-db.org/network/4932.YBR040W | Factor-induced gene 1 protein; Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling a [...] |
| FAT1 protein network | https://string-db.org/network/4932.YBR041W | Very long chain fatty acyl-CoA synthetase and fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of [...] |
| CST26 protein network | https://string-db.org/network/4932.YBR042C | Uncharacterized acyltransferase CST26; Acyltransferase; enzyme mainly responsible for the introduction of saturated very long chain fatty acids into neo-synthesized molecules of phosphatidylinosi [...] |
| QDR3 protein network | https://string-db.org/network/4932.YBR043C | Quinidine resistance protein 3; Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involve [...] |
| TCM62 protein network | https://string-db.org/network/4932.YBR044C | Mitochondrial chaperone TCM62; Protein involved in assembly of the succinate dehydrogenase complex; mitochondrial; putative chaperone. |
| GIP1 protein network | https://string-db.org/network/4932.YBR045C | GLC7-interacting protein 1; Meiosis-specific regulatory subunit of the Glc7p protein phosphatase; regulates spore wall formation and septin organization, required for expression of some late meio [...] |
| ZTA1 protein network | https://string-db.org/network/4932.YBR046C | Probable quinone oxidoreductase; NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-c [...] |
| FMP23 protein network | https://string-db.org/network/4932.YBR047W | Protein FMP23, mitochondrial; Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitocho [...] |
| RPS11B protein network | https://string-db.org/network/4932.YBR048W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication [...] |
| REB1 protein network | https://string-db.org/network/4932.YBR049C | DNA-binding protein REB1; RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination o [...] |
| REG2 protein network | https://string-db.org/network/4932.YBR050C | Protein REG2; Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteo [...] |
| YBR051W protein network | https://string-db.org/network/4932.YBR051W | Putative uncharacterized protein YBR051W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RFS1 protein network | https://string-db.org/network/4932.YBR052C | Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate [...] |
| YBR053C protein network | https://string-db.org/network/4932.YBR053C | Uncharacterized protein YBR053C; Putative protein of unknown function; induced by cell wall perturbation. |
| YRO2 protein network | https://string-db.org/network/4932.YBR054W | Protein with a putative role in response to acid stress; null mutant is sensitive to acetic acid; transcription is regulated by Haa1p and induced in the presence of acetic acid; protein observed [...] |
| PRP6 protein network | https://string-db.org/network/4932.YBR055C | Splicing factor; component of the U4/U6-U5 snRNP complex. |
| YBR056C-B protein network | https://string-db.org/network/4932.YBR056C-B | Putative uncharacterized protein YBR056C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely o [...] |
| YBR056W protein network | https://string-db.org/network/4932.YBR056W | Uncharacterized glycosyl hydrolase YBR056W; Putative glycoside hydrolase of the mitochondrial intermembrane space. |
| YBR056W-A protein network | https://string-db.org/network/4932.YBR056W-A | Uncharacterized protein YBR056W-A; Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps dubious ORF YBR056C-B; YBR056W-A has a paralog, YDR034 [...] |
| MUM2 protein network | https://string-db.org/network/4932.YBR057C | Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also int [...] |
| UBP14 protein network | https://string-db.org/network/4932.YBR058C | Ubiquitin carboxyl-terminal hydrolase 14; Ubiquitin-specific protease; specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar [...] |
| TSC3 protein network | https://string-db.org/network/4932.YBR058C-A | Protein that stimulates the activity of serine palmitoyltransferase; involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase. |
| AKL1 protein network | https://string-db.org/network/4932.YBR059C | Serine/threonine-protein kinase AKL1; Ser-Thr protein kinase; member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization. |
| ORC2 protein network | https://string-db.org/network/4932.YBR060C | Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with tri [...] |
| TRM7 protein network | https://string-db.org/network/4932.YBR061C | 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of tRNA anticodon loop; crucial biological role likely modification of tRNA- [...] |
| YBR062C protein network | https://string-db.org/network/4932.YBR062C | Uncharacterized RING finger protein YBR062C; Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway. |
| YBR063C protein network | https://string-db.org/network/4932.YBR063C | Putative protein of unknown function; YBR063C is not an essential gene. |
| YBR064W protein network | https://string-db.org/network/4932.YBR064W | Putative uncharacterized membrane protein YBR064W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially ov [...] |
| ECM2 protein network | https://string-db.org/network/4932.YBR065C | Pre-mRNA-splicing factor SLT11; Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7 [...] |
| NRG2 protein network | https://string-db.org/network/4932.YBR066C | Probable transcriptional regulator NRG2; Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; activated in stochastic pulses of nuclear localization [...] |
| TIP1 protein network | https://string-db.org/network/4932.YBR067C | Temperature shock-inducible protein 1; Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-ala [...] |
| BAP2 protein network | https://string-db.org/network/4932.YBR068C | Leu/Val/Ile amino-acid permease; High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted tran [...] |
| TAT1 protein network | https://string-db.org/network/4932.YBR069C | Valine/tyrosine/tryptophan amino-acid permease 1; Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers F [...] |
| ALG14 protein network | https://string-db.org/network/4932.YBR070C | UDP-N-acetylglucosamine transferase subunit ALG14; Component of UDP-GlcNAc transferase; required for second step of dolichyl-linked oligosaccharide synthesis; anchors catalytic subunit Alg13p to [...] |
| YBR071W protein network | https://string-db.org/network/4932.YBR071W | Uncharacterized protein YBR071W; Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR [...] |
| YBR072C-A protein network | https://string-db.org/network/4932.YBR072C-A | Uncharacterized protein YBR072C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| HSP26 protein network | https://string-db.org/network/4932.YBR072W | Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; long-lived protein that is preferentially retained in m [...] |
| RDH54 protein network | https://string-db.org/network/4932.YBR073W | DNA-dependent ATPase; DNA recombination/repair translocase, supercoils DNA and promotes DNA strand opening; stimulates strand exchange by modifying dsDNA topology; involved in recombinational rep [...] |
| PFF1 protein network | https://string-db.org/network/4932.YBR074W | Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to the M28 family of metalloproteases; has a lumenal-facing protease domain; proposed role in vacuol [...] |
| ECM8 protein network | https://string-db.org/network/4932.YBR076W | Non-essential protein of unknown function. |
| SLM4 protein network | https://string-db.org/network/4932.YBR077C | Protein SLM4; Component of the EGO and GSE complexes; essential for integrity and function of EGO; EGO is involved in the regulation of microautophagy and GSE is required for proper sorting of am [...] |
| ECM33 protein network | https://string-db.org/network/4932.YBR078W | Cell wall protein ECM33; GPI-anchored protein of unknown function; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; si [...] |
| RPG1 protein network | https://string-db.org/network/4932.YBR079C | eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates bind [...] |
| SEC18 protein network | https://string-db.org/network/4932.YBR080C | Vesicular-fusion protein SEC18; AAA ATPase and SNARE disassembly chaperone; required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and p [...] |
| SPT7 protein network | https://string-db.org/network/4932.YBR081C | Transcriptional activator SPT7; Subunit of the SAGA transcriptional regulatory complex; involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA [...] |
| UBC4 protein network | https://string-db.org/network/4932.YBR082C | Ubiquitin-conjugating enzyme (E2); key E2 partner with Ubc1p for the anaphase-promoting complex (APC); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; re [...] |
| TEC1 protein network | https://string-db.org/network/4932.YBR083W | Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on i [...] |
| RPL19A protein network | https://string-db.org/network/4932.YBR084C-A | Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bact [...] |
| MIS1 protein network | https://string-db.org/network/4932.YBR084W | C-1-tetrahydrofolate synthase, mitochondrial; Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activi [...] |
| YBR085C-A protein network | https://string-db.org/network/4932.YBR085C-A | Uncharacterized protein YBR085C-A; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in respon [...] |
| AAC3 protein network | https://string-db.org/network/4932.YBR085W | ADP,ATP carrier protein 3; Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; [...] |
| IST2 protein network | https://string-db.org/network/4932.YBR086C | Increased sodium tolerance protein 2; Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma mem [...] |
| RFC5 protein network | https://string-db.org/network/4932.YBR087W | Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor [...] |
| POL30 protein network | https://string-db.org/network/4932.YBR088C | Proliferating cell nuclear antigen (PCNA); functions as the sliding replication clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic [...] |
| NHP6B protein network | https://string-db.org/network/4932.YBR089C-A | Non-histone chromosomal protein 6B; High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; [...] |
| TIM12 protein network | https://string-db.org/network/4932.YBR091C | Mitochondrial import inner membrane translocase subunit TIM12; Essential protein of the inner mitochondrial membrane; peripherally localized; component of the TIM22 complex, which is a twin-pore [...] |
| PHO3 protein network | https://string-db.org/network/4932.YBR092C | Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin [...] |
| PHO5 protein network | https://string-db.org/network/4932.YBR093C | Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; i [...] |
| PBY1 protein network | https://string-db.org/network/4932.YBR094W | Probable tubulin--tyrosine ligase PBY1; Putative tubulin tyrosine ligase associated with P-bodies; may have a role in mRNA metabolism; yeast knockout collection strain identified as a pby1 null m [...] |
| RXT2 protein network | https://string-db.org/network/4932.YBR095C | Transcriptional regulatory protein RXT2; Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxi [...] |
| YBR096W protein network | https://string-db.org/network/4932.YBR096W | Uncharacterized protein YBR096W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER. |
| VPS15 protein network | https://string-db.org/network/4932.YBR097W | Serine/threonine-protein kinase VPS15; Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to [...] |
| MMS4 protein network | https://string-db.org/network/4932.YBR098W | Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phospho [...] |
| YBR099C protein network | https://string-db.org/network/4932.YBR099C | Putative uncharacterized protein YBR099C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps t [...] |
| FES1 protein network | https://string-db.org/network/4932.YBR101C | Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for destruction; cytosolic homolog of Sil1p, which is [...] |
| EXO84 protein network | https://string-db.org/network/4932.YBR102C | Exocyst complex component EXO84; Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of pos [...] |
| YBR103C-A protein network | https://string-db.org/network/4932.YBR103C-A | Putative uncharacterized protein YBR103C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by homol [...] |
| SIF2 protein network | https://string-db.org/network/4932.YBR103W | SIR4-interacting protein SIF2; WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specif [...] |
| YMC2 protein network | https://string-db.org/network/4932.YBR104W | Carrier protein YMC2, mitochondrial; Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) fa [...] |
| VID24 protein network | https://string-db.org/network/4932.YBR105C | Vacuolar import and degradation protein 24; GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bispho [...] |
| PHO88 protein network | https://string-db.org/network/4932.YBR106W | Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for [...] |
| IML3 protein network | https://string-db.org/network/4932.YBR107C | Inner kinetochore subunit IML3; Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of [...] |
| AIM3 protein network | https://string-db.org/network/4932.YBR108W | Altered inheritance of mitochondria protein 3; Protein that inhibits barbed-end actin filament elongation; interacts with Rvs167p; null mutant is viable and displays elevated frequency of mitocho [...] |
| CMD1 protein network | https://string-db.org/network/4932.YBR109C | Calmodulin; Ca2+ binding protein that regulates Ca2+ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca2+ dependent processes (stress-activated pathways), t [...] |
| ALG1 protein network | https://string-db.org/network/4932.YBR110W | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog A [...] |
| YSA1 protein network | https://string-db.org/network/4932.YBR111C | Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate; Belongs to the Nudix hydrolase family. N [...] |
| SUS1 protein network | https://string-db.org/network/4932.YBR111W-A | Transcription and mRNA export factor SUS1; Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activ [...] |
| CYC8 protein network | https://string-db.org/network/4932.YBR112C | General transcriptional co-repressor; acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the [...] |
| YBR113W protein network | https://string-db.org/network/4932.YBR113W | Putative uncharacterized membrane protein YBR113W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially ov [...] |
| RAD16 protein network | https://string-db.org/network/4932.YBR114W | Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nuc [...] |
| LYS2 protein network | https://string-db.org/network/4932.YBR115C | Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttransl [...] |
| YBR116C protein network | https://string-db.org/network/4932.YBR116C | Putative uncharacterized protein YBR116C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| TKL2 protein network | https://string-db.org/network/4932.YBR117C | Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthes [...] |
| TEF2 protein network | https://string-db.org/network/4932.YBR118W | Translational elongation factor EF-1 alpha; in the GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; associates wi [...] |
| MUD1 protein network | https://string-db.org/network/4932.YBR119W | U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing; Belongs to the RRM U1 A/B'' family. |
| CBP6 protein network | https://string-db.org/network/4932.YBR120C | Cytochrome B pre-mRNA-processing protein 6; Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit [...] |
| GRS1 protein network | https://string-db.org/network/4932.YBR121C | Glycine--tRNA ligase 1, mitochondrial; Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interac [...] |
| YBR121C-A protein network | https://string-db.org/network/4932.YBR121C-A | Uncharacterized protein YBR121C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely contained within [...] |
| MRPL36 protein network | https://string-db.org/network/4932.YBR122C | Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region. |
| TFC1 protein network | https://string-db.org/network/4932.YBR123C | Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular do [...] |
| PTC4 protein network | https://string-db.org/network/4932.YBR125C | Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylatio [...] |
| TPS1 protein network | https://string-db.org/network/4932.YBR126C | Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit; Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose, which is cri [...] |
| MEO1 protein network | https://string-db.org/network/4932.YBR126W-A | Uncharacterized protein YBR126W-A; Putative protein of unknown function; identified by gene-trapping, microarray analysis, and genome-wide homology searches; mRNA identified as translated by ribo [...] |
| YBR126W-B protein network | https://string-db.org/network/4932.YBR126W-B | Putative uncharacterized protein YBR126W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| VMA2 protein network | https://string-db.org/network/4932.YBR127C | V-type proton ATPase subunit B; Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase; electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding si [...] |
| ATG14 protein network | https://string-db.org/network/4932.YBR128C | Autophagy-related protein 14; Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I; Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additi [...] |
| OPY1 protein network | https://string-db.org/network/4932.YBR129C | Protein of unknown function; overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-thr [...] |
| SHE3 protein network | https://string-db.org/network/4932.YBR130C | SWI5-dependent HO expression protein 3; Protein adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bu [...] |
| YBR131C-A protein network | https://string-db.org/network/4932.YBR131C-A | Putative uncharacterized protein YBR131C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| CCZ1 protein network | https://string-db.org/network/4932.YBR131W | Vacuolar fusion protein CCZ1; Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt [...] |
| AGP2 protein network | https://string-db.org/network/4932.YBR132C | General amino acid permease AGP2; Plasma membrane regulator of polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces [...] |
| HSL7 protein network | https://string-db.org/network/4932.YBR133C | Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent localization to the bud neck in budded cells and periodic Hsl1p-dependent phosphorylation; required with Hsl1p, and Elm1p [...] |
| YBR134W protein network | https://string-db.org/network/4932.YBR134W | Putative uncharacterized protein YBR134W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| CKS1 protein network | https://string-db.org/network/4932.YBR135W | Cyclin-dependent protein kinase regulatory subunit and adaptor; interacts with Cdc28p (aka Cdk1p); required for G1/S and G2/M phase transitions and budding; mediates phosphorylation and degradati [...] |
| MEC1 protein network | https://string-db.org/network/4932.YBR136W | Serine/threonine-protein kinase MEC1; Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; si [...] |
| YBR137W protein network | https://string-db.org/network/4932.YBR137W | UPF0303 protein YBR137W; Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; intera [...] |
| YBR138C protein network | https://string-db.org/network/4932.YBR138C | Uncharacterized protein YBR138C; Cytoplasmic protein of unknown function; APCC(Cdh1) substrate; potentially phosphorylated by Cdc28p; YBR138C is not an essential gene. |
| YBR139W protein network | https://string-db.org/network/4932.YBR139W | Putative serine type carboxypeptidase; role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN [...] |
| IRA1 protein network | https://string-db.org/network/4932.YBR140C | Inhibitory regulator protein IRA1; GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient [...] |
| BMT2 protein network | https://string-db.org/network/4932.YBR141C | 25S rRNA (adenine(2142)-N(1))-methyltransferase; Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 2142; belong [...] |
| YBR141W-A protein network | https://string-db.org/network/4932.YBR141W-A | Putative uncharacterized protein YBR141W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the unchar [...] |
| MAK5 protein network | https://string-db.org/network/4932.YBR142W | Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits; Belongs to the DEAD box helicase [...] |
| SUP45 protein network | https://string-db.org/network/4932.YBR143C | Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of meth [...] |
| YBR144C protein network | https://string-db.org/network/4932.YBR144C | Uncharacterized protein YBR144C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YBR144C is not an essential ge [...] |
| ADH5 protein network | https://string-db.org/network/4932.YBR145W | Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication; Belongs to the zinc-containing alcohol dehydrogenase fam [...] |
| MRPS9 protein network | https://string-db.org/network/4932.YBR146W | Mitochondrial ribosomal protein of the small subunit. |
| RTC2 protein network | https://string-db.org/network/4932.YBR147W | Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p sug [...] |
| YSW1 protein network | https://string-db.org/network/4932.YBR148W | Spore-specific protein YSW1; Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expr [...] |
| ARA1 protein network | https://string-db.org/network/4932.YBR149W | D-arabinose dehydrogenase [NAD(P)+] heavy chain; NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradatio [...] |
| TBS1 protein network | https://string-db.org/network/4932.YBR150C | Uncharacterized transcriptional regulatory protein TBS1; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS [...] |
| APD1 protein network | https://string-db.org/network/4932.YBR151W | Actin patches distal protein 1; Protein of unknown function; required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cyt [...] |
| SPP381 protein network | https://string-db.org/network/4932.YBR152W | Pre-mRNA-splicing factor SPP381; mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia; Belong [...] |
| RIB7 protein network | https://string-db.org/network/4932.YBR153W | 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase; Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway; Belon [...] |
| RPB5 protein network | https://string-db.org/network/4932.YBR154C | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. |
| CNS1 protein network | https://string-db.org/network/4932.YBR155W | Hsp70/Hsp90 co-chaperone CNS1; TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70); stimulates ATPase activity of Ssa1p; ts mutants reduce Hsp82p function, overexpression sup [...] |
| SLI15 protein network | https://string-db.org/network/4932.YBR156C | Inner centromere protein-related protein SLI15; Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tens [...] |
| ICS2 protein network | https://string-db.org/network/4932.YBR157C | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization. |
| AMN1 protein network | https://string-db.org/network/4932.YBR158W | Antagonist of mitotic exit network protein 1; Protein required for daughter cell separation; multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat mot [...] |
| IFA38 protein network | https://string-db.org/network/4932.YBR159W | Very-long-chain 3-oxoacyl-CoA reductase; Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulat [...] |
| CDC28 protein network | https://string-db.org/network/4932.YBR160W | Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; r [...] |
| CSH1 protein network | https://string-db.org/network/4932.YBR161W | Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 [...] |
| TOS1 protein network | https://string-db.org/network/4932.YBR162C | Protein TOS1; Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucan [...] |
| YSY6 protein network | https://string-db.org/network/4932.YBR162W-A | Protein of unknown function; expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion. |
| EXO5 protein network | https://string-db.org/network/4932.YBR163W | Mitochondrial 5'-3' exonuclease and sliding exonuclease; required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regu [...] |
| ARL1 protein network | https://string-db.org/network/4932.YBR164C | ADP-ribosylation factor-like protein 1; Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; required fo [...] |
| UBS1 protein network | https://string-db.org/network/4932.YBR165W | Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p; functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic tr [...] |
| TYR1 protein network | https://string-db.org/network/4932.YBR166C | Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels; Belongs to the prephenate/arogenate dehydrogenase family. |
| POP7 protein network | https://string-db.org/network/4932.YBR167C | Ribonucleases P/MRP protein subunit POP7; Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MR [...] |
| PEX32 protein network | https://string-db.org/network/4932.YBR168W | Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream o [...] |
| SSE2 protein network | https://string-db.org/network/4932.YBR169C | Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; may be involved in protein folding; [...] |
| NPL4 protein network | https://string-db.org/network/4932.YBR170C | Nuclear protein localization protein 4; Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that a [...] |
| SEC66 protein network | https://string-db.org/network/4932.YBR171W | Translocation protein SEC66; Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent pro [...] |
| SMY2 protein network | https://string-db.org/network/4932.YBR172C | GYF domain protein; involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe M [...] |
| UMP1 protein network | https://string-db.org/network/4932.YBR173C | Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its a [...] |
| SWD3 protein network | https://string-db.org/network/4932.YBR175W | COMPASS component SWD3; Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propelle [...] |
| ECM31 protein network | https://string-db.org/network/4932.YBR176W | Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate. |
| EHT1 protein network | https://string-db.org/network/4932.YBR177C | Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mit [...] |
| YBR178W protein network | https://string-db.org/network/4932.YBR178W | Putative uncharacterized protein YBR178W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| FZO1 protein network | https://string-db.org/network/4932.YBR179C | Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires [...] |
| DTR1 protein network | https://string-db.org/network/4932.YBR180W | Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and [...] |
| RPS6B protein network | https://string-db.org/network/4932.YBR181C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S23 [...] |
| SMP1 protein network | https://string-db.org/network/4932.YBR182C | MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog, RLM1, that arose from the whole genome duplication; Belongs to the MEF2 family. |
| YBR182C-A protein network | https://string-db.org/network/4932.YBR182C-A | Uncharacterized protein YBR182C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YPC1 protein network | https://string-db.org/network/4932.YBR183W | Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 h [...] |
| YBR184W protein network | https://string-db.org/network/4932.YBR184W | Putative protein of unknown function; YBR184W is not an essential gene. |
| MBA1 protein network | https://string-db.org/network/4932.YBR185C | Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein e [...] |
| PCH2 protein network | https://string-db.org/network/4932.YBR186W | Pachytene checkpoint protein 2; Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when reco [...] |
| GDT1 protein network | https://string-db.org/network/4932.YBR187W | GCR1-dependent translation factor 1; Calcium transporter localized to the cis- and medial-Golgi apparatus; required for protein glycosylation; GFP-fusion protein localizes to the vacuole; TMEM165 [...] |
| NTC20 protein network | https://string-db.org/network/4932.YBR188C | Pre-mRNA-splicing factor NTC20; Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs. |
| RPS9B protein network | https://string-db.org/network/4932.YBR189W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication. |
| YBR190W protein network | https://string-db.org/network/4932.YBR190W | Putative uncharacterized protein YBR190W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RPL21A protein network | https://string-db.org/network/4932.YBR191W | Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication. |
| YBR191W-A protein network | https://string-db.org/network/4932.YBR191W-A | Putative uncharacterized protein YBR191W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| RIM2 protein network | https://string-db.org/network/4932.YBR192W | Mitochondrial carrier protein RIM2; Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mi [...] |
| MED8 protein network | https://string-db.org/network/4932.YBR193C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation. |
| AIM4 protein network | https://string-db.org/network/4932.YBR194W | Altered inheritance of mitochondria protein 4; Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and [...] |
| MSI1 protein network | https://string-db.org/network/4932.YBR195C | Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore str [...] |
| PGI1 protein network | https://string-db.org/network/4932.YBR196C | Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic [...] |
| YBR196C-A protein network | https://string-db.org/network/4932.YBR196C-A | Uncharacterized protein YBR196C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| YBR196C-B protein network | https://string-db.org/network/4932.YBR196C-B | Uncharacterized protein YBR196C-B; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| YBR197C protein network | https://string-db.org/network/4932.YBR197C | Uncharacterized protein YBR197C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative dis [...] |
| TAF5 protein network | https://string-db.org/network/4932.YBR198C | Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification. |
| KTR4 protein network | https://string-db.org/network/4932.YBR199W | Probable mannosyltransferase KTR4; Glycosyltransferase involved in protein glycosylation; transfers GDP-mannose to methyl-alpha-mannoside in vitro; member of the KRE2/MNT1 mannosyltransferase fam [...] |
| BEM1 protein network | https://string-db.org/network/4932.YBR200W | Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p [...] |
| YBR200W-A protein network | https://string-db.org/network/4932.YBR200W-A | Uncharacterized protein YBR200W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| YBR201C-A protein network | https://string-db.org/network/4932.YBR201C-A | Putative protein of unknown function. |
| DER1 protein network | https://string-db.org/network/4932.YBR201W | Degradation in the endoplasmic reticulum protein 1; ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled [...] |
| MCM7 protein network | https://string-db.org/network/4932.YBR202W | DNA replication licensing factor MCM7; Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promote [...] |
| COS111 protein network | https://string-db.org/network/4932.YBR203W | F-box protein COS111; Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in [...] |
| LDH1 protein network | https://string-db.org/network/4932.YBR204C | Lipid droplet hydrolase 1; Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid [...] |
| KTR3 protein network | https://string-db.org/network/4932.YBR205W | Probable mannosyltransferase KTR3; Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates u [...] |
| FTH1 protein network | https://string-db.org/network/4932.YBR207W | Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocy [...] |
| DUR1,2 protein network | https://string-db.org/network/4932.YBR208C | Allophanate hydrolase; Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression a [...] |
| YBR209W protein network | https://string-db.org/network/4932.YBR209W | Uncharacterized protein YBR209W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YBR209W is not an essential ge [...] |
| ERV15 protein network | https://string-db.org/network/4932.YBR210W | ER-derived vesicles protein ERV15; Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication. |
| AME1 protein network | https://string-db.org/network/4932.YBR211C | Inner kinetochore subunit AME1; Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spin [...] |
| NGR1 protein network | https://string-db.org/network/4932.YBR212W | RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial func [...] |
| MET8 protein network | https://string-db.org/network/4932.YBR213W | Siroheme biosynthesis protein MET8; Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate ass [...] |
| SDS24 protein network | https://string-db.org/network/4932.YBR214W | Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play [...] |
| HPC2 protein network | https://string-db.org/network/4932.YBR215W | Histone promoter control protein 2; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with s [...] |
| YBP1 protein network | https://string-db.org/network/4932.YBR216C | YAP1-binding protein 1; Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localiz [...] |
| ATG12 protein network | https://string-db.org/network/4932.YBR217W | Ubiquitin-like protein ATG12; Ubiquitin-like modifier involved in autophagy and the Cvt pathway; conserved; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjug [...] |
| PYC2 protein network | https://string-db.org/network/4932.YBR218C | Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic aci [...] |
| YBR219C protein network | https://string-db.org/network/4932.YBR219C | Putative protein of unknown function; YBR219C is not an essential gene. |
| YBR220C protein network | https://string-db.org/network/4932.YBR220C | Putative protein of unknown function; YBR220C is not an essential gene. |
| PDB1 protein network | https://string-db.org/network/4932.YBR221C | E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria. |
| YBR221W-A protein network | https://string-db.org/network/4932.YBR221W-A | Uncharacterized protein YBR221W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| PCS60 protein network | https://string-db.org/network/4932.YBR222C | Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of [...] |
| TDP1 protein network | https://string-db.org/network/4932.YBR223C | Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II; mutations in the human homolog, TDP1, result in th [...] |
| YBR223W-A protein network | https://string-db.org/network/4932.YBR223W-A | Putative uncharacterized protein YBR223W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| YBR225W protein network | https://string-db.org/network/4932.YBR225W | Uncharacterized protein YBR225W; Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components. |
| MCX1 protein network | https://string-db.org/network/4932.YBR227C | ATP-dependent clpX-like chaperone, mitochondrial; Non-proteolytic ATPase of the AAA family; stimulates incorporation of the pyridoxal phosphate cofactor into Hem1p (5-aminolevulinic acid synthase [...] |
| SLX1 protein network | https://string-db.org/network/4932.YBR228W | Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; functi [...] |
| ROT2 protein network | https://string-db.org/network/4932.YBR229C | Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically [...] |
| OM14 protein network | https://string-db.org/network/4932.YBR230C | Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributi [...] |
| YBR230W-A protein network | https://string-db.org/network/4932.YBR230W-A | Putative protein of unknown function; YBR230W-A has a paralog, COQ8, that arose from the whole genome duplication. |
| SWC5 protein network | https://string-db.org/network/4932.YBR231C | SWR1-complex protein 5; Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication s [...] |
| YBR232C protein network | https://string-db.org/network/4932.YBR232C | Putative uncharacterized protein YBR232C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| PBP2 protein network | https://string-db.org/network/4932.YBR233W | PAB1-binding protein 2; RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative [...] |
| DAD3 protein network | https://string-db.org/network/4932.YBR233W-A | Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the [...] |
| ARC40 protein network | https://string-db.org/network/4932.YBR234C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; Belongs to the WD repeat ARPC1 family. |
| VHC1 protein network | https://string-db.org/network/4932.YBR235W | Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; localizes to sites of conta [...] |
| ABD1 protein network | https://string-db.org/network/4932.YBR236C | mRNA cap guanine-N7 methyltransferase; Methyltransferase; catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; nuclear protein that relocalizes [...] |
| PRP5 protein network | https://string-db.org/network/4932.YBR237W | Pre-mRNA-processing ATP-dependent RNA helicase PRP5; RNA helicase in the DEAD-box family; necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association [...] |
| YBR238C protein network | https://string-db.org/network/4932.YBR238C | Mitochondrial membrane protein; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion i [...] |
| ERT1 protein network | https://string-db.org/network/4932.YBR239C | Transcriptional regulator; involved in regulation of gluconeogenesis and fermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of t [...] |
| THI2 protein network | https://string-db.org/network/4932.YBR240C | Thiamine biosynthesis regulatory protein; Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes wit [...] |
| YBR241C protein network | https://string-db.org/network/4932.YBR241C | Probable metabolite transport protein YBR241C; Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C [...] |
| YBR242W protein network | https://string-db.org/network/4932.YBR242W | HD domain-containing protein YBR242W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene [...] |
| ALG7 protein network | https://string-db.org/network/4932.YBR243C | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; UDP-N-acetyl-glucosamine-1-P transferase; transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first st [...] |
| GPX2 protein network | https://string-db.org/network/4932.YBR244W | Glutathione peroxidase-like peroxiredoxin 2; Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stre [...] |
| ISW1 protein network | https://string-db.org/network/4932.YBR245C | ISWI chromatin-remodeling complex ATPase ISW1; ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiat [...] |
| RRT2 protein network | https://string-db.org/network/4932.YBR246W | Diphthine methyltransferase; Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation react [...] |
| ENP1 protein network | https://string-db.org/network/4932.YBR247C | Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functional [...] |
| HIS7 protein network | https://string-db.org/network/4932.YBR248C | Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR) [...] |
| ARO4 protein network | https://string-db.org/network/4932.YBR249C | Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited; 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is f [...] |
| SPO23 protein network | https://string-db.org/network/4932.YBR250W | Sporulation protein 23; Protein of unknown function; associates with meiosis-specific protein Spo1p. |
| MRPS5 protein network | https://string-db.org/network/4932.YBR251W | Mitochondrial ribosomal protein of the small subunit. |
| DUT1 protein network | https://string-db.org/network/4932.YBR252W | Deoxyuridine 5'-triphosphate nucleotidohydrolase; Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into [...] |
| SRB6 protein network | https://string-db.org/network/4932.YBR253W | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation. |
| TRS20 protein network | https://string-db.org/network/4932.YBR254C | Core component of transport protein particle (TRAPP) complexes I-III; TRAPPs are multimeric guanine nucleotide-exchange factors for GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi [...] |
| RCF3 protein network | https://string-db.org/network/4932.YBR255C-A | Uncharacterized protein YBR255C-A; Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase); identif [...] |
| MTC4 protein network | https://string-db.org/network/4932.YBR255W | Maintenance of telomere capping protein 4; Protein of unknown function; required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [...] |
| RIB5 protein network | https://string-db.org/network/4932.YBR256C | Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway. |
| POP4 protein network | https://string-db.org/network/4932.YBR257W | RNases MRP/P 32.9 kDa subunit; Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates [...] |
| SHG1 protein network | https://string-db.org/network/4932.YBR258C | COMPASS component SHG1; Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres. |
| YBR259W protein network | https://string-db.org/network/4932.YBR259W | Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress. |
| RGD1 protein network | https://string-db.org/network/4932.YBR260C | GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization. |
| TAE1 protein network | https://string-db.org/network/4932.YBR261C | Alpha N-terminal protein methyltransferase 1; AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a r [...] |
| MIC12 protein network | https://string-db.org/network/4932.YBR262C | Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista jun [...] |
| SHM1 protein network | https://string-db.org/network/4932.YBR263W | Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid bios [...] |
| YPT10 protein network | https://string-db.org/network/4932.YBR264C | Rab family GTP-binding protein; contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cist [...] |
| TSC10 protein network | https://string-db.org/network/4932.YBR265W | 3-ketodihydrosphingosine reductase TSC10; 3-ketosphinganine reductase; catalyzes the second step in phytosphingosine synthesis; essential for growth in the absence of exogenous dihydrosphingosine [...] |
| SLM6 protein network | https://string-db.org/network/4932.YBR266C | Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase. |
| REI1 protein network | https://string-db.org/network/4932.YBR267W | Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic [...] |
| MRPL37 protein network | https://string-db.org/network/4932.YBR268W | Mitochondrial ribosomal protein of the large subunit. |
| SDH8 protein network | https://string-db.org/network/4932.YBR269C | Protein required for assembly of succinate dehydrogenase; interacts with flavinylated Sdh1p and may function as a chaperone for free Sdh1p, protecting its FAD cofactor from redox reactions before [...] |
| BIT2 protein network | https://string-db.org/network/4932.YBR270C | Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH [...] |
| EFM2 protein network | https://string-db.org/network/4932.YBR271W | Protein-lysine N-methyltransferase EFM2; S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which dimethylates translation elongation factor EF2 (Eft1p a [...] |
| HSM3 protein network | https://string-db.org/network/4932.YBR272C | DNA mismatch repair protein HSM3; Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle ( [...] |
| UBX7 protein network | https://string-db.org/network/4932.YBR273C | UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication. |
| CHK1 protein network | https://string-db.org/network/4932.YBR274W | Serine/threonine-protein kinase CHK1; Serine/threonine kinase and DNA damage checkpoint effector; mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal tran [...] |
| RIF1 protein network | https://string-db.org/network/4932.YBR275C | Telomere length regulator protein RIF1; Protein that binds to the Rap1p C-terminus; acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; involved in [...] |
| PPS1 protein network | https://string-db.org/network/4932.YBR276C | Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle; Belongs to the protein-tyrosine phosphatase family. Non [...] |
| YBR277C protein network | https://string-db.org/network/4932.YBR277C | Putative uncharacterized protein YBR277C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| DPB3 protein network | https://string-db.org/network/4932.YBR278W | Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the inter [...] |
| PAF1 protein network | https://string-db.org/network/4932.YBR279W | RNA polymerase II-associated protein 1; Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expressi [...] |
| SAF1 protein network | https://string-db.org/network/4932.YBR280C | SCF-associated factor 1; F-Box protein involved in proteasome-dependent degradation of Aah1p; involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interact [...] |
| DUG2 protein network | https://string-db.org/network/4932.YBR281C | Probable di- and tripeptidase DUG2; Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond i [...] |
| MRPL27 protein network | https://string-db.org/network/4932.YBR282W | Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP. |
| SSH1 protein network | https://string-db.org/network/4932.YBR283C | Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential. |
| YBR284W protein network | https://string-db.org/network/4932.YBR284W | Inactive deaminase YBR284W; Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic de [...] |
| YBR285W protein network | https://string-db.org/network/4932.YBR285W | Putative protein of unknown function; YBR285W is not an essential gene. |
| APE3 protein network | https://string-db.org/network/4932.YBR286W | Vacuolar aminopeptidase Y; processed to mature form by Prb1p. |
| YBR287W protein network | https://string-db.org/network/4932.YBR287W | Uncharacterized transporter YBR287W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene; Belongs to the auxin efflux [...] |
| APM3 protein network | https://string-db.org/network/4932.YBR288C | Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway. |
| SNF5 protein network | https://string-db.org/network/4932.YBR289W | Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytoso [...] |
| BSD2 protein network | https://string-db.org/network/4932.YBR290W | Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to vacuole where they are degraded; acts as an adaptor protein with Rsp5p in the regulated endoc [...] |
| CTP1 protein network | https://string-db.org/network/4932.YBR291C | Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family. |
| YBR292C protein network | https://string-db.org/network/4932.YBR292C | Uncharacterized protein YBR292C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YBR292C is not an essential ge [...] |
| VBA2 protein network | https://string-db.org/network/4932.YBR293W | Permease of basic amino acids in the vacuolar membrane; Belongs to the major facilitator superfamily. |
| SUL1 protein network | https://string-db.org/network/4932.YBR294W | High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous act [...] |
| PCA1 protein network | https://string-db.org/network/4932.YBR295W | Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutat [...] |
| PHO89 protein network | https://string-db.org/network/4932.YBR296C | Phosphate permease PHO89; Plasma membrane Na+/Pi cotransporter; active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphat [...] |
| YBR296C-A protein network | https://string-db.org/network/4932.YBR296C-A | Uncharacterized protein YBR296C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| MAL33 protein network | https://string-db.org/network/4932.YBR297W | Maltose fermentation regulatory protein MAL33; MAL-activator protein; part of complex locus MAL3; nonfunctional in genomic reference strain S288C; Belongs to the MAL13 family. |
| MAL31 protein network | https://string-db.org/network/4932.YBR298C | Maltose permease; high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; func [...] |
| YBR298C-A protein network | https://string-db.org/network/4932.YBR298C-A | Uncharacterized protein YBR298C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| MAL32 protein network | https://string-db.org/network/4932.YBR299W | Alpha-glucosidase MAL32; Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyz [...] |
| YBR300C protein network | https://string-db.org/network/4932.YBR300C | Putative uncharacterized protein YBR300C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| PAU24 protein network | https://string-db.org/network/4932.YBR301W | Seripauperin-24; Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anae [...] |
| COS2 protein network | https://string-db.org/network/4932.YBR302C | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting [...] |
| RER1 protein network | https://string-db.org/network/4932.YCL001W | Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER. |
| YCL001W-A protein network | https://string-db.org/network/4932.YCL001W-A | Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III; Belongs to the eukaryotic release factor 1 fami [...] |
| YCL001W-B protein network | https://string-db.org/network/4932.YCL001W-B | Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication; Belongs to the [...] |
| YCL002C protein network | https://string-db.org/network/4932.YCL002C | Putative protein of unknown function; YCL002C is not an essential gene. |
| PGS1 protein network | https://string-db.org/network/4932.YCL004W | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn [...] |
| LDB16 protein network | https://string-db.org/network/4932.YCL005W | Protein involved in lipid droplet (LD) assembly; forms a complex with Sei1p at ER-LD contact sites, stabilizing contact sites; ensures that LDs bud from the ER towards the cytosolic side of the m [...] |
| VMA9 protein network | https://string-db.org/network/4932.YCL005W-A | Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis. |
| YCL007C protein network | https://string-db.org/network/4932.YCL007C | Putative uncharacterized protein CWH36; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified ORF Y [...] |
| STP22 protein network | https://string-db.org/network/4932.YCL008C | Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease; Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins int [...] |
| ILV6 protein network | https://string-db.org/network/4932.YCL009C | Acetolactate synthase small subunit, mitochondrial; Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances [...] |
| SGF29 protein network | https://string-db.org/network/4932.YCL010C | SAGA-associated factor 29; Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in [...] |
| GBP2 protein network | https://string-db.org/network/4932.YCL011C | Single-strand telomeric DNA-binding protein GBP2; Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for [...] |
| YCL012C protein network | https://string-db.org/network/4932.YCL012C | UPF0357 protein YCL012C; Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; orthologs are present in S. bayanus, S. [...] |
| BUD3 protein network | https://string-db.org/network/4932.YCL014W | Bud site selection protein 3; Guanine nucleotide exchange factor (GEF) for Cdc42p; activates Cdc42p in early G1, accounting for the first stage of biphasic activation, with Cdc24p accounting for [...] |
| DCC1 protein network | https://string-db.org/network/4932.YCL016C | Sister chromatid cohesion protein DCC1; Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length ma [...] |
| NFS1 protein network | https://string-db.org/network/4932.YCL017C | Cysteine desulfurase, mitochondrial; Cysteine desulfurase; involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein loc [...] |
| LEU2 protein network | https://string-db.org/network/4932.YCL018W | Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate; Belo [...] |
| YCL021W-A protein network | https://string-db.org/network/4932.YCL021W-A | Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the vacuole. |
| YCL023C protein network | https://string-db.org/network/4932.YCL023C | Putative uncharacterized protein YCL023C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ve [...] |
| KCC4 protein network | https://string-db.org/network/4932.YCL024W | Probable serine/threonine-protein kinase KCC4; Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, sh [...] |
| AGP1 protein network | https://string-db.org/network/4932.YCL025C | Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor syst [...] |
| FRM2 protein network | https://string-db.org/network/4932.YCL026C-A | Fatty acid repression mutant protein 2; Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indic [...] |
| HBN1 protein network | https://string-db.org/network/4932.YCL026C-B | Putative nitroreductase HBN1; Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein bec [...] |
| FUS1 protein network | https://string-db.org/network/4932.YCL027W | Nuclear fusion protein FUS1; Membrane protein localized to the shmoo tip; required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polariz [...] |
| RNQ1 protein network | https://string-db.org/network/4932.YCL028W | [PIN(+)] prion; an infectious protein conformation that is generally an ordered protein aggregate. |
| BIK1 protein network | https://string-db.org/network/4932.YCL029C | Nuclear fusion protein BIK1; Microtubule-associated protein; component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells [...] |
| HIS4 protein network | https://string-db.org/network/4932.YCL030C | Histidine biosynthesis trifunctional protein; Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; cat [...] |
| RRP7 protein network | https://string-db.org/network/4932.YCL031C | Ribosomal RNA-processing protein 7; Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress. |
| STE50 protein network | https://string-db.org/network/4932.YCL032W | Adaptor protein for various signaling pathways; involved in mating response, invasive/filamentous growth, osmotolerance; acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex t [...] |
| MXR2 protein network | https://string-db.org/network/4932.YCL033C | Methionine-R-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan. |
| LSB5 protein network | https://string-db.org/network/4932.YCL034W | Protein involved in membrane-trafficking events at plasma membrane; interacts with actin regulators Sla1p and Las17p, ubiquitin, Arf3p to couple actin dynamics to membrane trafficking processes; [...] |
| GRX1 protein network | https://string-db.org/network/4932.YCL035C | Glutaredoxin-1; Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; [...] |
| GFD2 protein network | https://string-db.org/network/4932.YCL036W | Good for full DBP5 activity protein 2; Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplicat [...] |
| SRO9 protein network | https://string-db.org/network/4932.YCL037C | Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in hem [...] |
| ATG22 protein network | https://string-db.org/network/4932.YCL038C | Autophagy-related protein 22; Vacuolar integral membrane protein required for efflux of amino acids; required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutat [...] |
| GID7 protein network | https://string-db.org/network/4932.YCL039W | Glucose-induced degradation protein 7; Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose- [...] |
| GLK1 protein network | https://string-db.org/network/4932.YCL040W | Glucokinase-1; Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated [...] |
| YCL042W protein network | https://string-db.org/network/4932.YCL042W | Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm. |
| PDI1 protein network | https://string-db.org/network/4932.YCL043C | Protein disulfide isomerase; multifunctional oxidoreductase of the ER lumen, essential for disulfide bond formation in secretory and cell-surface proteins, processing of non-native disulfide bond [...] |
| MGR1 protein network | https://string-db.org/network/4932.YCL044C | Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; r [...] |
| EMC1 protein network | https://string-db.org/network/4932.YCL045C | Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Ga [...] |
| YCL046W protein network | https://string-db.org/network/4932.YCL046W | Putative uncharacterized protein YCL046W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| POF1 protein network | https://string-db.org/network/4932.YCL047C | Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinami [...] |
| SPS22 protein network | https://string-db.org/network/4932.YCL048W | Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall; Belongs [...] |
| YCL048W-A protein network | https://string-db.org/network/4932.YCL048W-A | Uncharacterized protein YCL048W-A; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that [...] |
| YCL049C protein network | https://string-db.org/network/4932.YCL049C | Uncharacterized protein YCL049C; Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene. |
| APA1 protein network | https://string-db.org/network/4932.YCL050C | AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis [...] |
| LRE1 protein network | https://string-db.org/network/4932.YCL051W | Laminarase-resistance protein LRE1; Protein involved in control of cell wall structure and stress response; direct inhibitor of the nuclear Dbf2 related (NDR) kinase Cbk1p-Mob2p; overproduction c [...] |
| PBN1 protein network | https://string-db.org/network/4932.YCL052C | Protein PBN1; Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; [...] |
| SPB1 protein network | https://string-db.org/network/4932.YCL054W | 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase; AdoMet-dependent methyltransferase; involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking s [...] |
| RDT1 protein network | https://string-db.org/network/4932.YCL054W-A | Uncharacterized protein RDT1; Short open reading frame, shows evidence of translation; may be new protein-coding gene that originated de novo from noncoding sequence; same allele found in at leas [...] |
| KAR4 protein network | https://string-db.org/network/4932.YCL055W | Karyogamy protein KAR4; Transcription factor required for response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth [...] |
| PEX34 protein network | https://string-db.org/network/4932.YCL056C | Protein that regulates peroxisome populations; peroxisomal integral membrane protein; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome mor [...] |
| MIC10 protein network | https://string-db.org/network/4932.YCL057C-A | Conserved component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of [...] |
| PRD1 protein network | https://string-db.org/network/4932.YCL057W | Saccharolysin; Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides [...] |
| FYV5 protein network | https://string-db.org/network/4932.YCL058C | Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeost [...] |
| ADF1 protein network | https://string-db.org/network/4932.YCL058W-A | Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand [...] |
| KRR1 protein network | https://string-db.org/network/4932.YCL059C | KRR1 small subunit processome component; Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit [...] |
| MRC1 protein network | https://string-db.org/network/4932.YCL061C | S-phase checkpoint protein required for DNA replication; couples DNA helicase and polymerase; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a paus [...] |
| VAC17 protein network | https://string-db.org/network/4932.YCL063W | Vacuole-related protein 17; Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p; involved in regulatio [...] |
| CHA1 protein network | https://string-db.org/network/4932.YCL064C | Catabolic L-serine/threonine dehydratase; Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole n [...] |
| YCL065W protein network | https://string-db.org/network/4932.YCL065W | Putative uncharacterized protein YCL065W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps HMLALPHA1. |
| HMLALPHA1 protein network | https://string-db.org/network/4932.YCL066W | Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression. |
| HMLALPHA2 protein network | https://string-db.org/network/4932.YCL067C | Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploi [...] |
| YCL068C protein network | https://string-db.org/network/4932.YCL068C | Putative protein of unknown function. |
| VBA3 protein network | https://string-db.org/network/4932.YCL069W | Permease of basic amino acids in the vacuolar membrane; VBA3 has a paralog, VBA5, that arose from a segmental duplication; Belongs to the major facilitator superfamily. |
| GEX1 protein network | https://string-db.org/network/4932.YCL073C | Glutathione exchanger 1; Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role [...] |
| YCL076W protein network | https://string-db.org/network/4932.YCL076W | Putative uncharacterized protein YCL076W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YCR001W protein network | https://string-db.org/network/4932.YCR001W | Uncharacterized protein YCR001W; Putative protein of unknown function; conserved among S. cerevisiae strains; YCR001W is not an essential gene. |
| CDC10 protein network | https://string-db.org/network/4932.YCR002C | Cell division control protein 10; Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form [...] |
| MRPL32 protein network | https://string-db.org/network/4932.YCR003W | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress. |
| YCP4 protein network | https://string-db.org/network/4932.YCR004C | Flavoprotein-like protein YCP4; Protein of unknown function; has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in [...] |
| CIT2 protein network | https://string-db.org/network/4932.YCR005C | Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate; expression is controlled by Rtg1p and Rtg2p trans [...] |
| YCR006C protein network | https://string-db.org/network/4932.YCR006C | Uncharacterized protein YCR006C; Putative protein of unknown function; conserved among S. cerevisiae strains; YCR006C is not an essential gene. |
| YCR007C protein network | https://string-db.org/network/4932.YCR007C | DUP240 protein YCR007C; Putative integral membrane protein; member of DUP240 gene family; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCR007C is not an essent [...] |
| SAT4 protein network | https://string-db.org/network/4932.YCR008W | Serine/threonine-protein kinase HAL4/SAT4; Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipo [...] |
| RVS161 protein network | https://string-db.org/network/4932.YCR009C | Reduced viability upon starvation protein 161; Amphiphysin-like lipid raft protein; N-BAR domain protein that interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocyto [...] |
| ADY2 protein network | https://string-db.org/network/4932.YCR010C | Accumulation of dyads protein 2; Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication. |
| ADP1 protein network | https://string-db.org/network/4932.YCR011C | Putative ATP-dependent permease of the ABC transporter family; Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. |
| PGK1 protein network | https://string-db.org/network/4932.YCR012W | 3-phosphoglycerate kinase; catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenes [...] |
| YCR013C protein network | https://string-db.org/network/4932.YCR013C | Putative uncharacterized protein YCR013C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both [...] |
| POL4 protein network | https://string-db.org/network/4932.YCR014C | DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA pol [...] |
| CTO1 protein network | https://string-db.org/network/4932.YCR015C | Protein required for cold tolerance; involved in phosphate uptake; YCR015C is not an essential gene. |
| YCR016W protein network | https://string-db.org/network/4932.YCR016W | Uncharacterized protein YCR016W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome [...] |
| CWH43 protein network | https://string-db.org/network/4932.YCR017C | Protein CWH43; GPI lipid remodelase; responsible for introducing ceramides into GPI anchors having a C26:0 fatty acid in sn-2 of the glycerol moiety; can also use lyso-GPI protein anchors and var [...] |
| SRD1 protein network | https://string-db.org/network/4932.YCR018C | Pre-rRNA-processing protein SRD1; Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation [...] |
| YCR018C-A protein network | https://string-db.org/network/4932.YCR018C-A | Putative protein of unknown function; encoded opposite a Ty1 LTR. |
| MAK32 protein network | https://string-db.org/network/4932.YCR019W | Protein necessary for stability of L-A dsRNA-containing particles. |
| PET18 protein network | https://string-db.org/network/4932.YCR020C | Protein of unknown function; has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin. |
| MAK31 protein network | https://string-db.org/network/4932.YCR020C-A | N-alpha-acetyltransferase 38, NatC auxiliary subunit; Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein fam [...] |
| HTL1 protein network | https://string-db.org/network/4932.YCR020W-B | High temperature lethal protein 1; Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chr [...] |
| HSP30 protein network | https://string-db.org/network/4932.YCR021C | 30 kDa heat shock protein; Negative regulator of the H(+)-ATPase Pma1p; stress-responsive protein; hydrophobic plasma membrane localized; induced by heat shock, ethanol treatment, weak organic ac [...] |
| YCR022C protein network | https://string-db.org/network/4932.YCR022C | Uncharacterized protein YCR022C; Putative protein of unknown function; conserved among S. cerevisiae strains; YCR022C is not an essential gene. |
| YCR023C protein network | https://string-db.org/network/4932.YCR023C | Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene. |
| SLM5 protein network | https://string-db.org/network/4932.YCR024C | Asparagine--tRNA ligase, mitochondrial; Mitochondrial asparaginyl-tRNA synthetase. |
| PMP1 protein network | https://string-db.org/network/4932.YCR024C-A | Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically seg [...] |
| YCR024C-B protein network | https://string-db.org/network/4932.YCR024C-B | Uncharacterized protein YCR024C-B; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| YCR025C protein network | https://string-db.org/network/4932.YCR025C | Uncharacterized protein YCR025C; Putative protein of unknown function; conserved across S. cerevisiae strains; YCR025C is not an essential gene. |
| NPP1 protein network | https://string-db.org/network/4932.YCR026C | Ectonucleotide pyrophosphatase/phosphodiesterase 1; Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and e [...] |
| RHB1 protein network | https://string-db.org/network/4932.YCR027C | Rheb-like protein RHB1; Putative Rheb-related GTPase; involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins. |
| FEN2 protein network | https://string-db.org/network/4932.YCR028C | Pantothenate transporter FEN2; Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication str [...] |
| RIM1 protein network | https://string-db.org/network/4932.YCR028C-A | ssDNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication; stimulates utilization by Mip1p DNA polymerase of RNA primers synthesized by Rpo41 [...] |
| SYP1 protein network | https://string-db.org/network/4932.YCR030C | Suppressor of yeast profilin deletion; Negative regulator of WASP-Arp23 complex; involved in endocytic site formation; directly inhibits Las17p stimulation of Arp23 complex-mediated actin assembl [...] |
| RPS14A protein network | https://string-db.org/network/4932.YCR031C | Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal p [...] |
| BPH1 protein network | https://string-db.org/network/4932.YCR032W | Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; muta [...] |
| SNT1 protein network | https://string-db.org/network/4932.YCR033W | Probable DNA-binding protein SNT1; Subunit of the Set3C deacetylase complex; interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolera [...] |
| ELO2 protein network | https://string-db.org/network/4932.YCR034W | Elongation of fatty acids protein 2; Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-g [...] |
| RRP43 protein network | https://string-db.org/network/4932.YCR035C | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8 [...] |
| RBK1 protein network | https://string-db.org/network/4932.YCR036W | Putative ribokinase; Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily. |
| PHO87 protein network | https://string-db.org/network/4932.YCR037C | Low-affinity inorganic phosphate (Pi) transporter; acts upstream of Pho81p in regulation of the PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane [...] |
| BUD5 protein network | https://string-db.org/network/4932.YCR038C | Bud site selection protein 5; GTP/GDP exchange factor for Rsr1p (Bud1p); required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types. |
| YCR038W-A protein network | https://string-db.org/network/4932.YCR038W-A | Putative uncharacterized protein YCR038W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| MATALPHA2 protein network | https://string-db.org/network/4932.YCR039C | Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha [...] |
| MATALPHA1 protein network | https://string-db.org/network/4932.YCR040W | Transcriptional co-activator that regulates mating-type-specific genes; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha m [...] |
| YCR041W protein network | https://string-db.org/network/4932.YCR041W | Uncharacterized protein YCR041W; Protein of unknown function; overexpression suppresses the high-frequency loss of mini-chromosomes, probably by increasing the rate of proper chromosome segregati [...] |
| TAF2 protein network | https://string-db.org/network/4932.YCR042C | TFIID subunit (150 kDa); involved in RNA polymerase II transcription initiation. |
| YCR043C protein network | https://string-db.org/network/4932.YCR043C | Uncharacterized protein YCR043C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene. |
| PER1 protein network | https://string-db.org/network/4932.YCR044C | Protein of the endoplasmic reticulum; required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; function [...] |
| RRT12 protein network | https://string-db.org/network/4932.YCR045C | Subtilase-type proteinase RRT12; Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER re [...] |
| IMG1 protein network | https://string-db.org/network/4932.YCR046C | Mitochondrial ribosomal protein of the large subunit; required for respiration and for maintenance of the mitochondrial genome. |
| BUD23 protein network | https://string-db.org/network/4932.YCR047C | Methyltransferase that methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displa [...] |
| YCR047W-A protein network | https://string-db.org/network/4932.YCR047W-A | Putative uncharacterized protein YCR047W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| ARE1 protein network | https://string-db.org/network/4932.YCR048W | Sterol O-acyltransferase 1; Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, A [...] |
| YCR051W protein network | https://string-db.org/network/4932.YCR051W | Ankyrin repeat-containing protein YCR051W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repe [...] |
| RSC6 protein network | https://string-db.org/network/4932.YCR052W | Component of the RSC chromatin remodeling complex; essential for mitotic growth; RSC6 has a paralog, SNF12, that arose from the whole genome duplication. |
| THR4 protein network | https://string-db.org/network/4932.YCR053W | Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway. |
| CTR86 protein network | https://string-db.org/network/4932.YCR054C | Copper transport protein 86; Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxi [...] |
| PWP2 protein network | https://string-db.org/network/4932.YCR057C | Periodic tryptophan protein 2; Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; [...] |
| YIH1 protein network | https://string-db.org/network/4932.YCR059C | Protein IMPACT homolog; Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of [...] |
| TAH1 protein network | https://string-db.org/network/4932.YCR060W | TPR repeat-containing protein associated with Hsp90; Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly of large [...] |
| YCR061W protein network | https://string-db.org/network/4932.YCR061W | Uncharacterized membrane protein YCR061W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8 [...] |
| BUD31 protein network | https://string-db.org/network/4932.YCR063W | Pre-mRNA-splicing factor BUD31; Component of the SF3b subcomplex of the U2 snRNP; increases efficiency of first and second step pre-mRNA splicing; diploid mutants display a random budding pattern [...] |
| HCM1 protein network | https://string-db.org/network/4932.YCR065W | Forkhead transcription factor; drives S-phase activation of genes involved in chromosome segregation, spindle dynamics, budding; also activates genes involved in respiration, use of alternative e [...] |
| RAD18 protein network | https://string-db.org/network/4932.YCR066W | Postreplication repair E3 ubiquitin-protein ligase RAD18; E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-str [...] |
| SED4 protein network | https://string-db.org/network/4932.YCR067C | Putative guanine nucleotide-exchange factor SED4; Integral ER membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins fro [...] |
| ATG15 protein network | https://string-db.org/network/4932.YCR068W | Putative lipase ATG15; Phospholipase; preferentially hydrolyses phosphatidylserine, with minor activity against cardiolipin and phosphatidylethanolamine; required for lysis of autophagic and CVT [...] |
| CPR4 protein network | https://string-db.org/network/4932.YCR069W | Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR4 has a [...] |
| IMG2 protein network | https://string-db.org/network/4932.YCR071C | Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49. |
| RSA4 protein network | https://string-db.org/network/4932.YCR072C | WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucle [...] |
| SSK22 protein network | https://string-db.org/network/4932.YCR073C | Serine/threonine-protein kinase SSK22; MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphory [...] |
| SOL2 protein network | https://string-db.org/network/4932.YCR073W-A | 6-phosphogluconolactonase-like protein 2; Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic acti [...] |
| ERS1 protein network | https://string-db.org/network/4932.YCR075C | Protein involved in cystine transport; localizes to the vacuole, plasma membrane and endosome; similarity to human cystinosin, a H(+)-driven transporter involved in L-cystine export from lysosome [...] |
| EGO2 protein network | https://string-db.org/network/4932.YCR075W-A | Uncharacterized protein YCR075W-A; Component of the EGO and GSE complexes; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplicat [...] |
| FUB1 protein network | https://string-db.org/network/4932.YCR076C | Silencing boundary-establishment protein FUB1; Proteasome-binding protein; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle [...] |
| PAT1 protein network | https://string-db.org/network/4932.YCR077C | DNA topoisomerase 2-associated protein PAT1; Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection [...] |
| PTC6 protein network | https://string-db.org/network/4932.YCR079W | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutan [...] |
| SRB8 protein network | https://string-db.org/network/4932.YCR081W | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose [...] |
| AHC2 protein network | https://string-db.org/network/4932.YCR082W | Component of the ADA histone acetyltransferase complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ahc1p to the complex. |
| TRX3 protein network | https://string-db.org/network/4932.YCR083W | Mitochondrial thioredoxin; highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained [...] |
| TUP1 protein network | https://string-db.org/network/4932.YCR084C | General transcriptional corepressor TUP1; General repressor of transcription; forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with h [...] |
| YCR085W protein network | https://string-db.org/network/4932.YCR085W | Uncharacterized protein YCR085W; Putative protein of unknown function; conserved among S. cerevisiae strains; YCR085W is not an essential gene. |
| CSM1 protein network | https://string-db.org/network/4932.YCR086W | Monopolin complex subunit CSM1; Nucleolar protein that mediates homolog segregation during meiosis I; forms a complex with Lrs4p and then Mam1p at kinetochores; required for condensin recruitment [...] |
| YCR087C-A protein network | https://string-db.org/network/4932.YCR087C-A | UPF0743 protein YCR087C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene; Belongs to the UPF0 [...] |
| YCR087W protein network | https://string-db.org/network/4932.YCR087W | Putative uncharacterized protein YCR087W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps un [...] |
| ABP1 protein network | https://string-db.org/network/4932.YCR088W | Actin-binding protein of the cortical actin cytoskeleton; important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; inhibits barbed-end actin filame [...] |
| FIG2 protein network | https://string-db.org/network/4932.YCR089W | Factor-induced gene 2 protein; Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating; FIG2 has a paralog, AGA1, that arose f [...] |
| YCR090C protein network | https://string-db.org/network/4932.YCR090C | UPF0587 protein YCR090C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene; Belongs to [...] |
| KIN82 protein network | https://string-db.org/network/4932.YCR091W | Serine/threonine-protein kinase KIN82; Putative serine/threonine protein kinase; implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippa [...] |
| MSH3 protein network | https://string-db.org/network/4932.YCR092C | Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for [...] |
| CDC39 protein network | https://string-db.org/network/4932.YCR093W | General negative regulator of transcription subunit 1; Subunit of the CCR4-NOT1 core complex; this complex has multiple roles in the regulation of mRNA levels including regulation of transcriptio [...] |
| CDC50 protein network | https://string-db.org/network/4932.YCR094W | Cell division control protein 50; Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polar [...] |
| OCA4 protein network | https://string-db.org/network/4932.YCR095C | Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts. |
| YCR095W-A protein network | https://string-db.org/network/4932.YCR095W-A | Putative protein of unknown function. |
| HMRA2 protein network | https://string-db.org/network/4932.YCR096C | Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversi [...] |
| HMRA1 protein network | https://string-db.org/network/4932.YCR097W | Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells. |
| YCR097W-A protein network | https://string-db.org/network/4932.YCR097W-A | Putative uncharacterized protein YCR097W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by homol [...] |
| GIT1 protein network | https://string-db.org/network/4932.YCR098C | Glycerophosphoinositol transporter 1; Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression [...] |
| YCR099C protein network | https://string-db.org/network/4932.YCR099C | Uncharacterized protein YCR099C; Putative protein of unknown function. |
| YCR100C protein network | https://string-db.org/network/4932.YCR100C | Uncharacterized protein YCR100C; Putative protein of unknown function. |
| YCR101C protein network | https://string-db.org/network/4932.YCR101C | Uncharacterized protein YCR101C; Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene. |
| YCR102C protein network | https://string-db.org/network/4932.YCR102C | Uncharacterized protein YCR102C; Putative protein of unknown function; involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family; Belongs to the [...] |
| YCR102W-A protein network | https://string-db.org/network/4932.YCR102W-A | Putative uncharacterized protein YCR102W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| PAU3 protein network | https://string-db.org/network/4932.YCR104W | Seripauperin-3; Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen [...] |
| ADH7 protein network | https://string-db.org/network/4932.YCR105W | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in alde [...] |
| RDS1 protein network | https://string-db.org/network/4932.YCR106W | Regulator of drug sensitivity 1; Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide. |
| AAD3 protein network | https://string-db.org/network/4932.YCR107W | Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD3 has a paralog, AAD15, that arose f [...] |
| YCR108C protein network | https://string-db.org/network/4932.YCR108C | Uncharacterized protein YCR108C; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| RMD1 protein network | https://string-db.org/network/4932.YDL001W | Cytoplasmic protein required for sporulation. |
| NHP10 protein network | https://string-db.org/network/4932.YDL002C | Non-histone protein 10; Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends, protecting them from exonucleatic cleavage; deletion affects telomere maintenance [...] |
| MCD1 protein network | https://string-db.org/network/4932.YDL003W | Sister chromatid cohesion protein 1; Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and transloc [...] |
| ATP16 protein network | https://string-db.org/network/4932.YDL004W | Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulat [...] |
| MED2 protein network | https://string-db.org/network/4932.YDL005C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; relocalizes to the [...] |
| PTC1 protein network | https://string-db.org/network/4932.YDL006W | Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing [...] |
| YDL007C-A protein network | https://string-db.org/network/4932.YDL007C-A | Putative protein of unknown function. |
| RPT2 protein network | https://string-db.org/network/4932.YDL007W | ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for normal peptide hy [...] |
| APC11 protein network | https://string-db.org/network/4932.YDL008W | Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the me [...] |
| YDL009C protein network | https://string-db.org/network/4932.YDL009C | Uncharacterized protein YDL009C; Protein of unknown function; mRNA identified as translated by ribosome profiling data; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially ove [...] |
| GRX6 protein network | https://string-db.org/network/4932.YDL010W | Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paral [...] |
| YDL011C protein network | https://string-db.org/network/4932.YDL011C | Putative uncharacterized protein YDL011C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharac [...] |
| YDL012C protein network | https://string-db.org/network/4932.YDL012C | Cysteine-rich and transmembrane domain-containing protein YDL012C; Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to [...] |
| SLX5 protein network | https://string-db.org/network/4932.YDL013W | Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex; role in Ub-mediated degradation of histone variant Cse4p preventing mislocalization to euchromatin; role in proteolysis of spindl [...] |
| NOP1 protein network | https://string-db.org/network/4932.YDL014W | rRNA 2'-O-methyltransferase fibrillarin; Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex, which is required for processin [...] |
| TSC13 protein network | https://string-db.org/network/4932.YDL015C | Very-long-chain enoyl-CoA reductase; Enoyl reductase; catalyzes last step in each cycle of very long chain fatty acid elongation; localizes to ER, highly enriched in a structure marking nuclear-v [...] |
| YDL016C protein network | https://string-db.org/network/4932.YDL016C | Putative uncharacterized protein YDL016C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| CDC7 protein network | https://string-db.org/network/4932.YDL017W | Cell division control protein 7; DDK (Dbf4-dependent kinase) catalytic subunit; required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p c [...] |
| ERP3 protein network | https://string-db.org/network/4932.YDL018C | Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport. |
| OSH2 protein network | https://string-db.org/network/4932.YDL019C | Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function e [...] |
| RPN4 protein network | https://string-db.org/network/4932.YDL020C | Protein RPN4; Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is trans [...] |
| GPM2 protein network | https://string-db.org/network/4932.YDL021W | Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM2 has a paralog, GPM3, that arose from the whole genome duplic [...] |
| YDL022C-A protein network | https://string-db.org/network/4932.YDL022C-A | Uncharacterized protein YDL022C-A; Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially overlaps the verified gene DIA3; identified by fungal homol [...] |
| GPD1 protein network | https://string-db.org/network/4932.YDL022W | NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; p [...] |
| YDL023C protein network | https://string-db.org/network/4932.YDL023C | Putative uncharacterized protein YDL023C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in othe [...] |
| DIA3 protein network | https://string-db.org/network/4932.YDL024C | Probable acid phosphatase DIA3; Protein of unknown function; involved in invasive and pseudohyphal growth. |
| RTK1 protein network | https://string-db.org/network/4932.YDL025C | Probable serine/threonine-protein kinase RTK1; Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance in [...] |
| YDL025W-A protein network | https://string-db.org/network/4932.YDL025W-A | Putative uncharacterized protein YDL025W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| YDL026W protein network | https://string-db.org/network/4932.YDL026W | Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| MRX9 protein network | https://string-db.org/network/4932.YDL027C | MIOREX complex component 9; Protein that associates with mitochondrial ribosome; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C [...] |
| MPS1 protein network | https://string-db.org/network/4932.YDL028C | Serine/threonine-protein kinase MPS1; Dual-specificity kinase; autophosphorylation required for function; required for spindle pole body (SPB) duplication and spindle checkpoint function; contrib [...] |
| ARP2 protein network | https://string-db.org/network/4932.YDL029W | Actin-related protein 2; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endo [...] |
| PRP9 protein network | https://string-db.org/network/4932.YDL030W | Pre-mRNA-splicing factor PRP9; Subunit of the SF3a splicing factor complex; required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex; Belongs to the SF3A3 fami [...] |
| DBP10 protein network | https://string-db.org/network/4932.YDL031W | Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis; Belongs to the DEAD box helicase [...] |
| YDL032W protein network | https://string-db.org/network/4932.YDL032W | Putative uncharacterized protein YDL032w; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ve [...] |
| SLM3 protein network | https://string-db.org/network/4932.YDL033C | tRNA-specific 2-thiouridylase; responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human homolog TRMU is implicated in myoclonus epilepsy associated with ragged red fibers (ME [...] |
| YDL034W protein network | https://string-db.org/network/4932.YDL034W | Putative uncharacterized protein YDL034W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps wi [...] |
| GPR1 protein network | https://string-db.org/network/4932.YDL035C | Plasma membrane G protein coupled receptor (GPCR); interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation [...] |
| PUS9 protein network | https://string-db.org/network/4932.YDL036C | Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a para [...] |
| BSC1 protein network | https://string-db.org/network/4932.YDL037C | Bypass of stop codon protein 1; Protein of unconfirmed function; similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent [...] |
| PRM7 protein network | https://string-db.org/network/4932.YDL039C | Pheromone-regulated protein; predicted to have one transmembrane segment; promoter contains Gcn4p binding elements; in W303 strain one continuous open reading frame comprising of YDL037C, the int [...] |
| NAT1 protein network | https://string-db.org/network/4932.YDL040C | Subunit of protein N-terminal acetyltransferase NatA; NatA comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins to influence multiple processes such as cell cycle progressi [...] |
| SIR2 protein network | https://string-db.org/network/4932.YDL042C | Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; in [...] |
| PRP11 protein network | https://string-db.org/network/4932.YDL043C | Pre-mRNA-splicing factor PRP11; Subunit of the SF3a splicing factor complex; required for spliceosome assembly. |
| MTF2 protein network | https://string-db.org/network/4932.YDL044C | Mitochondrial transcription factor 2; Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and coup [...] |
| FAD1 protein network | https://string-db.org/network/4932.YDL045C | FAD synthase; Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1. |
| MRP10 protein network | https://string-db.org/network/4932.YDL045W-A | Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs; oxidized by Mia40p during import into mitochondria. |
| NPC2 protein network | https://string-db.org/network/4932.YDL046W | Phosphatidylglycerol/phosphatidylinositol transfer protein; Sterol transport protein and functional homolog of human NPC2/He1; human NPC2 is a cholesterol-binding protein whose deficiency causes [...] |
| SIT4 protein network | https://string-db.org/network/4932.YDL047W | Serine/threonine-protein phosphatase PP1-1; Ceramide-activated, type 2A-related serine-threonine phosphatase; functions in G1/S transition of mitotic cycle; controls lifespan, mitochondrial funct [...] |
| STP4 protein network | https://string-db.org/network/4932.YDL048C | Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has [...] |
| KNH1 protein network | https://string-db.org/network/4932.YDL049C | Protein with similarity to Kre9p; Kre9p is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance. |
| LHP1 protein network | https://string-db.org/network/4932.YDL051W | La protein homolog; RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantig [...] |
| SLC1 protein network | https://string-db.org/network/4932.YDL052C | 1-acyl-sn-glycerol-3-phosphate acyltransferase; catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in [...] |
| PBP4 protein network | https://string-db.org/network/4932.YDL053C | Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the n [...] |
| MCH1 protein network | https://string-db.org/network/4932.YDL054C | Probable transporter MCH1; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane b [...] |
| PSA1 protein network | https://string-db.org/network/4932.YDL055C | GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure. |
| MBP1 protein network | https://string-db.org/network/4932.YDL056W | Transcription factor; involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synt [...] |
| YDL057W protein network | https://string-db.org/network/4932.YDL057W | Putative protein of unknown function; YDL057W is not an essential gene. |
| USO1 protein network | https://string-db.org/network/4932.YDL058W | Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex. |
| RAD59 protein network | https://string-db.org/network/4932.YDL059C | Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuc [...] |
| TSR1 protein network | https://string-db.org/network/4932.YDL060W | Ribosome biogenesis protein TSR1; Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits [...] |
| RPS29B protein network | https://string-db.org/network/4932.YDL061C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication [...] |
| SYO1 protein network | https://string-db.org/network/4932.YDL063C | Synchronized import protein 1; Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; binds to nascent Rpl5p during transl [...] |
| UBC9 protein network | https://string-db.org/network/4932.YDL064W | SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anap [...] |
| PEX19 protein network | https://string-db.org/network/4932.YDL065C | Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the [...] |
| IDP1 protein network | https://string-db.org/network/4932.YDL066W | Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ket [...] |
| COX9 protein network | https://string-db.org/network/4932.YDL067C | Subunit VIIa of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain. |
| CBS1 protein network | https://string-db.org/network/4932.YDL069C | Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader. |
| BDF2 protein network | https://string-db.org/network/4932.YDL070W | Bromodomain-containing factor 2; Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; [...] |
| YDL071C protein network | https://string-db.org/network/4932.YDL071C | Putative uncharacterized protein YDL071C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| YET3 protein network | https://string-db.org/network/4932.YDL072C | Endoplasmic reticulum transmembrane protein 3; Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases [...] |
| AHK1 protein network | https://string-db.org/network/4932.YDL073W | UPF0592 protein YDL073W; Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway; physically interacts with the cytoplasmic domain of Hkr1p, and with Sho1p, Pbs2p, and Ste11p; prev [...] |
| BRE1 protein network | https://string-db.org/network/4932.YDL074C | E3 ubiquitin ligase; forms heterodimer with Rad6p to regulate K63 polyubiquitination in response to oxidative stress and to monoubiquinate histone H2B-K123, which is required for the subsequent m [...] |
| RPL31A protein network | https://string-db.org/network/4932.YDL075W | Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31 [...] |
| RXT3 protein network | https://string-db.org/network/4932.YDL076C | Transcriptional regulatory protein RXT3; Component of the Rpd3L histone deacetylase complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress; [...] |
| VAM6 protein network | https://string-db.org/network/4932.YDL077C | Vacuolar morphogenesis protein 6; Guanine nucleotide exchange factor for the GTPase Gtr1p; subunit of the HOPS endocytic tethering complex; vacuole membrane protein; functions as a Rab GTPase eff [...] |
| MDH3 protein network | https://string-db.org/network/4932.YDL078C | Peroxisomal malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle. |
| MRK1 protein network | https://string-db.org/network/4932.YDL079C | Serine/threonine-protein kinase MRK1; Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress res [...] |
| THI3 protein network | https://string-db.org/network/4932.YDL080C | Thiamine metabolism regulatory protein THI3; Regulatory protein that binds Pdc2p and Thi2p transcription factors; activates thiamine biosynthesis transcription factors Pdc2p and Thi2p by binding [...] |
| RPP1A protein network | https://string-db.org/network/4932.YDL081C | 60S acidic ribosomal protein P1-alpha; Ribosomal stalk protein P1 alpha; involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P1 stimulates [...] |
| RPL13A protein network | https://string-db.org/network/4932.YDL082W | Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genom [...] |
| RPS16B protein network | https://string-db.org/network/4932.YDL083C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication. |
| SUB2 protein network | https://string-db.org/network/4932.YDL084W | ATP-dependent RNA helicase SUB2; Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceo [...] |
| YDL085C-A protein network | https://string-db.org/network/4932.YDL085C-A | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. |
| NDE2 protein network | https://string-db.org/network/4932.YDL085W | External NADH-ubiquinone oxidoreductase 2, mitochondrial; Mitochondrial external NADH dehydrogenase; catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytos [...] |
| YDL086W protein network | https://string-db.org/network/4932.YDL086W | Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene; Belongs to the d [...] |
| LUC7 protein network | https://string-db.org/network/4932.YDL087C | Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocali [...] |
| ASM4 protein network | https://string-db.org/network/4932.YDL088C | FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore asse [...] |
| NUR1 protein network | https://string-db.org/network/4932.YDL089W | Nuclear rim protein 1; Protein involved in regulation of mitotic exit; dephosphorylation target of Cdc14p in anaphase, which promotes timely rDNA segregation and allows mitotic progression; inter [...] |
| RAM1 protein network | https://string-db.org/network/4932.YDL090C | Beta subunit of the CAAX farnesyltransferase (FTase); this complex prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; [...] |
| UBX3 protein network | https://string-db.org/network/4932.YDL091C | UBX domain-containing protein 3; Clathrin-coated vesicle component, regulator of endocytosis; copurifies with the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing prot [...] |
| SRP14 protein network | https://string-db.org/network/4932.YDL092W | Signal recognition particle (SRP) subunit; interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during mem [...] |
| PMT5 protein network | https://string-db.org/network/4932.YDL093W | Dolichyl-phosphate-mannose--protein mannosyltransferase 5; Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts i [...] |
| PMT1 protein network | https://string-db.org/network/4932.YDL095W | Dolichyl-phosphate-mannose--protein mannosyltransferase 1; Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine re [...] |
| OPI6 protein network | https://string-db.org/network/4932.YDL096C | Putative uncharacterized protein OPI6; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verif [...] |
| RPN6 protein network | https://string-db.org/network/4932.YDL097C | Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; [...] |
| SNU23 protein network | https://string-db.org/network/4932.YDL098C | 23 kDa U4/U6.U5 small nuclear ribonucleoprotein component; Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome. |
| BUG1 protein network | https://string-db.org/network/4932.YDL099W | Binder of USO1 and GRH1 protein 1; Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion [...] |
| GET3 protein network | https://string-db.org/network/4932.YDL100C | ATPase GET3; Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; functions as a chaperone under ATP-depleted oxidative stress conditions; subunit of GET complex, involved [...] |
| DUN1 protein network | https://string-db.org/network/4932.YDL101C | DNA damage response protein kinase DUN1; Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic re [...] |
| POL3 protein network | https://string-db.org/network/4932.YDL102W | Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication d [...] |
| QRI1 protein network | https://string-db.org/network/4932.YDL103C | UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor b [...] |
| QRI7 protein network | https://string-db.org/network/4932.YDL104C | tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification [...] |
| NSE4 protein network | https://string-db.org/network/4932.YDL105W | Non-structural maintenance of chromosome element 4; Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatid [...] |
| PHO2 protein network | https://string-db.org/network/4932.YDL106C | Regulatory protein PHO2; Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of [...] |
| MSS2 protein network | https://string-db.org/network/4932.YDL107W | Protein MSS2, mitochondrial; Peripherally bound inner membrane protein of the mitochondrial matrix; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically wit [...] |
| KIN28 protein network | https://string-db.org/network/4932.YDL108W | Serine/threonine-protein kinase KIN28; Serine/threonine protein kinase, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates [...] |
| YDL109C protein network | https://string-db.org/network/4932.YDL109C | Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication. |
| TMA17 protein network | https://string-db.org/network/4932.YDL110C | Translation machinery-associated protein 17; ATPase dedicated chaperone that adapts proteasome assembly to stress; Tma17p is induced upon stress; interacts with Rpt6p to assist its pairing to Rpt [...] |
| RRP42 protein network | https://string-db.org/network/4932.YDL111C | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7). |
| TRM3 protein network | https://string-db.org/network/4932.YDL112W | tRNA (guanosine(18)-2'-O)-methyltransferase; 2'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs; Belongs to the class IV-like SAM- [...] |
| ATG20 protein network | https://string-db.org/network/4932.YDL113C | Autophagy-related protein 20; Sorting nexin family member; required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphati [...] |
| YDL114W protein network | https://string-db.org/network/4932.YDL114W | Uncharacterized oxidoreductase YDL114W; Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene; Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| YDL114W-A protein network | https://string-db.org/network/4932.YDL114W-A | Putative uncharacterized protein YDL114W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified based on [...] |
| IWR1 protein network | https://string-db.org/network/4932.YDL115C | RNA polymerase II nuclear localization protein IWR1; RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; inter [...] |
| NUP84 protein network | https://string-db.org/network/4932.YDL116W | Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localizat [...] |
| CYK3 protein network | https://string-db.org/network/4932.YDL117W | SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cyt [...] |
| HEM25 protein network | https://string-db.org/network/4932.YDL119C | Mitochondrial glycine transporter; required for the transport of glycine into mitochondria for initiation of heme biosynthesis, with YMC1 acting as a secondary transporter; homolog of human SLC25 [...] |
| YFH1 protein network | https://string-db.org/network/4932.YDL120W | Frataxin homolog intermediate form; Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-depende [...] |
| YDL121C protein network | https://string-db.org/network/4932.YDL121C | ER export of PMA1 protein 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein. |
| UBP1 protein network | https://string-db.org/network/4932.YDL122W | Ubiquitin carboxyl-terminal hydrolase 1; Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; cap [...] |
| SNA4 protein network | https://string-db.org/network/4932.YDL123W | Protein of unknown function; localized to the vacuolar outer membrane; predicted to be palmitoylated. |
| YDL124W protein network | https://string-db.org/network/4932.YDL124W | NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protei [...] |
| HNT1 protein network | https://string-db.org/network/4932.YDL125C | Hit family protein 1; Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of histidine triad (HIT) super [...] |
| CDC48 protein network | https://string-db.org/network/4932.YDL126C | Cell division control protein 48; AAA ATPase; subunit of polyUb-selective segregase complex involved in ERAD, INM-associated degradation (INMAD), mitotic spindle disassembly, macroautophagy, PMN, [...] |
| PCL2 protein network | https://string-db.org/network/4932.YDL127W | PHO85 cyclin-2; Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression throug [...] |
| VCX1 protein network | https://string-db.org/network/4932.YDL128W | Vacuolar calcium ion transporter; Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calc [...] |
| YDL129W protein network | https://string-db.org/network/4932.YDL129W | Uncharacterized protein YDL129W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative [...] |
| RPP1B protein network | https://string-db.org/network/4932.YDL130W | 60S acidic ribosomal protein P1-beta; Ribosomal protein P1 beta; component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; free (non-ri [...] |
| STF1 protein network | https://string-db.org/network/4932.YDL130W-A | ATPase-stabilizing factor 9 kDa, mitochondrial; Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of [...] |
| LYS21 protein network | https://string-db.org/network/4932.YDL131W | Homocitrate synthase, mitochondrial; Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine bios [...] |
| CDC53 protein network | https://string-db.org/network/4932.YDL132W | Cell division control protein 53; Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S tran [...] |
| RPL41B protein network | https://string-db.org/network/4932.YDL133C-A | Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a pa [...] |
| SRF1 protein network | https://string-db.org/network/4932.YDL133W | Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates [...] |
| PPH21 protein network | https://string-db.org/network/4932.YDL134C | Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal tr [...] |
| RDI1 protein network | https://string-db.org/network/4932.YDL135C | Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress. |
| RPL35B protein network | https://string-db.org/network/4932.YDL136W | Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication. |
| ARF2 protein network | https://string-db.org/network/4932.YDL137W | ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from [...] |
| RGT2 protein network | https://string-db.org/network/4932.YDL138W | Plasma membrane high glucose sensor that regulates glucose transport; low affinity sesnor that contains 12 predicted transmembrane segments and a long C-terminal tail required for hexose transpor [...] |
| SCM3 protein network | https://string-db.org/network/4932.YDL139C | Protein SCM3; Nonhistone component of centromeric chromatin; binds to histone H3 variant, Cse4p, and recruits it to centromeres; involved in the assembly and maintenance of Cse4-H4 at centromeres [...] |
| RPO21 protein network | https://string-db.org/network/4932.YDL140C | RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to ba [...] |
| BPL1 protein network | https://string-db.org/network/4932.YDL141W | Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin:apoprotein ligase; covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoe [...] |
| CRD1 protein network | https://string-db.org/network/4932.YDL142C | Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function and for correct i [...] |
| CCT4 protein network | https://string-db.org/network/4932.YDL143W | T-complex protein 1 subunit delta; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo. |
| YDL144C protein network | https://string-db.org/network/4932.YDL144C | Uncharacterized protein YDL144C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abun [...] |
| COP1 protein network | https://string-db.org/network/4932.YDL145C | Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway. |
| LDB17 protein network | https://string-db.org/network/4932.YDL146W | Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to t [...] |
| RPN5 protein network | https://string-db.org/network/4932.YDL147W | Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome i [...] |
| NOP14 protein network | https://string-db.org/network/4932.YDL148C | Nucleolar protein; forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for pr [...] |
| ATG9 protein network | https://string-db.org/network/4932.YDL149W | Autophagy-related protein 9; Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not [...] |
| RPC53 protein network | https://string-db.org/network/4932.YDL150W | RNA polymerase III subunit C53; Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family. |
| BUD30 protein network | https://string-db.org/network/4932.YDL151C | Putative uncharacterized protein BUD30; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closel [...] |
| SAS10 protein network | https://string-db.org/network/4932.YDL153C | Something about silencing protein 10; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silenci [...] |
| MSH5 protein network | https://string-db.org/network/4932.YDL154W | Protein of the MutS family; forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present [...] |
| CLB3 protein network | https://string-db.org/network/4932.YDL155W | G2/mitotic-specific cyclin-3; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulat [...] |
| CMR1 protein network | https://string-db.org/network/4932.YDL156W | DNA damage-binding protein CMR1; Nuclear protein with a role in protein quality control; localizes to the intranuclear quality control compartment (INQ) in response to proteasome inhibition or DN [...] |
| YDL157C protein network | https://string-db.org/network/4932.YDL157C | Uncharacterized protein YDL157C, mitochondrial; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; To [...] |
| YDL159C-B protein network | https://string-db.org/network/4932.YDL159C-B | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| STE7 protein network | https://string-db.org/network/4932.YDL159W | Serine/threonine-protein kinase STE7; Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway wher [...] |
| YDL159W-A protein network | https://string-db.org/network/4932.YDL159W-A | Uncharacterized protein YDL159W-A; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species. |
| DHH1 protein network | https://string-db.org/network/4932.YDL160C | Cytoplasmic DEAD-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacting with both decapping and deadenylase complexes; role in translational r [...] |
| MHF2 protein network | https://string-db.org/network/4932.YDL160C-A | Inner kinetochore subunit MHF2; Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blo [...] |
| ENT1 protein network | https://string-db.org/network/4932.YDL161W | Epsin-1; Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from [...] |
| YDL162C protein network | https://string-db.org/network/4932.YDL162C | Putative uncharacterized protein YDL162C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps EN [...] |
| YDL163W protein network | https://string-db.org/network/4932.YDL163W | Putative uncharacterized protein YDL163W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| CDC9 protein network | https://string-db.org/network/4932.YDL164C | DNA ligase I found in nucleus and mitochondria; essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recomb [...] |
| CDC36 protein network | https://string-db.org/network/4932.YDL165W | General negative regulator of transcription subunit 2; Component of the CCR4-NOT core complex, involved in mRNA decapping; this complex has multiple roles in regulating mRNA levels including regu [...] |
| FAP7 protein network | https://string-db.org/network/4932.YDL166C | Adenylate kinase isoenzyme 6 homolog FAP7; Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only t [...] |
| NRP1 protein network | https://string-db.org/network/4932.YDL167C | Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis. |
| SFA1 protein network | https://string-db.org/network/4932.YDL168W | Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long cha [...] |
| UGX2 protein network | https://string-db.org/network/4932.YDL169C | Protein of unknown function; transcript accumulates in response to any combination of stress conditions. |
| UGA3 protein network | https://string-db.org/network/4932.YDL170W | Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-am [...] |
| GLT1 protein network | https://string-db.org/network/4932.YDL171C | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; express [...] |
| YDL172C protein network | https://string-db.org/network/4932.YDL172C | Putative uncharacterized protein YDL172C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| PAR32 protein network | https://string-db.org/network/4932.YDL173W | Protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an [...] |
| DLD1 protein network | https://string-db.org/network/4932.YDL174C | Major mitochondrial D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochond [...] |
| AIR2 protein network | https://string-db.org/network/4932.YDL175C | Protein AIR2; RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p a [...] |
| YDL176W protein network | https://string-db.org/network/4932.YDL176W | Uncharacterized protein YDL176W; Protein of unknown function; predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of th [...] |
| YDL177C protein network | https://string-db.org/network/4932.YDL177C | IMPACT family member YDL177C; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene. |
| DLD2 protein network | https://string-db.org/network/4932.YDL178W | D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2; D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG [...] |
| PCL9 protein network | https://string-db.org/network/4932.YDL179W | PHO85 cyclin-9; Cyclin; forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p; PCL9 has a paralog, PCL2, that arose f [...] |
| YDL180W protein network | https://string-db.org/network/4932.YDL180W | Uncharacterized membrane protein YDL180W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. |
| INH1 protein network | https://string-db.org/network/4932.YDL181W | ATPase inhibitor, mitochondrial; Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has a calmodulin-binding m [...] |
| LYS20 protein network | https://string-db.org/network/4932.YDL182W | Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis [...] |
| YDL183C protein network | https://string-db.org/network/4932.YDL183C | Uncharacterized protein YDL183C; Protein that may form an active mitochondrial KHE system; mitochondrial inner-membrane protein; non-essential gene; KHE system stands for K+/H+ exchanger system; [...] |
| RPL41A protein network | https://string-db.org/network/4932.YDL184C | Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a pa [...] |
| VMA1 protein network | https://string-db.org/network/4932.YDL185W | Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific en [...] |
| YDL186W protein network | https://string-db.org/network/4932.YDL186W | Putative protein of unknown function; YDL186W is not an essential gene. |
| PPH22 protein network | https://string-db.org/network/4932.YDL188C | Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal tr [...] |
| RBS1 protein network | https://string-db.org/network/4932.YDL189W | RNA-binding suppressor of PAS kinase protein 1; Protein involved in assembly of the RNA polymerase III (Pol III) complex; high copy suppressor of Pol III assembly mutation and psk1 psk2 mutations [...] |
| UFD2 protein network | https://string-db.org/network/4932.YDL190C | E4 ubiquitin-protein ligase UFD2; Ubiquitin chain assembly factor (E4); cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3 [...] |
| RPL35A protein network | https://string-db.org/network/4932.YDL191W | Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication. |
| ARF1 protein network | https://string-db.org/network/4932.YDL192W | ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from [...] |
| NUS1 protein network | https://string-db.org/network/4932.YDL193W | Forms dehydrodolichyl diphosphate syntase complex with RER2 or SRT1; tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY, suggesting that Nus1p may be involved in protein t [...] |
| SNF3 protein network | https://string-db.org/network/4932.YDL194W | Plasma membrane low glucose sensor, regulates glucose transport; high affinity sensor that contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose [...] |
| SEC31 protein network | https://string-db.org/network/4932.YDL195W | Protein transport protein SEC31; Component of the Sec13p-Sec31p complex of the COPII vesicle coat; COPII coat is required for vesicle formation in ER to Golgi transport; mutant has increased aneu [...] |
| YDL196W protein network | https://string-db.org/network/4932.YDL196W | Putative uncharacterized protein YDL196W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame is [...] |
| ASF2 protein network | https://string-db.org/network/4932.YDL197C | Anti-silencing protein; causes derepression of silent loci when overexpressed. |
| GGC1 protein network | https://string-db.org/network/4932.YDL198C | Mitochondrial GTP/GDP carrier protein 1; Mitochondrial GTP/GDP transporter; essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial [...] |
| YDL199C protein network | https://string-db.org/network/4932.YDL199C | Putative metabolite transport protein YDL199C; Putative transporter; member of the sugar porter family; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. |
| MGT1 protein network | https://string-db.org/network/4932.YDL200C | DNA repair methyltransferase (6-O-methylguanine-DNA methylase); involved in protection against DNA alkylation damage; Belongs to the MGMT family. |
| TRM8 protein network | https://string-db.org/network/4932.YDL201W | Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position [...] |
| MRPL11 protein network | https://string-db.org/network/4932.YDL202W | Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2. |
| ACK1 protein network | https://string-db.org/network/4932.YDL203C | Activator of C kinase protein 1; Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging a [...] |
| RTN2 protein network | https://string-db.org/network/4932.YDL204W | Reticulon-like protein 2; Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritanc [...] |
| HEM3 protein network | https://string-db.org/network/4932.YDL205C | Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulat [...] |
| YDL206W protein network | https://string-db.org/network/4932.YDL206W | Putative protein of unknown function; YDL206W is not an essential protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. |
| GLE1 protein network | https://string-db.org/network/4932.YDL207W | Cytoplasmic nucleoporin required for polyadenylated mRNA export; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase ac [...] |
| NHP2 protein network | https://string-db.org/network/4932.YDL208W | H/ACA ribonucleoprotein complex subunit NHP2; Protein related to mammalian high mobility group (HMG) proteins; nuclear protein; essential for function of H/ACA-type snoRNPs, which are involved in [...] |
| CWC2 protein network | https://string-db.org/network/4932.YDL209C | Pre-mRNA-splicing factor CWC2; Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; b [...] |
| UGA4 protein network | https://string-db.org/network/4932.YDL210W | GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic ac [...] |
| YDL211C protein network | https://string-db.org/network/4932.YDL211C | Uncharacterized protein YDL211C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YDL211C has a paralog, TDA7, that arose from the whole genom [...] |
| SHR3 protein network | https://string-db.org/network/4932.YDL212W | Secretory component protein SHR3; Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface. |
| NOP6 protein network | https://string-db.org/network/4932.YDL213C | Nucleolar protein 6; rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-r [...] |
| PRR2 protein network | https://string-db.org/network/4932.YDL214C | Serine/threonine-protein kinase PRR2; Serine/threonine protein kinase; inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant h [...] |
| GDH2 protein network | https://string-db.org/network/4932.YDL215C | NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetical [...] |
| RRI1 protein network | https://string-db.org/network/4932.YDL216C | Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adap [...] |
| TIM22 protein network | https://string-db.org/network/4932.YDL217C | Mitochondrial import inner membrane translocase subunit TIM22; Essential core component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; fo [...] |
| YDL218W protein network | https://string-db.org/network/4932.YDL218W | Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin pat [...] |
| DTD1 protein network | https://string-db.org/network/4932.YDL219W | D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes; Belongs to the DTD fam [...] |
| CDC13 protein network | https://string-db.org/network/4932.YDL220C | Cell division control protein 13; Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles in regulation of telomerase, telomere end protection, conventional telomere replic [...] |
| FMP45 protein network | https://string-db.org/network/4932.YDL222C | SUR7 family protein FMP45; Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that [...] |
| HBT1 protein network | https://string-db.org/network/4932.YDL223C | Shmoo tip protein, substrate of Hub1p ubiquitin-like protein; mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis; HBT1 has a paralog, [...] |
| WHI4 protein network | https://string-db.org/network/4932.YDL224C | Protein WHI4; Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole geno [...] |
| SHS1 protein network | https://string-db.org/network/4932.YDL225W | Seventh homolog of septin 1; Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitm [...] |
| GCS1 protein network | https://string-db.org/network/4932.YDL226C | ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; required for prospore membrane formation; regulates phospholipase Spo14p; shares functional similarity [...] |
| HO protein network | https://string-db.org/network/4932.YDL227C | Homothallic switching endonuclease; Site-specific endonuclease; required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restrict [...] |
| YDL228C protein network | https://string-db.org/network/4932.YDL228C | Putative uncharacterized protein YDL228C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely ove [...] |
| SSB1 protein network | https://string-db.org/network/4932.YDL229W | Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 fami [...] |
| PTP1 protein network | https://string-db.org/network/4932.YDL230W | Tyrosine-protein phosphatase 1; Phosphotyrosine-specific protein phosphatase; dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondri [...] |
| BRE4 protein network | https://string-db.org/network/4932.YDL231C | Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transpor [...] |
| OST4 protein network | https://string-db.org/network/4932.YDL232W | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4; Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes protein asparagine-linked glycosyl [...] |
| MFG1 protein network | https://string-db.org/network/4932.YDL233W | Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein loca [...] |
| GYP7 protein network | https://string-db.org/network/4932.YDL234C | GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; contains a [...] |
| YPD1 protein network | https://string-db.org/network/4932.YDL235C | Osmotic stress-responsive phosphorelay intermediate sensor protein; phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response r [...] |
| PHO13 protein network | https://string-db.org/network/4932.YDL236W | 4-nitrophenylphosphatase; Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphog [...] |
| AIM6 protein network | https://string-db.org/network/4932.YDL237W | Altered inheritance of mitochondria protein 6; Protein of unknown function; required for respiratory growth; YDL237W is not an essential gene. |
| GUD1 protein network | https://string-db.org/network/4932.YDL238C | Guanine deaminase; a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in [...] |
| ADY3 protein network | https://string-db.org/network/4932.YDL239C | Accumulates dyads protein 3; Protein required for spore wall formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading ed [...] |
| YDL240C-A protein network | https://string-db.org/network/4932.YDL240C-A | Putative uncharacterized protein YDL240C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by seque [...] |
| LRG1 protein network | https://string-db.org/network/4932.YDL240W | Rho-GTPase-activating protein LRG1; GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regu [...] |
| YDL241W protein network | https://string-db.org/network/4932.YDL241W | Uncharacterized protein YDL241W; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDL241W is not an essential gene. |
| YDL242W protein network | https://string-db.org/network/4932.YDL242W | Uncharacterized protein YDL242W; Putative protein of unknown function; conserved across S. cerevisiae strains. |
| AAD4 protein network | https://string-db.org/network/4932.YDL243C | Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin; [...] |
| THI13 protein network | https://string-db.org/network/4932.YDL244W | 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI13; Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12 [...] |
| HXT15 protein network | https://string-db.org/network/4932.YDL245C | Hexose transporter HXT15; Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted [...] |
| SOR2 protein network | https://string-db.org/network/4932.YDL246C | Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase. |
| MPH2 protein network | https://string-db.org/network/4932.YDL247W | Alpha-glucosides permease MPH2; Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; almost identical to Mph3p; encoded in a subtelomeric position in a [...] |
| YDL247W-A protein network | https://string-db.org/network/4932.YDL247W-A | Putative uncharacterized protein YDL247W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by seque [...] |
| COS7 protein network | https://string-db.org/network/4932.YDL248W | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting [...] |
| NTH1 protein network | https://string-db.org/network/4932.YDR001C | Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; phosphorylated and activated by Cdc28p at the G1/S phase transition to c [...] |
| YRB1 protein network | https://string-db.org/network/4932.YDR002W | Ran-specific GTPase-activating protein 1; Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles bet [...] |
| RCR2 protein network | https://string-db.org/network/4932.YDR003W | Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma mem [...] |
| YDR003W-A protein network | https://string-db.org/network/4932.YDR003W-A | Uncharacterized protein YDR003W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| RAD57 protein network | https://string-db.org/network/4932.YDR004W | DNA repair protein RAD57; Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair o [...] |
| MAF1 protein network | https://string-db.org/network/4932.YDR005C | Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc1 [...] |
| SOK1 protein network | https://string-db.org/network/4932.YDR006C | Protein of unknown function; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to th [...] |
| TRP1 protein network | https://string-db.org/network/4932.YDR007W | Phosphoribosylanthranilate isomerase; catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated interna [...] |
| YDR008C protein network | https://string-db.org/network/4932.YDR008C | Putative uncharacterized protein YDR008C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps TR [...] |
| GAL3 protein network | https://string-db.org/network/4932.YDR009W | Protein GAL3; Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and A [...] |
| SNQ2 protein network | https://string-db.org/network/4932.YDR011W | Protein SNQ2; Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species; Belongs to the ABC transport [...] |
| RPL4B protein network | https://string-db.org/network/4932.YDR012W | Ribosomal 60S subunit protein L4B; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4B has a paralog, RPL4A, that arose from the whole genome duplication. |
| PSF1 protein network | https://string-db.org/network/4932.YDR013W | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery. |
| RAD61 protein network | https://string-db.org/network/4932.YDR014W | Protein RAD61; Subunit of a complex that inhibits sister chromatid cohesion; also negatively regulates chromosome condensation; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; bin [...] |
| HED1 protein network | https://string-db.org/network/4932.YDR014W-A | Meiosis-specific protein; down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; promotes synapsis and required for the normal morphogenesis of [...] |
| YDR015C protein network | https://string-db.org/network/4932.YDR015C | Putative uncharacterized protein YDR015C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified [...] |
| DAD1 protein network | https://string-db.org/network/4932.YDR016C | Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the [...] |
| KCS1 protein network | https://string-db.org/network/4932.YDR017C | Inositol hexakisphosphate and inositol heptakisphosphate kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress resp [...] |
| YDR018C protein network | https://string-db.org/network/4932.YDR018C | Uncharacterized acyltransferase YDR018C; Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase [...] |
| GCV1 protein network | https://string-db.org/network/4932.YDR019C | T subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of [...] |
| DAS2 protein network | https://string-db.org/network/4932.YDR020C | Putative uridine kinase DAS2; Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine [...] |
| FAL1 protein network | https://string-db.org/network/4932.YDR021W | ATP-dependent RNA helicase FAL1; Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; 18S rRNA biogenesis defect of the nu [...] |
| ATG31 protein network | https://string-db.org/network/4932.YDR022C | Autophagy-related protein 31; Autophagy-specific protein required for autophagosome formation; forms a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal struc [...] |
| SES1 protein network | https://string-db.org/network/4932.YDR023W | Serine--tRNA ligase, cytoplasmic; Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances d [...] |
| FYV1 protein network | https://string-db.org/network/4932.YDR024W | Putative uncharacterized protein FYV1; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely [...] |
| RPS11A protein network | https://string-db.org/network/4932.YDR025W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; N-terminally propionylated in vivo; RPS11A has a paralog, RPS11B, that aro [...] |
| NSI1 protein network | https://string-db.org/network/4932.YDR026C | RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, co [...] |
| VPS54 protein network | https://string-db.org/network/4932.YDR027C | Vacuolar protein sorting-associated protein 54; Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golg [...] |
| REG1 protein network | https://string-db.org/network/4932.YDR028C | Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; REG1 has [...] |
| RAD28 protein network | https://string-db.org/network/4932.YDR030C | Radiation-sensitive protein 28; Protein involved in DNA repair; related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair. |
| MIX14 protein network | https://string-db.org/network/4932.YDR031W | Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA re [...] |
| PST2 protein network | https://string-db.org/network/4932.YDR032C | Protoplast secreted protein 2; Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detec [...] |
| MRH1 protein network | https://string-db.org/network/4932.YDR033W | Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authent [...] |
| LYS14 protein network | https://string-db.org/network/4932.YDR034C | Lysine biosynthesis regulatory protein LYS14; Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; require [...] |
| YDR034C-A protein network | https://string-db.org/network/4932.YDR034C-A | Putative protein of unknown function; contained within the solo Ty1 LTR element YDRWdelta7. |
| YDR034W-B protein network | https://string-db.org/network/4932.YDR034W-B | Cysteine-rich and transmembrane domain-containing protein YDR034W-B; Predicted tail-anchored plasma membrane protein; contains conserved CYSTM module; related proteins in other organisms may be i [...] |
| ARO3 protein network | https://string-db.org/network/4932.YDR035W | Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited; 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and [...] |
| EHD3 protein network | https://string-db.org/network/4932.YDR036C | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitoch [...] |
| KRS1 protein network | https://string-db.org/network/4932.YDR037W | Lysine--tRNA ligase, cytoplasmic; Lysyl-tRNA synthetase. |
| ENA5 protein network | https://string-db.org/network/4932.YDR038C | Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily. |
| ENA2 protein network | https://string-db.org/network/4932.YDR039C | P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily [...] |
| ENA1 protein network | https://string-db.org/network/4932.YDR040C | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. |
| RSM10 protein network | https://string-db.org/network/4932.YDR041W | Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins. |
| YDR042C protein network | https://string-db.org/network/4932.YDR042C | Uncharacterized protein YDR042C; Putative protein of unknown function; expression is increased in ssu72-ts69 mutant. |
| NRG1 protein network | https://string-db.org/network/4932.YDR043C | Transcriptional regulator NRG1; Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including fil [...] |
| HEM13 protein network | https://string-db.org/network/4932.YDR044W | Oxygen-dependent coproporphyrinogen-III oxidase; Coproporphyrinogen III oxidase; oxygen-requiring enzyme that catalyzes sixth step in heme biosynthetic pathway; transcription is repressed by oxyg [...] |
| RPC11 protein network | https://string-db.org/network/4932.YDR045C | RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS. |
| BAP3 protein network | https://string-db.org/network/4932.YDR046C | Valine amino-acid permease; Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication; Belongs to [...] |
| HEM12 protein network | https://string-db.org/network/4932.YDR047W | Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porp [...] |
| VMS1 protein network | https://string-db.org/network/4932.YDR049W | Protein VMS1; Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associat [...] |
| TPI1 protein network | https://string-db.org/network/4932.YDR050C | Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites i [...] |
| DET1 protein network | https://string-db.org/network/4932.YDR051C | Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel; Belongs to t [...] |
| DBF4 protein network | https://string-db.org/network/4932.YDR052C | Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relativ [...] |
| CDC34 protein network | https://string-db.org/network/4932.YDR054C | Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by ta [...] |
| PST1 protein network | https://string-db.org/network/4932.YDR055W | Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated b [...] |
| EMC10 protein network | https://string-db.org/network/4932.YDR056C | Putative protein of unknown function; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi- [...] |
| YOS9 protein network | https://string-db.org/network/4932.YDR057W | Protein OS-9 homolog; ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; [...] |
| TGL2 protein network | https://string-db.org/network/4932.YDR058C | Lipase 2; Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli. |
| UBC5 protein network | https://string-db.org/network/4932.YDR059C | Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is h [...] |
| MAK21 protein network | https://string-db.org/network/4932.YDR060W | Ribosome biogenesis protein MAK21; Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates w [...] |
| YDR061W protein network | https://string-db.org/network/4932.YDR061W | Protein with similarity to ABC transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance. |
| LCB2 protein network | https://string-db.org/network/4932.YDR062W | Component of serine palmitoyltransferase; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ket [...] |
| AIM7 protein network | https://string-db.org/network/4932.YDR063W | Protein that interacts with Arp2/3 complex; interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia matu [...] |
| RPS13 protein network | https://string-db.org/network/4932.YDR064W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15. |
| RRG1 protein network | https://string-db.org/network/4932.YDR065W | Protein of unknown function; required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throug [...] |
| RTR2 protein network | https://string-db.org/network/4932.YDR066C | RNA polymerase II subunit B1 CTD phosphatase RTR2; Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [...] |
| OCA6 protein network | https://string-db.org/network/4932.YDR067C | Putative tyrosine-protein phosphatase OCA6; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; [...] |
| DOS2 protein network | https://string-db.org/network/4932.YDR068W | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. |
| DOA4 protein network | https://string-db.org/network/4932.YDR069C | Ubiquitin hydrolase; deubiquitinates intralumenal vesicle (ILVs) cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prev [...] |
| FMP16 protein network | https://string-db.org/network/4932.YDR070C | Protein FMP16, mitochondrial; Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in [...] |
| PAA1 protein network | https://string-db.org/network/4932.YDR071C | Polyamine N-acetyltransferase 1; Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be invo [...] |
| IPT1 protein network | https://string-db.org/network/4932.YDR072C | Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP [...] |
| SNF11 protein network | https://string-db.org/network/4932.YDR073W | Transcription regulatory protein SNF11; Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p [...] |
| TPS2 protein network | https://string-db.org/network/4932.YDR074W | Trehalose-phosphatase; Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditio [...] |
| PPH3 protein network | https://string-db.org/network/4932.YDR075W | Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint, the gene con [...] |
| RAD55 protein network | https://string-db.org/network/4932.YDR076W | DNA repair protein RAD55; Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair o [...] |
| SED1 protein network | https://string-db.org/network/4932.YDR077W | Cell wall protein SED1; Major stress-induced structural GPI-cell wall glycoprotein; associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two dist [...] |
| SHU2 protein network | https://string-db.org/network/4932.YDR078C | Suppressor of hydroxyurea sensitivity protein 2; Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu1, and promotes error-free DNA repair, Shu complex mediates [...] |
| TFB5 protein network | https://string-db.org/network/4932.YDR079C-A | Component of RNA polymerase II general transcription factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; relocalizes to the cytosol in response to hypoxia; homol [...] |
| PET100 protein network | https://string-db.org/network/4932.YDR079W | Protein PET100, mitochondrial; Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, an [...] |
| VPS41 protein network | https://string-db.org/network/4932.YDR080W | Vacuolar protein sorting-associated protein 41; Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting specifically with th [...] |
| PDC2 protein network | https://string-db.org/network/4932.YDR081C | Protein PDC2; Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; bind [...] |
| STN1 protein network | https://string-db.org/network/4932.YDR082W | Protein STN1; Telomere end-binding and capping protein; plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required fo [...] |
| RRP8 protein network | https://string-db.org/network/4932.YDR083W | 25S rRNA (adenine(645)-N(1))-methyltransferase; Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved [...] |
| TVP23 protein network | https://string-db.org/network/4932.YDR084C | Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; Belongs [...] |
| AFR1 protein network | https://string-db.org/network/4932.YDR085C | Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interac [...] |
| SSS1 protein network | https://string-db.org/network/4932.YDR086C | Protein transport protein SSS1; Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p); this complex forms a channel for passage of secretory proteins through the endoplasmic reticulum [...] |
| RRP1 protein network | https://string-db.org/network/4932.YDR087C | Ribosomal RNA-processing protein 1; Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associ [...] |
| SLU7 protein network | https://string-db.org/network/4932.YDR088C | Pre-mRNA-splicing factor SLU7; RNA splicing factor; required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain; B [...] |
| VTC5 protein network | https://string-db.org/network/4932.YDR089W | Uncharacterized protein YDR089W; Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and ove [...] |
| YDR090C protein network | https://string-db.org/network/4932.YDR090C | Uncharacterized membrane protein YDR090C; Putative protein of unknown function. |
| RLI1 protein network | https://string-db.org/network/4932.YDR091C | Translation initiation factor RLI1; Essential Fe-S protein; required for ribosome biogenesis, translation initiation/termination; facilitates binding of multifactor complex (MFC) of initiation fa [...] |
| UBC13 protein network | https://string-db.org/network/4932.YDR092W | E2 ubiquitin-conjugating enzyme; involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers red [...] |
| DNF2 protein network | https://string-db.org/network/4932.YDR093W | Phospholipid-transporting ATPase DNF2; Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and [...] |
| GIS1 protein network | https://string-db.org/network/4932.YDR096W | Transcriptional activator/repressor GIS1; Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC [...] |
| MSH6 protein network | https://string-db.org/network/4932.YDR097C | Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; p [...] |
| GRX3 protein network | https://string-db.org/network/4932.YDR098C | Monothiol glutaredoxin-3; Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells [...] |
| BMH2 protein network | https://string-db.org/network/4932.YDR099W | 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK [...] |
| TVP15 protein network | https://string-db.org/network/4932.YDR100W | Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p. |
| ARX1 protein network | https://string-db.org/network/4932.YDR101C | Probable metalloprotease ARX1; Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear [...] |
| YDR102C protein network | https://string-db.org/network/4932.YDR102C | Uncharacterized protein YDR102C; Putative protein of unknown function; conserved among S. cerevisiae strains; YDR102C is not an essential gene; homozygous diploid deletion strain exhibits high bu [...] |
| STE5 protein network | https://string-db.org/network/4932.YDR103W | Protein STE5; Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains block [...] |
| SPO71 protein network | https://string-db.org/network/4932.YDR104C | Sporulation-specific protein 71; Meiosis-specific protein required for prospore membrane morphogenesis; localizes to the prospore membrane (PSM) during sporulation; required for PSM elongation an [...] |
| TMS1 protein network | https://string-db.org/network/4932.YDR105C | Vacuolar membrane protein of unknown function; is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance. |
| ARP10 protein network | https://string-db.org/network/4932.YDR106W | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP [...] |
| TMN2 protein network | https://string-db.org/network/4932.YDR107C | Transmembrane 9 superfamily member 2; Protein with a role in cellular adhesion and filamentous growth; similar to Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of protei [...] |
| TRS85 protein network | https://string-db.org/network/4932.YDR108W | Trafficking protein particle complex III-specific subunit 85; Component of transport protein particle (TRAPP) complex III; TRAPPIII is a multimeric guanine nucleotide-exchange factor for the GTPa [...] |
| YDR109C protein network | https://string-db.org/network/4932.YDR109C | Uncharacterized sugar kinase YDR109C; Putative kinase; Belongs to the FGGY kinase family. |
| FOB1 protein network | https://string-db.org/network/4932.YDR110W | Nucleolar protein that binds the rDNA replication fork barrier site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to replication fork barrier (R [...] |
| ALT2 protein network | https://string-db.org/network/4932.YDR111C | Probable alanine aminotransferase; Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog, ALT1, t [...] |
| PDS1 protein network | https://string-db.org/network/4932.YDR113C | Securin; inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle depend [...] |
| YDR114C protein network | https://string-db.org/network/4932.YDR114C | Uncharacterized protein YDR114C; Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium. |
| MRX14 protein network | https://string-db.org/network/4932.YDR115W | Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein inc [...] |
| MRPL1 protein network | https://string-db.org/network/4932.YDR116C | Mitochondrial ribosomal protein of the large subunit. |
| TMA64 protein network | https://string-db.org/network/4932.YDR117C | Translation machinery-associated protein 64; Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been s [...] |
| APC4 protein network | https://string-db.org/network/4932.YDR118W | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/a [...] |
| YDR118W-A protein network | https://string-db.org/network/4932.YDR118W-A | Uncharacterized protein YDR118W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified using a combinati [...] |
| VBA4 protein network | https://string-db.org/network/4932.YDR119W | Protein of unknown function; proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possib [...] |
| COX26 protein network | https://string-db.org/network/4932.YDR119W-A | Cytochrome c oxidase subunit 26, mitochondrial; Stabilizes or regulates formation of respiratory chain supercomplexes composed of Complex III (ubiquinol-cytochrome c reductase) and Complex IV (cy [...] |
| TRM1 protein network | https://string-db.org/network/4932.YDR120C | tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial; tRNA methyltransferase; two forms of protein are made by alternative translation starts; localizes to both nucleus and mitochondrion to [...] |
| DPB4 protein network | https://string-db.org/network/4932.YDR121W | Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsi [...] |
| KIN1 protein network | https://string-db.org/network/4932.YDR122W | Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplicat [...] |
| INO2 protein network | https://string-db.org/network/4932.YDR123C | Protein INO2; Transcription factor; component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for d [...] |
| YDR124W protein network | https://string-db.org/network/4932.YDR124W | Uncharacterized protein YDR124W; Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor. |
| ECM18 protein network | https://string-db.org/network/4932.YDR125C | Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication; Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. |
| SWF1 protein network | https://string-db.org/network/4932.YDR126W | Palmitoyltransferase that acts on transmembrane proteins; including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a r [...] |
| ARO1 protein network | https://string-db.org/network/4932.YDR127W | 3-phosphoshikimate 1-carboxyvinyltransferase; Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; In the N-t [...] |
| MTC5 protein network | https://string-db.org/network/4932.YDR128W | Maintenance of telomere capping protein 5; Subunit of SEACAT, a subcomplex of the SEA complex; Mtc1p, along with Rtc1p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT [...] |
| SAC6 protein network | https://string-db.org/network/4932.YDR129C | Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, an [...] |
| FIN1 protein network | https://string-db.org/network/4932.YDR130C | Filament protein FIN1; Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubu [...] |
| YDR131C protein network | https://string-db.org/network/4932.YDR131C | F-box protein subunit of SCF ubiquitin ligase complex; substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex. |
| YDR132C protein network | https://string-db.org/network/4932.YDR132C | Uncharacterized protein YDR132C; Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, [...] |
| YDR133C protein network | https://string-db.org/network/4932.YDR133C | Putative uncharacterized protein YDR133C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps YD [...] |
| YCF1 protein network | https://string-db.org/network/4932.YDR135C | Metal resistance protein YCF1; Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole [...] |
| VPS61 protein network | https://string-db.org/network/4932.YDR136C | Putative uncharacterized protein VPS61; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closel [...] |
| RGP1 protein network | https://string-db.org/network/4932.YDR137W | Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p); this complex catalyzes nucleotide exchange on Ypt6p; Belongs to the RGP1 family. |
| HPR1 protein network | https://string-db.org/network/4932.YDR138W | Subunit of THO/TREX complexes; this complex couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; i [...] |
| RUB1 protein network | https://string-db.org/network/4932.YDR139C | NEDD8-like protein RUB1; Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba [...] |
| MTQ2 protein network | https://string-db.org/network/4932.YDR140W | eRF1 methyltransferase catalytic subunit MTQ2; S-adenosylmethionine-dependent methyltransferase; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the te [...] |
| DOP1 protein network | https://string-db.org/network/4932.YDR141C | Protein dopey; Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected [...] |
| PEX7 protein network | https://string-db.org/network/4932.YDR142C | Peroxisomal signal receptor for peroxisomal matrix proteins; recognizes the N-terminal nonapeptide signal (PTS2); WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodyspla [...] |
| SAN1 protein network | https://string-db.org/network/4932.YDR143C | Ubiquitin-protein ligase; involved in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydr [...] |
| MKC7 protein network | https://string-db.org/network/4932.YDR144C | Aspartic proteinase MKC7; GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a [...] |
| TAF12 protein network | https://string-db.org/network/4932.YDR145W | Subunit (61/68 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A; overexpression of the human ortholog [...] |
| SWI5 protein network | https://string-db.org/network/4932.YDR146C | Transcriptional factor SWI5; Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for [...] |
| EKI1 protein network | https://string-db.org/network/4932.YDR147W | Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine [...] |
| KGD2 protein network | https://string-db.org/network/4932.YDR148C | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which c [...] |
| YDR149C protein network | https://string-db.org/network/4932.YDR149C | Putative uncharacterized membrane protein YDR149C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the [...] |
| NUM1 protein network | https://string-db.org/network/4932.YDR150W | Protein required for nuclear migration; component of the mitochondria-ER-cortex-ancor (MECA); required for the association of mitochondria with the cell cortex and for accurate distribution of mi [...] |
| CTH1 protein network | https://string-db.org/network/4932.YDR151C | mRNA decay factor CTH1; Member of the CCCH zinc finger family; similar to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p [...] |
| GIR2 protein network | https://string-db.org/network/4932.YDR152W | Protein GIR2; Highly-acidic RWD domain-containing cytoplasmic protein; forms a highly conserved complex with Rbg2p that is responsible for efficient cell growth under amino acid starvation and bi [...] |
| ENT5 protein network | https://string-db.org/network/4932.YDR153C | Epsin-5; Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin ada [...] |
| YDR154C protein network | https://string-db.org/network/4932.YDR154C | Putative uncharacterized protein YDR154C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant exhibits [...] |
| CPR1 protein network | https://string-db.org/network/4932.YDR155C | Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; N-terminally pr [...] |
| RPA14 protein network | https://string-db.org/network/4932.YDR156W | RNA polymerase I subunit A14. |
| YDR157W protein network | https://string-db.org/network/4932.YDR157W | Uncharacterized protein YDR157W; Putative protein of unknown function; conserved across S. cerevisiae strains. |
| HOM2 protein network | https://string-db.org/network/4932.YDR158W | Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amin [...] |
| SAC3 protein network | https://string-db.org/network/4932.YDR159W | Nuclear mRNA export protein SAC3; mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elon [...] |
| SSY1 protein network | https://string-db.org/network/4932.YDR160W | SPS-sensor component SSY1; Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of [...] |
| ACL4 protein network | https://string-db.org/network/4932.YDR161W | Specific assembly chaperone for ribosomal protein Rpl4p; binds to an evolutionarily conserved surface extension of nascent Rpl4p and chaperones Rpl4p until its assembly into the pre-ribosome; tra [...] |
| NBP2 protein network | https://string-db.org/network/4932.YDR162C | NAP1-binding protein 2; Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1 [...] |
| CWC15 protein network | https://string-db.org/network/4932.YDR163W | Pre-mRNA-splicing factor CWC15; Non-essential protein involved in pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf15p; Belongs to the CWC15 family. |
| SEC1 protein network | https://string-db.org/network/4932.YDR164C | Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud nec [...] |
| TRM82 protein network | https://string-db.org/network/4932.YDR165W | Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 [...] |
| SEC5 protein network | https://string-db.org/network/4932.YDR166C | Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior [...] |
| TAF10 protein network | https://string-db.org/network/4932.YDR167W | Subunit (145 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification. |
| CDC37 protein network | https://string-db.org/network/4932.YDR168W | Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding; Belon [...] |
| STB3 protein network | https://string-db.org/network/4932.YDR169C | Protein STB3; Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released int [...] |
| YDR169C-A protein network | https://string-db.org/network/4932.YDR169C-A | Uncharacterized protein YDR169C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| SEC7 protein network | https://string-db.org/network/4932.YDR170C | Protein transport protein SEC7; Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors; involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; fou [...] |
| HSP42 protein network | https://string-db.org/network/4932.YDR171W | Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protei [...] |
| SUP35 protein network | https://string-db.org/network/4932.YDR172W | Eukaryotic peptide chain release factor GTP-binding subunit; Translation termination factor eRF3; has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] pri [...] |
| ARG82 protein network | https://string-db.org/network/4932.YDR173C | Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phos [...] |
| HMO1 protein network | https://string-db.org/network/4932.YDR174W | Chromatin associated high mobility group (HMG) family member; involved in compacting, bending, bridging and looping DNA; rDNA-binding component that regulates transcription from RNA polymerase I [...] |
| RSM24 protein network | https://string-db.org/network/4932.YDR175C | Mitochondrial ribosomal protein of the small subunit. |
| NGG1 protein network | https://string-db.org/network/4932.YDR176W | Subunit of chromatin modifying histone acetyltransferase complexes; member of the ADA complex, the SAGA complex, and the SLIK complex; transcriptional regulator involved in glucose repression of [...] |
| UBC1 protein network | https://string-db.org/network/4932.YDR177W | Ubiquitin-conjugating enzyme; key E2 partner with Ubc4p for the anaphase-promoting complex (APC); mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biog [...] |
| SDH4 protein network | https://string-db.org/network/4932.YDR178W | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane anchor subunit of succinate dehydrogenase (SDH); involved in coupling the oxidation of succinate to the tr [...] |
| CSN9 protein network | https://string-db.org/network/4932.YDR179C | Subunit of the Cop9 signalosome; Cop9 signalosome is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling [...] |
| NVJ3 protein network | https://string-db.org/network/4932.YDR179W-A | Uncharacterized protein YDR179W-A; Protein with a potential role in tethering ER and vacuoles; localizes to nucleus-vacuole junctions in an Mdm1p-dependent manner; contains a lipid-binding PXA do [...] |
| SCC2 protein network | https://string-db.org/network/4932.YDR180W | Sister chromatid cohesion protein 2; Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromat [...] |
| SAS4 protein network | https://string-db.org/network/4932.YDR181C | Something about silencing protein 4; Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activ [...] |
| CDC1 protein network | https://string-db.org/network/4932.YDR182W | Cell division control protein 1; Putative mannose-ethanolamine phosphate phosphodiesterase; involved in GPI-anchor remodeling prior to the attachment of cell wall proteins to beta 1,3-glucan, rem [...] |
| YDR182W-A protein network | https://string-db.org/network/4932.YDR182W-A | Uncharacterized protein YDR182W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| PLP1 protein network | https://string-db.org/network/4932.YDR183W | Phosducin-like protein 1; Protein that interacts with CCT (chaperonin containing TCP-1) complex; has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein re [...] |
| ATC1 protein network | https://string-db.org/network/4932.YDR184C | Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replica [...] |
| UPS3 protein network | https://string-db.org/network/4932.YDR185C | Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interac [...] |
| SND1 protein network | https://string-db.org/network/4932.YDR186C | Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for [...] |
| YDR187C protein network | https://string-db.org/network/4932.YDR187C | Putative uncharacterized membrane protein YDR187C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially ov [...] |
| CCT6 protein network | https://string-db.org/network/4932.YDR188W | T-complex protein 1 subunit zeta; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contai [...] |
| SLY1 protein network | https://string-db.org/network/4932.YDR189W | Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex. |
| RVB1 protein network | https://string-db.org/network/4932.YDR190C | RuvB-like protein 1; ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the [...] |
| HST4 protein network | https://string-db.org/network/4932.YDR191W | NAD-dependent histone deacetylase HST4; NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell [...] |
| NUP42 protein network | https://string-db.org/network/4932.YDR192C | FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and ma [...] |
| YDR193W protein network | https://string-db.org/network/4932.YDR193W | Putative uncharacterized protein YDR193W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| MSS116 protein network | https://string-db.org/network/4932.YDR194C | ATP-dependent RNA helicase MSS116, mitochondrial; Mitochondrial transcription elongation factor; DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; non-pol [...] |
| YDR194W-A protein network | https://string-db.org/network/4932.YDR194W-A | Uncharacterized protein YDR194W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| REF2 protein network | https://string-db.org/network/4932.YDR195W | RNA end formation protein 2; RNA-binding protein; involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which [...] |
| CAB5 protein network | https://string-db.org/network/4932.YDR196C | Dephospho-CoA kinase CAB5; Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable dephospho-CoA kinase (DPC [...] |
| CBS2 protein network | https://string-db.org/network/4932.YDR197W | Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader. |
| RKM2 protein network | https://string-db.org/network/4932.YDR198C | Ribosomal protein lysine methyltransferase; responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp; Belongs to the class V-like SAM-binding methyltransferase su [...] |
| YDR199W protein network | https://string-db.org/network/4932.YDR199W | Putative uncharacterized membrane protein YDR199W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially ov [...] |
| VPS64 protein network | https://string-db.org/network/4932.YDR200C | Vacuolar protein sorting-associated protein 64; Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone [...] |
| SPC19 protein network | https://string-db.org/network/4932.YDR201W | Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuc [...] |
| RAV2 protein network | https://string-db.org/network/4932.YDR202C | Regulator of V-ATPase in vacuolar membrane protein 2; Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) [...] |
| YDR203W protein network | https://string-db.org/network/4932.YDR203W | Putative uncharacterized protein YDR203W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely ove [...] |
| COQ4 protein network | https://string-db.org/network/4932.YDR204W | Protein with a role in ubiquinone (Coenzyme Q) biosynthesis; possibly functioning in stabilization of Coq7p; located on matrix face of mitochondrial inner membrane; component of a mitochondrial u [...] |
| MSC2 protein network | https://string-db.org/network/4932.YDR205W | Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of [...] |
| EBS1 protein network | https://string-db.org/network/4932.YDR206W | Protein involved in translation inhibition and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance reg [...] |
| UME6 protein network | https://string-db.org/network/4932.YDR207C | Transcriptional regulatory protein UME6; Rpd3L histone deacetylase complex subunit; key transcriptional regulator of early meiotic genes; involved in chromatin remodeling and transcriptional repr [...] |
| MSS4 protein network | https://string-db.org/network/4932.YDR208W | Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation. |
| YDR210W protein network | https://string-db.org/network/4932.YDR210W | Cysteine-rich and transmembrane domain-containing protein YDR210W; Predicted tail-anchored plasma membrane protein; contains a conserved CYSTM module; related proteins in other organisms may be i [...] |
| GCD6 protein network | https://string-db.org/network/4932.YDR211W | Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first ident [...] |
| TCP1 protein network | https://string-db.org/network/4932.YDR212W | Alpha subunit of chaperonin-containing T-complex; complex mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pa [...] |
| UPC2 protein network | https://string-db.org/network/4932.YDR213W | Sterol uptake control protein 2; Sterol regulatory element binding protein; induces sterol biosynthetic genes, upon sterol depletion; acts as a sterol sensor, binding ergosterol in sterol rich co [...] |
| AHA1 protein network | https://string-db.org/network/4932.YDR214W | Hsp90 co-chaperone AHA1; Co-chaperone that binds Hsp82p and activates its ATPase activity; plays a role in determining prion variants; similar to Hch1p; expression is regulated by stresses such a [...] |
| YDR215C protein network | https://string-db.org/network/4932.YDR215C | Uncharacterized protein YDR215C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays elevated [...] |
| ADR1 protein network | https://string-db.org/network/4932.YDR216W | Regulatory protein ADR1; Carbon source-responsive zinc-finger transcription factor; required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes requi [...] |
| RAD9 protein network | https://string-db.org/network/4932.YDR217C | DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M, plays a role in postreplication repair (PRR) pathway; transmits checkpoint signal by activating [...] |
| SPR28 protein network | https://string-db.org/network/4932.YDR218C | Sporulation-regulated protein 28; Sporulation-specific homolog of the CDC3/10/11/12 family of genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation; the [...] |
| MFB1 protein network | https://string-db.org/network/4932.YDR219C | Mitochondria-associated F-box protein; involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during [...] |
| YDR220C protein network | https://string-db.org/network/4932.YDR220C | Putative uncharacterized protein YDR220C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant exhibits [...] |
| GTB1 protein network | https://string-db.org/network/4932.YDR221W | Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from [...] |
| YDR222W protein network | https://string-db.org/network/4932.YDR222W | SVF1-like protein YDR222W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YDR222W has a paralog, YLR225C, that arose [...] |
| CRF1 protein network | https://string-db.org/network/4932.YDR223W | Transcription factor CRF1; Transcriptional corepressor; involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in t [...] |
| HTB1 protein network | https://string-db.org/network/4932.YDR224C | Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA repli [...] |
| HTA1 protein network | https://string-db.org/network/4932.YDR225W | Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p faci [...] |
| ADK1 protein network | https://string-db.org/network/4932.YDR226W | Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stre [...] |
| SIR4 protein network | https://string-db.org/network/4932.YDR227W | Regulatory protein SIR4; SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domain [...] |
| PCF11 protein network | https://string-db.org/network/4932.YDR228C | Protein PCF11; mRNA 3' end processing factor; essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds [...] |
| IVY1 protein network | https://string-db.org/network/4932.YDR229W | Protein IVY1; Phospholipid-binding protein that interacts with both Ypt7p and Vps33p; may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells ap [...] |
| COX20 protein network | https://string-db.org/network/4932.YDR231C | Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase; Belongs to the COX20 family. |
| HEM1 protein network | https://string-db.org/network/4932.YDR232W | 5-aminolevulinate synthase, mitochondrial; 5-aminolevulinate synthase; catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the [...] |
| RTN1 protein network | https://string-db.org/network/4932.YDR233C | Reticulon-like protein 1; Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritanc [...] |
| LYS4 protein network | https://string-db.org/network/4932.YDR234W | Homoaconitase, mitochondrial; Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway. |
| PRP42 protein network | https://string-db.org/network/4932.YDR235W | U1 small nuclear ribonucleoprotein component PRP42; U1 snRNP protein involved in splicing; required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats. |
| FMN1 protein network | https://string-db.org/network/4932.YDR236C | Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial in [...] |
| MRPL7 protein network | https://string-db.org/network/4932.YDR237W | Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein. |
| SEC26 protein network | https://string-db.org/network/4932.YDR238C | Coatomer subunit beta; Essential beta-coat protein of the COPI coatomer; involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mam [...] |
| YDR239C protein network | https://string-db.org/network/4932.YDR239C | Uncharacterized protein YDR239C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments. |
| SNU56 protein network | https://string-db.org/network/4932.YDR240C | 56 kDa U1 small nuclear ribonucleoprotein component; Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment c [...] |
| BUD26 protein network | https://string-db.org/network/4932.YDR241W | Putative uncharacterized protein BUD26; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closel [...] |
| AMD2 protein network | https://string-db.org/network/4932.YDR242W | Putative amidase. |
| PRP28 protein network | https://string-db.org/network/4932.YDR243C | Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; RNA binding protein; involved in RNA isomerization at the 5' splice site and for exchange of U6 for U1 snRNA at the 5' splice site; similar to [...] |
| PEX5 protein network | https://string-db.org/network/4932.YDR244W | Peroxisomal membrane signal receptor for peroxisomal matrix proteins; receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins; required for peroxisomal matrix [...] |
| MNN10 protein network | https://string-db.org/network/4932.YDR245W | Probable alpha-1,6-mannosyltransferase MNN10; Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltr [...] |
| TRS23 protein network | https://string-db.org/network/4932.YDR246W | Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic ( [...] |
| YDR246W-A protein network | https://string-db.org/network/4932.YDR246W-A | Uncharacterized protein YDR246W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| VHS1 protein network | https://string-db.org/network/4932.YDR247W | Serine/threonine-protein kinase VHS1; Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role [...] |
| YDR248C protein network | https://string-db.org/network/4932.YDR248C | Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II [...] |
| YDR249C protein network | https://string-db.org/network/4932.YDR249C | Uncharacterized protein YDR249C; Putative protein of unknown function. |
| YDR250C protein network | https://string-db.org/network/4932.YDR250C | Putative uncharacterized protein YDR250C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| PAM1 protein network | https://string-db.org/network/4932.YDR251W | Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a fil [...] |
| BTT1 protein network | https://string-db.org/network/4932.YDR252W | Heterotrimeric nascent polypeptide-associated complex beta3 subunit; complex binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-N [...] |
| MET32 protein network | https://string-db.org/network/4932.YDR253C | Transcriptional regulator MET32; Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; targets strong transcriptional activato [...] |
| CHL4 protein network | https://string-db.org/network/4932.YDR254W | Inner kinetochore subunit CHL4; Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; forms a stable complex with Iml3p; [...] |
| RMD5 protein network | https://string-db.org/network/4932.YDR255C | E3 ubiquitin-protein ligase RMD5; Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-b [...] |
| CTA1 protein network | https://string-db.org/network/4932.YDR256C | Catalase A; breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation; Belongs to the catalase family. |
| RKM4 protein network | https://string-db.org/network/4932.YDR257C | Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein. |
| HSP78 protein network | https://string-db.org/network/4932.YDR258C | Heat shock protein 78, mitochondrial; Oligomeric mitochondrial matrix chaperone; cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfol [...] |
| YAP6 protein network | https://string-db.org/network/4932.YDR259C | Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computa [...] |
| SWM1 protein network | https://string-db.org/network/4932.YDR260C | Subunit of the anaphase-promoting complex (APC); APC is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-spec [...] |
| EXG2 protein network | https://string-db.org/network/4932.YDR261C | Glucan 1,3-beta-glucosidase 2; Exo-1,3-beta-glucanase; involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. |
| YDR262W protein network | https://string-db.org/network/4932.YDR262W | FAS1 domain-containing protein YDR262W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damagin [...] |
| DIN7 protein network | https://string-db.org/network/4932.YDR263C | DNA damage-inducible protein DIN7; Mitochondrial nuclease functioning in DNA repair and replication; modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also ind [...] |
| AKR1 protein network | https://string-db.org/network/4932.YDR264C | Palmitoyltransferase AKR1; Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; i [...] |
| PEX10 protein network | https://string-db.org/network/4932.YDR265W | Peroxisome biogenesis factor 10; Peroxisomal membrane E3 ubiquitin ligase; required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING [...] |
| HEL2 protein network | https://string-db.org/network/4932.YDR266C | RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent pro [...] |
| CIA1 protein network | https://string-db.org/network/4932.YDR267C | Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at late step of Fe-S cluster assembly; forms CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorp [...] |
| MSW1 protein network | https://string-db.org/network/4932.YDR268W | Tryptophan--tRNA ligase, mitochondrial; Mitochondrial tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. |
| CCC2 protein network | https://string-db.org/network/4932.YDR270W | Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; similar to human proteins involved in Menkes and Wilsons diseases; protein ab [...] |
| GLO2 protein network | https://string-db.org/network/4932.YDR272W | Hydroxyacylglutathione hydrolase, cytoplasmic isozyme; Cytoplasmic glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO2 has a paralog, GLO4, that [...] |
| DON1 protein network | https://string-db.org/network/4932.YDR273W | Donuts protein 1; Meiosis-specific component of the spindle pole body; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edg [...] |
| YDR274C protein network | https://string-db.org/network/4932.YDR274C | Uncharacterized protein YDR274C; Putative protein of unknown function; conserved among S. cerevisiae strains; YDR274C is not an essential gene. |
| BSC2 protein network | https://string-db.org/network/4932.YDR275W | Bypass of stop codon protein 2; Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; null mutant displays incre [...] |
| PMP3 protein network | https://string-db.org/network/4932.YDR276C | Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed unde [...] |
| MTH1 protein network | https://string-db.org/network/4932.YDR277C | Protein MTH1; Negative regulator of the glucose-sensing signal transduction pathway; required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensor [...] |
| YDR278C protein network | https://string-db.org/network/4932.YDR278C | Uncharacterized protein YDR278C; Putative protein of unknown function; conserved among S. cerevisiae strains; YDR278C is not an essential gene. |
| RNH202 protein network | https://string-db.org/network/4932.YDR279W | Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS2 that causes Aicardi-Goutieres syndrome. |
| RRP45 protein network | https://string-db.org/network/4932.YDR280W | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, E [...] |
| PHM6 protein network | https://string-db.org/network/4932.YDR281C | Phosphate metabolism protein 6; Protein of unknown function; expression is regulated by phosphate levels. |
| MRX10 protein network | https://string-db.org/network/4932.YDR282C | MIOREX complex component 10; Mitochondrial inner membrane protein of unknown function; associates with mitochondrial ribosome; localizes to the inner membrane with the C terminus facing the inter [...] |
| GCN2 protein network | https://string-db.org/network/4932.YDR283C | eIF-2-alpha kinase GCN2; Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20 [...] |
| DPP1 protein network | https://string-db.org/network/4932.YDR284C | Diacylglycerol pyrophosphate (DGPP) phosphatase; zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; invo [...] |
| ZIP1 protein network | https://string-db.org/network/4932.YDR285W | Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; required for meiotic recombi [...] |
| YDR286C protein network | https://string-db.org/network/4932.YDR286C | Glutaredoxin-like protein YDR286C; Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; Belongs to the glutaredoxin family. YDR286C subfamily. |
| INM2 protein network | https://string-db.org/network/4932.YDR287W | Inositol monophosphatase; involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxo [...] |
| NSE3 protein network | https://string-db.org/network/4932.YDR288W | Non-structural maintenance of chromosome element 3; Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatid [...] |
| RTT103 protein network | https://string-db.org/network/4932.YDR289C | Regulator of Ty1 transposition protein 103; Protein involved in transcription termination by RNA polymerase II; interacts with exonuclease Rat1p and Rai1p; has an RPR domain (carboxy-terminal dom [...] |
| YDR290W protein network | https://string-db.org/network/4932.YDR290W | Putative uncharacterized protein YDR290W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| HRQ1 protein network | https://string-db.org/network/4932.YDR291W | ATP-dependent helicase HRQ1; 3'-5' DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; acts with Rad4p in nucl [...] |
| SRP101 protein network | https://string-db.org/network/4932.YDR292C | Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p. |
| SSD1 protein network | https://string-db.org/network/4932.YDR293C | Protein SSD1; Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific [...] |
| DPL1 protein network | https://string-db.org/network/4932.YDR294C | Dihydrosphingosine phosphate lyase; regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-p [...] |
| HDA2 protein network | https://string-db.org/network/4932.YDR295C | Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involve [...] |
| MHR1 protein network | https://string-db.org/network/4932.YDR296W | Mitochondrial ribosomal protein of the large subunit; also involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation o [...] |
| SUR2 protein network | https://string-db.org/network/4932.YDR297W | Sphingolipid C4-hydroxylase SUR2; Sphinganine C4-hydroxylase; catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis; Belongs to the sterol desaturase family. |
| ATP5 protein network | https://string-db.org/network/4932.YDR298C | Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OS [...] |
| BFR2 protein network | https://string-db.org/network/4932.YDR299W | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is indu [...] |
| PRO1 protein network | https://string-db.org/network/4932.YDR300C | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a para [...] |
| CFT1 protein network | https://string-db.org/network/4932.YDR301W | Protein CFT1; RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence s [...] |
| GPI11 protein network | https://string-db.org/network/4932.YDR302W | Glycosylphosphatidylinositol anchor biosynthesis protein 11; ER membrane protein involved in a late step of GPI anchor assembly; involved in the addition of phosphoethanolamine to the multiply ma [...] |
| RSC3 protein network | https://string-db.org/network/4932.YDR303C | Chromatin structure-remodeling complex protein RSC3; Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protei [...] |
| CPR5 protein network | https://string-db.org/network/4932.YDR304C | Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfold [...] |
| HNT2 protein network | https://string-db.org/network/4932.YDR305C | Bis(5'-adenosyl)-triphosphatase; Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding protei [...] |
| YDR306C protein network | https://string-db.org/network/4932.YDR306C | F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain. |
| PMT7 protein network | https://string-db.org/network/4932.YDR307W | Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7; Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation. |
| SRB7 protein network | https://string-db.org/network/4932.YDR308C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the globa [...] |
| GIC2 protein network | https://string-db.org/network/4932.YDR309C | GTPase-interacting component 2; Redundant rho-like GTPase Cdc42p effector; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding [...] |
| SUM1 protein network | https://string-db.org/network/4932.YDR310C | Suppressor of mar1-1 protein; Transcriptional repressor that regulates middle-sporulation genes; required for mitotic repression of middle sporulation-specific genes; also acts as general replica [...] |
| TFB1 protein network | https://string-db.org/network/4932.YDR311W | Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair, target for transcriptional activators; relocalizes to the cytosol in response to hypox [...] |
| SSF2 protein network | https://string-db.org/network/4932.YDR312W | Ribosome biogenesis protein SSF2; Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from [...] |
| PIB1 protein network | https://string-db.org/network/4932.YDR313C | E3 ubiquitin-protein ligase PIB1; RING-type ubiquitin ligase of the endosomal and vacuolar membranes; binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain. |
| RAD34 protein network | https://string-db.org/network/4932.YDR314C | Protein involved in nucleotide excision repair (NER); homologous to RAD4. |
| IPK1 protein network | https://string-db.org/network/4932.YDR315C | Inositol 1,3,4,5,6-pentakisphosphate 2-kinase; nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in othe [...] |
| OMS1 protein network | https://string-db.org/network/4932.YDR316W | Methyltransferase OMS1, mitochondrial; Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif and is predicted to be an RNA methyltransferase; multicopy suppresso [...] |
| HIM1 protein network | https://string-db.org/network/4932.YDR317W | Protein of unknown function involved in DNA repair. |
| MCM21 protein network | https://string-db.org/network/4932.YDR318W | Inner kinetochore subunit MCM21; Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits boun [...] |
| YFT2 protein network | https://string-db.org/network/4932.YDR319C | FIT family protein YFT2; Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous t [...] |
| SWA2 protein network | https://string-db.org/network/4932.YDR320C | Auxilin-like clathrin uncoating factor SWA2; Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles. |
| DAD4 protein network | https://string-db.org/network/4932.YDR320C-A | Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the [...] |
| YDR320W-B protein network | https://string-db.org/network/4932.YDR320W-B | Uncharacterized protein YDR320W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene D [...] |
| ASP1 protein network | https://string-db.org/network/4932.YDR321W | Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia; important enzyme for the treatment of acute lymphoblastic leukemia; [...] |
| TIM11 protein network | https://string-db.org/network/4932.YDR322C-A | Subunit e of mitochondrial F1F0-ATPase; ATPase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase, whic [...] |
| MRPL35 protein network | https://string-db.org/network/4932.YDR322W | Mitochondrial ribosomal protein of the large subunit; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily. |
| PEP7 protein network | https://string-db.org/network/4932.YDR323C | Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking [...] |
| UTP4 protein network | https://string-db.org/network/4932.YDR324C | U3 small nucleolar RNA-associated protein 4; Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; mem [...] |
| YCG1 protein network | https://string-db.org/network/4932.YDR325W | Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding by the complex; required for tRNA genes clust [...] |
| YSP2 protein network | https://string-db.org/network/4932.YDR326C | Membrane-anchored lipid-binding protein YSP2; Sterol-binding protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; contains two StART-like domains th [...] |
| YDR327W protein network | https://string-db.org/network/4932.YDR327W | Putative uncharacterized protein YDR327W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| SKP1 protein network | https://string-db.org/network/4932.YDR328C | Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex tha [...] |
| PEX3 protein network | https://string-db.org/network/4932.YDR329C | Peroxisomal biogenesis factor 3; Peroxisomal membrane protein (PMP); required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; [...] |
| UBX5 protein network | https://string-db.org/network/4932.YDR330W | UBX domain-containing protein that interacts with Cdc48p; ubiquitin regulatory X is also known as UBX. |
| GPI8 protein network | https://string-db.org/network/4932.YDR331W | GPI-anchor transamidase; ER membrane glycoprotein subunit of the GPI transamidase complex; adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a [...] |
| IRC3 protein network | https://string-db.org/network/4932.YDR332W | Putative ATP-dependent helicase IRC3; Double-stranded DNA-dependent helicase of the DExH/D-box family; required for maintenance of the mitochondrial (mt) genome; null mutant accumulates double-st [...] |
| RQC1 protein network | https://string-db.org/network/4932.YDR333C | Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Tae2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled t [...] |
| SWR1 protein network | https://string-db.org/network/4932.YDR334W | Helicase SWR1; Swi2/Snf2-related ATPase; structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; relocalizes to the cytosol in resp [...] |
| MSN5 protein network | https://string-db.org/network/4932.YDR335W | Protein MSN5; Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4 [...] |
| MRX8 protein network | https://string-db.org/network/4932.YDR336W | MIOREX complex component 8; Protein that associates with mitochondrial ribosome; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene. |
| MRPS28 protein network | https://string-db.org/network/4932.YDR337W | Mitochondrial ribosomal protein of the small subunit. |
| YDR338C protein network | https://string-db.org/network/4932.YDR338C | Uncharacterized transporter YDR338C; Putative protein of unknown function; member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) [...] |
| FCF1 protein network | https://string-db.org/network/4932.YDR339C | rRNA-processing protein FCF1; Putative PINc domain nuclease; required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 4 [...] |
| YDR341C protein network | https://string-db.org/network/4932.YDR341C | Arginine--tRNA ligase, cytoplasmic; Arginyl-tRNA synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDR341C has a paralog, MSR1, [...] |
| HXT7 protein network | https://string-db.org/network/4932.YDR342C | High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high gluc [...] |
| HXT6 protein network | https://string-db.org/network/4932.YDR343C | High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high [...] |
| YDR344C protein network | https://string-db.org/network/4932.YDR344C | Uncharacterized protein YDR344C; Putative protein of unknown function; conserved among S. cerevisiae strains. |
| HXT3 protein network | https://string-db.org/network/4932.YDR345C | Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplicat [...] |
| SVF1 protein network | https://string-db.org/network/4932.YDR346C | Survival factor 1; Protein with a potential role in cell survival pathways; required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apopt [...] |
| MRP1 protein network | https://string-db.org/network/4932.YDR347W | Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit m [...] |
| PAL1 protein network | https://string-db.org/network/4932.YDR348C | Protein of unknown function thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluo [...] |
| YPS7 protein network | https://string-db.org/network/4932.YDR349C | Aspartic proteinase yapsin-7; Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplas [...] |
| ATP22 protein network | https://string-db.org/network/4932.YDR350C | Specific translational activator for the mitochondrial ATP6 mRNA; Atp6p encodes a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane; Belongs to the ATP22 family. |
| SBE2 protein network | https://string-db.org/network/4932.YDR351W | Protein required for bud growth; involved in transport of cell wall components from the Golgi to the cell surface; SBE2 has a paralog, SBE22, that arose from the whole genome duplication. |
| YPQ2 protein network | https://string-db.org/network/4932.YDR352W | Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, wit [...] |
| TRR1 protein network | https://string-db.org/network/4932.YDR353W | Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxid [...] |
| YDR354C-A protein network | https://string-db.org/network/4932.YDR354C-A | Putative uncharacterized protein YDR354C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| TRP4 protein network | https://string-db.org/network/4932.YDR354W | Anthranilate phosphoribosyl transferase; transferase of the tryptophan biosynthetic pathway; catalyzes the phosphoribosylation of anthranilate; subject to the general control system of amino acid [...] |
| YDR355C protein network | https://string-db.org/network/4932.YDR355C | Putative uncharacterized protein YDR355C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| SPC110 protein network | https://string-db.org/network/4932.YDR356W | Inner plaque spindle pole body (SPB) component; ortholog of human kendrin; gamma-tubulin small complex (gamma-TuSC) receptor that interacts with Spc98p to recruit the complex to the nuclear side [...] |
| CNL1 protein network | https://string-db.org/network/4932.YDR357C | Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion [...] |
| GGA1 protein network | https://string-db.org/network/4932.YDR358W | ADP-ribosylation factor-binding protein GGA1; Golgi-localized protein with homology to gamma-adaptin; interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate [...] |
| EAF1 protein network | https://string-db.org/network/4932.YDR359C | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initia [...] |
| OPI7 protein network | https://string-db.org/network/4932.YDR360W | Putative uncharacterized protein OPI7; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verif [...] |
| BCP1 protein network | https://string-db.org/network/4932.YDR361C | Essential protein involved in nuclear export of Mss4p; Mss4p is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicula [...] |
| TFC6 protein network | https://string-db.org/network/4932.YDR362C | Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that [...] |
| ESC2 protein network | https://string-db.org/network/4932.YDR363W | Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase [...] |
| SEM1 protein network | https://string-db.org/network/4932.YDR363W-A | 26S proteasome complex subunit SEM1; 19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA expor [...] |
| CDC40 protein network | https://string-db.org/network/4932.YDR364C | Pre-mRNA-processing factor 17; Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression, particularly at the G1/S phase transition [...] |
| ESF1 protein network | https://string-db.org/network/4932.YDR365C | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. |
| YDR366C protein network | https://string-db.org/network/4932.YDR366C | Uncharacterized protein YDR366C; Putative protein of unknown function. |
| KEI1 protein network | https://string-db.org/network/4932.YDR367W | Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally p [...] |
| YPR1 protein network | https://string-db.org/network/4932.YDR368W | Putative reductase 1; NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stres [...] |
| XRS2 protein network | https://string-db.org/network/4932.YDR369C | Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling. |
| DXO1 protein network | https://string-db.org/network/4932.YDR370C | Decapping and exoribonuclease protein 1; mRNA 5'-end-capping quality-control protein; has distributive, 5'-3' exoRNase activity; similar to Rai1p;; Belongs to the DXO/Dom3Z family. |
| YDR371C-A protein network | https://string-db.org/network/4932.YDR371C-A | Uncharacterized protein YDR371C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the unch [...] |
| CTS2 protein network | https://string-db.org/network/4932.YDR371W | Putative chitinase; functionally complements A. gossypii cts2 mutant sporulation defect. |
| VPS74 protein network | https://string-db.org/network/4932.YDR372C | Vacuolar protein sorting-associated protein 74; Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and [...] |
| FRQ1 protein network | https://string-db.org/network/4932.YDR373W | N-myristoylated calcium-binding protein; may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of [...] |
| PHO92 protein network | https://string-db.org/network/4932.YDR374C | Methylated RNA-binding protein 1; Posttranscriptional regulator of phosphate metabolism; facilitates PHO4 mRNA degradation by interacting with Pop2p; regulates PHO4 mRNA stability by binding to P [...] |
| WIP1 protein network | https://string-db.org/network/4932.YDR374W-A | Inner kinetochore subunit WIP1; Kinetochore localized protein of unknown function; interacts with Cnn1p (CENP-T); orthologous to human centromere constitutive-associated network (CCAN) subunit CE [...] |
| BCS1 protein network | https://string-db.org/network/4932.YDR375C | Mitochondrial chaperone BCS1; Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner memb [...] |
| ARH1 protein network | https://string-db.org/network/4932.YDR376W | Probable NADPH:adrenodoxin oxidoreductase, mitochondrial; Oxidoreductase of the mitochondrial inner membrane; involved in cytoplasmic and mitochondrial iron homeostasis and required for activity [...] |
| ATP17 protein network | https://string-db.org/network/4932.YDR377W | Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis. |
| LSM6 protein network | https://string-db.org/network/4932.YDR378C | U6 snRNA-associated Sm-like protein LSm6; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Ls [...] |
| SDH6 protein network | https://string-db.org/network/4932.YDR379C-A | Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; member of the LYR protein family; mutations in human ortholog SDHAF1 are asso [...] |
| RGA2 protein network | https://string-db.org/network/4932.YDR379W | GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p; [...] |
| ARO10 protein network | https://string-db.org/network/4932.YDR380W | Transaminated amino acid decarboxylase; Phenylpyruvate decarboxylase; catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway; i [...] |
| YDR381C-A protein network | https://string-db.org/network/4932.YDR381C-A | Protein of unknown function; localized to the mitochondrial outer membrane. |
| YRA1 protein network | https://string-db.org/network/4932.YDR381W | Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11 [...] |
| RPP2B protein network | https://string-db.org/network/4932.YDR382W | 60S acidic ribosomal protein P2-beta; Ribosomal protein P2 beta; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome [...] |
| NKP1 protein network | https://string-db.org/network/4932.YDR383C | Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4; Belongs to the NKP1 family. |
| ATO3 protein network | https://string-db.org/network/4932.YDR384C | Ammonia transport outward protein 3; Plasma membrane protein, putative ammonium transporter; regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mito [...] |
| EFT2 protein network | https://string-db.org/network/4932.YDR385W | Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue speci [...] |
| MUS81 protein network | https://string-db.org/network/4932.YDR386W | Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombina [...] |
| CIN10 protein network | https://string-db.org/network/4932.YDR387C | Probable metabolite transport protein YDR387C; Putative transporter; member of the sugar porter family; non-essential gene; overexpression results in elevated colony sectoring, an indicator of ch [...] |
| RVS167 protein network | https://string-db.org/network/4932.YDR388W | Reduced viability upon starvation protein 167; Calmodulin-binding actin-associated protein; roles in endocytic membrane tabulation and constriction, and exocytosis; N-BAR domain protein that inte [...] |
| SAC7 protein network | https://string-db.org/network/4932.YDR389W | GTPase-activating protein SAC7; GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regula [...] |
| UBA2 protein network | https://string-db.org/network/4932.YDR390C | Ubiquitin-activating enzyme E1-like; Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play [...] |
| YDR391C protein network | https://string-db.org/network/4932.YDR391C | Uncharacterized protein YDR391C; Putative protein of unknown function; possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP) [...] |
| SPT3 protein network | https://string-db.org/network/4932.YDR392W | Protein SPT3; Subunit of the SAGA and SAGA-like transcriptional regulatory complexes; interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to [...] |
| SHE9 protein network | https://string-db.org/network/4932.YDR393W | Sensitive to high expression protein 9, mitochondrial; Protein required for normal mitochondrial morphology; mitochondrial inner membrane protein; may be involved in fission of the inner membrane [...] |
| RPT3 protein network | https://string-db.org/network/4932.YDR394W | ATPase of the 19S regulatory particle of the 26S proteasome; one of ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B [...] |
| SXM1 protein network | https://string-db.org/network/4932.YDR395W | Importin beta SMX1; Nuclear transport factor (karyopherin); involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis s [...] |
| YDR396W protein network | https://string-db.org/network/4932.YDR396W | Putative uncharacterized protein YDR396W; Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric [...] |
| NCB2 protein network | https://string-db.org/network/4932.YDR397C | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcriptio [...] |
| UTP5 protein network | https://string-db.org/network/4932.YDR398W | U3 small nucleolar RNA-associated protein 5; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit. |
| HPT1 protein network | https://string-db.org/network/4932.YDR399W | Dimeric hypoxanthine-guanine phosphoribosyltransferase; catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxant [...] |
| URH1 protein network | https://string-db.org/network/4932.YDR400W | Uridine nucleosidase (uridine-cytidine N-ribohydrolase); cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways; Belongs to the I [...] |
| DIT2 protein network | https://string-db.org/network/4932.YDR402C | Cytochrome P450-DIT2; N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cyt [...] |
| DIT1 protein network | https://string-db.org/network/4932.YDR403W | Sporulation-specific enzyme required for spore wall maturation; involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of [...] |
| RPB7 protein network | https://string-db.org/network/4932.YDR404C | RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay pr [...] |
| MRP20 protein network | https://string-db.org/network/4932.YDR405W | Mitochondrial ribosomal protein of the large subunit. |
| PDR15 protein network | https://string-db.org/network/4932.YDR406W | ATP-dependent permease PDR15; Plasma membrane ATP binding cassette (ABC) transporter; multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by [...] |
| YDR406W-A protein network | https://string-db.org/network/4932.YDR406W-A | Putative uncharacterized protein YDR406W-A; Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR. |
| TRS120 protein network | https://string-db.org/network/4932.YDR407C | Trafficking protein particle complex II-specific subunit 120; Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase [...] |
| ADE8 protein network | https://string-db.org/network/4932.YDR408C | Phosphoribosylglycinamide formyltransferase; Phosphoribosyl-glycinamide transformylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway. |
| SIZ1 protein network | https://string-db.org/network/4932.YDR409W | SUMO E3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to primarily cytoplasmic proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated b [...] |
| STE14 protein network | https://string-db.org/network/4932.YDR410C | Protein-S-isoprenylcysteine O-methyltransferase; Farnesyl cysteine-carboxyl methyltransferase; mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS p [...] |
| DFM1 protein network | https://string-db.org/network/4932.YDR411C | DER1-like family member protein 1; Endoplasmic reticulum (ER) localized protein; involved in ER-associated protein degradation (ERAD), ER stress, and homeostasis; interacts with components of ERA [...] |
| RRP17 protein network | https://string-db.org/network/4932.YDR412W | Ribosomal RNA-processing protein 17; Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclea [...] |
| YDR413C protein network | https://string-db.org/network/4932.YDR413C | Putative uncharacterized protein YDR413C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the essentia [...] |
| ERD1 protein network | https://string-db.org/network/4932.YDR414C | Protein ERD1; Predicted membrane protein required for lumenal ER protein retention; mutants secrete the endogenous ER protein, BiP (Kar2p); Belongs to the ERD1 family. |
| YDR415C protein network | https://string-db.org/network/4932.YDR415C | Probable aminopeptidase YDR415C; Putative aminopeptidase; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to the vacuole. |
| SYF1 protein network | https://string-db.org/network/4932.YDR416W | Pre-mRNA-splicing factor SYF1; Member of the NineTeen Complex (NTC); that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null muta [...] |
| YDR417C protein network | https://string-db.org/network/4932.YDR417C | Putative uncharacterized protein YDR417C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RPL12B protein network | https://string-db.org/network/4932.YDR418W | Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, R [...] |
| RAD30 protein network | https://string-db.org/network/4932.YDR419W | DNA polymerase eta; involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formatio [...] |
| HKR1 protein network | https://string-db.org/network/4932.YDR420W | Signaling mucin HKR1; Mucin family member that functions as an osmosensor in the HOG pathway; large, highly glycosylated protein that functions redundantly with Msb2p in Sho1p-mediated osmostress [...] |
| ARO80 protein network | https://string-db.org/network/4932.YDR421W | Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids. |
| SIP1 protein network | https://string-db.org/network/4932.YDR422C | Alternate beta-subunit of the Snf1p kinase complex; may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) [...] |
| CAD1 protein network | https://string-db.org/network/4932.YDR423C | AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing pr [...] |
| DYN2 protein network | https://string-db.org/network/4932.YDR424C | Cytoplasmic light chain dynein, microtubule motor protein; required for intracellular transport and cell division; involved in mitotic spindle positioning; forms complex with dynein intermediate [...] |
| SNX41 protein network | https://string-db.org/network/4932.YDR425W | Sorting nexin; involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p. |
| RPN9 protein network | https://string-db.org/network/4932.YDR427W | Non-ATPase regulatory subunit of the 26S proteasome; similar to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembl [...] |
| BNA7 protein network | https://string-db.org/network/4932.YDR428C | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. |
| TIF35 protein network | https://string-db.org/network/4932.YDR429C | eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; is essential for translation; stimulates resumption of ribosomal scanning during trans [...] |
| CYM1 protein network | https://string-db.org/network/4932.YDR430C | Mitochondrial presequence protease; Lysine-specific metalloprotease of the pitrilysin family; metalloprotease of the intermembrane space; degrades proteins and presequence peptides cleaved from i [...] |
| YDR431W protein network | https://string-db.org/network/4932.YDR431W | Putative uncharacterized protein YDR431W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| NPL3 protein network | https://string-db.org/network/4932.YDR432W | Nucleolar protein 3; RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; represses translation initiation by binding eIF4G; requir [...] |
| YDR433W protein network | https://string-db.org/network/4932.YDR433W | Putative uncharacterized protein YDR433W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| GPI17 protein network | https://string-db.org/network/4932.YDR434W | GPI transamidase component GPI17; Transmembrane protein; subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog. |
| PPM1 protein network | https://string-db.org/network/4932.YDR435C | Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; requir [...] |
| PPZ2 protein network | https://string-db.org/network/4932.YDR436W | Serine/threonine-protein phosphatase PP-Z2; Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle pr [...] |
| GPI19 protein network | https://string-db.org/network/4932.YDR437W | Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in glycosylphosphatidylinositol (GPI) anchor [...] |
| THI74 protein network | https://string-db.org/network/4932.YDR438W | Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication; shows sequence homology to human gene SLC35F3, a thiamine transporte [...] |
| LRS4 protein network | https://string-db.org/network/4932.YDR439W | Monopolin complex subunit LRS4; Nucleolar protein that forms a complex with Csm1p; and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin [...] |
| DOT1 protein network | https://string-db.org/network/4932.YDR440W | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage resp [...] |
| APT2 protein network | https://string-db.org/network/4932.YDR441C | Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a [...] |
| SSN2 protein network | https://string-db.org/network/4932.YDR443C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; esse [...] |
| YDR444W protein network | https://string-db.org/network/4932.YDR444W | Putative lipase YDR444W; Putative hydrolase acting on ester bonds; Belongs to the putative lipase ROG1 family. |
| YDR445C protein network | https://string-db.org/network/4932.YDR445C | Putative uncharacterized protein YDR445C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| ECM11 protein network | https://string-db.org/network/4932.YDR446W | Meiosis-specific protein; component of the Synaptonemal Complex (SC) along with Gmc2p; required for efficient crossover formation and for the efficient loading of the SC transverse filament prote [...] |
| RPS17B protein network | https://string-db.org/network/4932.YDR447C | Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplica [...] |
| ADA2 protein network | https://string-db.org/network/4932.YDR448W | Transcriptional adapter 2; Transcription coactivator; component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes. |
| UTP6 protein network | https://string-db.org/network/4932.YDR449C | Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA. |
| RPS18A protein network | https://string-db.org/network/4932.YDR450W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication [...] |
| YHP1 protein network | https://string-db.org/network/4932.YDR451C | Homeobox protein YHP1; Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the [...] |
| PPN1 protein network | https://string-db.org/network/4932.YDR452W | Endopolyphosphatase; Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate sh [...] |
| TSA2 protein network | https://string-db.org/network/4932.YDR453C | Peroxiredoxin TSA2; Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; [...] |
| GUK1 protein network | https://string-db.org/network/4932.YDR454C | Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins. |
| YDR455C protein network | https://string-db.org/network/4932.YDR455C | Putative uncharacterized protein YDR455C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| NHX1 protein network | https://string-db.org/network/4932.YDR456W | Endosomal/prevacuolar sodium/hydrogen exchanger; Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; require [...] |
| TOM1 protein network | https://string-db.org/network/4932.YDR457W | E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with [...] |
| HEH2 protein network | https://string-db.org/network/4932.YDR458C | Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cyc [...] |
| PFA5 protein network | https://string-db.org/network/4932.YDR459C | Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHH [...] |
| TFB3 protein network | https://string-db.org/network/4932.YDR460W | Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and [...] |
| MFA1 protein network | https://string-db.org/network/4932.YDR461W | Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal p [...] |
| MRPL28 protein network | https://string-db.org/network/4932.YDR462W | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress. |
| STP1 protein network | https://string-db.org/network/4932.YDR463W | Transcription factor; contains a N-terminal regulatory motif (RI) that acts as a cytoplasmic retention determinant and as an Asi dependent degron in the nucleus; undergoes proteolytic processing [...] |
| YDR464C-A protein network | https://string-db.org/network/4932.YDR464C-A | Putative uncharacterized protein YDR464C-A; Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide [...] |
| SPP41 protein network | https://string-db.org/network/4932.YDR464W | Protein of unknown function; involved in negative regulation of expression of spliceosome components PRP4 and PRP3; relocalizes to the cytosol in response to hypoxia. |
| RMT2 protein network | https://string-db.org/network/4932.YDR465C | Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress. |
| PKH3 protein network | https://string-db.org/network/4932.YDR466W | Serine/threonine-protein kinase PKH3; Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p; yeast Pkh1p and Pkh2p are two redundant upstream activators of Pkc1p; identified as a [...] |
| TLG1 protein network | https://string-db.org/network/4932.YDR468C | Essential t-SNARE that mediates fusion of vesicles with the late Golgi; forms a complex with Tlg2p and Vti1p; mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking c [...] |
| SDC1 protein network | https://string-db.org/network/4932.YDR469W | COMPASS component SDC1; Subunit of the COMPASS (Set1C) complex; COMPASS methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediat [...] |
| UGO1 protein network | https://string-db.org/network/4932.YDR470C | Outer membrane component of the mitochondrial fusion machinery; binds to Fzo1p and Mgm1p to link these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner memb [...] |
| RPL27B protein network | https://string-db.org/network/4932.YDR471W | Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication. |
| TRS31 protein network | https://string-db.org/network/4932.YDR472W | Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic ( [...] |
| PRP3 protein network | https://string-db.org/network/4932.YDR473C | U4/U6 small nuclear ribonucleoprotein PRP3; Splicing factor; component of the U4/U6-U5 snRNP complex. |
| JIP4 protein network | https://string-db.org/network/4932.YDR475C | Uncharacterized protein JIP4; Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference [...] |
| YDR476C protein network | https://string-db.org/network/4932.YDR476C | Uncharacterized protein YDR476C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene. |
| SNF1 protein network | https://string-db.org/network/4932.YDR477W | AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and [...] |
| SNM1 protein network | https://string-db.org/network/4932.YDR478W | Ribonuclease MRP complex subunit; ribonuclease (RNase) MRP cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RN [...] |
| PEX29 protein network | https://string-db.org/network/4932.YDR479C | ER-resident protein involved in peroxisomal biogenesis; ER-localized protein that associates with peroxisomes; interacts with Pex30p and reticulons Rtn1p and Yop1p to regulate peroxisome biogenes [...] |
| DIG2 protein network | https://string-db.org/network/4932.YDR480W | Down-regulator of invasive growth 2; MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; relat [...] |
| PHO8 protein network | https://string-db.org/network/4932.YDR481C | Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by pr [...] |
| CWC21 protein network | https://string-db.org/network/4932.YDR482C | Pre-mRNA-splicing factor CWC21; Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similari [...] |
| KRE2 protein network | https://string-db.org/network/4932.YDR483W | Glycolipid 2-alpha-mannosyltransferase; Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication. |
| VPS52 protein network | https://string-db.org/network/4932.YDR484W | Vacuolar protein sorting-associated protein 52; Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golg [...] |
| VPS72 protein network | https://string-db.org/network/4932.YDR485C | Vacuolar protein sorting-associated protein 72; Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that pr [...] |
| VPS60 protein network | https://string-db.org/network/4932.YDR486C | Protein involved in late endosome to vacuole transport; cytoplasmic and vacuolar membrane protein; required for normal filament maturation during pseudohyphal growth; may function in targeting ca [...] |
| RIB3 protein network | https://string-db.org/network/4932.YDR487C | 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase); required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration. |
| PAC11 protein network | https://string-db.org/network/4932.YDR488C | WD repeat-containing protein PAC11; Dynein intermediate chain, microtubule motor protein; required for intracellular transport and cell division; acts in cytoplasmic dynein pathway; forms complex [...] |
| SLD5 protein network | https://string-db.org/network/4932.YDR489W | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; Belongs to the GINS4/SLD5 fa [...] |
| PKH1 protein network | https://string-db.org/network/4932.YDR490C | Serine/threonine-protein kinase PKH1; Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of sign [...] |
| IZH1 protein network | https://string-db.org/network/4932.YDR492W | ADIPOR-like receptor IZH1; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc defic [...] |
| MZM1 protein network | https://string-db.org/network/4932.YDR493W | Mitochondrial zinc maintenance protein 1, mitochondrial; Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the comple [...] |
| RSM28 protein network | https://string-db.org/network/4932.YDR494W | Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation. |
| VPS3 protein network | https://string-db.org/network/4932.YDR495C | Vacuolar protein sorting-associated protein 3; Component of CORVET membrane tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidificat [...] |
| PUF6 protein network | https://string-db.org/network/4932.YDR496C | Pumilio-homology domain protein; binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; required at post-transcriptional step for e [...] |
| ITR1 protein network | https://string-db.org/network/4932.YDR497C | Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the [...] |
| SEC20 protein network | https://string-db.org/network/4932.YDR498C | Membrane glycoprotein v-SNARE; involved in retrograde transport from the Golgi to the endoplasmic reticulum (ER); required for N- and O-glycosylation in the Golgi but not in the ER and for effici [...] |
| LCD1 protein network | https://string-db.org/network/4932.YDR499W | Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication [...] |
| RPL37B protein network | https://string-db.org/network/4932.YDR500C | Ribosomal 60S subunit protein L37B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; protein abundance increases in response to DNA replication stress; [...] |
| PLM2 protein network | https://string-db.org/network/4932.YDR501W | Protein PLM2; Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents a [...] |
| SAM2 protein network | https://string-db.org/network/4932.YDR502C | S-adenosylmethionine synthase 2; S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondr [...] |
| LPP1 protein network | https://string-db.org/network/4932.YDR503C | Lipid phosphate phosphatase; catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular [...] |
| SPG3 protein network | https://string-db.org/network/4932.YDR504C | Stationary phase protein 3; Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; SWAT-GFP and mCherry fusion proteins [...] |
| PSP1 protein network | https://string-db.org/network/4932.YDR505C | Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; ove [...] |
| GMC1 protein network | https://string-db.org/network/4932.YDR506C | Putative multicopper oxidase GMC1; Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-l [...] |
| GIN4 protein network | https://string-db.org/network/4932.YDR507C | Serine/threonine-protein kinase GIN4; Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autopho [...] |
| GNP1 protein network | https://string-db.org/network/4932.YDR508C | High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amin [...] |
| YDR509W protein network | https://string-db.org/network/4932.YDR509W | Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YDR510C-A protein network | https://string-db.org/network/4932.YDR510C-A | Putative uncharacterized protein YDR510C-A; Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide [...] |
| SMT3 protein network | https://string-db.org/network/4932.YDR510W | Ubiquitin-like protein of the SUMO family; conjugated to lysine residues of target proteins; associates with transcriptionally active genes; regulates chromatid cohesion, chromosome segregation, [...] |
| SDH7 protein network | https://string-db.org/network/4932.YDR511W | Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; localized to the mitochondrial intermembrane space; required for acetate util [...] |
| EMI1 protein network | https://string-db.org/network/4932.YDR512C | Early meiotic induction protein 1; Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for spo [...] |
| GRX2 protein network | https://string-db.org/network/4932.YDR513W | Glutaredoxin-2; Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxi [...] |
| YDR514C protein network | https://string-db.org/network/4932.YDR514C | Uncharacterized protein YDR514C; Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the [...] |
| SLF1 protein network | https://string-db.org/network/4932.YDR515W | RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in [...] |
| EMI2 protein network | https://string-db.org/network/4932.YDR516C | Putative glucokinase-2; Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expres [...] |
| GRH1 protein network | https://string-db.org/network/4932.YDR517W | GRASP65 homolog protein 1; Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised f [...] |
| EUG1 protein network | https://string-db.org/network/4932.YDR518W | Protein disulfide-isomerase EUG1; Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with th [...] |
| FPR2 protein network | https://string-db.org/network/4932.YDR519W | Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from n [...] |
| URC2 protein network | https://string-db.org/network/4932.YDR520C | Uracil catabolism protein 2; Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar [...] |
| YDR521W protein network | https://string-db.org/network/4932.YDR521W | Putative uncharacterized protein YDR521W; Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol. |
| SPS2 protein network | https://string-db.org/network/4932.YDR522C | Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S [...] |
| SPS1 protein network | https://string-db.org/network/4932.YDR523C | Sporulation-specific protein 1; Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure [...] |
| AGE1 protein network | https://string-db.org/network/4932.YDR524C | ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif. |
| YDR524C-A protein network | https://string-db.org/network/4932.YDR524C-A | Putative uncharacterized protein YDR524C-A; Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide [...] |
| YDR524C-B protein network | https://string-db.org/network/4932.YDR524C-B | Uncharacterized protein YDR524C-B; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDR524C-B has a paralog, YCL048W-A, that arose [...] |
| YDR524W-C protein network | https://string-db.org/network/4932.YDR524W-C | Uncharacterized protein YDR524W-C; Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin. |
| API2 protein network | https://string-db.org/network/4932.YDR525W | Uncharacterized protein API2; Putative protein of unknown function; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious [...] |
| SNA2 protein network | https://string-db.org/network/4932.YDR525W-A | Protein of unknown function; has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; Belon [...] |
| YDR526C protein network | https://string-db.org/network/4932.YDR526C | Putative uncharacterized protein YDR526C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| RBA50 protein network | https://string-db.org/network/4932.YDR527W | Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1; Belongs to the RPAP1 family. |
| HLR1 protein network | https://string-db.org/network/4932.YDR528W | Protein involved in regulation of cell wall composition and integrity; also involved in cell wall response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; HLR1 has a [...] |
| QCR7 protein network | https://string-db.org/network/4932.YDR529C | Subunit 7 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-t [...] |
| APA2 protein network | https://string-db.org/network/4932.YDR530C | Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole ge [...] |
| CAB1 protein network | https://string-db.org/network/4932.YDR531W | Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase; catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regula [...] |
| KRE28 protein network | https://string-db.org/network/4932.YDR532C | Spindle pole body component KRE28; Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid [...] |
| HSP31 protein network | https://string-db.org/network/4932.YDR533C | Glutathione-independent glyoxalase HSP31; Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has sim [...] |
| FIT1 protein network | https://string-db.org/network/4932.YDR534C | Facilitator of iron transport 1; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron [...] |
| YDR535C protein network | https://string-db.org/network/4932.YDR535C | Putative uncharacterized protein YDR535C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YDR535C is not an ess [...] |
| STL1 protein network | https://string-db.org/network/4932.YDR536W | Sugar transporter STL1; Glycerol proton symporter of the plasma membrane; subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock. |
| PAD1 protein network | https://string-db.org/network/4932.YDR538W | Flavin prenyltransferase PAD1, mitochondrial; Phenylacrylic acid decarboxylase; confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivative [...] |
| FDC1 protein network | https://string-db.org/network/4932.YDR539W | Ferulic acid decarboxylase, also active on p-coumaric acid; essential for decarboxylation of aromatic carboxylic acids to corresponding vinyl derivatives; co-overproduction of Pad1p and Fdc1p gre [...] |
| IRC4 protein network | https://string-db.org/network/4932.YDR540C | Uncharacterized protein IRC4; Protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytopl [...] |
| YDR541C protein network | https://string-db.org/network/4932.YDR541C | Putative uncharacterized oxidoreductase YDR541C; Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localiz [...] |
| PAU10 protein network | https://string-db.org/network/4932.YDR542W | Seripauperin-10; Protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to the vacuole; member of the seripauperin [...] |
| YDR543C protein network | https://string-db.org/network/4932.YDR543C | Putative UPF0320 protein YDR543C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YDR544C protein network | https://string-db.org/network/4932.YDR544C | Putative uncharacterized protein YDR544C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YDR545C-A protein network | https://string-db.org/network/4932.YDR545C-A | Putative UPF0479 protein YDR545C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the ver [...] |
| YRF1-1 protein network | https://string-db.org/network/4932.YDR545W | Y' element ATP-dependent helicase protein 1 copy 1; Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially [...] |
| IRC22 protein network | https://string-db.org/network/4932.YEL001C | Increased recombination centers protein 22; Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased level [...] |
| WBP1 protein network | https://string-db.org/network/4932.YEL002C | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1; Beta subunit of the oligosaccharyl transferase glycoprotein complex; required for N-linked glycosylation of proteins i [...] |
| GIM4 protein network | https://string-db.org/network/4932.YEL003W | Prefoldin subunit 2; Subunit of the heterohexameric cochaperone prefoldin complex; complex binds specifically to cytosolic chaperonin and transfers target proteins to it. |
| YEA4 protein network | https://string-db.org/network/4932.YEL004W | UDP-N-acetylglucosamine transporter YEA4; Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER; Belongs to the nucleotide [...] |
| VAB2 protein network | https://string-db.org/network/4932.YEL005C | Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Vps21p-GFP; has potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of; Va [...] |
| YEA6 protein network | https://string-db.org/network/4932.YEL006W | Mitochondrial nicotinamide adenine dinucleotide transporter 2; Putative mitochondrial NAD+ transporter; member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog; [...] |
| MIT1 protein network | https://string-db.org/network/4932.YEL007W | Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1. |
| YEL008C-A protein network | https://string-db.org/network/4932.YEL008C-A | Putative uncharacterized protein YEL008C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YEL008W protein network | https://string-db.org/network/4932.YEL008W | Uncharacterized protein YEL008W; Putative protein of unknown function; conserved among S. cerevisiae strains; YEL008W is not an essential gene; predicted to be involved in metabolism. |
| GCN4 protein network | https://string-db.org/network/4932.YEL009C | General control protein GCN4; bZIP transcriptional activator of amino acid biosynthetic genes; activator responds to amino acid starvation; expression is tightly regulated at both the transcript [...] |
| GLC3 protein network | https://string-db.org/network/4932.YEL011W | Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplas [...] |
| UBC8 protein network | https://string-db.org/network/4932.YEL012W | Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplas [...] |
| VAC8 protein network | https://string-db.org/network/4932.YEL013W | Vacuolar protein 8; Phosphorylated and palmitoylated vacuolar membrane protein; interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form [...] |
| YEL014C protein network | https://string-db.org/network/4932.YEL014C | Uncharacterized protein YEL014C; Putative protein of unknown function; conserved among S. cerevisiae strains. |
| EDC3 protein network | https://string-db.org/network/4932.YEL015W | Enhancer of mRNA-decapping protein 3; Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B [...] |
| NPP2 protein network | https://string-db.org/network/4932.YEL016C | Ectonucleotide pyrophosphatase/phosphodiesterase 2; Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and e [...] |
| PMP2 protein network | https://string-db.org/network/4932.YEL017C-A | Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a para [...] |
| GTT3 protein network | https://string-db.org/network/4932.YEL017W | Glutathione transferase 3; Protein of unknown function may be involved in glutathione metabolism; function suggested by computational analysis of large-scale protein-protein interaction data; N- [...] |
| EAF5 protein network | https://string-db.org/network/4932.YEL018W | Chromatin modification-related protein EAF5; Non-essential subunit of the NuA4 acetyltransferase complex; Esa1p-associated factor; relocalizes to the cytosol in response to hypoxia. |
| MMS21 protein network | https://string-db.org/network/4932.YEL019C | Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that a [...] |
| PXP1 protein network | https://string-db.org/network/4932.YEL020C | Putative 2-hydroxyacyl-CoA lyase; Peroxisomal matrix protein; well-conserved in fungi; contains tripartite homology domain of thiamine pyrophosphate (TPP) enzymes; targeted to peroxisomes by Pex5 [...] |
| TIM9 protein network | https://string-db.org/network/4932.YEL020W-A | Mitochondrial import inner membrane translocase subunit TIM9; Essential protein of the mitochondrial intermembrane space; forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic pro [...] |
| URA3 protein network | https://string-db.org/network/4932.YEL021W | Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-f [...] |
| GEA2 protein network | https://string-db.org/network/4932.YEL022W | Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has [...] |
| YEL023C protein network | https://string-db.org/network/4932.YEL023C | Uncharacterized protein YEL023C; Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene. |
| RIP1 protein network | https://string-db.org/network/4932.YEL024W | Ubiquinol-cytochrome-c reductase; a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, [...] |
| YEL025C protein network | https://string-db.org/network/4932.YEL025C | Uncharacterized protein YEL025C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus. |
| SNU13 protein network | https://string-db.org/network/4932.YEL026W | 13 kDa ribonucleoprotein-associated protein; RNA binding protein; part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K prote [...] |
| VMA3 protein network | https://string-db.org/network/4932.YEL027W | V-type proton ATPase subunit c; Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for cop [...] |
| BUD16 protein network | https://string-db.org/network/4932.YEL029C | Putative pyridoxal kinase; a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to y [...] |
| ECM10 protein network | https://string-db.org/network/4932.YEL030W | Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extens [...] |
| SPF1 protein network | https://string-db.org/network/4932.YEL031W | Manganese-transporting ATPase 1; P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondri [...] |
| YEL032C-A protein network | https://string-db.org/network/4932.YEL032C-A | Putative uncharacterized protein YEL032C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| MCM3 protein network | https://string-db.org/network/4932.YEL032W | DNA replication licensing factor MCM3; Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex. |
| MTC7 protein network | https://string-db.org/network/4932.YEL033W | Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localiza [...] |
| YEL034C-A protein network | https://string-db.org/network/4932.YEL034C-A | Putative uncharacterized protein YEL034C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| HYP2 protein network | https://string-db.org/network/4932.YEL034W | Eukaryotic translation initiation factor 5A-1; Translation elongation factor eIF-5A; required for translation of proteins containing polyproline stretches, including Bni1p, and this leads to a re [...] |
| UTR5 protein network | https://string-db.org/network/4932.YEL035C | Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions. |
| ANP1 protein network | https://string-db.org/network/4932.YEL036C | Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to ami [...] |
| RAD23 protein network | https://string-db.org/network/4932.YEL037C | UV excision repair protein RAD23; Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation ac [...] |
| UTR4 protein network | https://string-db.org/network/4932.YEL038W | Enolase-phosphatase E1; Protein with sequence similarity to acireductone synthases; involved in methionine salvage; found in both the cytoplasm and nucleus; Belongs to the HAD-like hydrolase supe [...] |
| CYC7 protein network | https://string-db.org/network/4932.YEL039C | Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cy [...] |
| UTR2 protein network | https://string-db.org/network/4932.YEL040W | Probable glycosidase CRH2; Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glyco [...] |
| YEF1 protein network | https://string-db.org/network/4932.YEL041W | ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, [...] |
| GDA1 protein network | https://string-db.org/network/4932.YEL042W | Guanosine-diphosphatase; Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen, converting GDP to GMP after mannose is transferred to substra [...] |
| YEL043W protein network | https://string-db.org/network/4932.YEL043W | Uncharacterized protein YEL043W; Predicted cytoskeleton protein involved in intracellular signaling; based on quantitative analysis of protein-protein interaction maps; may interact with ribosome [...] |
| IES6 protein network | https://string-db.org/network/4932.YEL044W | Chromatin-remodeling complex subunit IES6; Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of no [...] |
| YEL045C protein network | https://string-db.org/network/4932.YEL045C | Uncharacterized protein YEL045C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion gives MMS sensitivity [...] |
| GLY1 protein network | https://string-db.org/network/4932.YEL046C | Low specificity L-threonine aldolase; Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis. |
| FRD1 protein network | https://string-db.org/network/4932.YEL047C | Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in pur [...] |
| TCA17 protein network | https://string-db.org/network/4932.YEL048C | TRAPP-associated protein TCA17; Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi [...] |
| PAU2 protein network | https://string-db.org/network/4932.YEL049W | Seripauperin-2; Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen [...] |
| RML2 protein network | https://string-db.org/network/4932.YEL050C | Mitochondrial ribosomal protein of the large subunit (L2); has similarity to E. coli L2 ribosomal protein; mutant allele (fat21) causes inability to utilize oleate, and induce oleic acid oxidatio [...] |
| YEL050W-A protein network | https://string-db.org/network/4932.YEL050W-A | Putative uncharacterized protein YEL050W-A; Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR. |
| VMA8 protein network | https://string-db.org/network/4932.YEL051W | Subunit D of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP [...] |
| AFG1 protein network | https://string-db.org/network/4932.YEL052W | Protein that may act as a chaperone for cytochrome c oxidase subunits; conserved protein; may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; loca [...] |
| MAK10 protein network | https://string-db.org/network/4932.YEL053C | N-alpha-acetyltransferase 35, NatC auxiliary subunit; Non-catalytic subunit of the NatC N-terminal acetyltransferase; required for replication of dsRNA virus; expression is glucose-repressible; h [...] |
| YEL053W-A protein network | https://string-db.org/network/4932.YEL053W-A | Putative uncharacterized membrane protein YEL053W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially [...] |
| RPL12A protein network | https://string-db.org/network/4932.YEL054C | Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, R [...] |
| POL5 protein network | https://string-db.org/network/4932.YEL055C | rDNA transcriptional regulator POL5; DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA repl [...] |
| HAT2 protein network | https://string-db.org/network/4932.YEL056W | Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 4 [...] |
| SDD1 protein network | https://string-db.org/network/4932.YEL057C | Uncharacterized protein YEL057C; Protein of unknown function; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance [...] |
| PCM1 protein network | https://string-db.org/network/4932.YEL058W | Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and gl [...] |
| SOM1 protein network | https://string-db.org/network/4932.YEL059C-A | Protein SOM1, mitochondrial; Subunit of the mitochondrial inner membrane peptidase (IMP); IMP is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cl [...] |
| HHY1 protein network | https://string-db.org/network/4932.YEL059W | Hypersensitivity to hygromycin-B protein 1; Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar traffick [...] |
| PRB1 protein network | https://string-db.org/network/4932.YEL060C | Cerevisin; Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity; serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full p [...] |
| CIN8 protein network | https://string-db.org/network/4932.YEL061C | Kinesin-like protein CIN8; Kinesin motor protein; involved in mitotic spindle assembly and chromosome segregation. |
| NPR2 protein network | https://string-db.org/network/4932.YEL062W | Nitrogen permease regulator 2; Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the [...] |
| CAN1 protein network | https://string-db.org/network/4932.YEL063C | Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, A [...] |
| AVT2 protein network | https://string-db.org/network/4932.YEL064C | Vacuolar amino acid transporter 2; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; Belongs to the amino acid/polyami [...] |
| SIT1 protein network | https://string-db.org/network/4932.YEL065W | Siderophore iron transporter 1; Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron de [...] |
| HPA3 protein network | https://string-db.org/network/4932.YEL066W | D-amino-acid N-acetyltransferase HPA3; D-Amino acid N-acetyltransferase that detoxifies D-amino acids; catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA [...] |
| YEL067C protein network | https://string-db.org/network/4932.YEL067C | Uncharacterized protein YEL067C; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| YEL068C protein network | https://string-db.org/network/4932.YEL068C | Uncharacterized protein YEL068C; Protein of unknown function; expressed at both mRNA and protein levels; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum and mCherr [...] |
| HXT13 protein network | https://string-db.org/network/4932.YEL069C | Hexose transporter HXT13; Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexos [...] |
| DSF1 protein network | https://string-db.org/network/4932.YEL070W | Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication. |
| DLD3 protein network | https://string-db.org/network/4932.YEL071W | D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ke [...] |
| RMD6 protein network | https://string-db.org/network/4932.YEL072W | Protein required for sporulation. |
| YEL073C protein network | https://string-db.org/network/4932.YEL073C | Uncharacterized protein YEL073C; Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline. |
| YEL074W protein network | https://string-db.org/network/4932.YEL074W | Putative UPF0320 protein YEL074W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; large scale expression analys [...] |
| YEL075C protein network | https://string-db.org/network/4932.YEL075C | Uncharacterized protein YEL075C; Putative protein of unknown function. |
| YEL075W-A protein network | https://string-db.org/network/4932.YEL075W-A | Putative uncharacterized protein YEL075W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YEL076C protein network | https://string-db.org/network/4932.YEL076C | Uncharacterized protein YEL076C; Putative protein of unknown function. |
| YEL076C-A protein network | https://string-db.org/network/4932.YEL076C-A | Putative protein of unknown function; Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily. |
| YEL077C protein network | https://string-db.org/network/4932.YEL077C | Helicase-like protein encoded within the telomeric Y' element. |
| MNN1 protein network | https://string-db.org/network/4932.YER001W | Alpha-1,3-mannosyltransferase; integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. ce [...] |
| NOP16 protein network | https://string-db.org/network/4932.YER002W | Nucleolar protein 16; Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; Belongs to the NOP16 family. |
| PMI40 protein network | https://string-db.org/network/4932.YER003C | Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation. |
| FMP52 protein network | https://string-db.org/network/4932.YER004W | Protein FMP52, mitochondrial; Protein of unknown function; localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation; Belongs to the FMP52 fam [...] |
| YND1 protein network | https://string-db.org/network/4932.YER005W | Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; [...] |
| NUG1 protein network | https://string-db.org/network/4932.YER006W | Nuclear GTP-binding protein NUG1; GTPase that associates with nuclear 60S pre-ribosomes; required for export of 60S ribosomal subunits from the nucleus. |
| TMA20 protein network | https://string-db.org/network/4932.YER007C-A | Translation machinery-associated protein 20; Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation [...] |
| PAC2 protein network | https://string-db.org/network/4932.YER007W | Protein PAC2; Microtubule effector required for tubulin heterodimer formation; binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and [...] |
| SEC3 protein network | https://string-db.org/network/4932.YER008C | Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-bindin [...] |
| NTF2 protein network | https://string-db.org/network/4932.YER009W | Nuclear transport factor 2; Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in n [...] |
| YER010C protein network | https://string-db.org/network/4932.YER010C | Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prok [...] |
| TIR1 protein network | https://string-db.org/network/4932.YER011W | Cold shock-induced protein TIR1; Cell wall mannoprotein; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shak [...] |
| PRE1 protein network | https://string-db.org/network/4932.YER012W | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle; Belongs to the peptidase T1B family. |
| PRP22 protein network | https://string-db.org/network/4932.YER013W | DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase; associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceoso [...] |
| BUD25 protein network | https://string-db.org/network/4932.YER014C-A | Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern. |
| HEM14 protein network | https://string-db.org/network/4932.YER014W | Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl e [...] |
| FAA2 protein network | https://string-db.org/network/4932.YER015W | Long-chain-fatty-acid--CoA ligase 2; Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, [...] |
| BIM1 protein network | https://string-db.org/network/4932.YER016W | Protein BIM1; Microtubule plus end-tracking protein; together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; h [...] |
| AFG3 protein network | https://string-db.org/network/4932.YER017C | Mitochondrial respiratory chain complexes assembly protein AFG3; Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required fo [...] |
| SPC25 protein network | https://string-db.org/network/4932.YER018C | Kinetochore protein SPC25; Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conse [...] |
| SBH2 protein network | https://string-db.org/network/4932.YER019C-A | Ssh1p-Sss1p-Sbh2p complex component; involved in protein translocation into the endoplasmic reticulum; SBH2 has a paralog, SBH1, that arose from the whole genome duplication; Belongs to the SEC61 [...] |
| ISC1 protein network | https://string-db.org/network/4932.YER019W | Inositol phosphosphingolipid phospholipase C; mitochondrial membrane localized; hydrolyzes complex sphingolipids to produce ceramide; activates genes required for non-fermentable carbon source me [...] |
| GPA2 protein network | https://string-db.org/network/4932.YER020W | Guanine nucleotide-binding protein alpha-2 subunit; Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrient [...] |
| RPN3 protein network | https://string-db.org/network/4932.YER021W | Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role [...] |
| SRB4 protein network | https://string-db.org/network/4932.YER022W | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygos [...] |
| PRO3 protein network | https://string-db.org/network/4932.YER023W | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. |
| YAT2 protein network | https://string-db.org/network/4932.YER024W | Carnitine O-acetyltransferase YAT2; Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane. |
| GCD11 protein network | https://string-db.org/network/4932.YER025W | Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human o [...] |
| CHO1 protein network | https://string-db.org/network/4932.YER026C | CDP-diacylglycerol--serine O-phosphatidyltransferase; Phosphatidylserine synthase; functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phospha [...] |
| GAL83 protein network | https://string-db.org/network/4932.YER027C | One of three possible beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; necessary and sufficient [...] |
| MIG3 protein network | https://string-db.org/network/4932.YER028C | Transcription corepressor MIG3; Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; invol [...] |
| SMB1 protein network | https://string-db.org/network/4932.YER029C | Small nuclear ribonucleoprotein-associated protein B; Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U [...] |
| CHZ1 protein network | https://string-db.org/network/4932.YER030W | Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and beno [...] |
| YPT31 protein network | https://string-db.org/network/4932.YER031C | GTP-binding protein YPT31/YPT8; Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, [...] |
| FIR1 protein network | https://string-db.org/network/4932.YER032W | Factor interacting with REF2; Protein involved in 3' mRNA processing; interacts with Ref2p; APCC(Cdh1) substrate; potential Cdc28p substrate. |
| ZRG8 protein network | https://string-db.org/network/4932.YER033C | Zinc-regulated protein 8; Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the [...] |
| YER034W protein network | https://string-db.org/network/4932.YER034W | Uncharacterized protein YER034W; Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress. |
| EDC2 protein network | https://string-db.org/network/4932.YER035W | Enhancer of mRNA-decapping protein 2; RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in t [...] |
| ARB1 protein network | https://string-db.org/network/4932.YER036C | ABC transporter ATP-binding protein ARB1; ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplas [...] |
| PHM8 protein network | https://string-db.org/network/4932.YER037W | Phosphate metabolism protein 8; Lysophosphatidic acid (LPA) phosphatase, nucleotidase; principle and physiological nucleotidase working on GMP, UMP and CMP; involved in LPA hydrolysis in response [...] |
| KRE29 protein network | https://string-db.org/network/4932.YER038C | DNA repair protein KRE29; Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; [...] |
| HVG1 protein network | https://string-db.org/network/4932.YER039C | Probable GDP-mannose transporter 2; Protein of unknown function; HVG1 has a paralog, VRG4, that arose from the whole genome duplication; Belongs to the TPT transporter family. SLC35D subfamily. |
| YER039C-A protein network | https://string-db.org/network/4932.YER039C-A | Putative protein of unknown function; YER039C-A is not an essential gene; Belongs to the TPT transporter family. SLC35D subfamily. |
| GLN3 protein network | https://string-db.org/network/4932.YER040W | Nitrogen regulatory protein GLN3; Transcriptional activator of genes regulated by nitrogen catabolite repression; localization and activity regulated by quality of nitrogen source and Ure2p. |
| YEN1 protein network | https://string-db.org/network/4932.YER041W | Holliday junction resolvase; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); localization is cell-cycle dependent and regulated b [...] |
| MXR1 protein network | https://string-db.org/network/4932.YER042W | Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; [...] |
| SAH1 protein network | https://string-db.org/network/4932.YER043C | Adenosylhomocysteinase; S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) [...] |
| ERG28 protein network | https://string-db.org/network/4932.YER044C | Ergosterol biosynthetic protein 28; Endoplasmic reticulum membrane protein; may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or teth [...] |
| MEI4 protein network | https://string-db.org/network/4932.YER044C-A | Meiosis-specific protein involved in forming DSBs; involved in double-strand break (DSBs) formation during meiotic recombination; required for chromosome synapsis and production of viable spores. |
| ACA1 protein network | https://string-db.org/network/4932.YER045C | ATF/CREB activator 1; ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; [...] |
| SPO73 protein network | https://string-db.org/network/4932.YER046W | Sporulation-specific protein 73; Meiosis-specific protein required for prospore membrane morphogenesis; required for the proper shape of the prospore membrane (PSM) and for spore wall formation; [...] |
| YER046W-A protein network | https://string-db.org/network/4932.YER046W-A | Putative uncharacterized protein YER046W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SAP1/Y [...] |
| SAP1 protein network | https://string-db.org/network/4932.YER047C | Protein SAP1; Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system. |
| CAJ1 protein network | https://string-db.org/network/4932.YER048C | Protein CAJ1; Nuclear type II J heat shock protein of the E. coli dnaJ family; contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during [...] |
| ISD11 protein network | https://string-db.org/network/4932.YER048W-A | Protein ISD11; Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration [...] |
| TPA1 protein network | https://string-db.org/network/4932.YER049W | Prolyl 3,4-dihydroxylase TPA1; Fe(II)/2-oxoglutarate-dependent dioxygenase family member; catalyzes the repair of methyl-base lesions in both ss and dsDNA by oxidative demethylation; Poly(rA)-bin [...] |
| RSM18 protein network | https://string-db.org/network/4932.YER050C | Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S18 ribosomal protein. |
| JHD1 protein network | https://string-db.org/network/4932.YER051W | JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe; Belongs to the JHDM1 histone demethylase fa [...] |
| HOM3 protein network | https://string-db.org/network/4932.YER052C | Aspartokinase; Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulat [...] |
| PIC2 protein network | https://string-db.org/network/4932.YER053C | Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expre [...] |
| YER053C-A protein network | https://string-db.org/network/4932.YER053C-A | Uncharacterized protein YER053C-A; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to D [...] |
| GIP2 protein network | https://string-db.org/network/4932.YER054C | GLC7-interacting protein 2; Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, [...] |
| HIS1 protein network | https://string-db.org/network/4932.YER055C | ATP phosphoribosyltransferase; a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription [...] |
| FCY2 protein network | https://string-db.org/network/4932.YER056C | Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress. |
| RPL34A protein network | https://string-db.org/network/4932.YER056C-A | Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication. |
| HMF1 protein network | https://string-db.org/network/4932.YER057C | Protein HMF1; Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in [...] |
| PET117 protein network | https://string-db.org/network/4932.YER058W | Protein PET117, mitochondrial; Protein required for assembly of cytochrome c oxidase; Belongs to the PET117 family. |
| PCL6 protein network | https://string-db.org/network/4932.YER059W | Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 ha [...] |
| FCY21 protein network | https://string-db.org/network/4932.YER060W | Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function; Belongs to the purine-cytosine permease (2.A.39) family. |
| FCY22 protein network | https://string-db.org/network/4932.YER060W-A | Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function; Belongs to the purine-cytosine permease (2.A.39) family. |
| CEM1 protein network | https://string-db.org/network/4932.YER061C | 3-oxoacyl-[acyl-carrier-protein] synthase homolog; Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can com [...] |
| GPP2 protein network | https://string-db.org/network/4932.YER062C | Glycerol-1-phosphate phosphohydrolase 2; DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidat [...] |
| THO1 protein network | https://string-db.org/network/4932.YER063W | Protein THO1; Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproductio [...] |
| VHR2 protein network | https://string-db.org/network/4932.YER064C | Transcription factor VHR2; Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distr [...] |
| ICL1 protein network | https://string-db.org/network/4932.YER065C | Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by [...] |
| YER066C-A protein network | https://string-db.org/network/4932.YER066C-A | Putative uncharacterized protein YER066C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| RRT13 protein network | https://string-db.org/network/4932.YER066W | Regulator of rDNA transcription protein 13; Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription. |
| YER067C-A protein network | https://string-db.org/network/4932.YER067C-A | Putative uncharacterized membrane protein YER067C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially [...] |
| RGI1 protein network | https://string-db.org/network/4932.YER067W | Respiratory growth induced protein 1; Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion or [...] |
| MOT2 protein network | https://string-db.org/network/4932.YER068W | General negative regulator of transcription subunit 4; Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and hist [...] |
| ARG5,6 protein network | https://string-db.org/network/4932.YER069W | Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step [...] |
| RNR1 protein network | https://string-db.org/network/4932.YER070W | Ribonucleoside-diphosphate reductase large chain 1; Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulat [...] |
| TDA2 protein network | https://string-db.org/network/4932.YER071C | Topoisomerase I damage affected protein 2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive t [...] |
| VTC1 protein network | https://string-db.org/network/4932.YER072W | Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vac [...] |
| ALD5 protein network | https://string-db.org/network/4932.YER073W | Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzym [...] |
| RPS24A protein network | https://string-db.org/network/4932.YER074W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplica [...] |
| YOS1 protein network | https://string-db.org/network/4932.YER074W-A | Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p. |
| PTP3 protein network | https://string-db.org/network/4932.YER075C | Tyrosine-protein phosphatase 3; Phosphotyrosine-specific protein phosphatase; involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Ho [...] |
| MRX1 protein network | https://string-db.org/network/4932.YER077C | MIOREX complex component 1; Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease [...] |
| ICP55 protein network | https://string-db.org/network/4932.YER078C | Intermediate cleaving peptidase 55; Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby in [...] |
| YER078W-A protein network | https://string-db.org/network/4932.YER078W-A | Uncharacterized protein YER078W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| YER079W protein network | https://string-db.org/network/4932.YER079W | Uncharacterized protein YER079W; Putative protein of unknown function. |
| AIM9 protein network | https://string-db.org/network/4932.YER080W | Altered inheritance of mitochondria protein 9, mitochondrial; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [...] |
| SER3 protein network | https://string-db.org/network/4932.YER081W | D-3-phosphoglycerate dehydrogenase 1; 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also [...] |
| UTP7 protein network | https://string-db.org/network/4932.YER082C | Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA. |
| GET2 protein network | https://string-db.org/network/4932.YER083C | Golgi to ER traffic protein 2; Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 [...] |
| YER084W protein network | https://string-db.org/network/4932.YER084W | Uncharacterized protein YER084W; Protein of unknown function; expressed at both mRNA and protein levels. |
| YER085C protein network | https://string-db.org/network/4932.YER085C | Uncharacterized protein YER085C; Putative protein of unknown function. |
| ILV1 protein network | https://string-db.org/network/4932.YER086W | Threonine dehydratase, mitochondrial; Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned n [...] |
| YER087C-A protein network | https://string-db.org/network/4932.YER087C-A | Putative uncharacterized protein YER087C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely o [...] |
| SBH1 protein network | https://string-db.org/network/4932.YER087C-B | Protein transport protein SBH1; Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst [...] |
| AIM10 protein network | https://string-db.org/network/4932.YER087W | Probable proline--tRNA ligase, mitochondrial; Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated fre [...] |
| DOT6 protein network | https://string-db.org/network/4932.YER088C | Transcriptional regulatory protein DOT6; Protein involved in rRNA and ribosome biogenesis; activated in stochastic pulses of nuclear localization; binds polymerase A and C motif; subunit of the R [...] |
| YER088W-B protein network | https://string-db.org/network/4932.YER088W-B | Putative uncharacterized protein YER088W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| PTC2 protein network | https://string-db.org/network/4932.YER089C | Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphoryla [...] |
| YER090C-A protein network | https://string-db.org/network/4932.YER090C-A | Uncharacterized protein YER090C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| TRP2 protein network | https://string-db.org/network/4932.YER090W | Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex wit [...] |
| MET6 protein network | https://string-db.org/network/4932.YER091C | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; involved in methionine biosynthesis and regeneration; requires a minimum of two g [...] |
| YER091C-A protein network | https://string-db.org/network/4932.YER091C-A | Putative uncharacterized protein YER091C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| IES5 protein network | https://string-db.org/network/4932.YER092W | Ino eighty subunit 5; Non-essential INO80 chromatin remodeling complex subunit; deletion affects telomere maintenance via recombination. |
| TSC11 protein network | https://string-db.org/network/4932.YER093C | Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p); TORC2 is a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved [...] |
| AIM11 protein network | https://string-db.org/network/4932.YER093C-A | Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; SWAT-GFP and mCherry fusi [...] |
| PUP3 protein network | https://string-db.org/network/4932.YER094C | Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10. |
| RAD51 protein network | https://string-db.org/network/4932.YER095W | DNA repair protein RAD51; Strand exchange protein; forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during veget [...] |
| SHC1 protein network | https://string-db.org/network/4932.YER096W | Protein SHC1; Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a p [...] |
| UBP9 protein network | https://string-db.org/network/4932.YER098W | Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication; Belongs to the peptidase C19 family. |
| PRS2 protein network | https://string-db.org/network/4932.YER099C | Ribose-phosphate pyrophosphokinase 2; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five [...] |
| UBC6 protein network | https://string-db.org/network/4932.YER100W | Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteas [...] |
| AST2 protein network | https://string-db.org/network/4932.YER101C | Protein AST2; Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the [...] |
| RPS8B protein network | https://string-db.org/network/4932.YER102W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8B has a paralog, RPS8A, that arose from the whole genome duplicatio [...] |
| SSA4 protein network | https://string-db.org/network/4932.YER103W | Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein [...] |
| RTT105 protein network | https://string-db.org/network/4932.YER104W | Protein with a role in regulation of Ty1 transposition. |
| NUP157 protein network | https://string-db.org/network/4932.YER105C | Nucleoporin NUP157; Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to [...] |
| MAM1 protein network | https://string-db.org/network/4932.YER106W | Monopolin complex subunit MAM1; Monopolin; meiosis-specific kinetochore-associated protein involved in monopolar attachment of sister kinetochores to the meiotic spindle; subunit of monopolin, a [...] |
| GLE2 protein network | https://string-db.org/network/4932.YER107C | Nucleoporin GLE2; RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. po [...] |
| KAP123 protein network | https://string-db.org/network/4932.YER110C | Importin subunit beta-4; Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, [...] |
| SWI4 protein network | https://string-db.org/network/4932.YER111C | Regulatory protein SWI4; DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targ [...] |
| LSM4 protein network | https://string-db.org/network/4932.YER112W | U6 snRNA-associated Sm-like protein LSm4; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Ls [...] |
| TMN3 protein network | https://string-db.org/network/4932.YER113C | Transmembrane 9 superfamily member 3; Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segmen [...] |
| BOI2 protein network | https://string-db.org/network/4932.YER114C | Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; B [...] |
| SPR6 protein network | https://string-db.org/network/4932.YER115C | Protein of unknown function; expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation. |
| SLX8 protein network | https://string-db.org/network/4932.YER116C | Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; role in proteolysis of spindle positioning protein Kar9, DNA repair proteins Rad52p and Rad57p; stimulated by SUMO-modified su [...] |
| RPL23B protein network | https://string-db.org/network/4932.YER117W | Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication. |
| SHO1 protein network | https://string-db.org/network/4932.YER118C | High osmolarity signaling protein SHO1; Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway [...] |
| AVT6 protein network | https://string-db.org/network/4932.YER119C | Vacuolar amino acid transporter 6; Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentali [...] |
| SCS2 protein network | https://string-db.org/network/4932.YER120W | Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PI4P levels by [...] |
| YER121W protein network | https://string-db.org/network/4932.YER121W | Uncharacterized protein YER121W; Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy. |
| GLO3 protein network | https://string-db.org/network/4932.YER122C | ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; shares functional similarity with Gcs1p. |
| YCK3 protein network | https://string-db.org/network/4932.YER123W | Casein kinase I homolog 3; Palmitoylated vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares es [...] |
| DSE1 protein network | https://string-db.org/network/4932.YER124C | Protein DSE1; Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-facto [...] |
| RSP5 protein network | https://string-db.org/network/4932.YER125W | NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p [...] |
| NSA2 protein network | https://string-db.org/network/4932.YER126C | Ribosome biogenesis protein NSA2; Protein constituent of 66S pre-ribosomal particles; contributes to processing of the 27S pre-rRNA; recruited by ribosomal proteins L17, L35, and L37 to assemblin [...] |
| LCP5 protein network | https://string-db.org/network/4932.YER127W | U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes pr [...] |
| VFA1 protein network | https://string-db.org/network/4932.YER128W | VPS4-associated protein 1; Protein that interacts with Vps4p and has a role in vacuolar sorting; stimulates the ATPase activity of Vps4; localizes to endosomes in a Vps4-dependent manner; overexp [...] |
| SAK1 protein network | https://string-db.org/network/4932.YER129W | Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal groth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a [...] |
| COM2 protein network | https://string-db.org/network/4932.YER130C | Zinc finger protein YER130C; Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bin [...] |
| RPS26B protein network | https://string-db.org/network/4932.YER131W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplica [...] |
| PMD1 protein network | https://string-db.org/network/4932.YER132C | Protein with an N-terminal kelch-like domain; putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions; PMD1 has a paralog, MDS3, t [...] |
| GLC7 protein network | https://string-db.org/network/4932.YER133W | Serine/threonine-protein phosphatase PP1-2; Type 1 S/T protein phosphatase (PP1) catalytic subunit; involved in glycogen metabolism, sporulation and mitotic progression; interacts with multiple r [...] |
| YER134C protein network | https://string-db.org/network/4932.YER134C | Magnesium-dependent acid phosphatase; member of the haloacid dehalogenase superfamily; non-essential gene; Belongs to the HAD-like hydrolase superfamily. |
| YER135C protein network | https://string-db.org/network/4932.YER135C | Uncharacterized protein YER135C; Putative protein of unknown function; conserved among S. cerevisiae strains; YER135C is not an essential gene. |
| GDI1 protein network | https://string-db.org/network/4932.YER136W | Rab GDP-dissociation inhibitor; GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding prote [...] |
| YER137C protein network | https://string-db.org/network/4932.YER137C | Uncharacterized protein YEL137C; Putative protein of unknown function. |
| YER138W-A protein network | https://string-db.org/network/4932.YER138W-A | Putative protein of unknown function; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication. |
| RTR1 protein network | https://string-db.org/network/4932.YER139C | RNA polymerase II subunit B1 CTD phosphatase RTR1; CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in euka [...] |
| EMP65 protein network | https://string-db.org/network/4932.YER140W | Endoplasmic reticulum membrane protein 65; Integral membrane protein of the ER; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defe [...] |
| COX15 protein network | https://string-db.org/network/4932.YER141W | Cytochrome c oxidase assembly protein COX15; Protein required for the hydroxylation of heme O to form heme A; heme A is an essential prosthetic group for cytochrome c oxidase; Belongs to the COX1 [...] |
| MAG1 protein network | https://string-db.org/network/4932.YER142C | 3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repai [...] |
| DDI1 protein network | https://string-db.org/network/4932.YER143W | DNA damage-inducible v-SNARE binding protein; role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and re [...] |
| UBP5 protein network | https://string-db.org/network/4932.YER144C | Putative ubiquitin-specific protease; concentrates at the bud neck; UBP5 has a paralog, DOA4, that arose from the whole genome duplication; Belongs to the peptidase C19 family. |
| FTR1 protein network | https://string-db.org/network/4932.YER145C | High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DN [...] |
| LSM5 protein network | https://string-db.org/network/4932.YER146W | U6 snRNA-associated Sm-like protein LSm5; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Ls [...] |
| SCC4 protein network | https://string-db.org/network/4932.YER147C | MAU2 chromatid cohesion factor homolog; Subunit of cohesin loading factor (Scc2p-Scc4p); complex is required for the loading of cohesin complexes onto chromosomes; involved in establishing sister [...] |
| SPT15 protein network | https://string-db.org/network/4932.YER148W | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene ca [...] |
| PEA2 protein network | https://string-db.org/network/4932.YER149C | Protein PEA2; Coiled-coil 12S polarisome subunit; required for polarity establishment, apical bud growth, shmoo formation, filamentous differentiation; involved in Bni1p localization at sites of [...] |
| SPI1 protein network | https://string-db.org/network/4932.YER150W | GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; SPI1 has a p [...] |
| UBP3 protein network | https://string-db.org/network/4932.YER151C | Ubiquitin carboxyl-terminal hydrolase 3; Ubiquitin-specific protease involved in transport and osmotic response; negatively regulates Ras/PKA signaling; interacts with Bre5p to coregulate anterog [...] |
| YER152C protein network | https://string-db.org/network/4932.YER152C | Uncharacterized protein YER152C; Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene. |
| PET122 protein network | https://string-db.org/network/4932.YER153C | Protein PET122, mitochondrial; Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane. |
| OXA1 protein network | https://string-db.org/network/4932.YER154W | Mitochondrial inner membrane insertase; mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; also has a role in insertion of carrier [...] |
| BEM2 protein network | https://string-db.org/network/4932.YER155C | GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential [...] |
| YER156C protein network | https://string-db.org/network/4932.YER156C | UPF0160 protein YER156C; Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a co [...] |
| COG3 protein network | https://string-db.org/network/4932.YER157W | Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to [...] |
| YER158C protein network | https://string-db.org/network/4932.YER158C | Uncharacterized protein YER158C; Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication. |
| BUR6 protein network | https://string-db.org/network/4932.YER159C | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcriptio [...] |
| SPT2 protein network | https://string-db.org/network/4932.YER161C | Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components; relocalizes to the cytosol i [...] |
| RAD4 protein network | https://string-db.org/network/4932.YER162C | Protein that recognizes and binds damaged DNA (with Rad23p) during NER; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins; Rad4 [...] |
| GCG1 protein network | https://string-db.org/network/4932.YER163C | Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mamm [...] |
| CHD1 protein network | https://string-db.org/network/4932.YER164W | Chromo domain-containing protein 1; Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin i [...] |
| PAB1 protein network | https://string-db.org/network/4932.YER165W | Polyadenylate-binding protein, cytoplasmic and nuclear; Poly(A) binding protein; part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly [...] |
| DNF1 protein network | https://string-db.org/network/4932.YER166W | Phospholipid-transporting ATPase DNF1; Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and [...] |
| BCK2 protein network | https://string-db.org/network/4932.YER167W | Protein BCK2; Serine/threonine-rich protein involved in PKC1 signaling pathway; protein kinase C (PKC1) signaling pathway controls cell integrity; overproduction suppresses pkc1 mutations. |
| CCA1 protein network | https://string-db.org/network/4932.YER168C | CCA tRNA nucleotidyltransferase, mitochondrial; ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use [...] |
| RPH1 protein network | https://string-db.org/network/4932.YER169W | DNA damage-responsive transcriptional repressor RPH1; JmjC domain-containing histone demethylase; targets tri- and dimethylated H3K36; associates with actively transcribed regions and promotes el [...] |
| ADK2 protein network | https://string-db.org/network/4932.YER170W | GTP:AMP phosphotransferase, mitochondrial; Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP d [...] |
| RAD3 protein network | https://string-db.org/network/4932.YER171W | 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human X [...] |
| BRR2 protein network | https://string-db.org/network/4932.YER172C | Pre-mRNA-splicing helicase BRR2; RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous [...] |
| RAD24 protein network | https://string-db.org/network/4932.YER173W | Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe [...] |
| GRX4 protein network | https://string-db.org/network/4932.YER174C | Monothiol glutaredoxin-4; Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells [...] |
| TMT1 protein network | https://string-db.org/network/4932.YER175C | Trans-aconitate methyltransferase; cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which [...] |
| YER175W-A protein network | https://string-db.org/network/4932.YER175W-A | Uncharacterized protein YER175W-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| ECM32 protein network | https://string-db.org/network/4932.YER176W | Putative ATP-dependent RNA helicase ECM32; DNA dependent ATPase/DNA helicase; helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termin [...] |
| BMH1 protein network | https://string-db.org/network/4932.YER177W | 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive s [...] |
| PDA1 protein network | https://string-db.org/network/4932.YER178W | E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; PDH complex is concen [...] |
| DMC1 protein network | https://string-db.org/network/4932.YER179W | Meiotic recombination protein DMC1; Meiosis-specific recombinase required for double-strand break repair; also required for pairing between homologous chromosomes; required for the normal morphog [...] |
| ISC10 protein network | https://string-db.org/network/4932.YER180C | Meiosis-specific protein ISC10; Protein required for sporulation; transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive ce [...] |
| SLO1 protein network | https://string-db.org/network/4932.YER180C-A | SCOCO-like protein 1; Protein interacting with Arl3p; Arl3p is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO. |
| FMP10 protein network | https://string-db.org/network/4932.YER182W | Uncharacterized mitochondrial membrane protein FMP10; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studie [...] |
| FAU1 protein network | https://string-db.org/network/4932.YER183C | 5-formyltetrahydrofolate cyclo-ligase; 5,10-methenyltetrahydrofolate synthetase; involved in folic acid biosynthesis. |
| TOG1 protein network | https://string-db.org/network/4932.YER184C | Transcription factor TOG1; Transcriptional activator of oleate genes; regulates genes involved in fatty acid utilization; zinc cluster protein; deletion confers sensitivity to Calcufluor white, a [...] |
| PUG1 protein network | https://string-db.org/network/4932.YER185W | Protoporphyrin uptake protein 1; Plasma membrane protein involved in protoprophyrin and heme transport; roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced unde [...] |
| YER186C protein network | https://string-db.org/network/4932.YER186C | Uncharacterized protein YER186C; Putative protein of unknown function. |
| YER187W protein network | https://string-db.org/network/4932.YER187W | Uncharacterized protein YER187W; Putative protein of unknown function; induced in respiratory-deficient cells; To yeast killer toxin KHS and to YGL262w. |
| YER188C-A protein network | https://string-db.org/network/4932.YER188C-A | UPF0320 protein YER188C-A; Putative protein of unknown function; Belongs to the UPF0320 family. |
| YER188W protein network | https://string-db.org/network/4932.YER188W | Uncharacterized protein YER188W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA [...] |
| YER189W protein network | https://string-db.org/network/4932.YER189W | Uncharacterized protein YER189W; Putative protein of unknown function. |
| YER190C-A protein network | https://string-db.org/network/4932.YER190C-A | Putative uncharacterized protein YER190C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| YER190C-B protein network | https://string-db.org/network/4932.YER190C-B | UPF0479 membrane protein YEL077W-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YRF1-2 protein network | https://string-db.org/network/4932.YER190W | Y' element ATP-dependent helicase protein 1 copy 2; Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially [...] |
| DEG1 protein network | https://string-db.org/network/4932.YFL001W | tRNA:pseudouridine synthase; introduces pseudouridines at position 38 or 39 in tRNA; also responsible for pseudouracil modification of some mRNAs; important for maintenance of translation efficie [...] |
| SPB4 protein network | https://string-db.org/network/4932.YFL002C | Putative ATP-dependent RNA helicase; nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients; Belon [...] |
| MSH4 protein network | https://string-db.org/network/4932.YFL003C | MutS protein homolog 4; Protein involved in meiotic recombination; required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bac [...] |
| VTC2 protein network | https://string-db.org/network/4932.YFL004W | Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; V [...] |
| SEC4 protein network | https://string-db.org/network/4932.YFL005W | Ras-related protein SEC4; Rab family GTPase; essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of t [...] |
| BLM10 protein network | https://string-db.org/network/4932.YFL007W | Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule [...] |
| SMC1 protein network | https://string-db.org/network/4932.YFL008W | Structural maintenance of chromosomes protein 1; Subunit of the multiprotein cohesin complex; essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chrom [...] |
| CDC4 protein network | https://string-db.org/network/4932.YFL009W | Cell division control protein 4; F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/ [...] |
| WWM1 protein network | https://string-db.org/network/4932.YFL010C | WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death t [...] |
| AUA1 protein network | https://string-db.org/network/4932.YFL010W-A | Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease. |
| HXT10 protein network | https://string-db.org/network/4932.YFL011W | Putative hexose transporter; expressed at low levels and expression is repressed by glucose. |
| YFL012W protein network | https://string-db.org/network/4932.YFL012W | Uncharacterized protein YFL012W; Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin. |
| IES1 protein network | https://string-db.org/network/4932.YFL013C | Subunit of the INO80 chromatin remodeling complex; relocalizes to the cytosol in response to hypoxia. |
| HSP12 protein network | https://string-db.org/network/4932.YFL014W | 12 kDa heat shock protein; Plasma membrane protein involved in maintaining membrane organization; involved in maintaining organization during stress conditions; induced by heat shock, oxidative s [...] |
| YFL015W-A protein network | https://string-db.org/network/4932.YFL015W-A | Putative uncharacterized membrane protein YFL015W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps O [...] |
| MDJ1 protein network | https://string-db.org/network/4932.YFL016C | DnaJ homolog 1, mitochondrial; Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misf [...] |
| GNA1 protein network | https://string-db.org/network/4932.YFL017C | Glucosamine-6-phosphate acetyltransferase; evolutionarily conserved; required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylg [...] |
| SMX2 protein network | https://string-db.org/network/4932.YFL017W-A | Small nuclear ribonucleoprotein G; Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 s [...] |
| LPD1 protein network | https://string-db.org/network/4932.YFL018C | Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme [...] |
| YFL019C protein network | https://string-db.org/network/4932.YFL019C | Uncharacterized protein YFL019C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YFL019C is not an essential ge [...] |
| PAU5 protein network | https://string-db.org/network/4932.YFL020C | Seripauperin-5; Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic condit [...] |
| GAT1 protein network | https://string-db.org/network/4932.YFL021W | Transcriptional regulatory protein GAT1; Transcriptional activator of nitrogen catabolite repression genes; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulat [...] |
| FRS2 protein network | https://string-db.org/network/4932.YFL022C | Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on prote [...] |
| BUD27 protein network | https://string-db.org/network/4932.YFL023W | Bud site selection protein 27; Unconventional prefoldin protein involved in translation initiation; required for correct assembly of RNAP I, II, and III in an Rpb5p-dependent manner; shuttles bet [...] |
| EPL1 protein network | https://string-db.org/network/4932.YFL024C | Enhancer of polycomb-like protein 1; Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome c [...] |
| BST1 protein network | https://string-db.org/network/4932.YFL025C | GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination [...] |
| STE2 protein network | https://string-db.org/network/4932.YFL026W | Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating betw [...] |
| GYP8 protein network | https://string-db.org/network/4932.YFL027C | GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle tran [...] |
| CAF16 protein network | https://string-db.org/network/4932.YFL028C | CCR4-associated factor 16; Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Med [...] |
| CAK1 protein network | https://string-db.org/network/4932.YFL029C | Serine/threonine-protein kinase CAK1; Cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; phosphorylates and activates Cdc28p; nucleotide-binding pocket differ [...] |
| AGX1 protein network | https://string-db.org/network/4932.YFL030W | Alanine--glyoxylate aminotransferase 1; Alanine:glyoxylate aminotransferase (AGT); catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in y [...] |
| YFL031C-A protein network | https://string-db.org/network/4932.YFL031C-A | Putative uncharacterized protein YFL031C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| HAC1 protein network | https://string-db.org/network/4932.YFL031W | Transcriptional activator HAC1; Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress [...] |
| RIM15 protein network | https://string-db.org/network/4932.YFL033C | Serine/threonine-protein kinase RIM15; Protein kinase involved in cell proliferation in response to nutrients; glucose-repressible; involved in signal transduction during cell proliferation in re [...] |
| RPL22B protein network | https://string-db.org/network/4932.YFL034C-A | Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paral [...] |
| MOB2 protein network | https://string-db.org/network/4932.YFL034C-B | Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific tr [...] |
| MIL1 protein network | https://string-db.org/network/4932.YFL034W | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p compone [...] |
| RPO41 protein network | https://string-db.org/network/4932.YFL036W | Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and [...] |
| TUB2 protein network | https://string-db.org/network/4932.YFL037W | Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of t [...] |
| YPT1 protein network | https://string-db.org/network/4932.YFL038C | GTP-binding protein YPT1; Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by [...] |
| ACT1 protein network | https://string-db.org/network/4932.YFL039C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. |
| YFL040W protein network | https://string-db.org/network/4932.YFL040W | Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport. |
| FET5 protein network | https://string-db.org/network/4932.YFL041W | Iron transport multicopper oxidase FET5; Multicopper oxidase; integral membrane protein with similarity to Fet3p; may have a role in iron transport. |
| LAM5 protein network | https://string-db.org/network/4932.YFL042C | Membrane-anchored lipid-binding protein LAM5; Putative sterol transfer protein; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracell [...] |
| OTU1 protein network | https://string-db.org/network/4932.YFL044C | Ubiquitin thioesterase OTU1; Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been u [...] |
| SEC53 protein network | https://string-db.org/network/4932.YFL045C | Phosphomannomutase; involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen; Belongs to the eukaryotic PM [...] |
| FMP32 protein network | https://string-db.org/network/4932.YFL046W | Protein FMP32, mitochondrial; Putative assembly factor for cytochrome c oxidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; has simi [...] |
| RGD2 protein network | https://string-db.org/network/4932.YFL047W | Rho-GTPase-activating protein RGD2; GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress. |
| EMP47 protein network | https://string-db.org/network/4932.YFL048C | Protein EMP47; Integral membrane component of ER-derived COPII-coated vesicles; functionS in ER to Golgi transport; EMP47 has a paralog, EMP46, that arose from the whole genome duplication; Belon [...] |
| SWP82 protein network | https://string-db.org/network/4932.YFL049W | SWI/SNF global transcription activator complex subunit SWP82; Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in [...] |
| ALR2 protein network | https://string-db.org/network/4932.YFL050C | Magnesium transporter ALR2; Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition. |
| YFL051C protein network | https://string-db.org/network/4932.YFL051C | Uncharacterized membrane protein YFL051C; Putative protein of unknown function; SWAT-GFP fusion protein localizes to the cell periphery while mCherry fusion protein localizes to both the cell per [...] |
| ZNF1 protein network | https://string-db.org/network/4932.YFL052W | Zinc cluster transcription factor that regulates respiratory growth; binds to promoters of genes involved in respiration, gluconeogenesis, and the glyoxylate shunt; required for normal carbon sou [...] |
| DAK2 protein network | https://string-db.org/network/4932.YFL053W | Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation; Belongs to the dihydroxyacetone kinase (DAK) family. |
| AQY3 protein network | https://string-db.org/network/4932.YFL054C | Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol. |
| AGP3 protein network | https://string-db.org/network/4932.YFL055W | Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays [...] |
| THI5 protein network | https://string-db.org/network/4932.YFL058W | 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5; Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, [...] |
| SNZ3 protein network | https://string-db.org/network/4932.YFL059W | Probable pyridoxal 5'-phosphate synthase subunit SNZ3; Member of a stationary phase-induced gene family; expressed in the presence of galactose; transcription of SNZ3 is induced prior to diauxic [...] |
| SNO3 protein network | https://string-db.org/network/4932.YFL060C | Probable pyridoxal 5'-phosphate synthase subunit SNO3; Protein of unknown function; nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin. |
| DDI2 protein network | https://string-db.org/network/4932.YFL061W | Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as M [...] |
| COS4 protein network | https://string-db.org/network/4932.YFL062W | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting [...] |
| YFL063W protein network | https://string-db.org/network/4932.YFL063W | Putative UPF0320 protein YFL063W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YFL064C protein network | https://string-db.org/network/4932.YFL064C | Uncharacterized protein YFL064C; Putative protein of unknown function. |
| YFL065C protein network | https://string-db.org/network/4932.YFL065C | Uncharacterized protein YFL065C; Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation. |
| YFL066C protein network | https://string-db.org/network/4932.YFL066C | Helicase-like protein encoded within the telomeric Y' element; induced by treatment with 8-methoxypsoralen and UVA irradiation; SWAT-GFP and mCherry fusion proteins localize to the nucleus. |
| YFL067W protein network | https://string-db.org/network/4932.YFL067W | Uncharacterized membrane protein YFL067W; Protein of unknown function; down-regulated at low calcium levels; mCherry fusion protein localizes to the vacuole. |
| YFL068W protein network | https://string-db.org/network/4932.YFL068W | UPF0479 membrane protein YFL068W; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol. |
| LOC1 protein network | https://string-db.org/network/4932.YFR001W | 60S ribosomal subunit assembly/export protein LOC1; Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particle [...] |
| NIC96 protein network | https://string-db.org/network/4932.YFR002W | Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with [...] |
| YPI1 protein network | https://string-db.org/network/4932.YFR003C | Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evid [...] |
| RPN11 protein network | https://string-db.org/network/4932.YFR004W | Ubiquitin carboxyl-terminal hydrolase RPN11; Metalloprotease subunit of 19S regulatory particle; part of 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; [...] |
| SAD1 protein network | https://string-db.org/network/4932.YFR005C | Pre-mRNA-splicing factor SAD1; Conserved zinc-finger domain protein involved in pre-mRNA splicing; critical for splicing of nearly all intron-containing genes; required for assembly of U4 snRNA i [...] |
| YFR006W protein network | https://string-db.org/network/4932.YFR006W | Uncharacterized peptidase YFR006W; Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene. |
| YFH7 protein network | https://string-db.org/network/4932.YFR007W | ATP-dependent kinase YFH7; Putative kinase with similarity to the PRK/URK/PANK kinase subfamily; the PRK/URK/PANK subfamily of P-loop kinases is also known as phosphoribulokinase/uridine kinase/b [...] |
| FAR7 protein network | https://string-db.org/network/4932.YFR008W | Factor arrest protein 7; Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protei [...] |
| GCN20 protein network | https://string-db.org/network/4932.YFR009W | Protein GCN20; Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA; Belongs to the ABC transporter superfamily [...] |
| UBP6 protein network | https://string-db.org/network/4932.YFR010W | Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains en bloc, rather than from the distal tip of the chai [...] |
| YFR010W-A protein network | https://string-db.org/network/4932.YFR010W-A | Uncharacterized protein YFR010W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the unch [...] |
| MIC19 protein network | https://string-db.org/network/4932.YFR011C | Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista jun [...] |
| DCV1 protein network | https://string-db.org/network/4932.YFR012W | Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome dupl [...] |
| YFR012W-A protein network | https://string-db.org/network/4932.YFR012W-A | Uncharacterized protein YFR012W-A; Putative protein of unknown function; identified by homology. |
| IOC3 protein network | https://string-db.org/network/4932.YFR013W | ISWI one complex protein 3; Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal din [...] |
| CMK1 protein network | https://string-db.org/network/4932.YFR014C | Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian [...] |
| GSY1 protein network | https://string-db.org/network/4932.YFR015C | Glycogen [starch] synthase isoform 1; Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, [...] |
| YFR016C protein network | https://string-db.org/network/4932.YFR016C | Uncharacterized protein YFR016C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFR016C is not an essential [...] |
| IGD1 protein network | https://string-db.org/network/4932.YFR017C | Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine ferment [...] |
| YFR018C protein network | https://string-db.org/network/4932.YFR018C | Uncharacterized protein YFR018C; Putative protein of unknown function; SWAT-GFP and seamless GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the [...] |
| FAB1 protein network | https://string-db.org/network/4932.YFR019W | 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis. |
| CSS2 protein network | https://string-db.org/network/4932.YFR020W | Protein of unknown function, secreted when constitutively expressed; SWAT-GFP fusion protein localizes to the endoplasmic reticulum (ER) and extracellular region, while mCherry fusion protein loc [...] |
| ATG18 protein network | https://string-db.org/network/4932.YFR021W | Autophagy-related protein 18; Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol ( [...] |
| ROG3 protein network | https://string-db.org/network/4932.YFR022W | Protein ROG3; Alpha-arrestin involved in ubiquitin-dependent endocytosis; contributes to desensitization of agonist-occupied alpha-factor receptor Ste2p by Rsp5p-independent internalization; PPXY [...] |
| PES4 protein network | https://string-db.org/network/4932.YFR023W | Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication. |
| LSB3 protein network | https://string-db.org/network/4932.YFR024C-A | Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance [...] |
| HIS2 protein network | https://string-db.org/network/4932.YFR025C | Histidinol-phosphatase; Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is [...] |
| ULI1 protein network | https://string-db.org/network/4932.YFR026C | Protein of unknown function; involved in and induced by the endoplasmic reticulum unfolded protein response (UPR); SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum. |
| ECO1 protein network | https://string-db.org/network/4932.YFR027W | N-acetyltransferase ECO1; Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mc [...] |
| CDC14 protein network | https://string-db.org/network/4932.YFR028C | Tyrosine-protein phosphatase CDC14; Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response; held i [...] |
| PTR3 protein network | https://string-db.org/network/4932.YFR029W | SPS-sensor component PTR3; Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of [...] |
| MET10 protein network | https://string-db.org/network/4932.YFR030W | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. |
| SMC2 protein network | https://string-db.org/network/4932.YFR031C | Structural maintenance of chromosomes protein 2; Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family membe [...] |
| RPL2A protein network | https://string-db.org/network/4932.YFR031C-A | Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication. |
| RRT5 protein network | https://string-db.org/network/4932.YFR032C | Regulator of rDNA transcription protein 5; Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at hi [...] |
| RPL29 protein network | https://string-db.org/network/4932.YFR032C-A | Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ri [...] |
| YFR032C-B protein network | https://string-db.org/network/4932.YFR032C-B | Uncharacterized protein YFR032C-B; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| QCR6 protein network | https://string-db.org/network/4932.YFR033C | Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron tran [...] |
| PHO4 protein network | https://string-db.org/network/4932.YFR034C | Phosphate system positive regulatory protein PHO4; Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate [...] |
| YFR035C protein network | https://string-db.org/network/4932.YFR035C | Uncharacterized protein YFR035C; Putative protein of unknown function; deletion mutant exhibits synthetic phenotype with alpha-synuclein. |
| CDC26 protein network | https://string-db.org/network/4932.YFR036W | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/a [...] |
| RSC8 protein network | https://string-db.org/network/4932.YFR037C | Chromatin structure-remodeling complex protein RSC8; Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Sw [...] |
| IRC5 protein network | https://string-db.org/network/4932.YFR038W | Uncharacterized ATP-dependent helicase IRC5; Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; SWAT-GFP and [...] |
| OSW7 protein network | https://string-db.org/network/4932.YFR039C | Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; may be involved in response to high salt and changes in carbon source; SWAT-GFP, seamless-GFP [...] |
| SAP155 protein network | https://string-db.org/network/4932.YFR040W | SIT4-associating protein SAP155; Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and S [...] |
| ERJ5 protein network | https://string-db.org/network/4932.YFR041C | ER-localized J domain-containing protein 5; Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene le [...] |
| KEG1 protein network | https://string-db.org/network/4932.YFR042W | Beta-1,6-glucan synthesis-associated protein KEG1; Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required [...] |
| IRC6 protein network | https://string-db.org/network/4932.YFR043C | Increased recombination centers protein 6; Clathrin coat accessory factor; involved in clathrin-mediated vesicle trafficking; may function to link the AP-1 clathrin adaptor complex with the Rab G [...] |
| DUG1 protein network | https://string-db.org/network/4932.YFR044C | Cys-Gly metallodipeptidase DUG1; Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative [...] |
| YFR045W protein network | https://string-db.org/network/4932.YFR045W | Uncharacterized mitochondrial carrier YFR045W; Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white. |
| CNN1 protein network | https://string-db.org/network/4932.YFR046C | Inner kinetochore subunit CNN1; Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2- [...] |
| BNA6 protein network | https://string-db.org/network/4932.YFR047C | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated [...] |
| RMD8 protein network | https://string-db.org/network/4932.YFR048W | Cytosolic protein required for sporulation. |
| YMR31 protein network | https://string-db.org/network/4932.YFR049W | 37S ribosomal protein YMR-31, mitochondrial; Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase; recruits E3 subunit (Lpd1p) to the E1-E2 (Kgd1p, Kgd2p) core; has similarity to human [...] |
| PRE4 protein network | https://string-db.org/network/4932.YFR050C | Beta 7 subunit of the 20S proteasome; Belongs to the peptidase T1B family. |
| RET2 protein network | https://string-db.org/network/4932.YFR051C | Delta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; Belongs to the adaptor complexes medium subunit f [...] |
| YFR052C-A protein network | https://string-db.org/network/4932.YFR052C-A | Putative uncharacterized protein YFR052C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF HXK1/Y [...] |
| RPN12 protein network | https://string-db.org/network/4932.YFR052W | Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and [...] |
| HXK1 protein network | https://string-db.org/network/4932.YFR053C | Hexokinase-1; Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; g [...] |
| YFR054C protein network | https://string-db.org/network/4932.YFR054C | Uncharacterized protein YFR054C; Putative protein of unknown function; conserved among S. cerevisiae strains. |
| IRC7 protein network | https://string-db.org/network/4932.YFR055W | Putative cystathionine beta-lyase; Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in [...] |
| YFR056C protein network | https://string-db.org/network/4932.YFR056C | Putative uncharacterized protein YFR056C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| YFR057W protein network | https://string-db.org/network/4932.YFR057W | Uncharacterized protein YFR057W; Putative protein of unknown function. |
| ERG26 protein network | https://string-db.org/network/4932.YGL001C | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergoste [...] |
| ERP6 protein network | https://string-db.org/network/4932.YGL002W | Protein ERP6; Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throu [...] |
| CDH1 protein network | https://string-db.org/network/4932.YGL003C | Activator of anaphase-promoting complex/cyclosome (APC/C); antagonist of the spindle assembly checkpoint; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specifi [...] |
| RPN14 protein network | https://string-db.org/network/4932.YGL004C | 26S proteasome regulatory subunit RPN14; Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the [...] |
| COG7 protein network | https://string-db.org/network/4932.YGL005C | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi com [...] |
| PMC1 protein network | https://string-db.org/network/4932.YGL006W | Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalia [...] |
| YGL006W-A protein network | https://string-db.org/network/4932.YGL006W-A | Uncharacterized protein YGL006W-A; Putative protein of unknown function; identified by SAGE. |
| YGL007C-A protein network | https://string-db.org/network/4932.YGL007C-A | Uncharacterized protein YGL007C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits s [...] |
| BRP1 protein network | https://string-db.org/network/4932.YGL007W | Uncharacterized protein BRP1; Putative protein of unknown function; conserved among S. cerevisiae strains; located in the upstream region of PMA1; deletion leads to polyamine resistance due to do [...] |
| PMA1 protein network | https://string-db.org/network/4932.YGL008C | Plasma membrane P2-type H+-ATPase; pumps protons out of cell; major regulator of cytoplasmic pH and plasma membrane potential; long-lived protein asymmetrically distributed at plasma membrane bet [...] |
| LEU1 protein network | https://string-db.org/network/4932.YGL009C | 3-isopropylmalate dehydratase; Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway; Belongs to the aconitase/IPM isomerase family. |
| MPO1 protein network | https://string-db.org/network/4932.YGL010W | Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene. |
| SCL1 protein network | https://string-db.org/network/4932.YGL011C | Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mit [...] |
| ERG4 protein network | https://string-db.org/network/4932.YGL012W | C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol; Belongs to the ERG4/ERG24 family. |
| PDR1 protein network | https://string-db.org/network/4932.YGL013C | Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response [...] |
| YGL014C-A protein network | https://string-db.org/network/4932.YGL014C-A | Uncharacterized protein YGL014C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression pro [...] |
| PUF4 protein network | https://string-db.org/network/4932.YGL014W | Pumilio homology domain family member 4; Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds [...] |
| YGL015C protein network | https://string-db.org/network/4932.YGL015C | Uncharacterized protein YGL015C; Putative protein of unknown function; null mutants accumulate cargo in the Golgi. |
| KAP122 protein network | https://string-db.org/network/4932.YGL016W | Importin beta-like protein KAP122; Karyopherin beta; responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pl [...] |
| ATE1 protein network | https://string-db.org/network/4932.YGL017W | Arginyl-tRNA--protein transferase 1; Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to deg [...] |
| JAC1 protein network | https://string-db.org/network/4932.YGL018C | J-type co-chaperone JAC1, mitochondrial; Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabol [...] |
| CKB1 protein network | https://string-db.org/network/4932.YGL019W | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including [...] |
| GET1 protein network | https://string-db.org/network/4932.YGL020C | Golgi to ER traffic protein 1; Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 [...] |
| ALK1 protein network | https://string-db.org/network/4932.YGL021W | Serine/threonine-protein kinase Haspin homolog ALK1; Protein kinase; along with its paralog, ALK2, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper [...] |
| STT3 protein network | https://string-db.org/network/4932.YGL022W | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3; Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of [...] |
| PIB2 protein network | https://string-db.org/network/4932.YGL023C | Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27. |
| YGL024W protein network | https://string-db.org/network/4932.YGL024W | Putative uncharacterized protein YGL024W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completely [...] |
| PGD1 protein network | https://string-db.org/network/4932.YGL025C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct targe [...] |
| TRP5 protein network | https://string-db.org/network/4932.YGL026C | Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis; In the N-terminal section; belongs to the TrpA family. |
| CWH41 protein network | https://string-db.org/network/4932.YGL027C | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER prot [...] |
| SCW11 protein network | https://string-db.org/network/4932.YGL028C | Probable family 17 glucosidase SCW11; Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p. |
| CGR1 protein network | https://string-db.org/network/4932.YGL029W | rRNA-processing protein CGR1; Protein involved in nucleolar integrity and processing of pre-rRNA; has a role in processing rRNA for the 60S ribosome subunit; transcript is induced in response to [...] |
| RPL30 protein network | https://string-db.org/network/4932.YGL030W | Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog. |
| RPL24A protein network | https://string-db.org/network/4932.YGL031C | Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has [...] |
| AGA2 protein network | https://string-db.org/network/4932.YGL032C | Adhesion subunit of a-agglutinin of a-cells; C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchora [...] |
| HOP2 protein network | https://string-db.org/network/4932.YGL033W | Homologous-pairing protein 2; Meiosis-specific protein that localizes to chromosomes; prevents synapsis between nonhomologous chromosomes and ensures synapsis between homologs; complexes with Mnd [...] |
| YGL034C protein network | https://string-db.org/network/4932.YGL034C | Uncharacterized protein YGL034C; Putative protein of unknown function; conserved among S. cerevisiae strains; YGL034C is not an essential gene. |
| MIG1 protein network | https://string-db.org/network/4932.YGL035C | Regulatory protein MIG1; Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and th [...] |
| YGL036W protein network | https://string-db.org/network/4932.YGL036W | Uncharacterized protein YGL036W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene. |
| PNC1 protein network | https://string-db.org/network/4932.YGL037C | Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; lacks a peroxisomal targeting signal but [...] |
| OCH1 protein network | https://string-db.org/network/4932.YGL038C | Initiation-specific alpha-1,6-mannosyltransferase; Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins; [...] |
| YGL039W protein network | https://string-db.org/network/4932.YGL039W | Putative uncharacterized oxidoreductase YGL039W; Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols. |
| HEM2 protein network | https://string-db.org/network/4932.YGL040C | Delta-aminolevulinic acid dehydratase; Aminolevulinate dehydratase; a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis [...] |
| YGL041C protein network | https://string-db.org/network/4932.YGL041C | Putative uncharacterized protein YGL041C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YGL041C-B protein network | https://string-db.org/network/4932.YGL041C-B | Uncharacterized protein YGL041C-B; Putative protein of unknown function; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum. |
| YGL041W-A protein network | https://string-db.org/network/4932.YGL041W-A | Uncharacterized protein YGL041W-A, mitochondrial; Putative protein of unknown function; conserved in fungi; identified by expression profiling and mass spectrometry. |
| DST1 protein network | https://string-db.org/network/4932.YGL043W | General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; [...] |
| RNA15 protein network | https://string-db.org/network/4932.YGL044C | mRNA 3'-end-processing protein RNA15; Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in c [...] |
| RIM8 protein network | https://string-db.org/network/4932.YGL045W | pH-response regulator protein palF/RIM8; Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for a [...] |
| ALG13 protein network | https://string-db.org/network/4932.YGL047W | UDP-N-acetylglucosamine transferase subunit ALG13; Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER mem [...] |
| RPT6 protein network | https://string-db.org/network/4932.YGL048C | ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein lig [...] |
| TIF4632 protein network | https://string-db.org/network/4932.YGL049C | Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts w [...] |
| TYW3 protein network | https://string-db.org/network/4932.YGL050W | tRNA wybutosine-synthesizing protein 3; tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA [...] |
| MST27 protein network | https://string-db.org/network/4932.YGL051W | Multicopy suppressor of SEC21 protein 27; Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles [...] |
| YGL052W protein network | https://string-db.org/network/4932.YGL052W | Putative uncharacterized protein YGL052W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| PRM8 protein network | https://string-db.org/network/4932.YGL053W | Pheromone-regulated protein; contains with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene fa [...] |
| ERV14 protein network | https://string-db.org/network/4932.YGL054C | ER-derived vesicles protein ERV14; COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection prote [...] |
| OLE1 protein network | https://string-db.org/network/4932.YGL055W | Acyl-CoA desaturase 1; Delta(9) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria. |
| SDS23 protein network | https://string-db.org/network/4932.YGL056C | Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; SDS23 has [...] |
| GEP7 protein network | https://string-db.org/network/4932.YGL057C | Genetic interactor of prohibitin 7, mitochondrial; Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authen [...] |
| RAD6 protein network | https://string-db.org/network/4932.YGL058W | Ubiquitin-conjugating enzyme (E2); involved in postreplication repair as a heterodimer with Rad18p, regulation of K63 polyubiquitination in response to oxidative stress, DSBR and checkpoint contr [...] |
| PKP2 protein network | https://string-db.org/network/4932.YGL059W | Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p an [...] |
| YBP2 protein network | https://string-db.org/network/4932.YGL060W | YAP1-binding protein 2; Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance [...] |
| DUO1 protein network | https://string-db.org/network/4932.YGL061C | Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Dam1p to connect the DASH complex with microtubules (MT); couples kinetochores to the force produced by MT depolymerizati [...] |
| PYC1 protein network | https://string-db.org/network/4932.YGL062W | Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic aci [...] |
| YGL063C-A protein network | https://string-db.org/network/4932.YGL063C-A | Putative uncharacterized protein YGL063C-A; Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide [...] |
| PUS2 protein network | https://string-db.org/network/4932.YGL063W | Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modi [...] |
| MRH4 protein network | https://string-db.org/network/4932.YGL064C | Mitochondrial ATP-dependent RNA helicase of the DEAD-box family; required for assembly of the large subunit of mitochondrial ribosomes; binds to the large subunit rRNA, 21S_rRNA; localizes to the [...] |
| ALG2 protein network | https://string-db.org/network/4932.YGL065C | Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temp [...] |
| SGF73 protein network | https://string-db.org/network/4932.YGL066W | SAGA-associated factor 73; Subunit of DUBm module of SAGA and SLIK; has roles in anchoring deubiquitination module (DUBm) into SAGA and SLIK complexes, maintaining organization and ubiquitin-bind [...] |
| NPY1 protein network | https://string-db.org/network/4932.YGL067W | NADH diphosphatase (pyrophosphatase); hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member. |
| MNP1 protein network | https://string-db.org/network/4932.YGL068W | Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L7/L12 and human MRPL7 ribosomal proteins; associates with the mitochondrial nucleoid; required for normal respirat [...] |
| YGL069C protein network | https://string-db.org/network/4932.YGL069C | Putative uncharacterized protein YGL069C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| RPB9 protein network | https://string-db.org/network/4932.YGL070C | RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription. |
| AFT1 protein network | https://string-db.org/network/4932.YGL071W | Iron-regulated transcriptional activator AFT1; Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to chang [...] |
| YGL072C protein network | https://string-db.org/network/4932.YGL072C | Putative uncharacterized protein YGL072C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| HSF1 protein network | https://string-db.org/network/4932.YGL073W | Trimeric heat shock transcription factor; activates multiple genes in response to highly diverse stresses; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; mon [...] |
| MPS2 protein network | https://string-db.org/network/4932.YGL075C | Monopolar spindle protein 2; Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potenti [...] |
| RPL7A protein network | https://string-db.org/network/4932.YGL076C | Ribosomal 60S subunit protein L7A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a con [...] |
| HNM1 protein network | https://string-db.org/network/4932.YGL077C | Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with pho [...] |
| DBP3 protein network | https://string-db.org/network/4932.YGL078C | ATP-dependent RNA helicase DBP3; RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but de [...] |
| KXD1 protein network | https://string-db.org/network/4932.YGL079W | Subunit of the BLOC-1 complex involved in endosomal maturation; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome; Belongs to the [...] |
| MPC1 protein network | https://string-db.org/network/4932.YGL080W | Highly conserved subunit of mitochondrial pyruvate carrier (MPC); MPC is a mitochondrial inner membrane complex that mediates pyruvate uptake and comprises Mpc1p and Mpc2p during fermentative gro [...] |
| YGL081W protein network | https://string-db.org/network/4932.YGL081W | Uncharacterized protein YGL081W; Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis. |
| YGL082W protein network | https://string-db.org/network/4932.YGL082W | Uncharacterized protein YGL082W; Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the [...] |
| SCY1 protein network | https://string-db.org/network/4932.YGL083W | Protein kinase-like protein SCY1; Putative kinase; suppressor of GTPase mutant; similar to bovine rhodopsin kinase; may have a role in intracellular sterol transport. |
| GUP1 protein network | https://string-db.org/network/4932.YGL084C | Glycerol uptake protein 1; Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality [...] |
| LCL3 protein network | https://string-db.org/network/4932.YGL085W | Probable endonuclease LCL3; Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochond [...] |
| MAD1 protein network | https://string-db.org/network/4932.YGL086W | Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p u [...] |
| MMS2 protein network | https://string-db.org/network/4932.YGL087C | Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-ass [...] |
| MF(ALPHA)2 protein network | https://string-db.org/network/4932.YGL089C | Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more [...] |
| LIF1 protein network | https://string-db.org/network/4932.YGL090W | Ligase-interacting factor 1; Component of the DNA ligase IV complex; this complex mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; [...] |
| NBP35 protein network | https://string-db.org/network/4932.YGL091C | Cytosolic Fe-S cluster assembly factor NBP35; Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol [...] |
| NUP145 protein network | https://string-db.org/network/4932.YGL092W | Nucleoporin NUP145C; Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural [...] |
| SPC105 protein network | https://string-db.org/network/4932.YGL093W | Spindle pole body component SPC105; Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromati [...] |
| PAN2 protein network | https://string-db.org/network/4932.YGL094C | Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; Bel [...] |
| VPS45 protein network | https://string-db.org/network/4932.YGL095C | Protein of the Sec1p/Munc-18 family; essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-deriv [...] |
| TOS8 protein network | https://string-db.org/network/4932.YGL096W | Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell [...] |
| SRM1 protein network | https://string-db.org/network/4932.YGL097W | Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphoryla [...] |
| USE1 protein network | https://string-db.org/network/4932.YGL098W | Essential SNARE protein localized to the ER; involved in retrograde traffic from the Golgi to the ER and Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating [...] |
| LSG1 protein network | https://string-db.org/network/4932.YGL099W | Large subunit GTPase 1; Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm; Belongs to the TRAFAC class YlqF/YawG G [...] |
| SEH1 protein network | https://string-db.org/network/4932.YGL100W | Nucleoporin SEH1; Subunit of the Nup84 nuclear pore and SEACAT subcomplexes; involved in nucleocytoplasmic transport and NPC biogenesis in the nuclear pore subcomplex; subunit of SEACAT, a subcom [...] |
| YGL101W protein network | https://string-db.org/network/4932.YGL101W | HD domain-containing protein YGL101W; Protein of unknown function; non-essential gene; interacts with the DNA helicase Hpr5p; YGL101W has a paralog, YBR242W, that arose from the whole genome dupl [...] |
| YGL102C protein network | https://string-db.org/network/4932.YGL102C | Putative uncharacterized protein YGL102C; Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein. |
| RPL28 protein network | https://string-db.org/network/4932.YGL103W | Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance. |
| VPS73 protein network | https://string-db.org/network/4932.YGL104C | Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; VPS73 has a paralog, YBR241C, that arose from the whole genome duplicati [...] |
| ARC1 protein network | https://string-db.org/network/4932.YGL105W | tRNA-aminoacylation cofactor ARC1; Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery, stimulating catalysis, and ensuring localization; also binds qu [...] |
| MLC1 protein network | https://string-db.org/network/4932.YGL106W | Essential light chain for Myo1p; light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actom [...] |
| RMD9 protein network | https://string-db.org/network/4932.YGL107C | Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane a [...] |
| YGL108C protein network | https://string-db.org/network/4932.YGL108C | Uncharacterized protein YGL108C; Protein of unknown function, predicted to be palmitoylated; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol, while N-termina [...] |
| CUE3 protein network | https://string-db.org/network/4932.YGL110C | Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination. |
| NSA1 protein network | https://string-db.org/network/4932.YGL111W | Ribosome biogenesis protein NSA1; Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis. |
| TAF6 protein network | https://string-db.org/network/4932.YGL112C | Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in respons [...] |
| SLD3 protein network | https://string-db.org/network/4932.YGL113W | Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that be [...] |
| YGL114W protein network | https://string-db.org/network/4932.YGL114W | Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters. |
| SNF4 protein network | https://string-db.org/network/4932.YGL115W | Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, repress [...] |
| CDC20 protein network | https://string-db.org/network/4932.YGL116W | Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; ce [...] |
| YGL117W protein network | https://string-db.org/network/4932.YGL117W | Uncharacterized protein YGL117W; Putative protein of unknown function. |
| COQ8 protein network | https://string-db.org/network/4932.YGL119W | Atypical kinase COQ8, mitochondrial; ATPase required for ubiquinone biosynthesis and respiratory growth; maintains levels of CoQ biosynthetic proteins; binds to CoQ biosynthesis intermediates; Ub [...] |
| PRP43 protein network | https://string-db.org/network/4932.YGL120C | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43; RNA helicase in the DEAH-box family; functions in both RNA polymerase I and polymerase II transcript metabolism; catalyzes removal of U2 [...] |
| GPG1 protein network | https://string-db.org/network/4932.YGL121C | Proposed gamma subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overprodu [...] |
| NAB2 protein network | https://string-db.org/network/4932.YGL122C | Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; stimulates RNA polymerase III transcription by enhancing TFIIIB binding to promoters; [...] |
| RPS2 protein network | https://string-db.org/network/4932.YGL123W | Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated o [...] |
| MON1 protein network | https://string-db.org/network/4932.YGL124C | Vacuolar fusion protein MON1; Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7 [...] |
| MET13 protein network | https://string-db.org/network/4932.YGL125W | Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway. |
| SCS3 protein network | https://string-db.org/network/4932.YGL126W | FIT family protein SCS3; Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthe [...] |
| SOH1 protein network | https://string-db.org/network/4932.YGL127C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazo [...] |
| CWC23 protein network | https://string-db.org/network/4932.YGL128C | Pre-mRNA-splicing factor CWC23; Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf2 [...] |
| RSM23 protein network | https://string-db.org/network/4932.YGL129C | Mitochondrial ribosomal protein of the small subunit; has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p [...] |
| CEG1 protein network | https://string-db.org/network/4932.YGL130W | mRNA-capping enzyme subunit alpha; Guanylyltransferase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of [...] |
| SNT2 protein network | https://string-db.org/network/4932.YGL131C | Subunit of Snt2C complex, RING finger ubiquitin ligase (E3); physically associates with Ecm5p and Rpd3p; along with Ecm5p, recruits Rpd3p to small number of promoters; colocalizes with Ecm5p, ind [...] |
| ITC1 protein network | https://string-db.org/network/4932.YGL133W | Imitation switch two complex protein 1; Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes, repression of early meiotic genes during mi [...] |
| PCL10 protein network | https://string-db.org/network/4932.YGL134W | Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate; PCL10 has a paralog, PCL8, that arose from the whole genome duplication. |
| RPL1B protein network | https://string-db.org/network/4932.YGL135W | Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplicati [...] |
| MRM2 protein network | https://string-db.org/network/4932.YGL136C | Mitochondrial 2' O-ribose methyltransferase; required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Sp [...] |
| SEC27 protein network | https://string-db.org/network/4932.YGL137W | Coatomer subunit beta; Essential beta'-coat protein of the COPI coatomer; involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% s [...] |
| YGL138C protein network | https://string-db.org/network/4932.YGL138C | Uncharacterized protein YGL138C; Putative protein of unknown function; has no significant sequence similarity to any known protein. |
| FLC3 protein network | https://string-db.org/network/4932.YGL139W | Putative flavin carrier protein 3; Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; FLC3 has a paralog, FLC1, that arose from the whole genome duplication; Belongs to th [...] |
| YGL140C protein network | https://string-db.org/network/4932.YGL140C | Uncharacterized membrane protein YGL140C; Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains. |
| HUL5 protein network | https://string-db.org/network/4932.YGL141W | Probable E3 ubiquitin-protein ligase HUL5; Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubi [...] |
| GPI10 protein network | https://string-db.org/network/4932.YGL142C | GPI mannosyltransferase 3; Integral membrane protein involved in GPI anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the glycosylphosphati [...] |
| MRF1 protein network | https://string-db.org/network/4932.YGL143C | Mitochondrial translation release factor; involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome in [...] |
| ROG1 protein network | https://string-db.org/network/4932.YGL144C | Putative lipase ROG1; Lipase with specificity for monoacylglycerol; preferred substrate is 1-oleoylglycerol; null mutation affects lipid droplet morphology and overexpression causes increased acc [...] |
| TIP20 protein network | https://string-db.org/network/4932.YGL145W | Peripheral membrane protein required for COPI vesicle fusion to the ER; mediates Sey1p-independent homotypic ER fusion; prohibits back-fusion of COPII vesicles with the ER; forms a tethering comp [...] |
| RRT6 protein network | https://string-db.org/network/4932.YGL146C | Regulator of rDNA transcription protein 6; Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two pu [...] |
| RPL9A protein network | https://string-db.org/network/4932.YGL147C | Ribosomal 60S subunit protein L9A; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9A has a paralog, RPL9B, that arose from a single-locus duplication. |
| ARO2 protein network | https://string-db.org/network/4932.YGL148W | Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; prot [...] |
| INO80 protein network | https://string-db.org/network/4932.YGL150C | Chromatin-remodeling ATPase INO80; ATPase and nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA hel [...] |
| NUT1 protein network | https://string-db.org/network/4932.YGL151W | Component of the RNA polymerase II mediator complex; mediator is required for transcriptional activation and also has a role in basal transcription. |
| YGL152C protein network | https://string-db.org/network/4932.YGL152C | Putative uncharacterized protein YGL152C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| PEX14 protein network | https://string-db.org/network/4932.YGL153W | Peroxisomal membrane protein PEX14; Central component of the peroxisomal importomer complex; peroxisomal protein import machinery docking complex component; interacts with both PTS1 (Pex5p) and P [...] |
| LYS5 protein network | https://string-db.org/network/4932.YGL154C | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate [...] |
| CDC43 protein network | https://string-db.org/network/4932.YGL155W | Beta subunit of geranylgeranyltransferase type I; subunit of the Ram2p-Cdc43p heterodimer that catalyzes the geranylgeranylation of the cysteine residue in proteins containing a C-terminal CaaX s [...] |
| AMS1 protein network | https://string-db.org/network/4932.YGL156W | Alpha-mannosidase; Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway. |
| ARI1 protein network | https://string-db.org/network/4932.YGL157W | NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily. |
| RCK1 protein network | https://string-db.org/network/4932.YGL158W | Serine/threonine-protein kinase RCK1; Protein kinase involved in oxidative stress response; promotes pseudohyphal growth via activation of Ubp3p phosphorylation; identified as suppressor of S. po [...] |
| YGL159W protein network | https://string-db.org/network/4932.YGL159W | Uncharacterized protein YGL159W; Putative protein of unknown function; deletion mutant has no detectable phenotype. |
| AIM14 protein network | https://string-db.org/network/4932.YGL160W | Probable metalloreductase AIM14; NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-media [...] |
| YIP5 protein network | https://string-db.org/network/4932.YGL161C | Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated tran [...] |
| SUT1 protein network | https://string-db.org/network/4932.YGL162W | Sterol uptake protein 1; Zn(II)2Cys6 family transcription factor; positively regulates sterol uptake genes under anaerobic conditions; involved in hypoxic gene expression; represses filamentation [...] |
| RAD54 protein network | https://string-db.org/network/4932.YGL163C | DNA repair and recombination protein RAD54; DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-st [...] |
| YRB30 protein network | https://string-db.org/network/4932.YGL164C | Ran-specific GTPase-activating protein 30; RanGTP-binding protein; inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in high [...] |
| YGL165C protein network | https://string-db.org/network/4932.YGL165C | Putative uncharacterized protein YGL165C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| CUP2 protein network | https://string-db.org/network/4932.YGL166W | Transcriptional activator protein CUP2; Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; [...] |
| PMR1 protein network | https://string-db.org/network/4932.YGL167C | Calcium-transporting ATPase 1; High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ tr [...] |
| HUR1 protein network | https://string-db.org/network/4932.YGL168W | Putative uncharacterized protein HUR1; Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene. |
| SUA5 protein network | https://string-db.org/network/4932.YGL169W | Threonylcarbamoyl-AMP synthase; Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6- [...] |
| SPO74 protein network | https://string-db.org/network/4932.YGL170C | Sporulation-specific protein 74; Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formati [...] |
| ROK1 protein network | https://string-db.org/network/4932.YGL171W | ATP-dependent RNA helicase ROK1; RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames [...] |
| NUP49 protein network | https://string-db.org/network/4932.YGL172W | FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; f [...] |
| XRN1 protein network | https://string-db.org/network/4932.YGL173C | 5'-3' exoribonuclease 1; Evolutionarily-conserved 5'-3' exonuclease; component of cytoplasmic processing (P) bodies involved in mRNA decay; also enters the nucleus and positively regulates transc [...] |
| BUD13 protein network | https://string-db.org/network/4932.YGL174W | Pre-mRNA-splicing factor CWC26; Subunit of the RES complex; RES complex is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar [...] |
| SAE2 protein network | https://string-db.org/network/4932.YGL175C | DNA endonuclease SAE2; Endonuclease required for telomere elongation; required for telomeric 5' C-rich strand resection; involved in ds-break repair and processing hairpin DNA structures with the [...] |
| YGL176C protein network | https://string-db.org/network/4932.YGL176C | Uncharacterized protein YGL176C; Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype. |
| YGL177W protein network | https://string-db.org/network/4932.YGL177W | Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| MPT5 protein network | https://string-db.org/network/4932.YGL178W | Suppressor protein MPT5; mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); [...] |
| TOS3 protein network | https://string-db.org/network/4932.YGL179C | Serine/threonine-protein kinase TOS3; Protein kinase; related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, [...] |
| ATG1 protein network | https://string-db.org/network/4932.YGL180W | Serine/threonine-protein kinase ATG1; Protein serine/threonine kinase; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for [...] |
| GTS1 protein network | https://string-db.org/network/4932.YGL181W | Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal [...] |
| YGL182C protein network | https://string-db.org/network/4932.YGL182C | Putative uncharacterized protein YGL182C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| MND1 protein network | https://string-db.org/network/4932.YGL183C | Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks. |
| STR3 protein network | https://string-db.org/network/4932.YGL184C | Peroxisomal cystathionine beta-lyase; converts cystathionine into homocysteine; may be redox regulated by Gto1p; involved in the release of the aromatic thiol 3-mercaptohexanol during wine fermen [...] |
| YGL185C protein network | https://string-db.org/network/4932.YGL185C | Putative protein with sequence similar to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. |
| TPN1 protein network | https://string-db.org/network/4932.YGL186C | Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, [...] |
| COX4 protein network | https://string-db.org/network/4932.YGL187C | Subunit IV of cytochrome c oxidase; the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; pho [...] |
| YGL188C protein network | https://string-db.org/network/4932.YGL188C | Putative uncharacterized protein YGL188C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YGL188C-A protein network | https://string-db.org/network/4932.YGL188C-A | Uncharacterized protein YGL188C-A; Putative protein of unknown function. |
| RPS26A protein network | https://string-db.org/network/4932.YGL189C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26A has a paralog, RPS26B, that arose from the whole genome duplica [...] |
| CDC55 protein network | https://string-db.org/network/4932.YGL190C | Regulatory subunit B of protein phosphatase 2A (PP2A); Zds1p/2p-dependent localization to cytoplasm promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuc [...] |
| COX13 protein network | https://string-db.org/network/4932.YGL191W | Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome [...] |
| IME4 protein network | https://string-db.org/network/4932.YGL192W | N6-adenosine-methyltransferase IME4; mRNA N6-adenosine methyltransferase required for entry into meiosis; mediates N6-adenosine methylation of bulk mRNA during the induction of sporulation which [...] |
| YGL193C protein network | https://string-db.org/network/4932.YGL193C | Uncharacterized protein YGL193C; Haploid-specific gene repressed by a1-alpha2; turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold. |
| HOS2 protein network | https://string-db.org/network/4932.YGL194C | Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic- [...] |
| GCN1 protein network | https://string-db.org/network/4932.YGL195W | eIF-2-alpha kinase activator GCN1; Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA; Belongs to the GCN1 f [...] |
| DSD1 protein network | https://string-db.org/network/4932.YGL196W | D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification [...] |
| MDS3 protein network | https://string-db.org/network/4932.YGL197W | Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like dom [...] |
| YIP4 protein network | https://string-db.org/network/4932.YGL198W | Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated tran [...] |
| YGL199C protein network | https://string-db.org/network/4932.YGL199C | Putative uncharacterized protein YGL199C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| EMP24 protein network | https://string-db.org/network/4932.YGL200C | Endosomal protein P24B; Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; inte [...] |
| MCM6 protein network | https://string-db.org/network/4932.YGL201C | DNA replication licensing factor MCM6; Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; forms [...] |
| ARO8 protein network | https://string-db.org/network/4932.YGL202W | Aromatic/aminoadipate aminotransferase 1; Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis. |
| KEX1 protein network | https://string-db.org/network/4932.YGL203C | Pheromone-processing carboxypeptidase KEX1; Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys an [...] |
| POX1 protein network | https://string-db.org/network/4932.YGL205W | Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix. |
| CHC1 protein network | https://string-db.org/network/4932.YGL206C | Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains [...] |
| SPT16 protein network | https://string-db.org/network/4932.YGL207W | Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and [...] |
| SIP2 protein network | https://string-db.org/network/4932.YGL208W | One of three beta subunits of the Snf1 kinase complex; involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and th [...] |
| MIG2 protein network | https://string-db.org/network/4932.YGL209W | Regulatory protein MIG2; Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced gene repression; under low glucose conditions relocalizes to mitochondrion, where it inter [...] |
| YPT32 protein network | https://string-db.org/network/4932.YGL210W | GTP-binding protein YPT32/YPT11; Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance inc [...] |
| NCS6 protein network | https://string-db.org/network/4932.YGL211W | Cytoplasmic tRNA 2-thiolation protein 1; Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRN [...] |
| VAM7 protein network | https://string-db.org/network/4932.YGL212W | Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SN [...] |
| SKI8 protein network | https://string-db.org/network/4932.YGL213C | Antiviral protein SKI8; Ski complex component and WD-repeat protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null m [...] |
| YGL214W protein network | https://string-db.org/network/4932.YGL214W | Putative uncharacterized protein YGL214W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation phe [...] |
| CLG1 protein network | https://string-db.org/network/4932.YGL215W | PHO85 cyclin CLG1; Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2. |
| KIP3 protein network | https://string-db.org/network/4932.YGL216W | Kinesin-like protein KIP3; Kinesin-related antiparallel sliding motor protein; involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genom [...] |
| YGL217C protein network | https://string-db.org/network/4932.YGL217C | Putative uncharacterized protein YGL217C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| YGL218W protein network | https://string-db.org/network/4932.YGL218W | Putative uncharacterized protein YGL218W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| MDM34 protein network | https://string-db.org/network/4932.YGL219C | Mitochondrial distribution and morphology protein 34; Mitochondrial component of the ERMES complex; links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange [...] |
| BOL2 protein network | https://string-db.org/network/4932.YGL220W | BolA-like protein 2; Cytosolic protein involved in repression of iron regulon transcription; forms an iron-independent complex with Fra1p, Grx3p, and Grx4p; null mutant fails to repress the iron [...] |
| NIF3 protein network | https://string-db.org/network/4932.YGL221C | NGG1-interacting factor 3; Protein of unknown function; similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified [...] |
| EDC1 protein network | https://string-db.org/network/4932.YGL222C | Enhancer of mRNA-decapping protein 1; RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role i [...] |
| COG1 protein network | https://string-db.org/network/4932.YGL223C | Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to [...] |
| SDT1 protein network | https://string-db.org/network/4932.YGL224C | Suppressor of disruption of TFIIS; Pyrimidine nucleotidase; responsible for production of nicotinamide riboside and nicotinic acid riboside; overexpression suppresses the 6-AU sensitivity of tran [...] |
| VRG4 protein network | https://string-db.org/network/4932.YGL225W | Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication; Belongs to the TPT transporter family. [...] |
| OST5 protein network | https://string-db.org/network/4932.YGL226C-A | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5; Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylati [...] |
| MTC3 protein network | https://string-db.org/network/4932.YGL226W | Maintenance of telomere capping protein 3, mitochondrial; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick wi [...] |
| VID30 protein network | https://string-db.org/network/4932.YGL227W | Vacuolar import and degradation protein 30; Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; [...] |
| SHE10 protein network | https://string-db.org/network/4932.YGL228W | Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; putative GPI-anchored protein; overexpression causes growth arrest;; SWAT-GFP, seamless-GFP a [...] |
| SAP4 protein network | https://string-db.org/network/4932.YGL229C | SIT4-associating protein SAP4; Protein required for function of the Sit4p protein phosphatase; member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, a [...] |
| YGL230C protein network | https://string-db.org/network/4932.YGL230C | Uncharacterized protein YGL230C; Putative protein of unknown function; non-essential gene. |
| EMC4 protein network | https://string-db.org/network/4932.YGL231C | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC [...] |
| TAN1 protein network | https://string-db.org/network/4932.YGL232W | Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modificati [...] |
| SEC15 protein network | https://string-db.org/network/4932.YGL233W | Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fus [...] |
| ADE5,7 protein network | https://string-db.org/network/4932.YGL234W | Bifunctional purine biosynthetic protein ADE5,7; Enzyme of the 'de novo' purine nucleotide biosynthetic pathway; contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase ac [...] |
| YGL235W protein network | https://string-db.org/network/4932.YGL235W | Uncharacterized protein YGL235W; Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 [...] |
| MTO1 protein network | https://string-db.org/network/4932.YGL236C | Mitochondrial protein; forms heterodimer complex with Mss1p that performs 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in pa [...] |
| HAP2 protein network | https://string-db.org/network/4932.YGL237C | Transcriptional activator HAP2; Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator o [...] |
| CSE1 protein network | https://string-db.org/network/4932.YGL238W | Importin alpha re-exporter; Nuclear envelope protein that acts as a recycling factor; mediates the nuclear export of Srp1p (importin alpha) back to the cytoplasm after its import substrates have [...] |
| DOC1 protein network | https://string-db.org/network/4932.YGL240W | Anaphase-promoting complex subunit DOC1; Processivity factor; required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to [...] |
| KAP114 protein network | https://string-db.org/network/4932.YGL241W | Importin subunit beta-5; Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those [...] |
| YGL242C protein network | https://string-db.org/network/4932.YGL242C | Ankyrin repeat-containing protein YGL242C; Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable. |
| TAD1 protein network | https://string-db.org/network/4932.YGL243W | tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala; Belongs to the ADAT1 family. |
| RTF1 protein network | https://string-db.org/network/4932.YGL244W | RNA polymerase-associated protein RTF1; Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences t [...] |
| GUS1 protein network | https://string-db.org/network/4932.YGL245W | Glutamate--tRNA ligase, cytoplasmic; Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of bo [...] |
| RAI1 protein network | https://string-db.org/network/4932.YGL246C | Nuclear protein with decapping endonuclease activity; targets mRNAs with unmethylated 7-methylguanosine cap structures and 5'-triphosphates; binds to and stabilizes the exoribonuclease Rat1p; req [...] |
| BRR6 protein network | https://string-db.org/network/4932.YGL247W | Nucleus export protein BRR6; Essential nuclear envelope integral membrane protein; interacts and functions with Apq12p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore comple [...] |
| PDE1 protein network | https://string-db.org/network/4932.YGL248W | 3',5'-cyclic-nucleotide phosphodiesterase 1; Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase [...] |
| ZIP2 protein network | https://string-db.org/network/4932.YGL249W | Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replica [...] |
| RMR1 protein network | https://string-db.org/network/4932.YGL250W | Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion pro [...] |
| HFM1 protein network | https://string-db.org/network/4932.YGL251C | Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; h [...] |
| RTG2 protein network | https://string-db.org/network/4932.YGL252C | Retrograde regulation protein 2; Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; R [...] |
| HXK2 protein network | https://string-db.org/network/4932.YGL253W | Hexokinase-2; Hexokinase isoenzyme 2; phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose; represses expression of HXK1, GLK1, induces expression of its own gene; a [...] |
| FZF1 protein network | https://string-db.org/network/4932.YGL254W | Zinc finger protein FZF1; Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants d [...] |
| ZRT1 protein network | https://string-db.org/network/4932.YGL255W | Zinc-regulated transporter 1; High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p t [...] |
| ADH4 protein network | https://string-db.org/network/4932.YGL256W | Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in respons [...] |
| MNT2 protein network | https://string-db.org/network/4932.YGL257C | Alpha-1,3-mannosyltransferase MNT2; Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans; Belongs to the MNN1/MNT family. |
| VEL1 protein network | https://string-db.org/network/4932.YGL258W | Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has a paralog, YOR387C, that arose from a single-locus duplicat [...] |
| YGL258W-A protein network | https://string-db.org/network/4932.YGL258W-A | Uncharacterized protein YGL258W-A; Putative protein of unknown function. |
| YPS5 protein network | https://string-db.org/network/4932.YGL259W | Yapsin-5; Protein with similarity to GPI-anchored aspartic proteases; such proteases are Yap1p and Yap3p; mCherry fusion protein localizes to the vacuole; Belongs to the peptidase A1 family. |
| YGL260W protein network | https://string-db.org/network/4932.YGL260W | Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium; Belongs to the UPF [...] |
| PAU11 protein network | https://string-db.org/network/4932.YGL261C | Putative protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2. |
| YGL262W protein network | https://string-db.org/network/4932.YGL262W | Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene; To yeast YER [...] |
| COS12 protein network | https://string-db.org/network/4932.YGL263W | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting [...] |
| EFM5 protein network | https://string-db.org/network/4932.YGR001C | Protein-lysine N-methyltransferase EFM5; S-adenosylmethionine-dependent lysine methyltransferase; involved in the trimethylation of eEF1A (Tef1p/Tef2p) at lysine 79; green fluorescent protein (GF [...] |
| SWC4 protein network | https://string-db.org/network/4932.YGR002C | SWR1-complex protein 4; Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex. |
| CUL3 protein network | https://string-db.org/network/4932.YGR003W | Cullin-3; Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53 [...] |
| PEX31 protein network | https://string-db.org/network/4932.YGR004W | Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps med [...] |
| TFG2 protein network | https://string-db.org/network/4932.YGR005C | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30. |
| PRP18 protein network | https://string-db.org/network/4932.YGR006W | Pre-mRNA-splicing factor 18; Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p [...] |
| ECT1 protein network | https://string-db.org/network/4932.YGR007W | Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphoc [...] |
| STF2 protein network | https://string-db.org/network/4932.YGR008C | ATPase-stabilizing factor 15 kDa protein; Protein involved in resistance to desiccation stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptos [...] |
| SEC9 protein network | https://string-db.org/network/4932.YGR009C | t-SNARE protein required for secretory vesicle-plasma membrane fusion; similar to but not functionally redundant with Spo20p; interacts non-exocyst bound Sec6p; SNAP-25 homolog. |
| NMA2 protein network | https://string-db.org/network/4932.YGR010W | Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NA [...] |
| MCY1 protein network | https://string-db.org/network/4932.YGR012W | Putative cysteine synthase; localized to the mitochondrial outer membrane. |
| SNU71 protein network | https://string-db.org/network/4932.YGR013W | U1 small nuclear ribonucleoprotein component SNU71; Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; Belongs to the SNU71 family. |
| MSB2 protein network | https://string-db.org/network/4932.YGR014W | Signaling mucin MSB2; Mucin family member involved in various signaling pathways; functions as osmosensor in the Sho1p-mediated HOG pathway; functions in Cdc42p- and MAP kinase-dependent filament [...] |
| YGR015C protein network | https://string-db.org/network/4932.YGR015C | Ethanol acetyltransferase 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion. |
| YGR016W protein network | https://string-db.org/network/4932.YGR016W | Uncharacterized membrane protein YGR016W; Putative protein of unknown function. |
| YGR017W protein network | https://string-db.org/network/4932.YGR017W | Uncharacterized protein YGR017W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm. |
| UGA1 protein network | https://string-db.org/network/4932.YGR019W | 4-aminobutyrate aminotransferase; Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; requ [...] |
| VMA7 protein network | https://string-db.org/network/4932.YGR020C | Subunit F of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar [...] |
| YGR021W protein network | https://string-db.org/network/4932.YGR021W | Probable transcriptional regulatory protein HAH1; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; B [...] |
| YGR022C protein network | https://string-db.org/network/4932.YGR022C | Putative uncharacterized protein YGR022C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost compl [...] |
| MTL1 protein network | https://string-db.org/network/4932.YGR023W | Protein MTL1; Putative plasma membrane sensor; involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to [...] |
| THG1 protein network | https://string-db.org/network/4932.YGR024C | tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse (3'-5') polymerization with certain substrates [...] |
| YGR026W protein network | https://string-db.org/network/4932.YGR026W | Uncharacterized membrane protein YGR026W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery. |
| RPS25A protein network | https://string-db.org/network/4932.YGR027C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplica [...] |
| MSP1 protein network | https://string-db.org/network/4932.YGR028W | Protein MSP1; Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; functions as an extrac [...] |
| ERV1 protein network | https://string-db.org/network/4932.YGR029W | Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space [...] |
| POP6 protein network | https://string-db.org/network/4932.YGR030C | Ribonucleases P/MRP protein subunit POP6; Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop7p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MR [...] |
| NAG1 protein network | https://string-db.org/network/4932.YGR031C-A | Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO3 [...] |
| IMO32 protein network | https://string-db.org/network/4932.YGR031W | Probable alcohol acetyltransferase; Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene c [...] |
| GSC2 protein network | https://string-db.org/network/4932.YGR032W | Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1 [...] |
| TIM21 protein network | https://string-db.org/network/4932.YGR033C | Mitochondrial import inner membrane translocase subunit TIM21; Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and wi [...] |
| RPL26B protein network | https://string-db.org/network/4932.YGR034W | Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosoma [...] |
| YGR035C protein network | https://string-db.org/network/4932.YGR035C | Uncharacterized protein YGR035C; Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes [...] |
| CAX4 protein network | https://string-db.org/network/4932.YGR036C | Dolichyldiphosphatase; Dolichyl pyrophosphate (Dol-P-P) phosphatase; has a luminally oriented active site in the ER; cleaves the anhydride linkage in Dol-P-P; required for Dol-P-P-linked oligosac [...] |
| ACB1 protein network | https://string-db.org/network/4932.YGR037C | Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unco [...] |
| ORM1 protein network | https://string-db.org/network/4932.YGR038W | Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogen [...] |
| YGR039W protein network | https://string-db.org/network/4932.YGR039W | Uncharacterized protein YGR039W; Putative protein of unknown function; conserved among S. cerevisiae strains; YGR039W is not an essential gene. |
| KSS1 protein network | https://string-db.org/network/4932.YGR040W | Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate [...] |
| BUD9 protein network | https://string-db.org/network/4932.YGR041W | Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the dist [...] |
| MTE1 protein network | https://string-db.org/network/4932.YGR042W | Uncharacterized protein YGR042W; Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and [...] |
| NQM1 protein network | https://string-db.org/network/4932.YGR043C | Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication [...] |
| RME1 protein network | https://string-db.org/network/4932.YGR044C | Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; m [...] |
| YGR045C protein network | https://string-db.org/network/4932.YGR045C | Uncharacterized protein YGR045C; Putative protein of unknown function; conserved across S. cerevisiae strains. |
| TAM41 protein network | https://string-db.org/network/4932.YGR046W | Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displ [...] |
| TFC4 protein network | https://string-db.org/network/4932.YGR047C | Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIII [...] |
| UFD1 protein network | https://string-db.org/network/4932.YGR048W | Ubiquitin fusion degradation protein 1; Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substra [...] |
| SCM4 protein network | https://string-db.org/network/4932.YGR049W | Protein SCM4; Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutat [...] |
| YGR050C protein network | https://string-db.org/network/4932.YGR050C | Uncharacterized protein YGR050C; Protein of unknown function; mRNA identified as translated by ribosome profiling data. |
| FMP48 protein network | https://string-db.org/network/4932.YGR052W | Probable serine/threonine-protein kinase FMP48; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ind [...] |
| YGR053C protein network | https://string-db.org/network/4932.YGR053C | Uncharacterized protein YGR053C; Putative protein of unknown function. |
| YGR054W protein network | https://string-db.org/network/4932.YGR054W | Eukaryotic initiation factor eIF2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A; Belongs [...] |
| MUP1 protein network | https://string-db.org/network/4932.YGR055W | High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; To yeast low affinity methionine permease (MUP3). |
| RSC1 protein network | https://string-db.org/network/4932.YGR056W | Chromatin structure-remodeling complex subunit RSC1; Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential brom [...] |
| LST7 protein network | https://string-db.org/network/4932.YGR057C | Protein LST7; Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, [...] |
| PEF1 protein network | https://string-db.org/network/4932.YGR058W | Peflin; Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p [...] |
| SPR3 protein network | https://string-db.org/network/4932.YGR059W | Sporulation-regulated protein 3; Sporulation-specific homolog of the CDC3/10/11/12 family of genes; septin protein involved in sporulation; regulated by ABFI; the yeast CDC3/10/11/12 family is a [...] |
| ERG25 protein network | https://string-db.org/network/4932.YGR060W | Methylsterol monooxygenase; C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumul [...] |
| ADE6 protein network | https://string-db.org/network/4932.YGR061C | Phosphoribosylformylglycinamidine synthase; Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway. |
| COX18 protein network | https://string-db.org/network/4932.YGR062C | Cytochrome c oxidase assembly protein COX18, mitochondrial; Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically an [...] |
| SPT4 protein network | https://string-db.org/network/4932.YGR063C | Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and along with RNAP I and II has multiple roles regulating transc [...] |
| YGR064W protein network | https://string-db.org/network/4932.YGR064W | Putative uncharacterized protein YGR064W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| VHT1 protein network | https://string-db.org/network/4932.YGR065C | Vitamin H transporter; High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily mem [...] |
| YGR066C protein network | https://string-db.org/network/4932.YGR066C | Uncharacterized protein YGR066C; Putative protein of unknown function. |
| YGR067C protein network | https://string-db.org/network/4932.YGR067C | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p. |
| ART5 protein network | https://string-db.org/network/4932.YGR068C | Arrestin-related trafficking adapter 5; Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membra [...] |
| YGR068W-A protein network | https://string-db.org/network/4932.YGR068W-A | Putative uncharacterized protein YGR068W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| YGR069W protein network | https://string-db.org/network/4932.YGR069W | Putative uncharacterized protein YGR069W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| ROM1 protein network | https://string-db.org/network/4932.YGR070W | Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome [...] |
| ENV11 protein network | https://string-db.org/network/4932.YGR071C | Late endosome and vacuole interface protein 11; Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased [...] |
| UPF3 protein network | https://string-db.org/network/4932.YGR072W | Component of the nonsense-mediated mRNA decay (NMD) pathway; along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance; Belongs to the REN [...] |
| SMD1 protein network | https://string-db.org/network/4932.YGR074W | Small nuclear ribonucleoprotein Sm D1; Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and [...] |
| PRP38 protein network | https://string-db.org/network/4932.YGR075C | Pre-mRNA-splicing factor 38; Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dis [...] |
| MRPL25 protein network | https://string-db.org/network/4932.YGR076C | Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan. |
| PEX8 protein network | https://string-db.org/network/4932.YGR077C | Peroxisomal biogenesis factor 8; Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING fing [...] |
| PAC10 protein network | https://string-db.org/network/4932.YGR078C | Prefoldin subunit 3; Part of the heteromeric co-chaperone GimC/prefoldin complex; complex promotes efficient protein folding; Belongs to the prefoldin subunit alpha family. |
| YGR079W protein network | https://string-db.org/network/4932.YGR079W | Putative protein of unknown function; YGR079W is not an essential gene. |
| TWF1 protein network | https://string-db.org/network/4932.YGR080W | Twinfilin-1; Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering [...] |
| SLX9 protein network | https://string-db.org/network/4932.YGR081C | Ribosome biogenesis protein SLX9; Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion muta [...] |
| TOM20 protein network | https://string-db.org/network/4932.YGR082W | Mitochondrial import receptor subunit TOM20; Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed pr [...] |
| GCD2 protein network | https://string-db.org/network/4932.YGR083C | Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative r [...] |
| MRP13 protein network | https://string-db.org/network/4932.YGR084C | Mitochondrial ribosomal protein of the small subunit. |
| RPL11B protein network | https://string-db.org/network/4932.YGR085C | Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal [...] |
| PIL1 protein network | https://string-db.org/network/4932.YGR086C | Sphingolipid long chain base-responsive protein PIL1; Eisosome core component; eisosomes are large immobile cell cortex structures associated with endocytosis; detected in phosphorylated state in [...] |
| PDC6 protein network | https://string-db.org/network/4932.YGR087C | Minor isoform of pyruvate decarboxylase; decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced durin [...] |
| CTT1 protein network | https://string-db.org/network/4932.YGR088W | Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide. |
| NNF2 protein network | https://string-db.org/network/4932.YGR089W | Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data su [...] |
| UTP22 protein network | https://string-db.org/network/4932.YGR090W | U3 small nucleolar RNA-associated protein 22; Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their del [...] |
| PRP31 protein network | https://string-db.org/network/4932.YGR091W | Pre-mRNA-processing factor 31; Splicing factor; component of the U4/U6-U5 snRNP complex; Belongs to the PRP31 family. |
| DBF2 protein network | https://string-db.org/network/4932.YGR092W | Cell cycle protein kinase DBF2; Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; a [...] |
| DRN1 protein network | https://string-db.org/network/4932.YGR093W | CWF19-like protein DRN1; Splicing factor that modulates turnover of branched RNAs by Dbr1p; interacts with spliceosomal components and branched RNA splicing products; enhances Dbr1p debranching i [...] |
| VAS1 protein network | https://string-db.org/network/4932.YGR094W | Valine--tRNA ligase, mitochondrial; Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant; Belo [...] |
| RRP46 protein network | https://string-db.org/network/4932.YGR095C | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5). |
| TPC1 protein network | https://string-db.org/network/4932.YGR096W | Mitochondrial thiamine pyrophosphate carrier 1; Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears t [...] |
| ASK10 protein network | https://string-db.org/network/4932.YGR097W | Activator of SKN7 protein 10; Regulator of the Fps1p glycerol channel; under nonstress conditions, binds to Fps1p to positively regulate glycerol transport; under osmotic stress, multiple phospho [...] |
| ESP1 protein network | https://string-db.org/network/4932.YGR098C | Separin; Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to [...] |
| TEL2 protein network | https://string-db.org/network/4932.YGR099W | Telomere length regulation protein TEL2; Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast [...] |
| MDR1 protein network | https://string-db.org/network/4932.YGR100W | Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function. |
| PCP1 protein network | https://string-db.org/network/4932.YGR101W | Rhomboid protein 1, mitochondrial; Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the [...] |
| GTF1 protein network | https://string-db.org/network/4932.YGR102C | Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is sa [...] |
| NOP7 protein network | https://string-db.org/network/4932.YGR103W | Pescadillo homolog; Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit [...] |
| SRB5 protein network | https://string-db.org/network/4932.YGR104C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper [...] |
| VMA21 protein network | https://string-db.org/network/4932.YGR105W | Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; diverged ortholog of human XMEA (X-linked Myopathy with Excessive A [...] |
| VOA1 protein network | https://string-db.org/network/4932.YGR106C | ER protein that functions in assembly of the V0 sector of V-ATPase; functions with other assembly factors; null mutation enhances the vacuolar ATPase (V-ATPase) deficiency of a vma21 mutant impai [...] |
| CLB1 protein network | https://string-db.org/network/4932.YGR108W | G2/mitotic-specific cyclin-1; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a des [...] |
| CLB6 protein network | https://string-db.org/network/4932.YGR109C | S-phase entry cyclin-6; B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Cl [...] |
| CLD1 protein network | https://string-db.org/network/4932.YGR110W | Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transpos [...] |
| YGR111W protein network | https://string-db.org/network/4932.YGR111W | Uncharacterized protein YGR111W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus. |
| SHY1 protein network | https://string-db.org/network/4932.YGR112W | Cytochrome oxidase assembly protein SHY1; Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV super [...] |
| DAM1 protein network | https://string-db.org/network/4932.YGR113W | Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Duo1p to connect the DASH complex with the microtubules (MT); couples kinetochores to the force produced by MT depolymeri [...] |
| YGR115C protein network | https://string-db.org/network/4932.YGR115C | Putative uncharacterized protein YGR115C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| SPT6 protein network | https://string-db.org/network/4932.YGR116W | Transcription elongation factor SPT6; Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chro [...] |
| YGR117C protein network | https://string-db.org/network/4932.YGR117C | Uncharacterized protein YGR117C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. |
| RPS23A protein network | https://string-db.org/network/4932.YGR118W | Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23 [...] |
| NUP57 protein network | https://string-db.org/network/4932.YGR119C | FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; f [...] |
| COG2 protein network | https://string-db.org/network/4932.YGR120C | Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; t [...] |
| MEP1 protein network | https://string-db.org/network/4932.YGR121C | Ammonium transporter MEP1; Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repr [...] |
| YGR121W-A protein network | https://string-db.org/network/4932.YGR121W-A | Uncharacterized protein YGR121W-A; Putative protein of unknown function. |
| YGR122C-A protein network | https://string-db.org/network/4932.YGR122C-A | Putative uncharacterized protein YGR122C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; similar to YLR334C [...] |
| YGR122W protein network | https://string-db.org/network/4932.YGR122W | Uncharacterized protein YGR122W; Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null [...] |
| PPT1 protein network | https://string-db.org/network/4932.YGR123C | Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus an [...] |
| ASN2 protein network | https://string-db.org/network/4932.YGR124W | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication. |
| YGR125W protein network | https://string-db.org/network/4932.YGR125W | Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent prot [...] |
| YGR126W protein network | https://string-db.org/network/4932.YGR126W | Uncharacterized protein YGR126W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to [...] |
| YGR127W protein network | https://string-db.org/network/4932.YGR127W | Uncharacterized protein YGR127W; Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response. |
| UTP8 protein network | https://string-db.org/network/4932.YGR128C | U3 small nucleolar RNA-associated protein 8; Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that [...] |
| SYF2 protein network | https://string-db.org/network/4932.YGR129W | Pre-mRNA-splicing factor SYF2; Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalize [...] |
| YGR130C protein network | https://string-db.org/network/4932.YGR130C | Uncharacterized protein YGR130C; Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinosito [...] |
| FHN1 protein network | https://string-db.org/network/4932.YGR131W | Non-classical export protein 2 homolog 1; Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-bind [...] |
| PHB1 protein network | https://string-db.org/network/4932.YGR132C | Prohibitin-1; Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant o [...] |
| PEX4 protein network | https://string-db.org/network/4932.YGR133W | Ubiquitin-conjugating enzyme E2-21 kDa; Peroxisomal ubiquitin conjugating enzyme; required for peroxisomal matrix protein import and peroxisome biogenesis. |
| CAF130 protein network | https://string-db.org/network/4932.YGR134W | Protein CAF130; Subunit of the CCR4-NOT transcriptional regulatory complex; CCR4-NOT complex is evolutionarily-conserved and involved in controlling mRNA initiation, elongation, and degradation. |
| PRE9 protein network | https://string-db.org/network/4932.YGR135W | Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform; Belon [...] |
| LSB1 protein network | https://string-db.org/network/4932.YGR136W | LAS seventeen-binding protein 1; Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-term [...] |
| YGR137W protein network | https://string-db.org/network/4932.YGR137W | Putative uncharacterized protein YGR137W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| TPO2 protein network | https://string-db.org/network/4932.YGR138C | Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TP [...] |
| CBF2 protein network | https://string-db.org/network/4932.YGR140W | Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different mult [...] |
| VPS62 protein network | https://string-db.org/network/4932.YGR141W | Vacuolar protein sorting (VPS) protein; required for cytoplasm to vacuole targeting of proteins; VPS62 has a paralog, TDA6, that arose from the whole genome duplication. |
| BTN2 protein network | https://string-db.org/network/4932.YGR142W | v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and pla [...] |
| SKN1 protein network | https://string-db.org/network/4932.YGR143W | Protein involved in sphingolipid biosynthesis; type II membrane protein; SKN1 has a paralog, KRE6, that arose from the whole genome duplication. |
| THI4 protein network | https://string-db.org/network/4932.YGR144W | Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the s [...] |
| ENP2 protein network | https://string-db.org/network/4932.YGR145W | Ribosome biogenesis protein ENP2; Component of the SSU; required for pre-18S rRNA processing, biogenesis of the small ribosomal subunit; interacts with U3 snoRNA, Mpp10p and Bfr2p; contains WD re [...] |
| ECL1 protein network | https://string-db.org/network/4932.YGR146C | Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results i [...] |
| YGR146C-A protein network | https://string-db.org/network/4932.YGR146C-A | Uncharacterized protein YGR146C-A; Putative protein of unknown function. |
| NAT2 protein network | https://string-db.org/network/4932.YGR147C | Putative N-terminal acetyltransferase 2; Protein of unknown function; has an apparent role in acetylation of N-terminal methionine residues. |
| RPL24B protein network | https://string-db.org/network/4932.YGR148C | Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has [...] |
| GPC1 protein network | https://string-db.org/network/4932.YGR149W | Glycerophosphocholine acyltransferase (GPCAT); involved in in phosphatidylcholine (PC) synthesis; uses acetyl-CoA to acylate glycero-3-phosphocholine to yield lyso-PC; also catalyzes acylation of [...] |
| CCM1 protein network | https://string-db.org/network/4932.YGR150C | Mitochondrial group I intron splicing factor CCM1; Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial [...] |
| YGR151C protein network | https://string-db.org/network/4932.YGR151C | Uncharacterized protein YGR151C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely wit [...] |
| RSR1 protein network | https://string-db.org/network/4932.YGR152C | Ras-related protein RSR1; GTP-binding protein of the Ras superfamily; required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized [...] |
| YGR153W protein network | https://string-db.org/network/4932.YGR153W | Uncharacterized protein YGR153W; Putative protein of unknown function. |
| GTO1 protein network | https://string-db.org/network/4932.YGR154C | Glutathione S-transferase omega-like 1; Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization. |
| CYS4 protein network | https://string-db.org/network/4932.YGR155W | Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; adv [...] |
| PTI1 protein network | https://string-db.org/network/4932.YGR156W | Protein PTI1; Essential component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in respo [...] |
| CHO2 protein network | https://string-db.org/network/4932.YGR157W | Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylchol [...] |
| MTR3 protein network | https://string-db.org/network/4932.YGR158C | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6). |
| NSR1 protein network | https://string-db.org/network/4932.YGR159C | Nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis; binds to single stranded telomeric DNA and mRNA; methylated by Hmt1p; intera [...] |
| YGR160W protein network | https://string-db.org/network/4932.YGR160W | Putative uncharacterized protein YGR160W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| RTS3 protein network | https://string-db.org/network/4932.YGR161C | Putative component of the protein phosphatase type 2A complex. |
| YGR161W-C protein network | https://string-db.org/network/4932.YGR161W-C | Uncharacterized protein YGR161W-C; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species. |
| TIF4631 protein network | https://string-db.org/network/4932.YGR162W | Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in bio [...] |
| GTR2 protein network | https://string-db.org/network/4932.YGR163W | GTP-binding protein GTR2; Subunit of a TORC1-stimulating GTPase complex; subunit of the Gtr1-Gtr2 GTPase complex that stimulates TORC1 in response to amino acid stimulation; stimulates the GTPase [...] |
| YGR164W protein network | https://string-db.org/network/4932.YGR164W | Uncharacterized protein YGR164W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| MRPS35 protein network | https://string-db.org/network/4932.YGR165W | Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets. |
| TRS65 protein network | https://string-db.org/network/4932.YGR166W | Trafficking protein particle complex II-specific subunit 65; Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase [...] |
| CLC1 protein network | https://string-db.org/network/4932.YGR167W | Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the cl [...] |
| YGR168C protein network | https://string-db.org/network/4932.YGR168C | Putative protein of unknown function; YGR168C is not an essential gene. |
| PUS6 protein network | https://string-db.org/network/4932.YGR169C | tRNA:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not e [...] |
| LSO2 protein network | https://string-db.org/network/4932.YGR169C-A | Protein with a potential role in response to iron deprivation; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions; null mutant exhibits slow gr [...] |
| PSD2 protein network | https://string-db.org/network/4932.YGR170W | Phosphatidylserine decarboxylase 2 alpha chain; Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar me [...] |
| MSM1 protein network | https://string-db.org/network/4932.YGR171C | Methionine--tRNA ligase, mitochondrial; Mitochondrial methionyl-tRNA synthetase (MetRS); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS althou [...] |
| YIP1 protein network | https://string-db.org/network/4932.YGR172C | Integral membrane protein; required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; human homolog YI [...] |
| RBG2 protein network | https://string-db.org/network/4932.YGR173W | Ribosome-interacting GTPase 2; Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein; Belongs to the TRAFAC cla [...] |
| CBP4 protein network | https://string-db.org/network/4932.YGR174C | Assembly factor CBP4; Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly o [...] |
| YGR174W-A protein network | https://string-db.org/network/4932.YGR174W-A | Uncharacterized protein YGR174W-A; Putative protein of unknown function; predicted to have a role in cell budding based on computational "guilt by association" analysis. |
| ERG1 protein network | https://string-db.org/network/4932.YGR175C | Squalene epoxidase; catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug te [...] |
| YGR176W protein network | https://string-db.org/network/4932.YGR176W | Putative uncharacterized protein YGR176W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| ATF2 protein network | https://string-db.org/network/4932.YGR177C | Alcohol O-acetyltransferase 2; Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking. |
| PBP1 protein network | https://string-db.org/network/4932.YGR178C | PAB1-binding protein 1; Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA p [...] |
| OKP1 protein network | https://string-db.org/network/4932.YGR179C | Inner kinetochore subunit OKP1; Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions [...] |
| RNR4 protein network | https://string-db.org/network/4932.YGR180C | Ribonucleoside-diphosphate reductase small chain 2; Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated b [...] |
| TIM13 protein network | https://string-db.org/network/4932.YGR181W | Mitochondrial import inner membrane translocase subunit TIM13; Mitochondrial intermembrane space protein; forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 co [...] |
| YGR182C protein network | https://string-db.org/network/4932.YGR182C | Putative uncharacterized protein YGR182C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| QCR9 protein network | https://string-db.org/network/4932.YGR183C | Subunit 9 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquin [...] |
| UBR1 protein network | https://string-db.org/network/4932.YGR184C | E3 ubiquitin ligase (N-recognin); heterodimerizes with Rad6p to recognize and ubiquitinate substrates of the N-end rule pathway; role in endoplasmic reticulum-associated protein degradation (ERAD [...] |
| TYS1 protein network | https://string-db.org/network/4932.YGR185C | Tyrosine--tRNA ligase, cytoplasmic; Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in huma [...] |
| TFG1 protein network | https://string-db.org/network/4932.YGR186W | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74. |
| HGH1 protein network | https://string-db.org/network/4932.YGR187C | Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (B [...] |
| BUB1 protein network | https://string-db.org/network/4932.YGR188C | Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylat [...] |
| CRH1 protein network | https://string-db.org/network/4932.YGR189C | Probable glycosidase CRH1; Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes [...] |
| YGR190C protein network | https://string-db.org/network/4932.YGR190C | Putative uncharacterized protein YGR190C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified [...] |
| HIP1 protein network | https://string-db.org/network/4932.YGR191W | High-affinity histidine permease; also involved in the transport of manganese ions. |
| TDH3 protein network | https://string-db.org/network/4932.YGR192C | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglyce [...] |
| PDX1 protein network | https://string-db.org/network/4932.YGR193C | E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoami [...] |
| XKS1 protein network | https://string-db.org/network/4932.YGR194C | Xylulokinase; converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains. |
| SKI6 protein network | https://string-db.org/network/4932.YGR195W | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4). |
| FYV8 protein network | https://string-db.org/network/4932.YGR196C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. |
| SNG1 protein network | https://string-db.org/network/4932.YGR197C | Protein involved in resistance to nitrosoguanidine and 6-azauracil; expression is regulated by transcription factors involved in multidrug resistance; SNG1 has a paralog, YJR015W, that arose from [...] |
| YPP1 protein network | https://string-db.org/network/4932.YGR198W | Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4p; is required, along with Efr3p, for the assembly and recruitment of multiple copies of the kina [...] |
| PMT6 protein network | https://string-db.org/network/4932.YGR199W | Dolichyl-phosphate-mannose--protein mannosyltransferase 6; Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory pro [...] |
| ELP2 protein network | https://string-db.org/network/4932.YGR200C | Subunit of Elongator complex; binds to microtubules via conserved alkaline residues; has two seven-bladed WD40 β propellers; Elongator complex is required for modification of wobble nucleosi [...] |
| YGR201C protein network | https://string-db.org/network/4932.YGR201C | Putative elongation factor 1 gamma homolog; Putative protein of unknown function. |
| PCT1 protein network | https://string-db.org/network/4932.YGR202C | Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an eleme [...] |
| YCH1 protein network | https://string-db.org/network/4932.YGR203W | CDC25-like phosphatase YCH1; Phosphatase with sequence similarity to Cdc25p; Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion pr [...] |
| YGR204C-A protein network | https://string-db.org/network/4932.YGR204C-A | Uncharacterized protein YGR204C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| ADE3 protein network | https://string-db.org/network/4932.YGR204W | C-1-tetrahydrofolate synthase, cytoplasmic; Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase; involved in single carbon metabolism and required for biosynthesis of purines, thymidyla [...] |
| TDA10 protein network | https://string-db.org/network/4932.YGR205W | Probable ATP-dependent kinase TDA10; ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to e [...] |
| MVB12 protein network | https://string-db.org/network/4932.YGR206W | Multivesicular body sorting factor 12; ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers; the ESCRT-I core complex (Stp22p, Vps28p, Srn2p) is involved in ubiquitin-dependent so [...] |
| CIR1 protein network | https://string-db.org/network/4932.YGR207C | Probable electron transfer flavoprotein subunit beta; Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF [...] |
| SER2 protein network | https://string-db.org/network/4932.YGR208W | Phosphoserine phosphatase of the phosphoglycerate pathway; involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source. |
| TRX2 protein network | https://string-db.org/network/4932.YGR209C | Thioredoxin-2; Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa [...] |
| YGR210C protein network | https://string-db.org/network/4932.YGR210C | Uncharacterized GTP-binding protein YGR210C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. |
| ZPR1 protein network | https://string-db.org/network/4932.YGR211W | Essential protein with two zinc fingers; present in nucleus of growing cells, relocates to cytoplasm in starved cells via a process mediated by Cpr1p; binds translation elongation factor eEF-1 (T [...] |
| SLI1 protein network | https://string-db.org/network/4932.YGR212W | N-acetyltransferase; confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myri [...] |
| RTA1 protein network | https://string-db.org/network/4932.YGR213C | Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-t [...] |
| RPS0A protein network | https://string-db.org/network/4932.YGR214W | Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human r [...] |
| RSM27 protein network | https://string-db.org/network/4932.YGR215W | Mitochondrial ribosomal protein of the small subunit. |
| GPI1 protein network | https://string-db.org/network/4932.YGR216C | Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1; Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first inte [...] |
| CCH1 protein network | https://string-db.org/network/4932.YGR217W | Calcium-channel protein CCH1; Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interact [...] |
| CRM1 protein network | https://string-db.org/network/4932.YGR218W | Exportin-1; Major karyopherin; involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin. |
| MRPL9 protein network | https://string-db.org/network/4932.YGR220C | Mitochondrial ribosomal protein of the large subunit. |
| TOS2 protein network | https://string-db.org/network/4932.YGR221C | Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p; TOS2 has a paralog [...] |
| PET54 protein network | https://string-db.org/network/4932.YGR222W | Protein PET54; Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 [...] |
| HSV2 protein network | https://string-db.org/network/4932.YGR223C | SVP1-like protein 2; Phosphatidylinositol 3,5-bisphosphate-binding protein; plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-p [...] |
| AZR1 protein network | https://string-db.org/network/4932.YGR224W | Azole resistance protein 1; Plasma membrane transporter of the major facilitator superfamily; involved in resistance to azole drugs such as ketoconazole and fluconazole. |
| AMA1 protein network | https://string-db.org/network/4932.YGR225W | Meiosis-specific APC/C activator protein AMA1; Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p de [...] |
| YGR226C protein network | https://string-db.org/network/4932.YGR226C | Putative uncharacterized protein YGR226C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| DIE2 protein network | https://string-db.org/network/4932.YGR227W | Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase; located in the ER; functions in pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycos [...] |
| YGR228W protein network | https://string-db.org/network/4932.YGR228W | Putative uncharacterized protein YGR228W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| SMI1 protein network | https://string-db.org/network/4932.YGR229C | Cell wall assembly regulator SMI1; Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity. |
| BNS1 protein network | https://string-db.org/network/4932.YGR230W | Protein of unknown function; overexpression bypasses need for Spo12p, but not required for meiosis; BNS1 has a paralog, SPO12, that arose from the whole genome duplication. |
| PHB2 protein network | https://string-db.org/network/4932.YGR231C | Prohibitin-2; Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant o [...] |
| NAS6 protein network | https://string-db.org/network/4932.YGR232W | Probable 26S proteasome regulatory subunit p28; Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex [...] |
| PHO81 protein network | https://string-db.org/network/4932.YGR233C | Phosphate system positive regulatory protein PHO81; Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibit [...] |
| YHB1 protein network | https://string-db.org/network/4932.YGR234W | Flavohemoprotein; Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growt [...] |
| MIC26 protein network | https://string-db.org/network/4932.YGR235C | MICOS subunit MIC26; Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the main [...] |
| SPG1 protein network | https://string-db.org/network/4932.YGR236C | Stationary phase gene 1 protein; Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protei [...] |
| YGR237C protein network | https://string-db.org/network/4932.YGR237C | Uncharacterized protein YGR237C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. |
| KEL2 protein network | https://string-db.org/network/4932.YGR238C | Kelch repeat-containing protein 2; Protein that negatively regulates mitotic exit; forms a complex with Kel1p and Bud14p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, [...] |
| PEX21 protein network | https://string-db.org/network/4932.YGR239C | Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; constitutively expressed; partially redundant with Pex18p [...] |
| PFK1 protein network | https://string-db.org/network/4932.YGR240C | Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose inducti [...] |
| YAP1802 protein network | https://string-db.org/network/4932.YGR241C | Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication; Belongs to the AP180 famil [...] |
| YGR242W protein network | https://string-db.org/network/4932.YGR242W | Putative uncharacterized protein YGR242W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| MPC3 protein network | https://string-db.org/network/4932.YGR243W | Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on nonfermentable carbon sources, and heterodimerizes with Mpc1p to form the respiratory isoform of M [...] |
| LSC2 protein network | https://string-db.org/network/4932.YGR244C | Beta subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate. |
| SDA1 protein network | https://string-db.org/network/4932.YGR245C | Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; [...] |
| BRF1 protein network | https://string-db.org/network/4932.YGR246C | TFIIIB B-related factor; one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is hom [...] |
| CPD1 protein network | https://string-db.org/network/4932.YGR247W | 2',3'-cyclic-nucleotide 3'-phosphodiesterase; Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; n [...] |
| SOL4 protein network | https://string-db.org/network/4932.YGR248W | 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication. |
| MGA1 protein network | https://string-db.org/network/4932.YGR249W | Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants. |
| RIE1 protein network | https://string-db.org/network/4932.YGR250C | Uncharacterized RNA-binding protein YGR250C; Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundan [...] |
| NOP19 protein network | https://string-db.org/network/4932.YGR251W | Nucleolar protein 19; Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts [...] |
| GCN5 protein network | https://string-db.org/network/4932.YGR252W | Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, alt [...] |
| PUP2 protein network | https://string-db.org/network/4932.YGR253C | Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta; Belongs to the peptidase T1A family. |
| ENO1 protein network | https://string-db.org/network/4932.YGR254W | Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed i [...] |
| COQ6 protein network | https://string-db.org/network/4932.YGR255C | Flavin-dependent monooxygenase involved in ubiquinone biosynthesis; responsible for hydroxylation at position C5 and deamination at C4 during ubiquinone (Coenzyme Q) biosynthesis; localizes to ma [...] |
| GND2 protein network | https://string-db.org/network/4932.YGR256W | 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, [...] |
| MTM1 protein network | https://string-db.org/network/4932.YGR257C | Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5'-phosphate (PLP) transporter, important for delivery of PLP cofactor to mitochondrial enzymes; involved in mit [...] |
| RAD2 protein network | https://string-db.org/network/4932.YGR258C | DNA repair protein RAD2; Single-stranded DNA endonuclease; cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF [...] |
| YGR259C protein network | https://string-db.org/network/4932.YGR259C | Putative uncharacterized protein YGR259C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost compl [...] |
| TNA1 protein network | https://string-db.org/network/4932.YGR260W | High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or p [...] |
| APL6 protein network | https://string-db.org/network/4932.YGR261C | Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membran [...] |
| BUD32 protein network | https://string-db.org/network/4932.YGR262C | Protein kinase; component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; Pyrococcus Bud32 ortholog functions as a P-loop ATPase rather than a protein kinase in the context of the [...] |
| SAY1 protein network | https://string-db.org/network/4932.YGR263C | Steryl acetyl hydrolase 1; Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integ [...] |
| MES1 protein network | https://string-db.org/network/4932.YGR264C | Methionine--tRNA ligase, cytoplasmic; Methionyl-tRNA synthetase; forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases [...] |
| YGR266W protein network | https://string-db.org/network/4932.YGR266W | Uncharacterized protein YGR266W; Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial ou [...] |
| FOL2 protein network | https://string-db.org/network/4932.YGR267C | GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant. |
| HUA1 protein network | https://string-db.org/network/4932.YGR268C | Proline-rich protein HUA1; Cytoplasmic protein containing a zinc finger domain; sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction [...] |
| YGR269W protein network | https://string-db.org/network/4932.YGR269W | Uncharacterized protein YGR269W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the unchara [...] |
| YTA7 protein network | https://string-db.org/network/4932.YGR270W | Tat-binding homolog 7; Protein that localizes to chromatin; has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H [...] |
| EFG1 protein network | https://string-db.org/network/4932.YGR271C-A | rRNA-processing protein EFG1; Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluoresce [...] |
| SLH1 protein network | https://string-db.org/network/4932.YGR271W | Antiviral helicase SLH1; Putative RNA helicase related to Ski2p; involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses; Belongs to the heli [...] |
| YGR273C protein network | https://string-db.org/network/4932.YGR273C | Uncharacterized protein YGR273C; Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; not an essential gene; YGR273C has a para [...] |
| TAF1 protein network | https://string-db.org/network/4932.YGR274C | TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1 [...] |
| RTT102 protein network | https://string-db.org/network/4932.YGR275W | Regulator of Ty1 transposition protein 102; Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transpos [...] |
| RNH70 protein network | https://string-db.org/network/4932.YGR276C | RNA exonuclease 1; 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts; Belongs to the REXO1/REXO3 family. |
| CAB4 protein network | https://string-db.org/network/4932.YGR277C | Phosphopantetheine adenylyltransferase; Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable pantetheine- [...] |
| CWC22 protein network | https://string-db.org/network/4932.YGR278W | Pre-mRNA-splicing factor CWC22; Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. p [...] |
| SCW4 protein network | https://string-db.org/network/4932.YGR279C | Probable family 17 glucosidase SCW4; Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog, SCW10, that arose from the whole gen [...] |
| PXR1 protein network | https://string-db.org/network/4932.YGR280C | Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; c [...] |
| YOR1 protein network | https://string-db.org/network/4932.YGR281W | Oligomycin resistance ATP-dependent permease YOR1; Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomy [...] |
| BGL2 protein network | https://string-db.org/network/4932.YGR282C | Endo-beta-1,3-glucanase; major protein of the cell wall, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall. |
| YGR283C protein network | https://string-db.org/network/4932.YGR283C | Putative methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion [...] |
| ERV29 protein network | https://string-db.org/network/4932.YGR284C | Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress; Belongs [...] |
| ZUO1 protein network | https://string-db.org/network/4932.YGR285C | Zuotin; Ribosome-associated chaperone; zuotin functions in ribosome biogenesis and as a chaperone for nascent polypeptide chains in partnership with Ssz1p and SSb1/2; contains a DnaJ domain and f [...] |
| BIO2 protein network | https://string-db.org/network/4932.YGR286C | Biotin synthase, mitochondrial; Biotin synthase; catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant; Be [...] |
| IMA1 protein network | https://string-db.org/network/4932.YGR287C | Oligo-1,6-glucosidase IMA1; Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; preferred specificity for isomaltose, alpha-methylglucoside, and [...] |
| MAL13 protein network | https://string-db.org/network/4932.YGR288W | Maltose fermentation regulatory protein MAL13; MAL-activator protein; part of complex locus MAL1; nonfunctional in genomic reference strain S288C; Belongs to the MAL13 family. |
| MAL11 protein network | https://string-db.org/network/4932.YGR289C | General alpha-glucoside permease; High-affinity maltose transporter (alpha-glucoside transporter); inducible; encoded in the MAL1 complex locus; broad substrate specificity that includes maltotri [...] |
| YGR290W protein network | https://string-db.org/network/4932.YGR290W | Putative uncharacterized membrane protein YGR290W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; putative HLH [...] |
| YGR291C protein network | https://string-db.org/network/4932.YGR291C | Putative uncharacterized protein YGR291C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| MAL12 protein network | https://string-db.org/network/4932.YGR292W | Alpha-glucosidase MAL12; Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltot [...] |
| PAU12 protein network | https://string-db.org/network/4932.YGR294W | Seripauperin-12; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to both the endoplasmic reticul [...] |
| COS6 protein network | https://string-db.org/network/4932.YGR295C | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting [...] |
| YGR296C-A protein network | https://string-db.org/network/4932.YGR296C-A | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TEL07R. |
| YGR296C-B protein network | https://string-db.org/network/4932.YGR296C-B | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; contained completely within TEL07R. |
| YRF1-3 protein network | https://string-db.org/network/4932.YGR296W | Y' element ATP-dependent helicase protein 1 copy 3; Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially [...] |
| RPL14B protein network | https://string-db.org/network/4932.YHL001W | Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abunda [...] |
| HSE1 protein network | https://string-db.org/network/4932.YHL002W | Class E vacuolar protein-sorting machinery protein HSE1; Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicl [...] |
| LAG1 protein network | https://string-db.org/network/4932.YHL003C | Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA repli [...] |
| MRP4 protein network | https://string-db.org/network/4932.YHL004W | Mitochondrial ribosomal protein of the small subunit. |
| YHL005C protein network | https://string-db.org/network/4932.YHL005C | Uncharacterized protein YHL005C; Putative protein of unknown function; conserved among S. cerevisiae strains; YHL005C is not an essential gene. |
| SHU1 protein network | https://string-db.org/network/4932.YHL006C | Suppressor of HU sensitivity involved in recombination protein 1; Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu2, and promotes error-free DNA repair, medi [...] |
| STE20 protein network | https://string-db.org/network/4932.YHL007C | Serine/threonine-protein kinase STE20; Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol upt [...] |
| YHL008C protein network | https://string-db.org/network/4932.YHL008C | Uncharacterized transporter YHL008C; Putative protein of unknown function; may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green f [...] |
| YAP3 protein network | https://string-db.org/network/4932.YHL009C | Basic leucine zipper (bZIP) transcription factor. |
| ETP1 protein network | https://string-db.org/network/4932.YHL010C | RING finger protein ETP1; Protein of unknown function required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nucl [...] |
| PRS3 protein network | https://string-db.org/network/4932.YHL011C | Ribose-phosphate pyrophosphokinase 3; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five [...] |
| YHL012W protein network | https://string-db.org/network/4932.YHL012W | Probable UTP--glucose-1-phosphate uridylyltransferase; Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication; Belongs to [...] |
| OTU2 protein network | https://string-db.org/network/4932.YHL013C | OTU domain-containing protein 2; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cy [...] |
| YLF2 protein network | https://string-db.org/network/4932.YHL014C | Obg-like ATPase homolog; Protein of unknown function; has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in hig [...] |
| RPS20 protein network | https://string-db.org/network/4932.YHL015W | Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and [...] |
| YHL015W-A protein network | https://string-db.org/network/4932.YHL015W-A | Uncharacterized protein YHL015W-A; Putative protein of unknown function. |
| DUR3 protein network | https://string-db.org/network/4932.YHL016C | Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degra [...] |
| YHL017W protein network | https://string-db.org/network/4932.YHL017W | Uncharacterized membrane protein YHL071W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, P [...] |
| YHL018W protein network | https://string-db.org/network/4932.YHL018W | Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS. |
| APM2 protein network | https://string-db.org/network/4932.YHL019C | Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit fami [...] |
| OPI1 protein network | https://string-db.org/network/4932.YHL020C | Transcriptional repressor OPI1; Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic [...] |
| AIM17 protein network | https://string-db.org/network/4932.YHL021C | Probable oxidoreductase AIM17; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced [...] |
| SPO11 protein network | https://string-db.org/network/4932.YHL022C | Meiosis-specific protein that initiates meiotic recombination; initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; requi [...] |
| NPR3 protein network | https://string-db.org/network/4932.YHL023C | Nitrogen permease regulator 3; Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of SEAC, a coatomer-related complex that associates dynamically with the vacuole; Np [...] |
| RIM4 protein network | https://string-db.org/network/4932.YHL024W | Meiotic activator RIM4; Putative RNA-binding protein; required for the expression of early and middle sporulation genes. |
| SNF6 protein network | https://string-db.org/network/4932.YHL025W | Transcription regulatory protein SNF6; Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with S [...] |
| YHL026C protein network | https://string-db.org/network/4932.YHL026C | Uncharacterized protein YHL026C; Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; SWAT-GFP fusion protein localizes to the cell [...] |
| RIM101 protein network | https://string-db.org/network/4932.YHL027W | pH-response transcription factor pacC/RIM101; Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to alkaline conditions; involve [...] |
| WSC4 protein network | https://string-db.org/network/4932.YHL028W | Cell wall integrity and stress response component 4; Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins in [...] |
| OCA5 protein network | https://string-db.org/network/4932.YHL029C | Oxidant-induced cell-cycle arrest protein 5; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA vi [...] |
| ECM29 protein network | https://string-db.org/network/4932.YHL030W | Proteasome component ECM29; Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; inhibits proteasomal ATPase activity; degraded by the mature pro [...] |
| GOS1 protein network | https://string-db.org/network/4932.YHL031C | Golgi SNAP receptor complex member 1; v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28. |
| GUT1 protein network | https://string-db.org/network/4932.YHL032C | Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is [...] |
| RPL8A protein network | https://string-db.org/network/4932.YHL033C | Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Do [...] |
| SBP1 protein network | https://string-db.org/network/4932.YHL034C | Single-stranded nucleic acid-binding protein; Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; binds to mRNAs under glucose s [...] |
| VMR1 protein network | https://string-db.org/network/4932.YHL035C | ABC transporter ATP-binding protein/permease VMR1; Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug [...] |
| MUP3 protein network | https://string-db.org/network/4932.YHL036W | Low affinity methionine permease; similar to Mup1p. |
| CBP2 protein network | https://string-db.org/network/4932.YHL038C | Cytochrome B pre-mRNA-processing protein 2; Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; a [...] |
| EFM1 protein network | https://string-db.org/network/4932.YHL039W | Protein-lysine N-methyltransferase EFM1; Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; [...] |
| ARN1 protein network | https://string-db.org/network/4932.YHL040C | ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to [...] |
| YHL041W protein network | https://string-db.org/network/4932.YHL041W | Uncharacterized protein YHL041W; Putative protein of unknown function; conserved across S. cerevisiae strains. |
| YHL042W protein network | https://string-db.org/network/4932.YHL042W | Putative uncharacterized protein YHL042W; Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP and mCherry fusion proteins l [...] |
| ECM34 protein network | https://string-db.org/network/4932.YHL043W | Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cy [...] |
| YHL044W protein network | https://string-db.org/network/4932.YHL044W | DUP240 protein YHL044W; Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern. |
| YHL045W protein network | https://string-db.org/network/4932.YHL045W | Putative protein of unknown function; not an essential gene. |
| PAU13 protein network | https://string-db.org/network/4932.YHL046C | Seripauperin-13; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock; SWAT-GFP and mCherry f [...] |
| YHL046W-A protein network | https://string-db.org/network/4932.YHL046W-A | Putative uncharacterized protein YHL046W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF ARN2/Y [...] |
| ARN2 protein network | https://string-db.org/network/4932.YHL047C | Siderophore iron transporter ARN2; Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderop [...] |
| YHL048C-A protein network | https://string-db.org/network/4932.YHL048C-A | Uncharacterized protein YHL048C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| COS8 protein network | https://string-db.org/network/4932.YHL048W | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting [...] |
| YHL049C protein network | https://string-db.org/network/4932.YHL049C | Uncharacterized protein YHL049C; Putative protein of unknown function. |
| YHL050C protein network | https://string-db.org/network/4932.YHL050C | Uncharacterized protein YHL050C; Putative protein of unknown function; potential Cdc28p substrate. |
| YHL050W-A protein network | https://string-db.org/network/4932.YHL050W-A | Putative UPF0479 protein YHL050W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping [...] |
| OSH7 protein network | https://string-db.org/network/4932.YHR001W | Oxysterol-binding protein; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essent [...] |
| QCR10 protein network | https://string-db.org/network/4932.YHR001W-A | Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qc [...] |
| LEU5 protein network | https://string-db.org/network/4932.YHR002W | Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not enc [...] |
| TCD1 protein network | https://string-db.org/network/4932.YHR003C | tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; lo [...] |
| NEM1 protein network | https://string-db.org/network/4932.YHR004C | Nuclear envelope morphology protein 1; Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuc [...] |
| GPA1 protein network | https://string-db.org/network/4932.YHR005C | Guanine nucleotide-binding protein alpha-1 subunit; Subunit of the G protein involved in pheromone response; GTP-binding alpha subunit of the heterotrimeric G protein; negatively regulates the ma [...] |
| TIM10 protein network | https://string-db.org/network/4932.YHR005C-A | Mitochondrial import inner membrane translocase subunit TIM10; Essential protein of the mitochondrial intermembrane space; forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic pro [...] |
| STP2 protein network | https://string-db.org/network/4932.YHR006W | Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 ha [...] |
| ERG11 protein network | https://string-db.org/network/4932.YHR007C | Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-reg [...] |
| SOD2 protein network | https://string-db.org/network/4932.YHR008C | Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 c [...] |
| TDA3 protein network | https://string-db.org/network/4932.YHR009C | Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of t [...] |
| RPL27A protein network | https://string-db.org/network/4932.YHR010W | Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication. |
| DIA4 protein network | https://string-db.org/network/4932.YHR011W | Serine--tRNA ligase, mitochondrial; Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth; Belongs to the class-II aminoacyl-tRNA synthetase fam [...] |
| VPS29 protein network | https://string-db.org/network/4932.YHR012W | Vacuolar protein sorting-associated protein 29; Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex wi [...] |
| ARD1 protein network | https://string-db.org/network/4932.YHR013C | Subunit of protein N-terminal acetyltransferase NatA; NatA comprises Nat1p, Ard1p, Nat5p; acetylates many proteins to influence telomeric silencing, cell cycle, heat-shock resistance, mating, spo [...] |
| SPO13 protein network | https://string-db.org/network/4932.YHR014W | Meiosis-specific protein SPO13; Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during [...] |
| MIP6 protein network | https://string-db.org/network/4932.YHR015W | Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplicati [...] |
| YSC84 protein network | https://string-db.org/network/4932.YHR016C | Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralo [...] |
| YSC83 protein network | https://string-db.org/network/4932.YHR017W | UPF0744 protein YSC83; Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83. |
| ARG4 protein network | https://string-db.org/network/4932.YHR018C | Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. |
| DED81 protein network | https://string-db.org/network/4932.YHR019C | Asparagine--tRNA ligase, cytoplasmic; Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA; Belongs to the cl [...] |
| YHR020W protein network | https://string-db.org/network/4932.YHR020W | Putative proline--tRNA ligase YHR020W; Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity [...] |
| RPS27B protein network | https://string-db.org/network/4932.YHR021C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplica [...] |
| ECM12 protein network | https://string-db.org/network/4932.YHR021W-A | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. |
| YHR022C protein network | https://string-db.org/network/4932.YHR022C | Putative protein of unknown function; YHR022C is not an essential gene. |
| YHR022C-A protein network | https://string-db.org/network/4932.YHR022C-A | Uncharacterized protein YHR022C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| MYO1 protein network | https://string-db.org/network/4932.YHR023W | Myosin-1; Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ [...] |
| MAS2 protein network | https://string-db.org/network/4932.YHR024C | Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins. |
| THR1 protein network | https://string-db.org/network/4932.YHR025W | Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulat [...] |
| VMA16 protein network | https://string-db.org/network/4932.YHR026W | Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain. |
| RPN1 protein network | https://string-db.org/network/4932.YHR027C | Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for prote [...] |
| DAP2 protein network | https://string-db.org/network/4932.YHR028C | Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p. |
| YHI9 protein network | https://string-db.org/network/4932.YHR029C | Uncharacterized isomerase YHI9; Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the Phz [...] |
| SLT2 protein network | https://string-db.org/network/4932.YHR030C | Mitogen-activated protein kinase SLT2/MPK1; Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved [...] |
| RRM3 protein network | https://string-db.org/network/4932.YHR031C | DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; structurally and f [...] |
| YHR032C-A protein network | https://string-db.org/network/4932.YHR032C-A | Putative uncharacterized protein YHR032C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| ERC1 protein network | https://string-db.org/network/4932.YHR032W | Ethionine resistance-conferring protein 1; Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporte [...] |
| YHR032W-A protein network | https://string-db.org/network/4932.YHR032W-A | Uncharacterized protein YHR032W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubio [...] |
| YHR033W protein network | https://string-db.org/network/4932.YHR033W | Uncharacterized protein YHR033W; Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication [...] |
| PIH1 protein network | https://string-db.org/network/4932.YHR034C | Protein interacting with Hsp90 1; Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes [...] |
| NEL1 protein network | https://string-db.org/network/4932.YHR035W | GTPase-activating protein NEL1; Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene; Belongs to the SEC23/SEC24 family. SE [...] |
| BRL1 protein network | https://string-db.org/network/4932.YHR036W | Nucleus export protein BRL1; Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore com [...] |
| PUT2 protein network | https://string-db.org/network/4932.YHR037W | Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II [...] |
| RRF1 protein network | https://string-db.org/network/4932.YHR038W | Ribosome-recycling factor, mitochondrial; Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondri [...] |
| MSC7 protein network | https://string-db.org/network/4932.YHR039C | Putative aldehyde dehydrogenase-like protein YHR039C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defectiv [...] |
| VMA10 protein network | https://string-db.org/network/4932.YHR039C-A | Subunit G of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification; the V1 peripheral me [...] |
| BCD1 protein network | https://string-db.org/network/4932.YHR040W | Box C/D snoRNA protein 1; Essential protein required for the accumulation of box C/D snoRNA. |
| SRB2 protein network | https://string-db.org/network/4932.YHR041C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance [...] |
| NCP1 protein network | https://string-db.org/network/4932.YHR042W | NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p; In the N-terminal section; belongs to the flavodoxin family. |
| DOG2 protein network | https://string-db.org/network/4932.YHR043C | 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG [...] |
| DOG1 protein network | https://string-db.org/network/4932.YHR044C | 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a [...] |
| YHR045W protein network | https://string-db.org/network/4932.YHR045W | Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic r [...] |
| INM1 protein network | https://string-db.org/network/4932.YHR046C | Inositol monophosphatase; involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposur [...] |
| AAP1 protein network | https://string-db.org/network/4932.YHR047C | Alanine/arginine aminopeptidase; Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication. |
| YHK8 protein network | https://string-db.org/network/4932.YHR048W | Probable drug/proton antiporter YHK8; Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in ce [...] |
| YHR049C-A protein network | https://string-db.org/network/4932.YHR049C-A | Putative uncharacterized protein YHR049C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| FSH1 protein network | https://string-db.org/network/4932.YHR049W | Family of serine hydrolases 1; Putative serine hydrolase; localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppresso [...] |
| SMF2 protein network | https://string-db.org/network/4932.YHR050W | Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the [...] |
| YHR050W-A protein network | https://string-db.org/network/4932.YHR050W-A | Putative uncharacterized protein YHR050W-A; Protein of unknown function; identified by expression profiling and mass spectrometry. |
| COX6 protein network | https://string-db.org/network/4932.YHR051W | Subunit VI of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels. |
| CIC1 protein network | https://string-db.org/network/4932.YHR052W | Proteasome-interacting protein CIC1; Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal [...] |
| YHR052W-A protein network | https://string-db.org/network/4932.YHR052W-A | Putative uncharacterized protein YHR052W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| CUP1-1 protein network | https://string-db.org/network/4932.YHR053C | Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the ge [...] |
| YHR054C protein network | https://string-db.org/network/4932.YHR054C | Uncharacterized protein YHR054C; Putative protein of unknown function; partial duplicate of RSC30/YHR056C, truncated remnant of segmental duplication; To yeast YHR056c. |
| YHR054W-A protein network | https://string-db.org/network/4932.YHR054W-A | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2. |
| CUP1-2 protein network | https://string-db.org/network/4932.YHR055C | Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the ge [...] |
| RSC30 protein network | https://string-db.org/network/4932.YHR056C | Chromatin structure-remodeling complex protein RSC30; Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/st [...] |
| YHR056W-A protein network | https://string-db.org/network/4932.YHR056W-A | Putative uncharacterized membrane protein YHR056W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely [...] |
| CPR2 protein network | https://string-db.org/network/4932.YHR057C | Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; seamless-GFP and [...] |
| MED6 protein network | https://string-db.org/network/4932.YHR058C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance i [...] |
| FYV4 protein network | https://string-db.org/network/4932.YHR059W | Protein FYV4, mitochondrial; Protein of unknown function; required for survival upon exposure to K1 killer toxin; Belongs to the mitochondrion-specific ribosomal protein mS41 family. |
| VMA22 protein network | https://string-db.org/network/4932.YHR060W | Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; local [...] |
| GIC1 protein network | https://string-db.org/network/4932.YHR061C | GTPase-interacting component 1; Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bu [...] |
| RPP1 protein network | https://string-db.org/network/4932.YHR062C | Ribonuclease P/MRP protein subunit RPP1; Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and fa [...] |
| PAN5 protein network | https://string-db.org/network/4932.YHR063C | 2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE. |
| SSZ1 protein network | https://string-db.org/network/4932.YHR064C | Ribosome-associated complex subunit SSZ1; Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1 [...] |
| RRP3 protein network | https://string-db.org/network/4932.YHR065C | ATP-dependent rRNA helicase RRP3; Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to [...] |
| SSF1 protein network | https://string-db.org/network/4932.YHR066W | Ribosome biogenesis protein SSF1; Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 h [...] |
| HTD2 protein network | https://string-db.org/network/4932.YHR067W | Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology. |
| DYS1 protein network | https://string-db.org/network/4932.YHR068W | Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulate [...] |
| RRP4 protein network | https://string-db.org/network/4932.YHR069C | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRr [...] |
| YHR069C-A protein network | https://string-db.org/network/4932.YHR069C-A | Putative uncharacterized membrane protein YHR069C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely [...] |
| TRM5 protein network | https://string-db.org/network/4932.YHR070W | tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; localized to both cytoplasm and mitochondria, and modifies both cy [...] |
| PCL5 protein network | https://string-db.org/network/4932.YHR071W | PHO85 cyclin-5; Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be [...] |
| ERG7 protein network | https://string-db.org/network/4932.YHR072W | Lanosterol synthase; an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; human LSS functionally complements the lethality of the erg7 nu [...] |
| NOP10 protein network | https://string-db.org/network/4932.YHR072W-A | Subunit of box H/ACA snoRNP complex; required for pseudouridylation and processing of pre-18S rRNA. |
| YHR073C-B protein network | https://string-db.org/network/4932.YHR073C-B | Uncharacterized protein YHR073C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified [...] |
| OSH3 protein network | https://string-db.org/network/4932.YHR073W | Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a [...] |
| YHR073W-A protein network | https://string-db.org/network/4932.YHR073W-A | Uncharacterized protein YHR073W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified [...] |
| QNS1 protein network | https://string-db.org/network/4932.YHR074W | Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide. |
| PPE1 protein network | https://string-db.org/network/4932.YHR075C | Protein phosphatase methylesterase 1; Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a sm [...] |
| PTC7 protein network | https://string-db.org/network/4932.YHR076W | Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced fo [...] |
| NMD2 protein network | https://string-db.org/network/4932.YHR077C | Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance. |
| YHR078W protein network | https://string-db.org/network/4932.YHR078W | Uncharacterized protein YHR078W; High osmolarity-regulated gene of unknown function. |
| IRE1 protein network | https://string-db.org/network/4932.YHR079C | Serine/threonine-protein kinase/endoribonuclease IRE1; Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p sy [...] |
| SAE3 protein network | https://string-db.org/network/4932.YHR079C-A | Pachytene arrest protein SAE3; Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Mei5p; proposed to be an assemb [...] |
| LAM4 protein network | https://string-db.org/network/4932.YHR080C | Membrane-anchored lipid-binding protein LAM4; Sterol-binding protein that localizes to puncta in the cortical ER; sterol binding occurs via two StART-like domains; one of six StART-like domain-co [...] |
| LRP1 protein network | https://string-db.org/network/4932.YHR081W | Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; forms a stable heterodimer with Rrp6p and regulates its exon [...] |
| KSP1 protein network | https://string-db.org/network/4932.YHR082C | Serine/threonine-protein kinase KSP1; Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation [...] |
| SAM35 protein network | https://string-db.org/network/4932.YHR083W | Component of the sorting and assembly machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and fa [...] |
| STE12 protein network | https://string-db.org/network/4932.YHR084W | Protein STE12; Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription [...] |
| IPI1 protein network | https://string-db.org/network/4932.YHR085W | Pre-rRNA-processing protein IPI1; Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribos [...] |
| NAM8 protein network | https://string-db.org/network/4932.YHR086W | RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specifi [...] |
| YHR086W-A protein network | https://string-db.org/network/4932.YHR086W-A | Uncharacterized protein YHR086W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and v [...] |
| RTC3 protein network | https://string-db.org/network/4932.YHR087W | Restriction of telomere capping protein 3; Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the [...] |
| RPF1 protein network | https://string-db.org/network/4932.YHR088W | Ribosome production factor 1; Protein involved in assembly and export of the large ribosomal subunit; nucleolar protein; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like moti [...] |
| GAR1 protein network | https://string-db.org/network/4932.YHR089C | H/ACA ribonucleoprotein complex subunit GAR1; Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA; Belongs to the GAR1 fam [...] |
| YNG2 protein network | https://string-db.org/network/4932.YHR090C | Chromatin modification-related protein YNG2; Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; reloca [...] |
| MSR1 protein network | https://string-db.org/network/4932.YHR091C | Arginine--tRNA ligase, mitochondrial; Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that a [...] |
| HXT4 protein network | https://string-db.org/network/4932.YHR092C | High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, t [...] |
| AHT1 protein network | https://string-db.org/network/4932.YHR093W | Hexose transport activator protein; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely re [...] |
| HXT1 protein network | https://string-db.org/network/4932.YHR094C | Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralo [...] |
| YHR095W protein network | https://string-db.org/network/4932.YHR095W | Putative uncharacterized protein YHR095W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| HXT5 protein network | https://string-db.org/network/4932.YHR096C | Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain rela [...] |
| YHR097C protein network | https://string-db.org/network/4932.YHR097C | Uncharacterized protein YHR097C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YHR097C has a paralog, PAL1, that [...] |
| SFB3 protein network | https://string-db.org/network/4932.YHR098C | SED5-binding protein 3; Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; scaffold [...] |
| TRA1 protein network | https://string-db.org/network/4932.YHR099W | Transcription-associated protein 1; Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar t [...] |
| GEP4 protein network | https://string-db.org/network/4932.YHR100C | Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; [...] |
| BIG1 protein network | https://string-db.org/network/4932.YHR101C | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. |
| KIC1 protein network | https://string-db.org/network/4932.YHR102W | Serine/threonine-protein kinase KIC1; Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole bod [...] |
| SBE22 protein network | https://string-db.org/network/4932.YHR103W | Protein involved in bud growth; involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; SBE22 has a paral [...] |
| GRE3 protein network | https://string-db.org/network/4932.YHR104W | Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the H [...] |
| YPT35 protein network | https://string-db.org/network/4932.YHR105W | Endosomal protein of unknown function; contains a phox (PX) homology domain; binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport; [...] |
| TRR2 protein network | https://string-db.org/network/4932.YHR106W | Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokar [...] |
| CDC12 protein network | https://string-db.org/network/4932.YHR107C | Cell division control protein 12; Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate w [...] |
| GGA2 protein network | https://string-db.org/network/4932.YHR108W | ADP-ribosylation factor-binding protein GGA2; Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; [...] |
| CTM1 protein network | https://string-db.org/network/4932.YHR109W | Cytochrome c lysine methyltransferase; trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth. |
| ERP5 protein network | https://string-db.org/network/4932.YHR110W | Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport. |
| UBA4 protein network | https://string-db.org/network/4932.YHR111W | Adenylyltransferase and sulfurtransferase UBA4; E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thi [...] |
| YHR112C protein network | https://string-db.org/network/4932.YHR112C | Uncharacterized trans-sulfuration enzyme YHR112C; Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway; Be [...] |
| APE4 protein network | https://string-db.org/network/4932.YHR113W | Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oli [...] |
| BZZ1 protein network | https://string-db.org/network/4932.YHR114W | SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; inter [...] |
| DMA1 protein network | https://string-db.org/network/4932.YHR115C | Ubiquitin-protein ligase (E3); controls septin dynamics, spindle position checkpoint (SPOC) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd1 [...] |
| COX23 protein network | https://string-db.org/network/4932.YHR116W | Cytochrome c oxidase-assembly factor COX23, mitochondrial; Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochro [...] |
| TOM71 protein network | https://string-db.org/network/4932.YHR117W | Protein TOM71; Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed [...] |
| ORC6 protein network | https://string-db.org/network/4932.YHR118C | Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; mutatio [...] |
| SET1 protein network | https://string-db.org/network/4932.YHR119W | Histone-lysine N-methyltransferase, H3 lysine-4 specific; Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation r [...] |
| MSH1 protein network | https://string-db.org/network/4932.YHR120W | DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during me [...] |
| LSM12 protein network | https://string-db.org/network/4932.YHR121W | Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion prot [...] |
| CIA2 protein network | https://string-db.org/network/4932.YHR122W | MIP18 family protein YHR122W; Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met [...] |
| EPT1 protein network | https://string-db.org/network/4932.YHR123W | Sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication. |
| NDT80 protein network | https://string-db.org/network/4932.YHR124W | Meiosis-specific transcription factor; required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters contai [...] |
| ANS1 protein network | https://string-db.org/network/4932.YHR126C | Probable GPI-anchored protein ANS1; Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the vacuole; transcription dependent upon Azf1p. |
| YHR127W protein network | https://string-db.org/network/4932.YHR127W | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. |
| FUR1 protein network | https://string-db.org/network/4932.YHR128W | Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway. |
| ARP1 protein network | https://string-db.org/network/4932.YHR129C | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ort [...] |
| YHR130C protein network | https://string-db.org/network/4932.YHR130C | Uncharacterized protein YHR130C; Putative protein of unknown function; conserved among S. cerevisiae strains; YHR130C is not an essential gene. |
| YHR131C protein network | https://string-db.org/network/4932.YHR131C | PH domain-containing protein YHR131C; Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain a [...] |
| ECM14 protein network | https://string-db.org/network/4932.YHR132C | Putative metallocarboxypeptidase ECM14; Putative metalloprotease with similarity to zinc carboxypeptidases; required for normal cell wall assembly; Belongs to the peptidase M14 family. |
| IGO2 protein network | https://string-db.org/network/4932.YHR132W-A | mRNA stability protein IGO2; Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protei [...] |
| NSG1 protein network | https://string-db.org/network/4932.YHR133C | Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the [...] |
| WSS1 protein network | https://string-db.org/network/4932.YHR134W | DNA-dependent metalloprotease WSS1; SUMO-ligase and SUMO-targeted metalloprotease; involved in DNA repair; removes DNA-protein crosslinks at stalled replication forks during replication of damage [...] |
| YCK1 protein network | https://string-db.org/network/4932.YHR135C | Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stab [...] |
| SPL2 protein network | https://string-db.org/network/4932.YHR136C | Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation by targeting Pho87p to the vacuole; upstream region harbo [...] |
| ARO9 protein network | https://string-db.org/network/4932.YHR137W | Aromatic aminotransferase II; catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. |
| YHR138C protein network | https://string-db.org/network/4932.YHR138C | Uncharacterized protein YHR138C; Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in r [...] |
| SPS100 protein network | https://string-db.org/network/4932.YHR139C | Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin; SPS100 has a p [...] |
| YHR139C-A protein network | https://string-db.org/network/4932.YHR139C-A | Uncharacterized protein YHR139C-A; Putative protein of unknown function; conserved across S. cerevisiae strains. |
| YHR140W protein network | https://string-db.org/network/4932.YHR140W | Putative integral membrane protein of unknown function. |
| RPL42B protein network | https://string-db.org/network/4932.YHR141C | Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal [...] |
| CHS7 protein network | https://string-db.org/network/4932.YHR142W | Chitin synthase export chaperone; Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replicati [...] |
| DSE2 protein network | https://string-db.org/network/4932.YHR143W | Protein DSE2; Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by [...] |
| RPC10 protein network | https://string-db.org/network/4932.YHR143W-A | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. |
| DCD1 protein network | https://string-db.org/network/4932.YHR144C | Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated. |
| YHR145C protein network | https://string-db.org/network/4932.YHR145C | Putative uncharacterized protein YHR145C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| CRP1 protein network | https://string-db.org/network/4932.YHR146W | Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication. |
| MRPL6 protein network | https://string-db.org/network/4932.YHR147C | Mitochondrial ribosomal protein of the large subunit. |
| IMP3 protein network | https://string-db.org/network/4932.YHR148W | U3 small nucleolar ribonucleoprotein protein IMP3; Component of the SSU processome; SSU processome is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediat [...] |
| SKG6 protein network | https://string-db.org/network/4932.YHR149C | Protein SKG6; Integral membrane protein; localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p; SKG6 has [...] |
| PEX28 protein network | https://string-db.org/network/4932.YHR150W | Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those [...] |
| MTC6 protein network | https://string-db.org/network/4932.YHR151C | Protein of unknown function; mtc6 is synthetically sick with cdc13-1; SWAT-GFP and mCherry fusion proteins localize to the vacuole while SWAT-GFP fusion also localizes to the endoplasmic reticulu [...] |
| SPO12 protein network | https://string-db.org/network/4932.YHR152W | Sporulation-specific protein 12; Nucleolar protein of unknown function; positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play [...] |
| SPO16 protein network | https://string-db.org/network/4932.YHR153C | Sporulation-specific protein 16; Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation. |
| RTT107 protein network | https://string-db.org/network/4932.YHR154W | Regulator of Ty1 transposition protein 107; Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces [...] |
| LAM1 protein network | https://string-db.org/network/4932.YHR155W | Membrane-anchored lipid-binding protein LAM1; Putative sterol transfer protein; localizes to puncta in the cortical ER; probable role in retrograde transport of sterols from the plasma membrane t [...] |
| LIN1 protein network | https://string-db.org/network/4932.YHR156C | Protein LIN1; Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicin [...] |
| REC104 protein network | https://string-db.org/network/4932.YHR157W | Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination. |
| KEL1 protein network | https://string-db.org/network/4932.YHR158C | Kelch repeat-containing protein 1; Protein required for proper cell fusion and cell morphology; forms a complex with Bud14p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, [...] |
| TDA11 protein network | https://string-db.org/network/4932.YHR159W | Topoisomerase I damage affected protein 11; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutan [...] |
| PEX18 protein network | https://string-db.org/network/4932.YHR160C | Peroxin; required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p; primarily responsible for peroxisomal import during growth o [...] |
| YAP1801 protein network | https://string-db.org/network/4932.YHR161C | Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication. |
| MPC2 protein network | https://string-db.org/network/4932.YHR162W | Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on fermentable carbon sources, and heterodimerizes with Mpc1p to form the fermentative isoform of MPC [...] |
| SOL3 protein network | https://string-db.org/network/4932.YHR163W | 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that [...] |
| DNA2 protein network | https://string-db.org/network/4932.YHR164C | Tripartite DNA replication factor; single-stranded DNA-dependent ATPase, ATP-dependent nuclease, helicase; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA r [...] |
| PRP8 protein network | https://string-db.org/network/4932.YHR165C | Pre-mRNA-splicing factor 8; Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; larges [...] |
| CDC23 protein network | https://string-db.org/network/4932.YHR166C | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/a [...] |
| THP2 protein network | https://string-db.org/network/4932.YHR167W | Subunit of the THO and TREX complexes; THO connects transcription elongation and mitotic recombination, and TREX is recruited to activated genes and couples transcription to mRNA export; involved [...] |
| MTG2 protein network | https://string-db.org/network/4932.YHR168W | GTPase MTG2, mitochondrial; Putative GTPase; member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitoch [...] |
| DBP8 protein network | https://string-db.org/network/4932.YHR169W | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulat [...] |
| NMD3 protein network | https://string-db.org/network/4932.YHR170W | Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; Belongs to [...] |
| ATG7 protein network | https://string-db.org/network/4932.YHR171W | Ubiquitin-like modifier-activating enzyme ATG7; Autophagy-related protein and dual specificity member of the E1 family; mediates the attachment of Atg12p to Atg5p and Atg8p to phosphatidylethanol [...] |
| SPC97 protein network | https://string-db.org/network/4932.YHR172W | Spindle pole body component SPC97; Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the [...] |
| YHR173C protein network | https://string-db.org/network/4932.YHR173C | Uncharacterized protein YHR173C; Protein of unknown function; expressed at both mRNA and protein levels; SWAT-GFP and mCherry fusion proteins localize to the vacuole. |
| ENO2 protein network | https://string-db.org/network/4932.YHR174W | Enolase II, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression induced in [...] |
| CTR2 protein network | https://string-db.org/network/4932.YHR175W | Low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation; regulated by no [...] |
| YHR175W-A protein network | https://string-db.org/network/4932.YHR175W-A | Uncharacterized membrane protein YHR175W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| FMO1 protein network | https://string-db.org/network/4932.YHR176W | Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulf [...] |
| YHR177W protein network | https://string-db.org/network/4932.YHR177W | Uncharacterized protein YHR177W; Putative transcription factor containing a WOPR domain; binds DNA in vitro; similar to C. albicans Wor1p transcription factor that regulates white-opaque switchin [...] |
| STB5 protein network | https://string-db.org/network/4932.YHR178W | Protein STB5; Transcription factor; involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that inter [...] |
| OYE2 protein network | https://string-db.org/network/4932.YHR179W | NADPH dehydrogenase 2; Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with dif [...] |
| YHR180C-B protein network | https://string-db.org/network/4932.YHR180C-B | Putative uncharacterized protein YHR180C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| YHR180W protein network | https://string-db.org/network/4932.YHR180W | Uncharacterized protein YHR180W; Putative protein of unknown function; conserved among S. cerevisiae strains. |
| YHR180W-A protein network | https://string-db.org/network/4932.YHR180W-A | Putative uncharacterized protein YHR180W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| SVP26 protein network | https://string-db.org/network/4932.YHR181W | Integral membrane protein of the early Golgi apparatus and ER; involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment. |
| YHR182W protein network | https://string-db.org/network/4932.YHR182W | Uncharacterized protein YHR182W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm [...] |
| GND1 protein network | https://string-db.org/network/4932.YHR183W | 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxi [...] |
| SSP1 protein network | https://string-db.org/network/4932.YHR184W | Sporulation-specific protein 1; Protein involved in the control of meiotic nuclear division; involved in the coordination of meiosis with spore formation; subunit of the leading edge protein (LEP [...] |
| PFS1 protein network | https://string-db.org/network/4932.YHR185C | Sporulation protein required for prospore membrane formation; required for prospore membrane formation at selected spindle poles; ensures functionality of all four spindle pole bodies during meio [...] |
| KOG1 protein network | https://string-db.org/network/4932.YHR186C | Subunit of TORC1; TORC1 is a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as [...] |
| IKI1 protein network | https://string-db.org/network/4932.YHR187W | Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymoci [...] |
| GPI16 protein network | https://string-db.org/network/4932.YHR188C | GPI transamidase component GPI16; Subunit of the glycosylphosphatidylinositol transamidase complex; transmembrane protein; adds GPIs to newly synthesized proteins; human PIG-Tp homolog. |
| PTH1 protein network | https://string-db.org/network/4932.YHR189W | Peptidyl-tRNA hydrolase; One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; s [...] |
| ERG9 protein network | https://string-db.org/network/4932.YHR190W | Squalene synthase; Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway. |
| CTF8 protein network | https://string-db.org/network/4932.YHR191C | Chromosome transmission fidelity protein 8; Subunit of a complex with Ctf18p; shares some subunits with Replication Factor C; required for sister chromatid cohesion; Belongs to the CTF8 family. |
| LNP1 protein network | https://string-db.org/network/4932.YHR192W | Endoplasmic reticulum junction formation protein lunapark; Lunapark family member involved in ER network formation; regulates the ER asymmetry-induced inheritance block during ER stress; localize [...] |
| EGD2 protein network | https://string-db.org/network/4932.YHR193C | Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes. |
| MDM31 protein network | https://string-db.org/network/4932.YHR194W | Mitochondrial distribution and morphology protein 31; Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal [...] |
| NVJ1 protein network | https://string-db.org/network/4932.YHR195W | Nucleus-vacuole junction protein 1; Nuclear envelope protein; anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuo [...] |
| UTP9 protein network | https://string-db.org/network/4932.YHR196W | Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA. |
| RIX1 protein network | https://string-db.org/network/4932.YHR197W | Pre-rRNA-processing protein RIX1; Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribos [...] |
| AIM18 protein network | https://string-db.org/network/4932.YHR198C | Altered inheritance of mitochondria protein 18, mitochondrial; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studie [...] |
| AIM46 protein network | https://string-db.org/network/4932.YHR199C | Altered inheritance of mitochondria protein 46, mitochondrial; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studie [...] |
| NBL1 protein network | https://string-db.org/network/4932.YHR199C-A | N-terminal-borealin-like protein; Subunit of the conserved chromosomal passenger complex (CPC); complex regulates mitotic chromosome segregation; not required for the kinase activity of the compl [...] |
| RPN10 protein network | https://string-db.org/network/4932.YHR200W | Non-ATPase base subunit of the 19S RP of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the regulatory particle (RP); binds selectively to polyubiquitin ch [...] |
| PPX1 protein network | https://string-db.org/network/4932.YHR201C | Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix; Belongs to the PPase class C family. |
| YHR202W protein network | https://string-db.org/network/4932.YHR202W | Uncharacterized protein YHR202W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fra [...] |
| RPS4B protein network | https://string-db.org/network/4932.YHR203C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplicatio [...] |
| MNL1 protein network | https://string-db.org/network/4932.YHR204W | ER degradation-enhancing alpha-mannosidase-like protein 1; Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; [...] |
| SCH9 protein network | https://string-db.org/network/4932.YHR205W | Serine/threonine-protein kinase SCH9; AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogene [...] |
| SKN7 protein network | https://string-db.org/network/4932.YHR206W | Transcription factor SKN7; Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component [...] |
| SET5 protein network | https://string-db.org/network/4932.YHR207C | Putative protein lysine methyltransferase SET5; Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical [...] |
| BAT1 protein network | https://string-db.org/network/4932.YHR208W | Branched-chain-amino-acid aminotransferase, mitochondrial; Mitochondrial branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; [...] |
| CRG1 protein network | https://string-db.org/network/4932.YHR209W | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methy [...] |
| YHR210C protein network | https://string-db.org/network/4932.YHR210C | Uncharacterized isomerase YHR210C; Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions; Belongs to the aldose epimerase family. |
| FLO5 protein network | https://string-db.org/network/4932.YHR211W | Flocculation protein FLO5; Lectin-like cell wall protein (flocculin) involved in flocculation; binds mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsi [...] |
| YHR212C protein network | https://string-db.org/network/4932.YHR212C | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YHR212C has a paralog, YAR060C, that arose from a segmental dup [...] |
| YHR212W-A protein network | https://string-db.org/network/4932.YHR212W-A | Uncharacterized protein YAR061W; Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GF [...] |
| YHR213W protein network | https://string-db.org/network/4932.YHR213W | Putative uncharacterized protein YAR062W; Pseudogenic fragment with similarity to flocculins; YHR213W has a paralog, YAR062W, that arose from a segmental duplication; Belongs to the flocculin fam [...] |
| YHR213W-A protein network | https://string-db.org/network/4932.YHR213W-A | Uncharacterized protein YHR213W-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YHR213W-B protein network | https://string-db.org/network/4932.YHR213W-B | Uncharacterized protein YHR213W-B; Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YHR21 [...] |
| YHR214C-D protein network | https://string-db.org/network/4932.YHR214C-D | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP and mCherry fusion proteins localize to the n [...] |
| YHR214C-E protein network | https://string-db.org/network/4932.YHR214C-E | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YHR214W protein network | https://string-db.org/network/4932.YHR214W | Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein; YHR214W has a paralog, YAR066W, that arose from a segmental duplication. |
| YHR214W-A protein network | https://string-db.org/network/4932.YHR214W-A | Putative uncharacterized protein YHR214W-A; Dubious open reading frame; induced by zinc deficiency; YHR214W-A has a paralog, YAR068W, that arose from a segmental duplication. |
| PHO12 protein network | https://string-db.org/network/4932.YHR215W | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that aro [...] |
| IMD2 protein network | https://string-db.org/network/4932.YHR216W | Inosine-5'-monophosphate dehydrogenase 2; Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resist [...] |
| YHR217C protein network | https://string-db.org/network/4932.YHR217C | Putative uncharacterized protein YHR217C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; located in the telome [...] |
| YHR218W protein network | https://string-db.org/network/4932.YHR218W | Helicase-like protein encoded within the telomeric Y' element. |
| YHR218W-A protein network | https://string-db.org/network/4932.YHR218W-A | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely within telomere TEL08L. |
| YHR219C-A protein network | https://string-db.org/network/4932.YHR219C-A | Putative UPF0479 protein YHR219C-A; Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology [...] |
| YHR219W protein network | https://string-db.org/network/4932.YHR219W | Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII. |
| YIL001W protein network | https://string-db.org/network/4932.YIL001W | Ankyrin repeat-containing protein YIL001W; Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive [...] |
| INP51 protein network | https://string-db.org/network/4932.YIL002C | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis [...] |
| YIL002W-A protein network | https://string-db.org/network/4932.YIL002W-A | Uncharacterized protein YIL002W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| CFD1 protein network | https://string-db.org/network/4932.YIL003W | Cytosolic Fe-S cluster assembly factor CFD1; Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein [...] |
| BET1 protein network | https://string-db.org/network/4932.YIL004C | Type II membrane protein required for vesicular transport; required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins; Belongs [...] |
| EPS1 protein network | https://string-db.org/network/4932.YIL005W | ER-retained PMA1-suppressing protein 1; ER protein with chaperone and co-chaperone activity; involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-asso [...] |
| YIA6 protein network | https://string-db.org/network/4932.YIL006W | Mitochondrial nicotinamide adenine dinucleotide transporter 1; Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial [...] |
| NAS2 protein network | https://string-db.org/network/4932.YIL007C | Probable 26S proteasome regulatory subunit p27; Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in assembly of the base subcomplex of the 19S proteasomal regulatory [...] |
| URM1 protein network | https://string-db.org/network/4932.YIL008W | Ubiquitin-related modifier 1; Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a prote [...] |
| EST3 protein network | https://string-db.org/network/4932.YIL009C-A | Telomere replication protein EST3; Component of the telomerase holoenzyme; involved in telomere replication; synthesis of the full-length protein results from a programmed +1 ribosomal frameshift [...] |
| FAA3 protein network | https://string-db.org/network/4932.YIL009W | Long-chain-fatty-acid--CoA ligase 3; Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C16:0-C18:0 chain lengths; green fluorescent protein (GFP)-fusion p [...] |
| DOT5 protein network | https://string-db.org/network/4932.YIL010W | Peroxiredoxin DOT5; Nuclear thiol peroxidase; functions as an alkyl-hydroperoxide reductase during post-diauxic growth; Belongs to the peroxiredoxin family. BCP/PrxQ subfamily. |
| TIR3 protein network | https://string-db.org/network/4932.YIL011W | Cell wall mannoprotein; member of Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; TIR3 has a paralog, TIR2, that arose [...] |
| PDR11 protein network | https://string-db.org/network/4932.YIL013C | ATP-dependent permease PDR11; ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; r [...] |
| YIL014C-A protein network | https://string-db.org/network/4932.YIL014C-A | Uncharacterized protein YIL014C-A; Putative protein of unknown function. |
| MNT3 protein network | https://string-db.org/network/4932.YIL014W | Alpha-1,3-mannosyltransferase; adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation; Belongs to the MNN1/MNT family. |
| BAR1 protein network | https://string-db.org/network/4932.YIL015W | Barrierpepsin; Aspartyl protease; secreted into the periplasmic space of mating type a cell; helps cells find mating partners; cleaves and inactivates alpha factor allowing cells to recover from [...] |
| SNL1 protein network | https://string-db.org/network/4932.YIL016W | HSP70 co-chaperone SNL1; Ribosome-associated protein; proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the ma [...] |
| VID28 protein network | https://string-db.org/network/4932.YIL017C | Vacuolar import and degradation protein 28; GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-b [...] |
| RPL2B protein network | https://string-db.org/network/4932.YIL018W | Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulat [...] |
| FAF1 protein network | https://string-db.org/network/4932.YIL019W | Protein required for pre-rRNA processing; also required for 40S ribosomal subunit assembly. |
| HIS6 protein network | https://string-db.org/network/4932.YIL020C | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-amino [...] |
| RPB3 protein network | https://string-db.org/network/4932.YIL021W | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. |
| TIM44 protein network | https://string-db.org/network/4932.YIL022W | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the TIM23 complex; tethers the import motor and regulatory factors (PAM complex) to the translocation channel [...] |
| YKE4 protein network | https://string-db.org/network/4932.YIL023C | Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) [...] |
| YIL025C protein network | https://string-db.org/network/4932.YIL025C | Putative uncharacterized protein YIL025C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| IRR1 protein network | https://string-db.org/network/4932.YIL026C | Subunit of the cohesin complex; which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms; relocalizes to the cytosol in respon [...] |
| EMC5 protein network | https://string-db.org/network/4932.YIL027C | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin [...] |
| YIL028W protein network | https://string-db.org/network/4932.YIL028W | Putative uncharacterized protein YIL028W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YIL029C protein network | https://string-db.org/network/4932.YIL029C | Uncharacterized protein YIL029C; Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has a paralog, YPR071W, t [...] |
| SSM4 protein network | https://string-db.org/network/4932.YIL030C | ERAD-associated E3 ubiquitin-protein ligase DOA10; Membrane-embedded ubiquitin-protein ligase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein d [...] |
| ULP2 protein network | https://string-db.org/network/4932.YIL031W | Ubiquitin-like-specific protease 2; Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest [...] |
| YIL032C protein network | https://string-db.org/network/4932.YIL032C | Putative uncharacterized protein YIL032C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| BCY1 protein network | https://string-db.org/network/4932.YIL033C | Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); PKA is a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, str [...] |
| CAP2 protein network | https://string-db.org/network/4932.YIL034C | Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to c [...] |
| CKA1 protein network | https://string-db.org/network/4932.YIL035C | Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including [...] |
| CST6 protein network | https://string-db.org/network/4932.YIL036W | ATF/CREB activator 2; Basic leucine zipper (bZIP) transcription factor from ATF/CREB family involved in stress-responsive regulatory network; mediates transcriptional activation of NCE103 in resp [...] |
| PRM2 protein network | https://string-db.org/network/4932.YIL037C | Pheromone-regulated protein; predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion. |
| NOT3 protein network | https://string-db.org/network/4932.YIL038C | General negative regulator of transcription subunit 3; Component of the CCR4-NOT core complex, involved in mRNA decapping; involved in transcription initiation and elongation and in mRNA degradat [...] |
| TED1 protein network | https://string-db.org/network/4932.YIL039W | Protein TED1; GPI-glycan remodelase; conserved phosphoesterase domain-containing protein; acts together with Emp24p/Erv25p in cargo exit from the ER; functional ortholog of mammalian GPI-glycan r [...] |
| APQ12 protein network | https://string-db.org/network/4932.YIL040W | Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morpho [...] |
| GVP36 protein network | https://string-db.org/network/4932.YIL041W | BAR domain protein that localizes to early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, an [...] |
| PKP1 protein network | https://string-db.org/network/4932.YIL042C | Mitochondrial protein kinase; involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase P [...] |
| CBR1 protein network | https://string-db.org/network/4932.YIL043C | NADH-cytochrome b5 reductase 1; Cytochrome b reductase; not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type [...] |
| AGE2 protein network | https://string-db.org/network/4932.YIL044C | ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif. |
| PIG2 protein network | https://string-db.org/network/4932.YIL045W | GSY2-interacting protein PIG2; Putative type-1 protein phosphatase targeting subunit; tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; PIG2 has a paralog, GIP2, that arose fro [...] |
| MET30 protein network | https://string-db.org/network/4932.YIL046W | F-box protein containing five copies of the WD40 motif; controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and re [...] |
| YIL046W-A protein network | https://string-db.org/network/4932.YIL046W-A | Uncharacterized protein YIL046W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| SYG1 protein network | https://string-db.org/network/4932.YIL047C | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency. |
| NEO1 protein network | https://string-db.org/network/4932.YIL048W | Probable phospholipid-transporting ATPase NEO1; Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to E [...] |
| DFG10 protein network | https://string-db.org/network/4932.YIL049W | Probable polyprenol reductase; catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human homolog SRD5A3 confer CDG (Con [...] |
| PCL7 protein network | https://string-db.org/network/4932.YIL050W | Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cyc [...] |
| MMF1 protein network | https://string-db.org/network/4932.YIL051C | Mitochondrial protein required for transamination of isoleucine; but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; induction of expression in [...] |
| RPL34B protein network | https://string-db.org/network/4932.YIL052C | Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication. |
| GPP1 protein network | https://string-db.org/network/4932.YIL053W | Glycerol-1-phosphate phosphohydrolase 1; Constitutively expressed DL-glycerol-3-phosphate phosphatase; also known as glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response [...] |
| YIL054W protein network | https://string-db.org/network/4932.YIL054W | Uncharacterized membrane protein YIL054W; Protein of unknown function; expressed at both mRNA and protein levels. |
| YIL055C protein network | https://string-db.org/network/4932.YIL055C | Uncharacterized protein YIL055C; Putative protein of unknown function. |
| VHR1 protein network | https://string-db.org/network/4932.YIL056W | Transcription factor VHR1; Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis interme [...] |
| RGI2 protein network | https://string-db.org/network/4932.YIL057C | Respiratory growth induced protein 2; Protein of unknown function; involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high [...] |
| YIL060W protein network | https://string-db.org/network/4932.YIL060W | Uncharacterized protein YIL060W; Mitochondrial protein of unknown function; required for respiratory growth; mutant accumulates less glycogen than does wild type; null mutation results in a decre [...] |
| SNP1 protein network | https://string-db.org/network/4932.YIL061C | U1 small nuclear ribonucleoprotein 70 kDa homolog; Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) p [...] |
| ARC15 protein network | https://string-db.org/network/4932.YIL062C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. |
| YRB2 protein network | https://string-db.org/network/4932.YIL063C | Ran-specific GTPase-activating protein 2; Protein of unknown function; involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and F [...] |
| EFM4 protein network | https://string-db.org/network/4932.YIL064W | Protein-lysine N-methyltransferase EFM4; Lysine methyltransferase; involved in the dimethylation of eEF1A (Tef1p/Tef2p) at lysine 316; sequence similarity to S-adenosylmethionine-dependent methyl [...] |
| FIS1 protein network | https://string-db.org/network/4932.YIL065C | Protein involved in mitochondrial fission and peroxisome abundance; may have a distinct role in tethering protein aggregates to mitochondria in order to retain them in the mother cell; required f [...] |
| RNR3 protein network | https://string-db.org/network/4932.YIL066C | Ribonucleoside-diphosphate reductase large chain 2; Minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulat [...] |
| YIL067C protein network | https://string-db.org/network/4932.YIL067C | Uncharacterized protein of unknown function. |
| SEC6 protein network | https://string-db.org/network/4932.YIL068C | Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior [...] |
| RPS24B protein network | https://string-db.org/network/4932.YIL069C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplica [...] |
| MAM33 protein network | https://string-db.org/network/4932.YIL070C | Mitochondrial acidic protein MAM33; Specific translational activator for the mitochondrial COX1 mRNA; acidic protein of the mitochondrial matrix; related to the human complement receptor gC1q-R; [...] |
| PCI8 protein network | https://string-db.org/network/4932.YIL071C | Possible shared subunit of Cop9 signalosome (CSN) and eIF3; binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 si [...] |
| YIL071W-A protein network | https://string-db.org/network/4932.YIL071W-A | Putative uncharacterized protein YIL071W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely o [...] |
| HOP1 protein network | https://string-db.org/network/4932.YIL072W | Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formati [...] |
| SPO22 protein network | https://string-db.org/network/4932.YIL073C | Sporulation-specific protein 22; Meiosis-specific protein essential for chromosome synapsis; involved in completion of nuclear divisions during meiosis; induced early in meiosis. |
| SER33 protein network | https://string-db.org/network/4932.YIL074C | D-3-phosphoglycerate dehydrogenase 2; 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also [...] |
| RPN2 protein network | https://string-db.org/network/4932.YIL075C | Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress. |
| SEC28 protein network | https://string-db.org/network/4932.YIL076W | Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance i [...] |
| YIL077C protein network | https://string-db.org/network/4932.YIL077C | PUP1 protein homolog; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity [...] |
| THS1 protein network | https://string-db.org/network/4932.YIL078W | Threonine--tRNA ligase, cytoplasmic; Threonyl-tRNA synthetase; essential cytoplasmic protein; human homolog TARS can complement yeast null mutant. |
| AIR1 protein network | https://string-db.org/network/4932.YIL079C | Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR [...] |
| YIL082W protein network | https://string-db.org/network/4932.YIL082W | Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs) [...] |
| CAB2 protein network | https://string-db.org/network/4932.YIL083C | Phosphopantothenate--cysteine ligase CAB2; Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable phosphopa [...] |
| SDS3 protein network | https://string-db.org/network/4932.YIL084C | Transcriptional regulatory protein SDS3; Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity, involved in transcriptional silencing an [...] |
| KTR7 protein network | https://string-db.org/network/4932.YIL085C | Probable mannosyltransferase KTR7; Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from th [...] |
| AIM19 protein network | https://string-db.org/network/4932.YIL087C | Protein of unknown function; mitochondrial protein that physically interacts with Tim23p; null mutant displays reduced respiratory growth; Belongs to the AIM19 family. |
| AVT7 protein network | https://string-db.org/network/4932.YIL088C | Vacuolar amino acid transporter 7; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters. |
| YIL089W protein network | https://string-db.org/network/4932.YIL089W | Uncharacterized membrane protein YIL089W; Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking. |
| ICE2 protein network | https://string-db.org/network/4932.YIL090W | Protein ICE2; Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase [...] |
| UTP25 protein network | https://string-db.org/network/4932.YIL091C | U3 small nucleolar RNA-associated protein 25; Nucleolar protein; required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis. |
| YIL092W protein network | https://string-db.org/network/4932.YIL092W | Uncharacterized protein YIL092W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus. |
| RSM25 protein network | https://string-db.org/network/4932.YIL093C | Mitochondrial ribosomal protein of the small subunit. |
| LYS12 protein network | https://string-db.org/network/4932.YIL094C | Homoisocitrate dehydrogenase, mitochondrial; Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate [...] |
| PRK1 protein network | https://string-db.org/network/4932.YIL095W | Actin-regulating kinase PRK1; Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation [...] |
| BMT5 protein network | https://string-db.org/network/4932.YIL096C | Methyltransferase required for m3U2634 methylation of the 25S rRNA; S-adenosylmethionine-dependent; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome b [...] |
| FYV10 protein network | https://string-db.org/network/4932.YIL097W | Protein FYV10; Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to [...] |
| FMC1 protein network | https://string-db.org/network/4932.YIL098C | ATP synthase assembly factor FMC1, mitochondrial; Mitochondrial matrix protein; required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mu [...] |
| SGA1 protein network | https://string-db.org/network/4932.YIL099W | Intracellular sporulation-specific glucoamylase; involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation. |
| XBP1 protein network | https://string-db.org/network/4932.YIL101C | Transcriptional repressor; binds promoter sequences of cyclin genes, CYS3, and SMF2; not expressed during log phase of growth, but induced by stress or starvation during mitosis, and late in meio [...] |
| YIL102C protein network | https://string-db.org/network/4932.YIL102C | Uncharacterized protein YIL102C; Putative protein of unknown function. |
| YIL102C-A protein network | https://string-db.org/network/4932.YIL102C-A | Uncharacterized protein YIL102C-A; Putative protein of unknown function; identified based on comparisons of the genome sequences of six Saccharomyces species; SWAT-GFP, seamless-GFP and mCherry f [...] |
| DPH1 protein network | https://string-db.org/network/4932.YIL103W | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine re [...] |
| SHQ1 protein network | https://string-db.org/network/4932.YIL104C | Chaperone protein; required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; functions as an RNA mimic; forms a complex with Naf1p and interacts with H/ACA snoRNP component [...] |
| SLM1 protein network | https://string-db.org/network/4932.YIL105C | Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1; Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskel [...] |
| YIL105W-A protein network | https://string-db.org/network/4932.YIL105W-A | Uncharacterized protein YIL105W-A; Protein of unknown function; completely overlaps the verified gene SLM1; identified by gene-trapping, microarray-based expression analysis, and genome-wide homo [...] |
| MOB1 protein network | https://string-db.org/network/4932.YIL106W | DBF2 kinase activator protein MOB1; Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required fo [...] |
| PFK26 protein network | https://string-db.org/network/4932.YIL107C | 6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A. |
| YIL108W protein network | https://string-db.org/network/4932.YIL108W | Putative zinc metalloproteinase YIL108W; Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress; Belongs to the peptidase M10B family. |
| SEC24 protein network | https://string-db.org/network/4932.YIL109C | Protein transport protein SEC24; Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous t [...] |
| HPM1 protein network | https://string-db.org/network/4932.YIL110W | AdoMet-dependent methyltransferase; involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar prot [...] |
| COX5B protein network | https://string-db.org/network/4932.YIL111W | Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic gr [...] |
| HOS4 protein network | https://string-db.org/network/4932.YIL112W | Protein HOS4; Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate. |
| SDP1 protein network | https://string-db.org/network/4932.YIL113W | Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate locali [...] |
| POR2 protein network | https://string-db.org/network/4932.YIL114C | Mitochondrial outer membrane protein porin 2; Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stabili [...] |
| NUP159 protein network | https://string-db.org/network/4932.YIL115C | FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regul [...] |
| HIS5 protein network | https://string-db.org/network/4932.YIL116W | Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sen [...] |
| PRM5 protein network | https://string-db.org/network/4932.YIL117C | Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication. |
| RHO3 protein network | https://string-db.org/network/4932.YIL118W | GTP-binding protein RHO3; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase [...] |
| RPI1 protein network | https://string-db.org/network/4932.YIL119C | Negative RAS protein regulator protein; Transcription factor, allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpre [...] |
| QDR1 protein network | https://string-db.org/network/4932.YIL120W | Quinidine resistance protein 1; Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in spore wall assembly; sequence si [...] |
| QDR2 protein network | https://string-db.org/network/4932.YIL121W | Quinidine resistance protein 2; Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate sp [...] |
| POG1 protein network | https://string-db.org/network/4932.YIL122W | Transcriptional activator POG1; Nuclear chromatin-associated protein of unknown function; may have a role in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest [...] |
| SIM1 protein network | https://string-db.org/network/4932.YIL123W | Probable secreted beta-glucosidase SIM1; Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating tha [...] |
| AYR1 protein network | https://string-db.org/network/4932.YIL124W | Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycero [...] |
| KGD1 protein network | https://string-db.org/network/4932.YIL125W | 2-oxoglutarate dehydrogenase, mitochondrial; Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative deca [...] |
| STH1 protein network | https://string-db.org/network/4932.YIL126W | Nuclear protein STH1/NPS1; ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase [...] |
| RRT14 protein network | https://string-db.org/network/4932.YIL127C | Regulator of rDNA transcription protein 14; Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-f [...] |
| MET18 protein network | https://string-db.org/network/4932.YIL128W | DNA repair/transcription protein MET18/MMS19; Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex wi [...] |
| TAO3 protein network | https://string-db.org/network/4932.YIL129C | Cell morphogenesis protein PAG1; Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with [...] |
| ASG1 protein network | https://string-db.org/network/4932.YIL130W | Activator of stress genes 1; Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor whi [...] |
| FKH1 protein network | https://string-db.org/network/4932.YIL131C | Fork head protein homolog 1; Forkhead family transcription factor; rate-limiting replication origin activator; evolutionarily conserved lifespan regulator; binds multiple chromosomal elements wit [...] |
| CSM2 protein network | https://string-db.org/network/4932.YIL132C | Chromosome segregation in meiosis protein 2; Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Shu1, Shu2, and promotes error-free DNA repair,; Shu complex mediates inh [...] |
| RPL16A protein network | https://string-db.org/network/4932.YIL133C | Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a [...] |
| YIL134C-A protein network | https://string-db.org/network/4932.YIL134C-A | Uncharacterized protein YIL134C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| FLX1 protein network | https://string-db.org/network/4932.YIL134W | Mitochondrial FAD carrier protein FLX1; Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA [...] |
| VHS2 protein network | https://string-db.org/network/4932.YIL135C | Protein VHS2; Regulator of septin dynamics; involved in the regulation of septin dynamics at bud neck after mitotic entry, likely by stabilizing septin structure; regulated at post-translational [...] |
| OM45 protein network | https://string-db.org/network/4932.YIL136W | Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported vi [...] |
| TMA108 protein network | https://string-db.org/network/4932.YIL137C | Protein TMA108; Ribosome-associated, nascent chain binding factor; binds N-terminal region of nascent peptides during translation; recognizes target proteins via its putative metallopeptidase pep [...] |
| TPM2 protein network | https://string-db.org/network/4932.YIL138C | Tropomyosin-2; Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have dis [...] |
| REV7 protein network | https://string-db.org/network/4932.YIL139C | Accessory subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; [...] |
| AXL2 protein network | https://string-db.org/network/4932.YIL140W | Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate. |
| YIL141W protein network | https://string-db.org/network/4932.YIL141W | Putative uncharacterized protein YIL141W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| CCT2 protein network | https://string-db.org/network/4932.YIL142W | T-complex protein 1 subunit beta; Subunit beta of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo. |
| SSL2 protein network | https://string-db.org/network/4932.YIL143C | General transcription and DNA repair factor IIH helicase subunit XPB; Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, u [...] |
| NDC80 protein network | https://string-db.org/network/4932.YIL144W | Component of the kinetochore-associated Ndc80 complex; conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, and kinetochore assembly and clustering; evol [...] |
| PAN6 protein network | https://string-db.org/network/4932.YIL145C | Pantoate--beta-alanine ligase; Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologo [...] |
| ATG32 protein network | https://string-db.org/network/4932.YIL146C | Autophagy-related protein 32; Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitoch [...] |
| SLN1 protein network | https://string-db.org/network/4932.YIL147C | Osmosensing histidine protein kinase SLN1; Transmembrane histidine phosphotransfer kinase and osmosensor; regulates MAP kinase cascade; transmembrane protein with an intracellular kinase domain t [...] |
| RPL40A protein network | https://string-db.org/network/4932.YIL148W | Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homo [...] |
| MLP2 protein network | https://string-db.org/network/4932.YIL149C | Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telo [...] |
| MCM10 protein network | https://string-db.org/network/4932.YIL150C | Minichromosome maintenance protein 10; Essential chromatin-associated protein; involved in initiation of DNA replication; required for association of MCM2-7 complex with replication origins; requ [...] |
| ESL1 protein network | https://string-db.org/network/4932.YIL151C | hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl1p and Esl2p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease dom [...] |
| YIL152W protein network | https://string-db.org/network/4932.YIL152W | Uncharacterized protein YIL152W; Putative protein of unknown function. |
| RRD1 protein network | https://string-db.org/network/4932.YIL153W | Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; requir [...] |
| IMP2 protein network | https://string-db.org/network/4932.YIL154C | Sugar utilization regulatory protein IMP2; Transcriptional activator involved in maintenance of ion homeostasis; also involved in protection against DNA damage caused by bleomycin and other oxida [...] |
| GUT2 protein network | https://string-db.org/network/4932.YIL155C | Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependen [...] |
| UBP7 protein network | https://string-db.org/network/4932.YIL156W | Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP7 has a paralog, UBP11, that arose from the whole genome duplication. |
| YIL156W-B protein network | https://string-db.org/network/4932.YIL156W-B | Uncharacterized protein YIL156W-B; Putative protein of unknown function; originally identified based on homology to <i>Ashbya gossypii</i> and other related yeasts; SWAT-GFP and mCherry fusion pr [...] |
| COA1 protein network | https://string-db.org/network/4932.YIL157C | Cytochrome c oxidase assembly factor 1; Mitochondrial inner membrane protein; required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy [...] |
| AIM20 protein network | https://string-db.org/network/4932.YIL158W | Altered inheritance of mitochondria protein 20; Protein of unknown function; overexpression causes cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to vacuole; [...] |
| BNR1 protein network | https://string-db.org/network/4932.YIL159W | BNI1-related protein 1; Formin; nucleates the formation of linear actin filaments; involved in processes such as budding and mitotic spindle orientation which require the formation of polarized a [...] |
| POT1 protein network | https://string-db.org/network/4932.YIL160C | 3-ketoacyl-CoA thiolase, peroxisomal; 3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids. |
| YIL161W protein network | https://string-db.org/network/4932.YIL161W | Uncharacterized protein YIL161W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL [...] |
| SUC2 protein network | https://string-db.org/network/4932.YIL162W | Invertase; sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively. |
| YIL163C protein network | https://string-db.org/network/4932.YIL163C | Uncharacterized protein YIL163C; Protein of unknown function; mRNA identified as translated by ribosome profiling data. |
| NIT1 protein network | https://string-db.org/network/4932.YIL164C | Putative nitrilase-like protein NIT1; Nitrilase; member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adj [...] |
| YIL165C protein network | https://string-db.org/network/4932.YIL165C | Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute [...] |
| YIL166C protein network | https://string-db.org/network/4932.YIL166C | Uncharacterized transporter YIL166C; Putative protein with similarity to allantoate permease; similar to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expre [...] |
| CSS1 protein network | https://string-db.org/network/4932.YIL169C | Protein of unknown function, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extra [...] |
| YIL171W-A protein network | https://string-db.org/network/4932.YIL171W-A | Putative uncharacterized membrane protein YIL171W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps O [...] |
| IMA3 protein network | https://string-db.org/network/4932.YIL172C | Oligo-1,6-glucosidase IMA3; Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilizat [...] |
| VTH1 protein network | https://string-db.org/network/4932.YIL173W | VPS10 homolog 1; Putative membrane glycoprotein; has strong similarity to Vth2p and Pep1p/Vps10p; may be involved in vacuolar protein sorting. |
| PAU14 protein network | https://string-db.org/network/4932.YIL176C | Seripauperin-14; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau1p; Belongs to the SRP1/TIP1 family. Seripauperin [...] |
| YIL177C protein network | https://string-db.org/network/4932.YIL177C | Putative Y' element ATP-dependent helicase. |
| YIL177W-A protein network | https://string-db.org/network/4932.YIL177W-A | Putative UPF0479 protein YJL225W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the unc [...] |
| SGN1 protein network | https://string-db.org/network/4932.YIR001C | Cytoplasmic RNA-binding protein; contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in transl [...] |
| MPH1 protein network | https://string-db.org/network/4932.YIR002C | 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for [...] |
| AIM21 protein network | https://string-db.org/network/4932.YIR003W | Protein of unknown function; involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; Belongs to [...] |
| DJP1 protein network | https://string-db.org/network/4932.YIR004W | DnaJ-like protein 1; Cytosolic J-domain-containing protein; required for peroxisomal protein import and involved in peroxisome assembly; facilitates import of Mim1p and Mim2p into the mitochondri [...] |
| IST3 protein network | https://string-db.org/network/4932.YIR005W | Component of the U2 snRNP; required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing; diploid mutants have [...] |
| PAN1 protein network | https://string-db.org/network/4932.YIR006C | Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p; associates with actin patches on cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activa [...] |
| EGH1 protein network | https://string-db.org/network/4932.YIR007W | Ergosteryl-beta-glucosidase; Steryl-beta-glucosidase with broad specificity for aglycones; has a role in ergosteryl-beta-glucoside catabolism; required for normal vacuolar morphology; has similar [...] |
| PRI1 protein network | https://string-db.org/network/4932.YIR008C | Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair; Belongs to the eukaryotic-type primase small subunit family. |
| MSL1 protein network | https://string-db.org/network/4932.YIR009W | U2 small nuclear ribonucleoprotein B'; U2B component of U2 snRNP; involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not co [...] |
| DSN1 protein network | https://string-db.org/network/4932.YIR010W | Kinetochore-associated protein DSN1; Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; Dsn1p phosphorylation promote [...] |
| STS1 protein network | https://string-db.org/network/4932.YIR011C | Tethering factor for nuclear proteasome STS1; Protein required for localizing proteasomes to the nucleus; involved in cotranslational protein degradation; mediates interaction between nuclear imp [...] |
| SQT1 protein network | https://string-db.org/network/4932.YIR012W | Ribosome assembly protein SQT1; Specific chaperone for ribosomal protein Rpl10p; binds nascent Rpl10p during translation; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; [...] |
| GAT4 protein network | https://string-db.org/network/4932.YIR013C | Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT3, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative [...] |
| YIR014W protein network | https://string-db.org/network/4932.YIR014W | Vacuole localized DSC protein 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and [...] |
| RPR2 protein network | https://string-db.org/network/4932.YIR015W | Ribonuclease P protein subunit RPR2; Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RN [...] |
| YIR016W protein network | https://string-db.org/network/4932.YIR016W | Uncharacterized protein YIR016W; Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cyc [...] |
| MET28 protein network | https://string-db.org/network/4932.YIR017C | bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex; participates in the regulation of sulfur metabolism. |
| YIR018C-A protein network | https://string-db.org/network/4932.YIR018C-A | Uncharacterized protein YIR018C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| YAP5 protein network | https://string-db.org/network/4932.YIR018W | Basic leucine zipper (bZIP) iron-sensing transcription factor; involved in diauxic shift; YAP5 has a paralog, YAP7, that arose from the whole genome duplication. |
| FLO11 protein network | https://string-db.org/network/4932.YIR019C | Flocculation protein FLO11; GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal and invasive growth, flocculation, and biofilm formation; major determinant of colony mor [...] |
| YIR020C protein network | https://string-db.org/network/4932.YIR020C | Uncharacterized protein YIR020C; Protein of unknown function; mRNA identified as translated by ribosome profiling data; SWAT-GFP fusion protein localizes to the endoplasmic reticulum. |
| MRS1 protein network | https://string-db.org/network/4932.YIR021W | Splicing protein; required for splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the [...] |
| YIR021W-A protein network | https://string-db.org/network/4932.YIR021W-A | Uncharacterized protein YIR021W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| SEC11 protein network | https://string-db.org/network/4932.YIR022W | 18kDa catalytic subunit of the Signal Peptidase Complex (SPC); the Signal Peptidase Complex cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; other members are Spc1p, [...] |
| DAL81 protein network | https://string-db.org/network/4932.YIR023W | Transcriptional activator protein DAL81; Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequen [...] |
| INA22 protein network | https://string-db.org/network/4932.YIR024C | Inner membrane assembly complex subunit 22; F1F0 ATP synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) in [...] |
| MND2 protein network | https://string-db.org/network/4932.YIR025W | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent deg [...] |
| YVH1 protein network | https://string-db.org/network/4932.YIR026C | Tyrosine-protein phosphatase YVH1; Dual specificity protein phosphatase; regulates growth, sporulation, and glycogen accumulation in a cAMP-dependent protein kinase cascade dependent manner; muta [...] |
| DAL1 protein network | https://string-db.org/network/4932.YIR027C | Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression; Belongs to the metallo-dependent hydrolases supe [...] |
| DAL4 protein network | https://string-db.org/network/4932.YIR028W | Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; Belongs to the purine-cytosine permease (2.A.39) f [...] |
| DAL2 protein network | https://string-db.org/network/4932.YIR029W | Allantoicase; converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an in [...] |
| DCG1 protein network | https://string-db.org/network/4932.YIR030C | Protein of unknown function; expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain; Belongs to the HyuE racemase family. |
| DAL7 protein network | https://string-db.org/network/4932.YIR031C | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion [...] |
| DAL3 protein network | https://string-db.org/network/4932.YIR032C | Ureidoglycolate lyase; converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression is sensitive to nitrogen catabolite repression; this enzyme is someti [...] |
| MGA2 protein network | https://string-db.org/network/4932.YIR033W | ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear tar [...] |
| LYS1 protein network | https://string-db.org/network/4932.YIR034C | Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activi [...] |
| YIR035C protein network | https://string-db.org/network/4932.YIR035C | Uncharacterized oxidoreductase YIR035C; Putative cytoplasmic short-chain dehydrogenase/reductase. |
| IRC24 protein network | https://string-db.org/network/4932.YIR036C | Benzil reductase ((S)-benzoin forming) IRC24; Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with shor [...] |
| HYR1 protein network | https://string-db.org/network/4932.YIR037W | Glutathione peroxidase-like peroxiredoxin HYR1; Thiol peroxidase; functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p trans [...] |
| GTT1 protein network | https://string-db.org/network/4932.YIR038C | ER associated glutathione S-transferase; capable of homodimerization; glutathione transferase for Yvc1p vacuolar cation channel; expression induced during the diauxic shift and throughout station [...] |
| YPS6 protein network | https://string-db.org/network/4932.YIR039C | Aspartic proteinase yapsin-6; Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance. |
| YIR040C protein network | https://string-db.org/network/4932.YIR040C | Putative UPF0377 protein YIR040C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family [...] |
| PAU15 protein network | https://string-db.org/network/4932.YIR041W | Seripauperin-15; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; Bel [...] |
| YIR042C protein network | https://string-db.org/network/4932.YIR042C | Putative protein of unknown function; YIR042C is a non-essential gene. |
| PRE3 protein network | https://string-db.org/network/4932.YJL001W | Beta 1 subunit of the 20S proteasome; responsible for cleavage after acidic residues in peptides. |
| OST1 protein network | https://string-db.org/network/4932.YJL002C | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation [...] |
| COX16 protein network | https://string-db.org/network/4932.YJL003W | Mitochondrial inner membrane protein; required for assembly of cytochrome c oxidase. |
| SYS1 protein network | https://string-db.org/network/4932.YJL004C | Protein SYS1; Integral membrane protein of the Golgi; required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation. |
| CYR1 protein network | https://string-db.org/network/4932.YJL005W | Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress re [...] |
| CTK2 protein network | https://string-db.org/network/4932.YJL006C | Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to inc [...] |
| YJL007C protein network | https://string-db.org/network/4932.YJL007C | Uncharacterized protein YJL007C; Putative protein of unknown function; conserved among S. cerevisiae strains. |
| CCT8 protein network | https://string-db.org/network/4932.YJL008C | T-complex protein 1 subunit theta; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo. |
| YJL009W protein network | https://string-db.org/network/4932.YJL009W | Uncharacterized protein YJL009W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008 [...] |
| NOP9 protein network | https://string-db.org/network/4932.YJL010C | Nucleolar protein 9; Essential subunit of U3-containing 90S preribosome; involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for [...] |
| RPC17 protein network | https://string-db.org/network/4932.YJL011C | RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in respon [...] |
| VTC4 protein network | https://string-db.org/network/4932.YJL012C | Vacuolar transporter chaperone 4; Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuol [...] |
| MAD3 protein network | https://string-db.org/network/4932.YJL013C | Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promot [...] |
| CCT3 protein network | https://string-db.org/network/4932.YJL014W | T-complex protein 1 subunit gamma; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; capable of binding Q/N rich pro [...] |
| YJL015C protein network | https://string-db.org/network/4932.YJL015C | Putative uncharacterized protein YJL015C; Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encod [...] |
| TPH3 protein network | https://string-db.org/network/4932.YJL016W | Uncharacterized protein YJL016W; Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; contains two adjacent PH-like domains; conserved in closely related Saccharom [...] |
| MPS3 protein network | https://string-db.org/network/4932.YJL019W | Spindle pole body assembly component MPS3; Nuclear envelope protein; required for SPB insertion, SPB duplication, Kar5p localization near the SPB and nuclear fusion; interacts with Mps2p to tethe [...] |
| BBC1 protein network | https://string-db.org/network/4932.YJL020C | Myosin tail region-interacting protein MTI1; Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3 [...] |
| YJL022W protein network | https://string-db.org/network/4932.YJL022W | Putative uncharacterized protein YJL009W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| PET130 protein network | https://string-db.org/network/4932.YJL023C | Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| APS3 protein network | https://string-db.org/network/4932.YJL024C | AP-3 complex subunit sigma; Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 comple [...] |
| RRN7 protein network | https://string-db.org/network/4932.YJL025W | RNA polymerase I-specific transcription initiation factor RRN7; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA poly [...] |
| RNR2 protein network | https://string-db.org/network/4932.YJL026W | Ribonucleoside-diphosphate reductase small chain 1; Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated [...] |
| YJL027C protein network | https://string-db.org/network/4932.YJL027C | Uncharacterized protein YJL027C; Putative protein of unknown function. |
| YJL028W protein network | https://string-db.org/network/4932.YJL028W | Uncharacterized protein YJL028W; Protein of unknown function; may interact with ribosomes, based on co-purification experiments. |
| VPS53 protein network | https://string-db.org/network/4932.YJL029C | Vacuolar protein sorting-associated protein 53; Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golg [...] |
| MAD2 protein network | https://string-db.org/network/4932.YJL030W | Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prome [...] |
| BET4 protein network | https://string-db.org/network/4932.YJL031C | Alpha subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Yp [...] |
| HCA4 protein network | https://string-db.org/network/4932.YJL033W | DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; Belongs [...] |
| KAR2 protein network | https://string-db.org/network/4932.YJL034W | Endoplasmic reticulum chaperone BiP; ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble prote [...] |
| TAD2 protein network | https://string-db.org/network/4932.YJL035C | Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs; Belongs to the cytidine and deoxycytidy [...] |
| SNX4 protein network | https://string-db.org/network/4932.YJL036W | Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain [...] |
| IRC18 protein network | https://string-db.org/network/4932.YJL037W | Protein involved in outer spore wall assembly; possible role in assembly of the dityrosine layer; similar to adjacent ORF, LOH1; irc18 loh1 double mutant exhibits reduced dityrosine fluorescence [...] |
| LOH1 protein network | https://string-db.org/network/4932.YJL038C | Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence s [...] |
| NUP192 protein network | https://string-db.org/network/4932.YJL039C | Nucleoporin NUP192; Essential subunit of inner ring of nuclear pore complex (NPC); plays a role in modulating transport through the NPC; homologous to human NUP205. |
| NSP1 protein network | https://string-db.org/network/4932.YJL041W | FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenan [...] |
| MHP1 protein network | https://string-db.org/network/4932.YJL042W | MAP-homologous protein 1; Microtubule-associated protein involved in microtubule organization; involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest [...] |
| YJL043W protein network | https://string-db.org/network/4932.YJL043W | Putative protein of unknown function; YJL043W is a non-essential gene; To yeast YKR015c. |
| GYP6 protein network | https://string-db.org/network/4932.YJL044C | GTPase-activating protein (GAP) for yeast Rab family member Ypt6p; involved in vesicle mediated protein transport. |
| YJL045W protein network | https://string-db.org/network/4932.YJL045W | Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial; Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; [...] |
| AIM22 protein network | https://string-db.org/network/4932.YJL046W | Putative lipoate-protein ligase; required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss [...] |
| RTT101 protein network | https://string-db.org/network/4932.YJL047C | Cullin-8; Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; role in anaphase progression; required for recovery after DSB repair; implicated in Mms22-dependent DNA repair; involved [...] |
| YJL047C-A protein network | https://string-db.org/network/4932.YJL047C-A | Uncharacterized protein YJL047C-A; Putative protein of unknown function. |
| UBX6 protein network | https://string-db.org/network/4932.YJL048C | UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, [...] |
| CHM7 protein network | https://string-db.org/network/4932.YJL049W | Uncharacterized protein YJL049W; Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum presumably as part of an ESCRT-III like complex; null mutant has growth defect at 37 C in an [...] |
| MTR4 protein network | https://string-db.org/network/4932.YJL050W | ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RN [...] |
| IRC8 protein network | https://string-db.org/network/4932.YJL051W | Uncharacterized protein IRC8; Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in [...] |
| YJL052C-A protein network | https://string-db.org/network/4932.YJL052C-A | Uncharacterized protein YJL052C-A; Putative protein of unknown function; identified based on comparison to related yeast species; mCherry fusion protein localizes to the vacuole. |
| TDH1 protein network | https://string-db.org/network/4932.YJL052W | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglyce [...] |
| PEP8 protein network | https://string-db.org/network/4932.YJL053W | Carboxypeptidase Y-deficient protein 8; Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along wi [...] |
| TIM54 protein network | https://string-db.org/network/4932.YJL054W | Mitochondrial import inner membrane translocase subunit TIM54; Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane. |
| YJL055W protein network | https://string-db.org/network/4932.YJL055W | LOG family protein YJL055W; Putative protein of unknown function; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affe [...] |
| ZAP1 protein network | https://string-db.org/network/4932.YJL056C | Zinc-responsive transcriptional regulator ZAP1; Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses oth [...] |
| IKS1 protein network | https://string-db.org/network/4932.YJL057C | Probable serine/threonine-protein kinase IKS1; Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hyper [...] |
| BIT61 protein network | https://string-db.org/network/4932.YJL058C | Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2 [...] |
| YHC3 protein network | https://string-db.org/network/4932.YJL059W | Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeost [...] |
| BNA3 protein network | https://string-db.org/network/4932.YJL060W | Probable kynurenine--oxoglutarate transaminase BNA3; Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate. |
| NUP82 protein network | https://string-db.org/network/4932.YJL061W | Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable association [...] |
| LAS21 protein network | https://string-db.org/network/4932.YJL062W | GPI ethanolamine phosphate transferase 2; Integral plasma membrane protein; involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrit [...] |
| COA3 protein network | https://string-db.org/network/4932.YJL062W-A | Mitochondrial protein required for cytochrome c oxidase assembly; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; located in the mitochondr [...] |
| MRPL8 protein network | https://string-db.org/network/4932.YJL063C | Mitochondrial ribosomal protein of the large subunit. |
| YJL064W protein network | https://string-db.org/network/4932.YJL064W | Putative uncharacterized protein YJL064W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps t [...] |
| DLS1 protein network | https://string-db.org/network/4932.YJL065C | Protein DLS1; Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, [...] |
| MPM1 protein network | https://string-db.org/network/4932.YJL066C | Mitochondrial intermembrane space protein of unknown function. |
| YJL068C protein network | https://string-db.org/network/4932.YJL068C | Esterase that can function as an S-formylglutathione hydrolase; non-essential intracellular esterase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylgl [...] |
| UTP18 protein network | https://string-db.org/network/4932.YJL069C | Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; conta [...] |
| YJL070C protein network | https://string-db.org/network/4932.YJL070C | Inactive deaminase YJL070C; Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic de [...] |
| ARG2 protein network | https://string-db.org/network/4932.YJL071W | Amino-acid acetyltransferase, mitochondrial; Acetylglutamate synthase (glutamate N-acetyltransferase); mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precu [...] |
| PSF2 protein network | https://string-db.org/network/4932.YJL072C | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; Belongs to the GINS2/PSF2 fa [...] |
| JEM1 protein network | https://string-db.org/network/4932.YJL073W | DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2. |
| SMC3 protein network | https://string-db.org/network/4932.YJL074C | Structural maintenance of chromosomes protein 3; Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and [...] |
| NET1 protein network | https://string-db.org/network/4932.YJL076W | Nucleolar protein NET1; Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 [...] |
| ICS3 protein network | https://string-db.org/network/4932.YJL077C | Increased copper sensitivity protein 3; Protein with a role in copper homeostasis; possible role in vacuolar sorting and processing of secretory proteins; null mutants are hypersensitive to sorti [...] |
| YJL077W-A protein network | https://string-db.org/network/4932.YJL077W-A | Uncharacterized protein YJL077W-A; Protein of unknown function; mRNA identified as translated by ribosome profiling data; completely overlaps the verified gene YJL077C/ICS3. |
| YJL077W-B protein network | https://string-db.org/network/4932.YJL077W-B | Uncharacterized protein YJL077W-B; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| PRY3 protein network | https://string-db.org/network/4932.YJL078C | Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 prote [...] |
| PRY1 protein network | https://string-db.org/network/4932.YJL079C | Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and path [...] |
| SCP160 protein network | https://string-db.org/network/4932.YJL080C | Protein SCP160; Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating sig [...] |
| ARP4 protein network | https://string-db.org/network/4932.YJL081C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. |
| IML2 protein network | https://string-db.org/network/4932.YJL082W | Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mito [...] |
| TAX4 protein network | https://string-db.org/network/4932.YJL083W | Protein TAX4; EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs [...] |
| ALY2 protein network | https://string-db.org/network/4932.YJL084C | Arrestin-related trafficking adapter 3; Alpha arrestin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by [...] |
| EXO70 protein network | https://string-db.org/network/4932.YJL085W | Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2 [...] |
| TRL1 protein network | https://string-db.org/network/4932.YJL087C | tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner [...] |
| ARG3 protein network | https://string-db.org/network/4932.YJL088W | Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline. |
| SIP4 protein network | https://string-db.org/network/4932.YJL089W | Protein SIP4; C6 zinc cluster transcriptional activator; binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regul [...] |
| DPB11 protein network | https://string-db.org/network/4932.YJL090C | DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where [...] |
| GWT1 protein network | https://string-db.org/network/4932.YJL091C | GPI-anchored wall transfer protein 1; Protein involved in the inositol acylation of GlcN-PI; the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) forms glucosaminyl(acyl)phosphat [...] |
| SRS2 protein network | https://string-db.org/network/4932.YJL092W | DNA helicase and DNA-dependent ATPase; involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks [...] |
| TOK1 protein network | https://string-db.org/network/4932.YJL093C | Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inne [...] |
| KHA1 protein network | https://string-db.org/network/4932.YJL094C | K(+)/H(+) antiporter 1; Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throug [...] |
| BCK1 protein network | https://string-db.org/network/4932.YJL095W | Serine/threonine-protein kinase BCK1/SLK1/SSP31; MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphor [...] |
| MRPL49 protein network | https://string-db.org/network/4932.YJL096W | Mitochondrial ribosomal protein of the large subunit. |
| PHS1 protein network | https://string-db.org/network/4932.YJL097W | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase PHS1; Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane; involved in elongation of very long-chain fatty acids; evolutionarily conserve [...] |
| SAP185 protein network | https://string-db.org/network/4932.YJL098W | SIT4-associating protein SAP185; Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and [...] |
| CHS6 protein network | https://string-db.org/network/4932.YJL099W | Chitin biosynthesis protein CHS6; Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the [...] |
| LSB6 protein network | https://string-db.org/network/4932.YJL100W | Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; Belongs to the PI3/PI4-kinase f [...] |
| GSH1 protein network | https://string-db.org/network/4932.YJL101C | Glutamate--cysteine ligase; Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance [...] |
| MEF2 protein network | https://string-db.org/network/4932.YJL102W | Mitochondrial elongation factor involved in translational elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfam [...] |
| GSM1 protein network | https://string-db.org/network/4932.YJL103C | Glucose starvation modulator protein 1; Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequ [...] |
| PAM16 protein network | https://string-db.org/network/4932.YJL104W | Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits [...] |
| SET4 protein network | https://string-db.org/network/4932.YJL105W | Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication. |
| IME2 protein network | https://string-db.org/network/4932.YJL106W | Serine/threonine protein kinase involved in activation of meiosis; associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; human CDK2 [...] |
| YJL107C protein network | https://string-db.org/network/4932.YJL107C | Uncharacterized UPF0442 protein YJL107C; Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2 [...] |
| PRM10 protein network | https://string-db.org/network/4932.YJL108C | Pheromone-regulated protein; proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation. |
| UTP10 protein network | https://string-db.org/network/4932.YJL109C | Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance. |
| GZF3 protein network | https://string-db.org/network/4932.YJL110C | GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80 [...] |
| CCT7 protein network | https://string-db.org/network/4932.YJL111W | T-complex protein 1 subunit eta; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy t [...] |
| MDV1 protein network | https://string-db.org/network/4932.YJL112W | Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the self-assembled oligomeric form of the dynamin-related G [...] |
| ASF1 protein network | https://string-db.org/network/4932.YJL115W | Histone chaperone ASF1; Nucleosome assembly factor; involved in chromatin assembly, disassembly; required for recovery after DSB repair; role in H3K56 acetylation required for expression homeosta [...] |
| NCA3 protein network | https://string-db.org/network/4932.YJL116C | Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; SWAT-GFP, seamless-GFP and [...] |
| PHO86 protein network | https://string-db.org/network/4932.YJL117W | Inorganic phosphate transporter PHO86; Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of [...] |
| YJL118W protein network | https://string-db.org/network/4932.YJL118W | Uncharacterized protein YJL118W; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL118W is a non-essential gene; deletion enhances the toxicity of [...] |
| YJL119C protein network | https://string-db.org/network/4932.YJL119C | Putative uncharacterized protein YJL119C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YJL120W protein network | https://string-db.org/network/4932.YJL120W | Putative uncharacterized protein YJL120W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RPE1 protein network | https://string-db.org/network/4932.YJL121C | D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress. |
| ALB1 protein network | https://string-db.org/network/4932.YJL122W | Ribosome biogenesis protein ALB1; Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absenc [...] |
| MTC1 protein network | https://string-db.org/network/4932.YJL123C | Maintenance of telomere capping protein 1; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coat [...] |
| LSM1 protein network | https://string-db.org/network/4932.YJL124C | Sm-like protein LSm1; Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; also enters the nucle [...] |
| GCD14 protein network | https://string-db.org/network/4932.YJL125C | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at posit [...] |
| NIT2 protein network | https://string-db.org/network/4932.YJL126W | Deaminated glutathione amidase; Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which inter [...] |
| SPT10 protein network | https://string-db.org/network/4932.YJL127C | Protein SPT10; Histone H3 acetylase with a role in transcriptional regulation; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core [...] |
| YJL127C-B protein network | https://string-db.org/network/4932.YJL127C-B | UPF0618 protein YJL127C-B; Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i> SWAT-GFP and seamless-GFP fusion proteins localize [...] |
| YJL127W-A protein network | https://string-db.org/network/4932.YJL127W-A | Putative uncharacterized protein YJL127W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| PBS2 protein network | https://string-db.org/network/4932.YJL128C | MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition; Belongs to the protein kinase su [...] |
| TRK1 protein network | https://string-db.org/network/4932.YJL129C | Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p [...] |
| URA2 protein network | https://string-db.org/network/4932.YJL130C | Glutamine-dependent carbamoyl-phosphate synthase; Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyr [...] |
| AIM23 protein network | https://string-db.org/network/4932.YJL131C | Altered inheritance of mitochondria protein 23, mitochondrial; Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutan [...] |
| YJL132W protein network | https://string-db.org/network/4932.YJL132W | Uncharacterized protein YJL132W; Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essent [...] |
| YJL133C-A protein network | https://string-db.org/network/4932.YJL133C-A | Uncharacterized protein YJL133C-A; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| MRS3 protein network | https://string-db.org/network/4932.YJL133W | Mitochondrial RNA-splicing protein MRS3; Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport [...] |
| LCB3 protein network | https://string-db.org/network/4932.YJL134W | Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain b [...] |
| YJL135W protein network | https://string-db.org/network/4932.YJL135W | Putative uncharacterized protein YJL135W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RPS21B protein network | https://string-db.org/network/4932.YJL136C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplica [...] |
| YJL136W-A protein network | https://string-db.org/network/4932.YJL136W-A | Uncharacterized protein YJL136W-A; Putative protein of unknown function; identified by SAGE. |
| GLG2 protein network | https://string-db.org/network/4932.YJL137C | Glycogenin-2; Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog [...] |
| TIF2 protein network | https://string-db.org/network/4932.YJL138C | Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; [...] |
| YUR1 protein network | https://string-db.org/network/4932.YJL139C | Probable mannosyltransferase YUR1; Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from th [...] |
| RPB4 protein network | https://string-db.org/network/4932.YJL140W | RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay pr [...] |
| YAK1 protein network | https://string-db.org/network/4932.YJL141C | Dual specificity protein kinase YAK1; Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Ya [...] |
| IRC9 protein network | https://string-db.org/network/4932.YJL142C | Putative uncharacterized protein IRC9; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verif [...] |
| TIM17 protein network | https://string-db.org/network/4932.YJL143W | Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex; with Tim23p, contributes to the architecture and function of the import channel; may link [...] |
| YJL144W protein network | https://string-db.org/network/4932.YJL144W | Uncharacterized protein YJL144W; Cytoplasmic hydrophilin essential in desiccation-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abunda [...] |
| SFH5 protein network | https://string-db.org/network/4932.YJL145W | Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p [...] |
| IDS2 protein network | https://string-db.org/network/4932.YJL146W | Protein involved in modulation of Ime2p activity during meiosis; appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation [...] |
| MRX5 protein network | https://string-db.org/network/4932.YJL147C | MIOREX complex component 5; Protein that associates with mitochondrial ribosome; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fr [...] |
| RPA34 protein network | https://string-db.org/network/4932.YJL148W | RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p; Belongs to the eukaryotic RPA34 RNA polymerase sub [...] |
| DAS1 protein network | https://string-db.org/network/4932.YJL149W | F-box protein DAS1; Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C. |
| SNA3 protein network | https://string-db.org/network/4932.YJL151C | Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles [...] |
| YJL152W protein network | https://string-db.org/network/4932.YJL152W | Putative uncharacterized protein YJL152W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| INO1 protein network | https://string-db.org/network/4932.YJL153C | Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p [...] |
| VPS35 protein network | https://string-db.org/network/4932.YJL154C | Vacuolar protein sorting-associated protein 35; Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo p [...] |
| FBP26 protein network | https://string-db.org/network/4932.YJL155C | Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress. |
| SSY5 protein network | https://string-db.org/network/4932.YJL156C | SPS-sensor serine protease component SSY5; Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids [...] |
| FAR1 protein network | https://string-db.org/network/4932.YJL157C | CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degra [...] |
| CIS3 protein network | https://string-db.org/network/4932.YJL158C | Cell wall mannoprotein CIS3; Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family. |
| HSP150 protein network | https://string-db.org/network/4932.YJL159W | Cell wall mannoprotein HSP150; O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; in [...] |
| PIR5 protein network | https://string-db.org/network/4932.YJL160C | Cell wall protein PIR5; Putative protein of unknown function; member of the PIR (Proteins with Internal Repeats) family of cell wall proteins; SWAT-GFP fusion protein localizes to the endoplasmic [...] |
| FMP33 protein network | https://string-db.org/network/4932.YJL161W | Mitochondrial membrane protein FMP33; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| JJJ2 protein network | https://string-db.org/network/4932.YJL162C | J protein JJJ2; Protein of unknown function; contains a J-domain, which is a region with homology to the E. coli DnaJ protein. |
| YJL163C protein network | https://string-db.org/network/4932.YJL163C | Uncharacterized membrane protein YJL163C; Putative protein of unknown function. |
| TPK1 protein network | https://string-db.org/network/4932.YJL164C | cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cA [...] |
| HAL5 protein network | https://string-db.org/network/4932.YJL165C | Serine/threonine-protein kinase HAL5; Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs p [...] |
| QCR8 protein network | https://string-db.org/network/4932.YJL166W | Subunit 8 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expr [...] |
| ERG20 protein network | https://string-db.org/network/4932.YJL167W | Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and st [...] |
| SET2 protein network | https://string-db.org/network/4932.YJL168C | Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of [...] |
| ASG7 protein network | https://string-db.org/network/4932.YJL170C | Protein that regulates signaling from G protein beta subunit Ste4p; contributes to relocalization of Ste4p within the cell; specific to a-cells and induced by alpha-factor. |
| TOH1 protein network | https://string-db.org/network/4932.YJL171C | GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS [...] |
| CPS1 protein network | https://string-db.org/network/4932.YJL172W | Vacuolar carboxypeptidase S; expression is induced under low-nitrogen conditions. |
| RFA3 protein network | https://string-db.org/network/4932.YJL173C | Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, recombination; RPA protects again [...] |
| KRE9 protein network | https://string-db.org/network/4932.YJL174W | Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects. |
| YJL175W protein network | https://string-db.org/network/4932.YJL175W | Putative uncharacterized membrane protein YJL175W; Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil [...] |
| SWI3 protein network | https://string-db.org/network/4932.YJL176C | Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displa [...] |
| RPL17B protein network | https://string-db.org/network/4932.YJL177W | Ribosomal 60S subunit protein L17B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L17 and bacterial L22; R [...] |
| ATG27 protein network | https://string-db.org/network/4932.YJL178C | Autophagy-related protein 27; Type I membrane protein involved in autophagy and the Cvt pathway; may be involved in membrane delivery to the phagophore assembly site; Belongs to the ATG27 family. |
| PFD1 protein network | https://string-db.org/network/4932.YJL179W | Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin comp [...] |
| ATP12 protein network | https://string-db.org/network/4932.YJL180C | Protein ATP12, mitochondrial; Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial [...] |
| RBH1 protein network | https://string-db.org/network/4932.YJL181W | UPF0508 protein YJL181W; Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W [...] |
| YJL182C protein network | https://string-db.org/network/4932.YJL182C | Putative uncharacterized protein YJL182C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps un [...] |
| MNN11 protein network | https://string-db.org/network/4932.YJL183W | Probable alpha-1,6-mannosyltransferase MNN11; Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccha [...] |
| GON7 protein network | https://string-db.org/network/4932.YJL184W | Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress [...] |
| ATG36 protein network | https://string-db.org/network/4932.YJL185C | Autophagy-related protein 36; Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essent [...] |
| MNN5 protein network | https://string-db.org/network/4932.YJL186W | Alpha-1,2-mannosyltransferase; responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; [...] |
| SWE1 protein network | https://string-db.org/network/4932.YJL187C | Mitosis inhibitor protein kinase SWE1; Protein kinase that regulates the G2/M transition; negative regulator of the Cdc28p kinase; morphogenesis checkpoint kinase; positive regulator of sphingoli [...] |
| BUD19 protein network | https://string-db.org/network/4932.YJL188C | Putative uncharacterized protein BUD19; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closel [...] |
| RPL39 protein network | https://string-db.org/network/4932.YJL189W | Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammali [...] |
| RPS22A protein network | https://string-db.org/network/4932.YJL190C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication [...] |
| RPS14B protein network | https://string-db.org/network/4932.YJL191W | Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal p [...] |
| SOP4 protein network | https://string-db.org/network/4932.YJL192C | ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembran [...] |
| YJL193W protein network | https://string-db.org/network/4932.YJL193W | Uncharacterized transporter YJL193W; Putative protein of unknown function; predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/S [...] |
| CDC6 protein network | https://string-db.org/network/4932.YJL194W | Cell division control protein 6; Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and i [...] |
| ELO1 protein network | https://string-db.org/network/4932.YJL196C | Elongation of fatty acids protein 1; Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralo [...] |
| YJL197C-A protein network | https://string-db.org/network/4932.YJL197C-A | Uncharacterized protein YJL197C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the veri [...] |
| UBP12 protein network | https://string-db.org/network/4932.YJL197W | Ubiquitin carboxyl-terminal hydrolase 12; Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm; Belongs to the peptidase C19 family. |
| PHO90 protein network | https://string-db.org/network/4932.YJL198W | Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independe [...] |
| MBB1 protein network | https://string-db.org/network/4932.YJL199C | Uncharacterized protein MBB1; Putative protein of unknown function; conserved among S. cerevisiae strains, not conserved in closely related Saccharomyces species; protein detected in large-scale [...] |
| ACO2 protein network | https://string-db.org/network/4932.YJL200C | Homocitrate dehydratase, mitochondrial; Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by ami [...] |
| ECM25 protein network | https://string-db.org/network/4932.YJL201W | Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p. |
| PRP21 protein network | https://string-db.org/network/4932.YJL203W | Pre-mRNA-splicing factor PRP21; Subunit of the SF3a splicing factor complex; required for spliceosome assembly. |
| RCY1 protein network | https://string-db.org/network/4932.YJL204C | Recyclin-1; F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct in [...] |
| NCE101 protein network | https://string-db.org/network/4932.YJL205C | Non-classical export protein 1; Protein of unknown function; involved in secretion of proteins that lack classical secretory signal sequences; SWAT-GFP and mCherry fusion proteins localize to the [...] |
| YJL206C protein network | https://string-db.org/network/4932.YJL206C | Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induce [...] |
| LAA1 protein network | https://string-db.org/network/4932.YJL207C | AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with [...] |
| NUC1 protein network | https://string-db.org/network/4932.YJL208C | Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of ge [...] |
| CBP1 protein network | https://string-db.org/network/4932.YJL209W | Cytochrome B pre-mRNA-processing protein 1; Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex a [...] |
| PEX2 protein network | https://string-db.org/network/4932.YJL210W | Peroxisomal biogenesis factor 2; RING-finger peroxin and E3 ubiquitin ligase; peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p a [...] |
| YJL211C protein network | https://string-db.org/network/4932.YJL211C | Putative uncharacterized protein YJL211C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| OPT1 protein network | https://string-db.org/network/4932.YJL212C | Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family. |
| YJL213W protein network | https://string-db.org/network/4932.YJL213W | Uncharacterized protein YJL213W; Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit [...] |
| HXT8 protein network | https://string-db.org/network/4932.YJL214W | Hexose transporter HXT8; Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose. |
| IMA5 protein network | https://string-db.org/network/4932.YJL216C | Oligo-1,6-glucosidase IMA5; Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; most distant member of the IMA isomaltase family, but with simil [...] |
| REE1 protein network | https://string-db.org/network/4932.YJL217W | Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA exp [...] |
| YJL218W protein network | https://string-db.org/network/4932.YJL218W | Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus seque [...] |
| HXT9 protein network | https://string-db.org/network/4932.YJL219W | Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p [...] |
| YJL220W protein network | https://string-db.org/network/4932.YJL220W | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2. |
| IMA4 protein network | https://string-db.org/network/4932.YJL221C | Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima4p overexpressio [...] |
| VTH2 protein network | https://string-db.org/network/4932.YJL222W | VPS10 homolog 2; Putative membrane glycoprotein; has strong similarity to Vth1p and Pep1p/Vps10p; may be involved in vacuolar protein sorting. |
| YJL222W-A protein network | https://string-db.org/network/4932.YJL222W-A | Putative UPF0377 protein YIL174W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family [...] |
| YJL222W-B protein network | https://string-db.org/network/4932.YJL222W-B | Putative UPF0377 protein YIL175W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family [...] |
| PAU1 protein network | https://string-db.org/network/4932.YJL223C | Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; active during alcoholic fermentation; regulated [...] |
| YJL225C protein network | https://string-db.org/network/4932.YJL225C | Putative Y' element ATP-dependent helicase. |
| YJL225W-A protein network | https://string-db.org/network/4932.YJL225W-A | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YJL225C. |
| AVT1 protein network | https://string-db.org/network/4932.YJR001W | Vacuolar transporter; imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters. |
| MPP10 protein network | https://string-db.org/network/4932.YJR002W | U3 small nucleolar RNA-associated protein MPP10; Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and [...] |
| MRX12 protein network | https://string-db.org/network/4932.YJR003C | MIOREX complex component 12; Protein that associates with mitochondrial ribosome; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogene [...] |
| SAG1 protein network | https://string-db.org/network/4932.YJR004C | Alpha-agglutinin of alpha-cells; binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half i [...] |
| LSO1 protein network | https://string-db.org/network/4932.YJR005C-A | Protein with a potential role in response to iron deprivation; transcription increases during iron deprivation and during treatment with 2-(6-benzyl-2-pyridyl)quinazoline (BPQ) and copper; regula [...] |
| APL1 protein network | https://string-db.org/network/4932.YJR005W | Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex. |
| POL31 protein network | https://string-db.org/network/4932.YJR006W | Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p, Rev7p and Pol32p; relocalizes to the cytoso [...] |
| SUI2 protein network | https://string-db.org/network/4932.YJR007W | Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting th [...] |
| MHO1 protein network | https://string-db.org/network/4932.YJR008W | MEMO1 family protein MHO1; Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stre [...] |
| TDH2 protein network | https://string-db.org/network/4932.YJR009C | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate [...] |
| SPC1 protein network | https://string-db.org/network/4932.YJR010C-A | Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase [...] |
| MET3 protein network | https://string-db.org/network/4932.YJR010W | Sulfate adenylyltransferase; ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine me [...] |
| YJR011C protein network | https://string-db.org/network/4932.YJR011C | Uncharacterized protein YJR011C; Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS. |
| YJR012C protein network | https://string-db.org/network/4932.YJR012C | Uncharacterized protein YJR012C; Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighbori [...] |
| GPI14 protein network | https://string-db.org/network/4932.YJR013W | GPI mannosyltransferase 1; Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I; involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M. |
| TMA22 protein network | https://string-db.org/network/4932.YJR014W | Translation machinery-associated protein 22; Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human D [...] |
| YJR015W protein network | https://string-db.org/network/4932.YJR015W | Putative protein of unknown function; localizes to endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; not an essential gene; YJR015W h [...] |
| ILV3 protein network | https://string-db.org/network/4932.YJR016C | Dihydroxy-acid dehydratase, mitochondrial; Dihydroxyacid dehydratase; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids. |
| ESS1 protein network | https://string-db.org/network/4932.YJR017C | Peptidyl-prolyl cis-trans isomerase ESS1; Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated S/T residues N-terminal to proline; regulates phosphorylation of RNAPII large su [...] |
| YJR018W protein network | https://string-db.org/network/4932.YJR018W | Putative uncharacterized protein YJR018W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| TES1 protein network | https://string-db.org/network/4932.YJR019C | Peroxisomal acyl-CoA thioesterase; likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase dur [...] |
| REC107 protein network | https://string-db.org/network/4932.YJR021C | Recombination protein 107; Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a [...] |
| LSM8 protein network | https://string-db.org/network/4932.YJR022W | U6 snRNA-associated Sm-like protein LSm8; Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is al [...] |
| YJR023C protein network | https://string-db.org/network/4932.YJR023C | Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing. |
| MDE1 protein network | https://string-db.org/network/4932.YJR024C | 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspof [...] |
| BNA1 protein network | https://string-db.org/network/4932.YJR025C | 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilic acid dioxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p. |
| RBH2 protein network | https://string-db.org/network/4932.YJR030C | UPF0508 protein YJR030C; Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; non-essential gene; contains a PH-like domain; RBH2 has [...] |
| GEA1 protein network | https://string-db.org/network/4932.YJR031C | Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has [...] |
| CPR7 protein network | https://string-db.org/network/4932.YJR032W | Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; pl [...] |
| RAV1 protein network | https://string-db.org/network/4932.YJR033C | Regulator of V-ATPase in vacuolar membrane protein 1; Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex promotes assembly of the V-ATPase holoenzyme; required for transport between [...] |
| PET191 protein network | https://string-db.org/network/4932.YJR034W | Mitochondrial protein PET191; Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermemb [...] |
| RAD26 protein network | https://string-db.org/network/4932.YJR035W | DNA repair and recombination protein RAD26; Protein involved in transcription-coupled nucleotide excision repair; repairs UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elo [...] |
| HUL4 protein network | https://string-db.org/network/4932.YJR036C | Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex; Belongs to the HUL4 family. |
| YJR037W protein network | https://string-db.org/network/4932.YJR037W | Putative uncharacterized protein YJR037W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ve [...] |
| YJR038C protein network | https://string-db.org/network/4932.YJR038C | Putative uncharacterized protein YJR038C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YJR039W protein network | https://string-db.org/network/4932.YJR039W | Uncharacterized protein YJR039W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| GEF1 protein network | https://string-db.org/network/4932.YJR040W | Anion/proton exchange transporter GEF1; Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to ver [...] |
| URB2 protein network | https://string-db.org/network/4932.YJR041C | Protein required for normal metabolism of the rRNA primary transcript; nucleolar protein; proposed to be involved in ribosome biogenesis. |
| NUP85 protein network | https://string-db.org/network/4932.YJR042W | Nucleoporin NUP85; Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal n [...] |
| POL32 protein network | https://string-db.org/network/4932.YJR043C | Third subunit of DNA polymerase delta; involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; forms a complex with Rev3p, [...] |
| VPS55 protein network | https://string-db.org/network/4932.YJR044C | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); [...] |
| SSC1 protein network | https://string-db.org/network/4932.YJR045C | Heat shock protein SSC1, mitochondrial; Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein [...] |
| TAH11 protein network | https://string-db.org/network/4932.YJR046W | Cell division cycle protein CDT1; DNA replication licensing factor; required for pre-replication complex assembly; Belongs to the Cdt1 family. |
| ANB1 protein network | https://string-db.org/network/4932.YJR047C | Eukaryotic translation initiation factor 5A-2; Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; ex [...] |
| CYC1 protein network | https://string-db.org/network/4932.YJR048W | Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome [...] |
| UTR1 protein network | https://string-db.org/network/4932.YJR049C | ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication. |
| ISY1 protein network | https://string-db.org/network/4932.YJR050W | Pre-mRNA-splicing factor ISY1; Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs; interacts with [...] |
| OSM1 protein network | https://string-db.org/network/4932.YJR051W | Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; has two t [...] |
| RAD7 protein network | https://string-db.org/network/4932.YJR052W | Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad16p) during NER; required for repair of non-transcribed chromatin; subunit of [...] |
| BFA1 protein network | https://string-db.org/network/4932.YJR053W | Mitotic check point protein BFA1; Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p; contributes to GAP activity, inactivating Tem1 by stimulating GTP hydrolysis following damage [...] |
| KCH1 protein network | https://string-db.org/network/4932.YJR054W | Uncharacterized vacuolar membrane protein YJR054W; Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up [...] |
| HIT1 protein network | https://string-db.org/network/4932.YJR055W | Protein involved in C/D snoRNP assembly; regulates abundance of Rsa1p; required for growth at high temperature; similar to human ZNHIT3. |
| YJR056C protein network | https://string-db.org/network/4932.YJR056C | Uncharacterized protein YJR056C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus [...] |
| CDC8 protein network | https://string-db.org/network/4932.YJR057W | Thymidylate and uridylate kinase; functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; [...] |
| APS2 protein network | https://string-db.org/network/4932.YJR058C | AP-2 complex subunit sigma; Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalia [...] |
| PTK2 protein network | https://string-db.org/network/4932.YJR059W | Serine/threonine-protein kinase PTK2/STK2; Serine/threonine protein kinase; involved in regulation of ion transport across plasma membrane; carboxyl terminus is essential for glucose-dependent Pm [...] |
| CBF1 protein network | https://string-db.org/network/4932.YJR060W | Centromere-binding protein 1; Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); aff [...] |
| YJR061W protein network | https://string-db.org/network/4932.YJR061W | Uncharacterized protein YJR061W; Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplica [...] |
| NTA1 protein network | https://string-db.org/network/4932.YJR062C | Amidase; removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated deg [...] |
| RPA12 protein network | https://string-db.org/network/4932.YJR063W | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activ [...] |
| CCT5 protein network | https://string-db.org/network/4932.YJR064W | T-complex protein 1 subunit epsilon; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo. |
| ARP3 protein network | https://string-db.org/network/4932.YJR065C | Actin-related protein 3; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endo [...] |
| TOR1 protein network | https://string-db.org/network/4932.YJR066W | Serine/threonine-protein kinase TOR1; PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcr [...] |
| YAE1 protein network | https://string-db.org/network/4932.YJR067C | Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly [...] |
| RFC2 protein network | https://string-db.org/network/4932.YJR068W | Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor [...] |
| HAM1 protein network | https://string-db.org/network/4932.YJR069C | Inosine triphosphate pyrophosphatase; Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyr [...] |
| LIA1 protein network | https://string-db.org/network/4932.YJR070C | Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutant [...] |
| NPA3 protein network | https://string-db.org/network/4932.YJR072C | GPN-loop GTPase 1; Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; invol [...] |
| OPI3 protein network | https://string-db.org/network/4932.YJR073C | Phosphatidyl-N-methylethanolamine N-methyltransferase; Methylene-fatty-acyl-phospholipid synthase; catalyzes the last two steps in phosphatidylcholine biosynthesis; also known as phospholipid met [...] |
| MOG1 protein network | https://string-db.org/network/4932.YJR074W | Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p. |
| HOC1 protein network | https://string-db.org/network/4932.YJR075W | Putative glycosyltransferase HOC1; Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn1 [...] |
| CDC11 protein network | https://string-db.org/network/4932.YJR076C | Cell division control protein 11; Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for rec [...] |
| MIR1 protein network | https://string-db.org/network/4932.YJR077C | Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated; Belongs to [...] |
| BNA2 protein network | https://string-db.org/network/4932.YJR078W | Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulat [...] |
| YJR079W protein network | https://string-db.org/network/4932.YJR079W | Uncharacterized protein YJR079W; Putative protein of unknown function; mutation results in impaired mitochondrial respiration. |
| AIM24 protein network | https://string-db.org/network/4932.YJR080C | Altered inheritance of mitochondria protein 24, mitochondrial; Protein with a role in determining mitochondrial architecture; inner membrane protein that interacts physically and genetically with [...] |
| EAF6 protein network | https://string-db.org/network/4932.YJR082C | Chromatin modification-related protein EAF6; Subunit of the NuA4 acetyltransferase complex; this complex acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3; Belon [...] |
| ACF4 protein network | https://string-db.org/network/4932.YJR083C | Assembly-complementing factor 4; Protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; p [...] |
| YJR084W protein network | https://string-db.org/network/4932.YJR084W | Cop9 signalosome complex subunit 12; Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phen [...] |
| YJR085C protein network | https://string-db.org/network/4932.YJR085C | TMEM14 protein homolog YJR085C; Protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purif [...] |
| STE18 protein network | https://string-db.org/network/4932.YJR086W | G protein gamma subunit; forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesyl [...] |
| YJR087W protein network | https://string-db.org/network/4932.YJR087W | Putative uncharacterized protein YJR087W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| EMC2 protein network | https://string-db.org/network/4932.YJR088C | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/E [...] |
| BIR1 protein network | https://string-db.org/network/4932.YJR089W | Protein BIR1; Subunit of chromosomal passenger complex (CPC); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spi [...] |
| GRR1 protein network | https://string-db.org/network/4932.YJR090C | F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCF(Grr1) complex; SCF( [...] |
| JSN1 protein network | https://string-db.org/network/4932.YJR091C | Protein JSN1; Member of the Puf family of RNA-binding proteins; interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpressi [...] |
| BUD4 protein network | https://string-db.org/network/4932.YJR092W | Anillin-like protein involved in bud-site selection; required for the axial budding pattern; required for the formation and disassembly of the double septin ring structure, and generally for sept [...] |
| FIP1 protein network | https://string-db.org/network/4932.YJR093C | Subunit of cleavage polyadenylation factor (CPF); interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p; Belo [...] |
| IME1 protein network | https://string-db.org/network/4932.YJR094C | Meiosis-inducing protein 1; Master regulator of meiosis that is active only during meiotic events; activates transcription of early meiotic genes through interaction with Ume6p; degraded by the 2 [...] |
| RPL43B protein network | https://string-db.org/network/4932.YJR094W-A | Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abund [...] |
| SFC1 protein network | https://string-db.org/network/4932.YJR095W | Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization. |
| YJR096W protein network | https://string-db.org/network/4932.YJR096W | Uncharacterized oxidoreductase YJR096W; Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS. |
| JJJ3 protein network | https://string-db.org/network/4932.YJR097W | Diphthamide biosynthesis protein 4; Protein of unknown function; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4; Belongs to the DPH4 family. |
| YJR098C protein network | https://string-db.org/network/4932.YJR098C | Uncharacterized protein YJR098C; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| YUH1 protein network | https://string-db.org/network/4932.YJR099W | Ubiquitin C-terminal hydrolase; cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for [...] |
| AIM25 protein network | https://string-db.org/network/4932.YJR100C | Altered inheritance rate of mitochondria protein 25; Mitochondria protein of unknown function; interacts genetically with TOR1 to regulate chronological lifespan, and the response to both heat sh [...] |
| RSM26 protein network | https://string-db.org/network/4932.YJR101W | Mitochondrial ribosomal protein of the small subunit. |
| VPS25 protein network | https://string-db.org/network/4932.YJR102C | Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; Belongs to the VPS25 family. |
| URA8 protein network | https://string-db.org/network/4932.YJR103W | Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; i [...] |
| SOD1 protein network | https://string-db.org/network/4932.YJR104C | Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative st [...] |
| ADO1 protein network | https://string-db.org/network/4932.YJR105W | Adenosine kinase; required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle. |
| ECM27 protein network | https://string-db.org/network/4932.YJR106W | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to [...] |
| LIH1 protein network | https://string-db.org/network/4932.YJR107W | Putative lipase; Belongs to the AB hydrolase superfamily. Lipase family. |
| ABM1 protein network | https://string-db.org/network/4932.YJR108W | Aberrant microtubules protein 1; Protein of unknown function; required for normal microtubule organization. |
| CPA2 protein network | https://string-db.org/network/4932.YJR109C | Carbamoyl-phosphate synthase arginine-specific large chain; Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arg [...] |
| YMR1 protein network | https://string-db.org/network/4932.YJR110W | Phosphoinositide 3-phosphatase; Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has s [...] |
| PXP2 protein network | https://string-db.org/network/4932.YJR111C | Uncharacterized protein YJR111C; Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some [...] |
| NNF1 protein network | https://string-db.org/network/4932.YJR112W | Kinetochore-associated protein NNF1; Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromos [...] |
| YJR112W-A protein network | https://string-db.org/network/4932.YJR112W-A | Uncharacterized protein YJR112W-A; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; identified based on homology to <i>Ashbya goss [...] |
| RSM7 protein network | https://string-db.org/network/4932.YJR113C | Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S7 ribosomal protein. |
| YJR114W protein network | https://string-db.org/network/4932.YJR114W | Putative uncharacterized protein YJR114W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| YJR115W protein network | https://string-db.org/network/4932.YJR115W | Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication. |
| TDA4 protein network | https://string-db.org/network/4932.YJR116W | Topoisomerase I damage affected protein 4; Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; Belongs to the TMEM56 family. |
| STE24 protein network | https://string-db.org/network/4932.YJR117W | CAAX prenyl protease 1; Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; [...] |
| ILM1 protein network | https://string-db.org/network/4932.YJR118C | Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth. |
| JHD2 protein network | https://string-db.org/network/4932.YJR119C | JmjC domain family histone demethylase; promotes global demethylation of H3K4 and repression of noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p methylt [...] |
| YJR120W protein network | https://string-db.org/network/4932.YJR120W | Putative uncharacterized protein YJR120W; Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defecti [...] |
| ATP2 protein network | https://string-db.org/network/4932.YJR121W | Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 [...] |
| IBA57 protein network | https://string-db.org/network/4932.YJR122W | Putative transferase CAF17, mitochondrial; Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur cluster [...] |
| RPS5 protein network | https://string-db.org/network/4932.YJR123W | Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 [...] |
| YJR124C protein network | https://string-db.org/network/4932.YJR124C | Uncharacterized membrane protein YJR124C; Putative protein of unknown function; expression induced under calcium shortage. |
| ENT3 protein network | https://string-db.org/network/4932.YJR125C | Epsin-3; Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p. |
| VPS70 protein network | https://string-db.org/network/4932.YJR126C | Protein of unknown function involved in vacuolar protein sorting; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; Belongs to the peptidase M28 family. M28B subfamily. |
| RSF2 protein network | https://string-db.org/network/4932.YJR127C | Respiration factor 2; Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respirat [...] |
| EFM3 protein network | https://string-db.org/network/4932.YJR129C | Protein-lysine N-methyltransferase EFM3; S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which trimethylates translation elongation factor EF2 (Eft1p [...] |
| STR2 protein network | https://string-db.org/network/4932.YJR130C | Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication; Belongs to the trans-sulfuration enzymes family. MET [...] |
| MNS1 protein network | https://string-db.org/network/4932.YJR131W | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue fro [...] |
| NMD5 protein network | https://string-db.org/network/4932.YJR132W | Nonsense-mediated mRNA decay protein 5; Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog. |
| XPT1 protein network | https://string-db.org/network/4932.YJR133W | Xanthine phosphoribosyltransferase 1; Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine. |
| SGM1 protein network | https://string-db.org/network/4932.YJR134C | Protein of unknown function; required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus; Belongs to the SGM1 family. |
| MCM22 protein network | https://string-db.org/network/4932.YJR135C | Inner kinetochore subunit MCM22; Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and mini [...] |
| TIM8 protein network | https://string-db.org/network/4932.YJR135W-A | Mitochondrial import inner membrane translocase subunit TIM8; Mitochondrial intermembrane space protein; forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 co [...] |
| TTI2 protein network | https://string-db.org/network/4932.YJR136C | TEL2-interacting protein 2; Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; involved in t [...] |
| MET5 protein network | https://string-db.org/network/4932.YJR137C | Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. |
| IML1 protein network | https://string-db.org/network/4932.YJR138W | GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the [...] |
| HOM6 protein network | https://string-db.org/network/4932.YJR139C | Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-bi [...] |
| HIR3 protein network | https://string-db.org/network/4932.YJR140C | Histone transcription regulator 3; Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing an [...] |
| YJR140W-A protein network | https://string-db.org/network/4932.YJR140W-A | Putative uncharacterized protein YJR140W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| IPA1 protein network | https://string-db.org/network/4932.YJR141W | Uncharacterized protein YJR141W; Essential protein of unknown function. |
| YJR142W protein network | https://string-db.org/network/4932.YJR142W | Uncharacterized protein YJR142W; 8-oxo-dGTP diphosphatase of the Nudix hydrolase family; converts diphosphates of damaged forms of thiamin to monophosphates; GST fusion protein is a Dbf2p-Mob1p p [...] |
| PMT4 protein network | https://string-db.org/network/4932.YJR143C | Dolichyl-phosphate-mannose--protein mannosyltransferase 4; Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appear [...] |
| MGM101 protein network | https://string-db.org/network/4932.YJR144W | Mitochondrial genome maintenance protein MGM101; Protein with a role in mitochondrial DNA recombinational repair; also involved in interstrand cross-link repair; binds to and catalyzes the anneal [...] |
| RPS4A protein network | https://string-db.org/network/4932.YJR145C | Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, t [...] |
| YJR146W protein network | https://string-db.org/network/4932.YJR146W | Uncharacterized protein YJR146W; Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2. |
| HMS2 protein network | https://string-db.org/network/4932.YJR147W | Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN [...] |
| BAT2 protein network | https://string-db.org/network/4932.YJR148W | Branched-chain-amino-acid aminotransferase, cytosolic; Cytosolic branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA catabolism; homolog of murine ECA39; highly exp [...] |
| YJR149W protein network | https://string-db.org/network/4932.YJR149W | Putative nitronate monooxygenase; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. |
| DAN1 protein network | https://string-db.org/network/4932.YJR150C | Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth. |
| DAN4 protein network | https://string-db.org/network/4932.YJR151C | Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth; Belongs to the SRP1/TIP1 family. |
| DAL5 protein network | https://string-db.org/network/4932.YJR152W | Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen [...] |
| PGU1 protein network | https://string-db.org/network/4932.YJR153W | Endo-polygalacturonase; pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins. |
| YJR154W protein network | https://string-db.org/network/4932.YJR154W | Uncharacterized protein YJR154W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; Belongs to the PhyH family. |
| AAD10 protein network | https://string-db.org/network/4932.YJR155W | Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise [...] |
| THI11 protein network | https://string-db.org/network/4932.YJR156C | 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI11; Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12 [...] |
| HXT16 protein network | https://string-db.org/network/4932.YJR158W | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a stra [...] |
| SOR1 protein network | https://string-db.org/network/4932.YJR159W | Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose; Belongs to the zinc-containing alcohol [...] |
| MPH3 protein network | https://string-db.org/network/4932.YJR160C | Alpha-glucosides permease MPH3; Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region [...] |
| COS5 protein network | https://string-db.org/network/4932.YJR161C | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting [...] |
| YJR162C protein network | https://string-db.org/network/4932.YJR162C | Putative UPF0320 protein YJR162C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| MET14 protein network | https://string-db.org/network/4932.YKL001C | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. |
| DID4 protein network | https://string-db.org/network/4932.YKL002W | DOA4-independent degradation protein 4; Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for de [...] |
| MRP17 protein network | https://string-db.org/network/4932.YKL003C | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. |
| AUR1 protein network | https://string-db.org/network/4932.YKL004W | Inositol phosphorylceramide synthase catalytic subunit AUR1; Phosphatidylinositol:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A re [...] |
| BYE1 protein network | https://string-db.org/network/4932.YKL005C | Transcription factor BYE1; Negative regulator of transcription elongation; contains a TFIIS-like domain that associates with chromatin and a PHD domain that interacts with H3K4me3; multicopy supp [...] |
| SFT1 protein network | https://string-db.org/network/4932.YKL006C-A | Intra-Golgi v-SNARE; required for transport of proteins between an early and a later Golgi compartment. |
| RPL14A protein network | https://string-db.org/network/4932.YKL006W | Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome du [...] |
| CAP1 protein network | https://string-db.org/network/4932.YKL007W | Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to [...] |
| LAC1 protein network | https://string-db.org/network/4932.YKL008C | Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, th [...] |
| MRT4 protein network | https://string-db.org/network/4932.YKL009W | Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus; Belongs to the universal ribosomal pro [...] |
| UFD4 protein network | https://string-db.org/network/4932.YKL010C | Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; rel [...] |
| CCE1 protein network | https://string-db.org/network/4932.YKL011C | Mitochondrial cruciform cutting endonuclease; cleaves Holliday junctions formed during recombination of mitochondrial DNA; CCE1 has a paralog, MRS1, that arose from the whole genome duplication. |
| PRP40 protein network | https://string-db.org/network/4932.YKL012W | Pre-mRNA-processing protein PRP40; U1 snRNP protein involved in splicing; interacts with the branchpoint-binding protein during the formation of the second commitment complex. |
| ARC19 protein network | https://string-db.org/network/4932.YKL013C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; mutation is functionally complemented by human ARPC4. |
| URB1 protein network | https://string-db.org/network/4932.YKL014C | Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribos [...] |
| PUT3 protein network | https://string-db.org/network/4932.YKL015W | Proline utilization trans-activator; Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regula [...] |
| ATP7 protein network | https://string-db.org/network/4932.YKL016C | Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis. |
| HCS1 protein network | https://string-db.org/network/4932.YKL017C | Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A st [...] |
| SWD2 protein network | https://string-db.org/network/4932.YKL018W | COMPASS component SWD2; Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is inv [...] |
| RAM2 protein network | https://string-db.org/network/4932.YKL019W | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (Ram2p-Ram1p heterodimer) cat [...] |
| SPT23 protein network | https://string-db.org/network/4932.YKL020C | ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear tar [...] |
| MAK11 protein network | https://string-db.org/network/4932.YKL021C | Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats. |
| CDC16 protein network | https://string-db.org/network/4932.YKL022C | Subunit of the anaphase-promoting complex/cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/a [...] |
| YKL023W protein network | https://string-db.org/network/4932.YKL023W | Uncharacterized protein YKL023W; Putative protein of unknown function; predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein locali [...] |
| URA6 protein network | https://string-db.org/network/4932.YKL024C | Uridylate kinase; catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP); Belongs to the adenyla [...] |
| PAN3 protein network | https://string-db.org/network/4932.YKL025C | Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; poly (A) mRNA binding subunit which recruits mRNA to the complex; the Pan2p-Pan3p complex controls poly(A) tail length and regul [...] |
| GPX1 protein network | https://string-db.org/network/4932.YKL026C | Glutathione peroxidase-like peroxiredoxin 1; Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholi [...] |
| TCD2 protein network | https://string-db.org/network/4932.YKL027W | tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; lo [...] |
| TFA1 protein network | https://string-db.org/network/4932.YKL028W | Transcription initiation factor IIE subunit alpha; TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening. |
| MAE1 protein network | https://string-db.org/network/4932.YKL029C | Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids. |
| YKL031W protein network | https://string-db.org/network/4932.YKL031W | Putative uncharacterized protein YKL031W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| IXR1 protein network | https://string-db.org/network/4932.YKL032C | Intrastrand cross-link recognition protein; Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; bin [...] |
| TTI1 protein network | https://string-db.org/network/4932.YKL033W | TEL2-interacting protein 1; Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. [...] |
| YKL033W-A protein network | https://string-db.org/network/4932.YKL033W-A | Uncharacterized hydrolase YKL033W-A; Putative protein of unknown function; similar to uncharacterized proteins from other fungi; Belongs to the HAD-like hydrolase superfamily. |
| TUL1 protein network | https://string-db.org/network/4932.YKL034W | Transmembrane E3 ubiquitin-protein ligase 1; Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containi [...] |
| UGP1 protein network | https://string-db.org/network/4932.YKL035W | UTP--glucose-1-phosphate uridylyltransferase; UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of [...] |
| YKL036C protein network | https://string-db.org/network/4932.YKL036C | Putative uncharacterized protein YKL036C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| AIM26 protein network | https://string-db.org/network/4932.YKL037W | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. |
| RGT1 protein network | https://string-db.org/network/4932.YKL038W | Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator an [...] |
| PTM1 protein network | https://string-db.org/network/4932.YKL039W | Membrane protein PTM1; Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication. |
| NFU1 protein network | https://string-db.org/network/4932.YKL040C | NifU-like protein, mitochondrial; Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress; acts along with Bol3 at a lat [...] |
| VPS24 protein network | https://string-db.org/network/4932.YKL041W | Vacuolar protein-sorting-associated protein 24; One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; inv [...] |
| SPC42 protein network | https://string-db.org/network/4932.YKL042W | Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane; Belongs to the SPC42 family. |
| PHD1 protein network | https://string-db.org/network/4932.YKL043W | Putative transcription factor PHD1; Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expre [...] |
| MMO1 protein network | https://string-db.org/network/4932.YKL044W | Uncharacterized protein YKL044W; Protein of unknown function; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the mitochondria; mRNA identified as translated by ribosome profiling [...] |
| PRI2 protein network | https://string-db.org/network/4932.YKL045W | Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair; Belongs to the eukaryotic-type primase large subunit family. |
| DCW1 protein network | https://string-db.org/network/4932.YKL046C | Mannan endo-1,6-alpha-mannosidase DCW1; Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p; Belongs to the glycosyl hydro [...] |
| ANR2 protein network | https://string-db.org/network/4932.YKL047W | Uncharacterized protein ANR2; Protein of unknown function; may have a role in lipid metabolism, based on localization to lipid droplets; predicted to be palmitoylated. |
| ELM1 protein network | https://string-db.org/network/4932.YKL048C | Serine/threonine-protein kinase ELM1; Serine/threonine protein kinase; regulates the orientation checkpoint, the morphogenesis checkpoint and the metabolic switch from fermentative to oxidative m [...] |
| CSE4 protein network | https://string-db.org/network/4932.YKL049C | Histone H3-like centromere protein; associated with promoters, accessible chromatin, RNAPII-bound regions; phosphorylated Cse4p associates with centromeres; required for proper kinetochore functi [...] |
| YKL050C protein network | https://string-db.org/network/4932.YKL050C | Uncharacterized protein YKL050C; Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p; YKL050C has [...] |
| SFK1 protein network | https://string-db.org/network/4932.YKL051W | Plasma membrane protein that may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane [...] |
| ASK1 protein network | https://string-db.org/network/4932.YKL052C | Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cel [...] |
| MDM35 protein network | https://string-db.org/network/4932.YKL053C-A | Mitochondrial distribution and morphology protein 35; Mitochondrial intermembrane space protein; forms complex with Ups2p that transfers phosphatidylserine from outer membrane to inner membrane f [...] |
| YKL053W protein network | https://string-db.org/network/4932.YKL053W | Putative uncharacterized protein YKL053W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ve [...] |
| DEF1 protein network | https://string-db.org/network/4932.YKL054C | RNAPII degradation factor; forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto c [...] |
| OAR1 protein network | https://string-db.org/network/4932.YKL055C | Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p; human homolog CBR4 complements yeast null mutant. |
| TMA19 protein network | https://string-db.org/network/4932.YKL056C | Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitocho [...] |
| NUP120 protein network | https://string-db.org/network/4932.YKL057C | Nucleoporin NUP120; Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal [...] |
| TOA2 protein network | https://string-db.org/network/4932.YKL058W | TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to s [...] |
| MPE1 protein network | https://string-db.org/network/4932.YKL059C | Protein MPE1; Essential conserved subunit of CPF cleavage and polyadenylation factor; plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA; contains [...] |
| FBA1 protein network | https://string-db.org/network/4932.YKL060C | Fructose 1,6-bisphosphate aldolase; required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitocho [...] |
| BLI1 protein network | https://string-db.org/network/4932.YKL061W | Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to the endosome. |
| MSN4 protein network | https://string-db.org/network/4932.YKL062W | Zinc finger protein MSN4; Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress respons [...] |
| YKL063C protein network | https://string-db.org/network/4932.YKL063C | Uncharacterized protein YKL063C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi. |
| MNR2 protein network | https://string-db.org/network/4932.YKL064W | Manganese resistance protein MNR2; Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ an [...] |
| YET1 protein network | https://string-db.org/network/4932.YKL065C | Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein; YET1 has a paralog, YET2, that arose from the whole [...] |
| YKL065W-A protein network | https://string-db.org/network/4932.YKL065W-A | Uncharacterized protein YKL065W-A; Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum (ER) while mCherry fusion localizes to both the ER and vacu [...] |
| YKL066W protein network | https://string-db.org/network/4932.YKL066W | Putative uncharacterized protein YKL066W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| YNK1 protein network | https://string-db.org/network/4932.YKL067W | Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autop [...] |
| NUP100 protein network | https://string-db.org/network/4932.YKL068W | FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier an [...] |
| YKL068W-A protein network | https://string-db.org/network/4932.YKL068W-A | Uncharacterized protein YKL068W-A; Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i>. |
| YKL069W protein network | https://string-db.org/network/4932.YKL069W | Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; [...] |
| YKL070W protein network | https://string-db.org/network/4932.YKL070W | Uncharacterized protein YKL070W; Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in hi [...] |
| YKL071W protein network | https://string-db.org/network/4932.YKL071W | Uncharacterized oxidoreductase YKL071W; Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; gr [...] |
| STB6 protein network | https://string-db.org/network/4932.YKL072W | Protein that binds Sin3p in a two-hybrid assay; STB6 has a paralog, STB2, that arose from the whole genome duplication; To yeast STB2. |
| LHS1 protein network | https://string-db.org/network/4932.YKL073W | Heat shock protein 70 homolog LHS1; Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 [...] |
| MUD2 protein network | https://string-db.org/network/4932.YKL074C | Splicing factor MUD2; Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar [...] |
| YKL075C protein network | https://string-db.org/network/4932.YKL075C | Uncharacterized protein YKL075C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptoz [...] |
| YKL077W protein network | https://string-db.org/network/4932.YKL077W | PMA1 stabilization in the Golgi protein 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. |
| DHR2 protein network | https://string-db.org/network/4932.YKL078W | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. |
| SMY1 protein network | https://string-db.org/network/4932.YKL079W | Kinesin-related protein SMY1; Kinesin-like myosin passenger-protein; interacts with Myo2p and enhances its interaction with Sec4p during transport of secretory vesicles; controls actin cable stru [...] |
| VMA5 protein network | https://string-db.org/network/4932.YKL080W | Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar [...] |
| TEF4 protein network | https://string-db.org/network/4932.YKL081W | Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex. |
| RRP14 protein network | https://string-db.org/network/4932.YKL082C | Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family; Belongs to the SURF6 family [...] |
| YKL083W protein network | https://string-db.org/network/4932.YKL083W | Putative uncharacterized protein YKL083W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| HOT13 protein network | https://string-db.org/network/4932.YKL084W | Helper of Tim protein 13; Zinc-binding mitochondrial intermembrane space (IMS) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimu [...] |
| MDH1 protein network | https://string-db.org/network/4932.YKL085W | Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; Belongs to the LDH/MDH superfamily. MDH t [...] |
| SRX1 protein network | https://string-db.org/network/4932.YKL086W | Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukar [...] |
| CYT2 protein network | https://string-db.org/network/4932.YKL087C | Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homol [...] |
| CAB3 protein network | https://string-db.org/network/4932.YKL088W | Coenzyme A biosynthesis protein 3; Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis; subunits of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex are: Cab3p, Sis2p [...] |
| MIF2 protein network | https://string-db.org/network/4932.YKL089W | Inner kinetochore subunit MIF2; Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; [...] |
| CUE2 protein network | https://string-db.org/network/4932.YKL090W | Ubiquitin-binding protein CUE2; Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination. |
| YKL091C protein network | https://string-db.org/network/4932.YKL091C | CRAL-TRIO domain-containing protein YKL091C; Putative phosphatidylinositol/phosphatidylcholine transfer protein; possibly involved in lipid metabolism; localizes to the nucleus; contains a CRAL/T [...] |
| BUD2 protein network | https://string-db.org/network/4932.YKL092C | Inhibitory regulator protein BUD2/CLA2; GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial [...] |
| MBR1 protein network | https://string-db.org/network/4932.YKL093W | Mitochondrial biogenesis regulation protein 1; Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; MBR1 has [...] |
| YJU3 protein network | https://string-db.org/network/4932.YKL094W | Monoglyceride lipase (MGL); functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family; Belongs to the AB hydrolase su [...] |
| YJU2 protein network | https://string-db.org/network/4932.YKL095W | Splicing factor YJU2; Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ("nineteen complex") and acts after Prp2p to promote the first catalytic r [...] |
| YKL096C-B protein network | https://string-db.org/network/4932.YKL096C-B | Uncharacterized protein YKL096C-B; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| CWP1 protein network | https://string-db.org/network/4932.YKL096W | Cell wall mannoprotein that localizes to birth scars of daughter cells; linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistan [...] |
| CWP2 protein network | https://string-db.org/network/4932.YKL096W-A | Covalently linked cell wall mannoprotein; major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored. |
| MTC2 protein network | https://string-db.org/network/4932.YKL098W | Protein of unknown function; mtc2 is synthetically sick with cdc13-1; Belongs to the MTC2 family. |
| UTP11 protein network | https://string-db.org/network/4932.YKL099C | U3 small nucleolar RNA-associated protein 11; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit. |
| YPF1 protein network | https://string-db.org/network/4932.YKL100C | Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation (ERAD) that degrades functional proteins rather than misfolded proteins; regulates ab [...] |
| YKL100W-A protein network | https://string-db.org/network/4932.YKL100W-A | Uncharacterized protein YKL100W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| HSL1 protein network | https://string-db.org/network/4932.YKL101W | Probable serine/threonine-protein kinase HSL1; Nim1p-related protein kinase; septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint; phosphory [...] |
| YKL102C protein network | https://string-db.org/network/4932.YKL102C | Uncharacterized protein YKL102C; Putative protein of unknown function; conserved across S. cerevisiae strains; deletion confers sensitivity to citric acid; predicted protein would include a thiol [...] |
| APE1 protein network | https://string-db.org/network/4932.YKL103C | Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathwa [...] |
| GFA1 protein network | https://string-db.org/network/4932.YKL104C | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glu [...] |
| SEG2 protein network | https://string-db.org/network/4932.YKL105C | Eisosome protein SEG2; Eisosome component; likely plays only a minor role in eisosome assembly; shown to interact with Seg1p by affinity purification and mass spec; SWAT-GFP and mCherry fusion pr [...] |
| YKL106C-A protein network | https://string-db.org/network/4932.YKL106C-A | Uncharacterized protein YKL106C-A; Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi. |
| AAT1 protein network | https://string-db.org/network/4932.YKL106W | Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis. |
| YKL107W protein network | https://string-db.org/network/4932.YKL107W | Uncharacterized oxidoreductase YKL107W; Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein. |
| SLD2 protein network | https://string-db.org/network/4932.YKL108W | DNA replication regulator SLD2; Single-stranded DNA origin-binding and annealing protein; required for initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), [...] |
| HAP4 protein network | https://string-db.org/network/4932.YKL109W | Transcriptional activator HAP4; Transcription factor; subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of re [...] |
| KTI12 protein network | https://string-db.org/network/4932.YKL110C | Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induce [...] |
| YKL111C protein network | https://string-db.org/network/4932.YKL111C | Putative uncharacterized protein YKL111C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| ABF1 protein network | https://string-db.org/network/4932.YKL112W | ARS-binding factor 1; DNA binding protein with possible chromatin-reorganizing activity; involved in transcriptional activation, gene silencing, and DNA replication and repair; Belongs to the BAF [...] |
| RAD27 protein network | https://string-db.org/network/4932.YKL113C | Flap endonuclease 1; 5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucl [...] |
| APN1 protein network | https://string-db.org/network/4932.YKL114C | DNA-(apurinic or apyrimidinic site) lyase 1; Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as [...] |
| PRR1 protein network | https://string-db.org/network/4932.YKL116C | Serine/threonine-protein kinase PRR1; Serine/threonine protein kinase; inhibits pheromone induced signaling downstream of MAPK, possibly at the level of the Ste12p transcription factor. |
| SBA1 protein network | https://string-db.org/network/4932.YKL117W | Co-chaperone protein SBA1; Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the [...] |
| YKL118W protein network | https://string-db.org/network/4932.YKL118W | Putative uncharacterized protein YKL118W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| VPH2 protein network | https://string-db.org/network/4932.YKL119C | Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endopla [...] |
| OAC1 protein network | https://string-db.org/network/4932.YKL120W | Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family. |
| DGR2 protein network | https://string-db.org/network/4932.YKL121W | Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds; DGR2 has a paralog, YMR102C, that arose from the whole genome duplication; Belon [...] |
| SRP21 protein network | https://string-db.org/network/4932.YKL122C | Subunit of the signal recognition particle (SRP); SRP functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus [...] |
| SSH4 protein network | https://string-db.org/network/4932.YKL124W | Protein SSH4; Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR [...] |
| RRN3 protein network | https://string-db.org/network/4932.YKL125W | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEA [...] |
| YPK1 protein network | https://string-db.org/network/4932.YKL126W | Serine/threonine-protein kinase YPK1; S/T protein kinase; phosphorylates, downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p by phosphorylation in response to compromised sphingo [...] |
| PGM1 protein network | https://string-db.org/network/4932.YKL127W | Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; PGM1 has a paralog, PGM2, that arose from th [...] |
| PMU1 protein network | https://string-db.org/network/4932.YKL128C | Probable phosphoglycerate mutase PMU1; Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade [...] |
| MYO3 protein network | https://string-db.org/network/4932.YKL129C | Myosin-3; One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cyt [...] |
| SHE2 protein network | https://string-db.org/network/4932.YKL130C | SWI5-dependent HO expression protein 2; RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain prot [...] |
| RMA1 protein network | https://string-db.org/network/4932.YKL132C | Probable folylpolyglutamate synthase; Putative dihydrofolate synthetase; similar to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected i [...] |
| YKL133C protein network | https://string-db.org/network/4932.YKL133C | Putative protein of unknown function; not required for growth of cells lacking the mitochondrial genome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; YKL133C has a paralog, [...] |
| OCT1 protein network | https://string-db.org/network/4932.YKL134C | Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may [...] |
| APL2 protein network | https://string-db.org/network/4932.YKL135C | AP-1 complex subunit beta-1; Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increa [...] |
| CMC1 protein network | https://string-db.org/network/4932.YKL137W | Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twi [...] |
| MRPL31 protein network | https://string-db.org/network/4932.YKL138C | Mitochondrial ribosomal protein of the large subunit. |
| HSK3 protein network | https://string-db.org/network/4932.YKL138C-A | Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the [...] |
| CTK1 protein network | https://string-db.org/network/4932.YKL139W | Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p [...] |
| TGL1 protein network | https://string-db.org/network/4932.YKL140W | Sterol esterase TGL1; Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lip [...] |
| SDH3 protein network | https://string-db.org/network/4932.YKL141W | Subunit of succinate dehydrogenase and of TIM22 translocase; functions as cytochrome b subunit of succinate dehydrogenase, which couples oxidation of succinate to transfer of electrons to ubiquin [...] |
| MRP8 protein network | https://string-db.org/network/4932.YKL142W | Uncharacterized protein MRP8; Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abun [...] |
| LTV1 protein network | https://string-db.org/network/4932.YKL143W | Protein LTV1; Component of the GSE complex; GSE is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low t [...] |
| RPC25 protein network | https://string-db.org/network/4932.YKL144C | RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p. |
| RPT1 protein network | https://string-db.org/network/4932.YKL145W | ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for optimal CDC20 tra [...] |
| YKL145W-A protein network | https://string-db.org/network/4932.YKL145W-A | Uncharacterized protein YKL145W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the veri [...] |
| AVT3 protein network | https://string-db.org/network/4932.YKL146W | Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters. |
| SDH1 protein network | https://string-db.org/network/4932.YKL148C | Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FA [...] |
| DBR1 protein network | https://string-db.org/network/4932.YKL149C | RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity [...] |
| MCR1 protein network | https://string-db.org/network/4932.YKL150W | Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. |
| NNR2 protein network | https://string-db.org/network/4932.YKL151C | Widely-conserved NADHX dehydratase; converts (S)-NADHX to NADH in ATP-dependent manner; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methy [...] |
| GPM1 protein network | https://string-db.org/network/4932.YKL152C | Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis; Belongs to the phosphogl [...] |
| YKL153W protein network | https://string-db.org/network/4932.YKL153W | Putative uncharacterized protein YKL153W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both [...] |
| SRP102 protein network | https://string-db.org/network/4932.YKL154W | Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane. |
| RSM22 protein network | https://string-db.org/network/4932.YKL155C | Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase. |
| YKL156C-A protein network | https://string-db.org/network/4932.YKL156C-A | Putative uncharacterized protein YKL156C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| RPS27A protein network | https://string-db.org/network/4932.YKL156W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplica [...] |
| APE2 protein network | https://string-db.org/network/4932.YKL157W | Aminopeptidase 2, mitochondrial; Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication; Belo [...] |
| RCN1 protein network | https://string-db.org/network/4932.YKL159C | Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region. |
| ELF1 protein network | https://string-db.org/network/4932.YKL160W | Transcription elongation factor with a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic vi [...] |
| KDX1 protein network | https://string-db.org/network/4932.YKL161C | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK [...] |
| YKL162C protein network | https://string-db.org/network/4932.YKL162C | Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; Belongs to [...] |
| YKL162C-A protein network | https://string-db.org/network/4932.YKL162C-A | Putative uncharacterized protein YKL162C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| PIR3 protein network | https://string-db.org/network/4932.YKL163W | O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathw [...] |
| PIR1 protein network | https://string-db.org/network/4932.YKL164C | O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity p [...] |
| MCD4 protein network | https://string-db.org/network/4932.YKL165C | GPI ethanolamine phosphate transferase 1; Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; [...] |
| YKL165C-A protein network | https://string-db.org/network/4932.YKL165C-A | Putative uncharacterized YKL165C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| TPK3 protein network | https://string-db.org/network/4932.YKL166C | cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-b [...] |
| MRP49 protein network | https://string-db.org/network/4932.YKL167C | Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation. |
| KKQ8 protein network | https://string-db.org/network/4932.YKL168C | Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication; Belongs to the protein kinase superfamily. CAMK Ser/Th [...] |
| MRPL38 protein network | https://string-db.org/network/4932.YKL170W | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress [...] |
| NNK1 protein network | https://string-db.org/network/4932.YKL171W | Nitrogen network kinase 1; Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation o [...] |
| EBP2 protein network | https://string-db.org/network/4932.YKL172W | rRNA-processing protein EBP2; Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal [...] |
| SNU114 protein network | https://string-db.org/network/4932.YKL173W | Pre-mRNA-splicing factor SNU114; GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the splic [...] |
| TPO5 protein network | https://string-db.org/network/4932.YKL174C | Polyamine transporter TPO5; Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles; Belongs to the amino acid-polyamine-org [...] |
| ZRT3 protein network | https://string-db.org/network/4932.YKL175W | Zinc-regulated transporter 3; Vacuolar membrane zinc transporter; transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc defic [...] |
| LST4 protein network | https://string-db.org/network/4932.YKL176C | Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino a [...] |
| YKL177W protein network | https://string-db.org/network/4932.YKL177W | Putative uncharacterized protein YKL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| STE3 protein network | https://string-db.org/network/4932.YKL178C | Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed [...] |
| COY1 protein network | https://string-db.org/network/4932.YKL179C | Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function. |
| RPL17A protein network | https://string-db.org/network/4932.YKL180W | Ribosomal 60S subunit protein L17A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; copurifies with the Dam1 complex (aka DASH complex); homologous to [...] |
| PRS1 protein network | https://string-db.org/network/4932.YKL181W | Ribose-phosphate pyrophosphokinase 1; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key [...] |
| FAS1 protein network | https://string-db.org/network/4932.YKL182W | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydrat [...] |
| YKL183C-A protein network | https://string-db.org/network/4932.YKL183C-A | Uncharacterized protein YKL183C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| LOT5 protein network | https://string-db.org/network/4932.YKL183W | Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress. |
| SPE1 protein network | https://string-db.org/network/4932.YKL184W | Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and incre [...] |
| ASH1 protein network | https://string-db.org/network/4932.YKL185W | Transcriptional regulatory protein ASH1; Component of the Rpd3L histone deacetylase complex; zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaph [...] |
| MTR2 protein network | https://string-db.org/network/4932.YKL186C | mRNA transport regulator; essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA. |
| FAT3 protein network | https://string-db.org/network/4932.YKL187C | Uncharacterized protein YKL187C; Protein required for fatty acid uptake; protein abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detec [...] |
| PXA2 protein network | https://string-db.org/network/4932.YKL188C | Peroxisomal long-chain fatty acid import protein 1; Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar [...] |
| HYM1 protein network | https://string-db.org/network/4932.YKL189W | Protein HYM1; Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growt [...] |
| CNB1 protein network | https://string-db.org/network/4932.YKL190W | Calcineurin B; regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (stress-response transcription factor); other calcineurin subunit e [...] |
| DPH2 protein network | https://string-db.org/network/4932.YKL191W | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine re [...] |
| ACP1 protein network | https://string-db.org/network/4932.YKL192C | Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p. |
| SDS22 protein network | https://string-db.org/network/4932.YKL193C | Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear l [...] |
| MST1 protein network | https://string-db.org/network/4932.YKL194C | Threonine--tRNA ligase, mitochondrial; Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; lacks a [...] |
| MIA40 protein network | https://string-db.org/network/4932.YKL195W | Import and assembly protein in mitochondrial intermembrane space; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cyste [...] |
| YKT6 protein network | https://string-db.org/network/4932.YKL196C | Synaptobrevin homolog YKT6; Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar f [...] |
| PEX1 protein network | https://string-db.org/network/4932.YKL197C | Peroxisomal ATPase PEX1; AAA-peroxin; heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; [...] |
| PTK1 protein network | https://string-db.org/network/4932.YKL198C | Serine/threonine-protein kinase PTK1/STK1; Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog [...] |
| MNN4 protein network | https://string-db.org/network/4932.YKL201C | Protein MNN4; Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and st [...] |
| TOR2 protein network | https://string-db.org/network/4932.YKL203C | Serine/threonine-protein kinase TOR2; PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulat [...] |
| EAP1 protein network | https://string-db.org/network/4932.YKL204W | eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repres [...] |
| LOS1 protein network | https://string-db.org/network/4932.YKL205W | Exportin-T; Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm; deletion mutation extends replicative l [...] |
| ADD66 protein network | https://string-db.org/network/4932.YKL206C | Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its [...] |
| EMC3 protein network | https://string-db.org/network/4932.YKL207W | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein respons [...] |
| CBT1 protein network | https://string-db.org/network/4932.YKL208W | Cytochrome b termination protein 1; Protein involved in 5' RNA end processing; substrates include mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of t [...] |
| STE6 protein network | https://string-db.org/network/4932.YKL209C | Alpha-factor-transporting ATPase; Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 [...] |
| UBA1 protein network | https://string-db.org/network/4932.YKL210W | Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress. |
| TRP3 protein network | https://string-db.org/network/4932.YKL211C | Multifunctional tryptophan biosynthesis protein; Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme compl [...] |
| SAC1 protein network | https://string-db.org/network/4932.YKL212W | Phosphoinositide phosphatase SAC1; Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; [...] |
| DOA1 protein network | https://string-db.org/network/4932.YKL213C | WD repeat protein required for ubiquitin-mediated protein degradation; ubiquitin binding cofactor that complexes with Cdc48p; required for ribophagy; controls cellular ubiquitin concentration; pr [...] |
| YRA2 protein network | https://string-db.org/network/4932.YKL214C | RNA annealing protein YRA2; Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nuc [...] |
| OXP1 protein network | https://string-db.org/network/4932.YKL215C | 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increas [...] |
| URA1 protein network | https://string-db.org/network/4932.YKL216W | Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid. |
| JEN1 protein network | https://string-db.org/network/4932.YKL217W | Carboxylic acid transporter protein homolog; Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinit [...] |
| SRY1 protein network | https://string-db.org/network/4932.YKL218C | 3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) [...] |
| COS9 protein network | https://string-db.org/network/4932.YKL219W | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting [...] |
| FRE2 protein network | https://string-db.org/network/4932.YKL220C | Ferric/cupric reductase transmembrane component 2; Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by [...] |
| MCH2 protein network | https://string-db.org/network/4932.YKL221W | Probable transporter MCH2; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane b [...] |
| YKL222C protein network | https://string-db.org/network/4932.YKL222C | Uncharacterized transcriptional regulatory protein YKL222C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators f [...] |
| YKL223W protein network | https://string-db.org/network/4932.YKL223W | Putative UPF0377 protein YKL223W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family [...] |
| PAU16 protein network | https://string-db.org/network/4932.YKL224C | Seripauperin-16; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; Bel [...] |
| YKL225W protein network | https://string-db.org/network/4932.YKL225W | Putative UPF0320 protein YKL225W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| VPS1 protein network | https://string-db.org/network/4932.YKR001C | Vacuolar protein sorting-associated protein 1; Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some prote [...] |
| PAP1 protein network | https://string-db.org/network/4932.YKR002W | Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also [...] |
| OSH6 protein network | https://string-db.org/network/4932.YKR003W | Member of an oxysterol-binding protein family; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; GFP-fusion pr [...] |
| ECM9 protein network | https://string-db.org/network/4932.YKR004C | Non-essential protein of unknown function. |
| YKR005C protein network | https://string-db.org/network/4932.YKR005C | Uncharacterized protein YKR005C; Putative protein of unknown function. |
| MRPL13 protein network | https://string-db.org/network/4932.YKR006C | Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation. |
| MEH1 protein network | https://string-db.org/network/4932.YKR007W | Protein MEH1; Component of the EGO and GSE complexes; EGO is involved in the regulation of microautophagy and GSE is required for proper sorting of amino acid permease Gap1p; loss results in a de [...] |
| RSC4 protein network | https://string-db.org/network/4932.YKR008W | Chromatin structure-remodeling complex subunit RSC4; Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA [...] |
| FOX2 protein network | https://string-db.org/network/4932.YKR009C | Peroxisomal hydratase-dehydrogenase-epimerase; 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; mutation is fu [...] |
| TOF2 protein network | https://string-db.org/network/4932.YKR010C | Topoisomerase 1-associated factor 2; Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregat [...] |
| YKR011C protein network | https://string-db.org/network/4932.YKR011C | Uncharacterized protein YKR011C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication s [...] |
| PRY2 protein network | https://string-db.org/network/4932.YKR013W | Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and path [...] |
| YPT52 protein network | https://string-db.org/network/4932.YKR014C | GTP-binding protein YPT52; Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the C [...] |
| YKR015C protein network | https://string-db.org/network/4932.YKR015C | Uncharacterized protein YKR015C; Putative protein of unknown function; To yeast YJL043w. |
| MIC60 protein network | https://string-db.org/network/4932.YKR016W | Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista jun [...] |
| HEL1 protein network | https://string-db.org/network/4932.YKR017C | RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); Belongs to the RBR fa [...] |
| IRS4 protein network | https://string-db.org/network/4932.YKR019C | Increased rDNA silencing protein 4; EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns p [...] |
| VPS51 protein network | https://string-db.org/network/4932.YKR020W | Vacuolar protein sorting-associated protein 51; Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golg [...] |
| ALY1 protein network | https://string-db.org/network/4932.YKR021W | Arrestin-related trafficking adapter 6; Alpha arrestin, substrate of calcineurin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; dephosphor [...] |
| NTR2 protein network | https://string-db.org/network/4932.YKR022C | Pre-mRNA-splicing factor NTR2; Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly [...] |
| YKR023W protein network | https://string-db.org/network/4932.YKR023W | Uncharacterized protein YKR023W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| DBP7 protein network | https://string-db.org/network/4932.YKR024C | Putative ATP-dependent RNA helicase of the DEAD-box family; involved in ribosomal biogenesis; required at post-transcriptional step for efficient retrotransposition; essential for growth under an [...] |
| RPC37 protein network | https://string-db.org/network/4932.YKR025W | RNA polymerase III subunit C37. |
| GCN3 protein network | https://string-db.org/network/4932.YKR026C | Alpha subunit of translation initiation factor eIF2B; guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; positive regulator of GCN4 expression; a [...] |
| BCH2 protein network | https://string-db.org/network/4932.YKR027W | Protein BCH2; Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the [...] |
| SAP190 protein network | https://string-db.org/network/4932.YKR028W | SIT4-associating protein SAP190; Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and [...] |
| SET3 protein network | https://string-db.org/network/4932.YKR029C | Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins tha [...] |
| GMH1 protein network | https://string-db.org/network/4932.YKR030W | Golgi membrane protein of unknown function; interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or pr [...] |
| SPO14 protein network | https://string-db.org/network/4932.YKR031C | Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; diff [...] |
| DAL80 protein network | https://string-db.org/network/4932.YKR034W | Nitrogen regulatory protein DAL80; Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding famil [...] |
| OPI8 protein network | https://string-db.org/network/4932.YKR035C | Putative uncharacterized protein OPI8; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verif [...] |
| DID2 protein network | https://string-db.org/network/4932.YKR035W-A | Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may [...] |
| CAF4 protein network | https://string-db.org/network/4932.YKR036C | CCR4-associated factor 4; WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and pla [...] |
| SPC34 protein network | https://string-db.org/network/4932.YKR037C | Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuc [...] |
| KAE1 protein network | https://string-db.org/network/4932.YKR038C | tRNA N6-adenosine threonylcarbamoyltransferase; Highly conserved ATPase of HSP70/DnaK family; essential functional component of the EKC/KEOPS complex, with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/ [...] |
| GAP1 protein network | https://string-db.org/network/4932.YKR039W | General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth. |
| YKR040C protein network | https://string-db.org/network/4932.YKR040C | Putative uncharacterized protein YKR040C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| YKR041W protein network | https://string-db.org/network/4932.YKR041W | Uncharacterized protein YKR041W; Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking. |
| UTH1 protein network | https://string-db.org/network/4932.YKR042W | Probable secreted beta-glucosidase UTH1; Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during s [...] |
| SHB17 protein network | https://string-db.org/network/4932.YKR043C | Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; [...] |
| UIP5 protein network | https://string-db.org/network/4932.YKR044W | Protein of unknown function that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates. |
| YKR045C protein network | https://string-db.org/network/4932.YKR045C | Uncharacterized protein YKR045C; Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm. |
| PET10 protein network | https://string-db.org/network/4932.YKR046C | Protein of unknown function that localizes to lipid particles; localization suggests a role in lipid metabolism; expression pattern suggests a role in respiratory growth; computational analysis o [...] |
| NAP1 protein network | https://string-db.org/network/4932.YKR048C | Nucleosome assembly protein; Histone chaperone; involved in histone exchange by removing and replacing histone H2A-H2B dimers or histone variant dimers from assembled nucleosomes; involved in the [...] |
| FMP46 protein network | https://string-db.org/network/4932.YKR049C | Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the FMP46 family. |
| TRK2 protein network | https://string-db.org/network/4932.YKR050W | Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplic [...] |
| YKR051W protein network | https://string-db.org/network/4932.YKR051W | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. |
| MRS4 protein network | https://string-db.org/network/4932.YKR052C | Mitochondrial RNA-splicing protein MRS4; Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; m [...] |
| YSR3 protein network | https://string-db.org/network/4932.YKR053C | Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication; Belongs to the type 2 lip [...] |
| DYN1 protein network | https://string-db.org/network/4932.YKR054C | Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spin [...] |
| RHO4 protein network | https://string-db.org/network/4932.YKR055W | GTP-binding protein RHO4; Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extens [...] |
| TRM2 protein network | https://string-db.org/network/4932.YKR056W | tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair; Belongs [...] |
| RPS21A protein network | https://string-db.org/network/4932.YKR057W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplica [...] |
| GLG1 protein network | https://string-db.org/network/4932.YKR058W | Glycogenin-1; Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; SWAT-GFP and mCherry fusion proteins localize to th [...] |
| TIF1 protein network | https://string-db.org/network/4932.YKR059W | Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; [...] |
| UTP30 protein network | https://string-db.org/network/4932.YKR060W | Ribosome biogenesis protein UTP30; Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit; Belongs to the [...] |
| KTR2 protein network | https://string-db.org/network/4932.YKR061W | Probable mannosyltransferase KTR2; Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from th [...] |
| TFA2 protein network | https://string-db.org/network/4932.YKR062W | TFIIE small subunit; involved in RNA polymerase II transcription initiation; Belongs to the TFIIE beta subunit family. |
| LAS1 protein network | https://string-db.org/network/4932.YKR063C | Protein LAS1; Endonuclease involved in pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to modulate rRNA processing and ribosome biogenesis; may coordinate [...] |
| OAF3 protein network | https://string-db.org/network/4932.YKR064W | Oleate activated transcription factor 3; Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype an [...] |
| PAM17 protein network | https://string-db.org/network/4932.YKR065C | Presequence translocated-associated motor subunit PAM17, mitochondrial; Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact [...] |
| CCP1 protein network | https://string-db.org/network/4932.YKR066C | Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress. |
| GPT2 protein network | https://string-db.org/network/4932.YKR067W | Glycerol-3-phosphate O-acyltransferase 2; Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; located in lipid particles and the ER; involved in the stepwise acylation of glycer [...] |
| BET3 protein network | https://string-db.org/network/4932.YKR068C | Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1, regulating ER-Golgi traffic ( [...] |
| MET1 protein network | https://string-db.org/network/4932.YKR069W | Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; requ [...] |
| YKR070W protein network | https://string-db.org/network/4932.YKR070W | Uncharacterized protein YKR070W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| DRE2 protein network | https://string-db.org/network/4932.YKR071C | Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p in an early step in the CIA pathway; ortholo [...] |
| SIS2 protein network | https://string-db.org/network/4932.YKR072C | Phosphopantothenoylcysteine decarboxylase subunit SIS2; Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of phosphopantothenoylcysteine d [...] |
| YKR073C protein network | https://string-db.org/network/4932.YKR073C | Uncharacterized protein YKR073C; Putative protein of unknown function; conserved across S. cerevisiae strains. |
| AIM29 protein network | https://string-db.org/network/4932.YKR074W | Altered inheritance rate of mitochondria protein 29; Protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevate [...] |
| YKR075C protein network | https://string-db.org/network/4932.YKR075C | Uncharacterized protein YKR075C; Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; [...] |
| ECM4 protein network | https://string-db.org/network/4932.YKR076W | Glutathione S-transferase omega-like 2; S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathio [...] |
| MSA2 protein network | https://string-db.org/network/4932.YKR077W | Putative transcriptional activator; interacts with G1-specific transcription factor MBF and G1-specific promoters; MSA2 has a paralog, MSA1, that arose from the whole genome duplication. |
| YKR078W protein network | https://string-db.org/network/4932.YKR078W | Uncharacterized protein YKR078W; Cytoplasmic protein of unknown function; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate [...] |
| TRZ1 protein network | https://string-db.org/network/4932.YKR079C | Ribonuclease Z; tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer suscep [...] |
| MTD1 protein network | https://string-db.org/network/4932.YKR080W | Methylenetetrahydrofolate dehydrogenase [NAD(+)]; NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase; plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is re [...] |
| RPF2 protein network | https://string-db.org/network/4932.YKR081C | Ribosome biogenesis protein RPF2; Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; inter [...] |
| NUP133 protein network | https://string-db.org/network/4932.YKR082W | Nucleoporin NUP133; Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplas [...] |
| DAD2 protein network | https://string-db.org/network/4932.YKR083C | Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the [...] |
| HBS1 protein network | https://string-db.org/network/4932.YKR084C | Elongation factor 1 alpha-like protein; GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA r [...] |
| MRPL20 protein network | https://string-db.org/network/4932.YKR085C | Mitochondrial ribosomal protein of the large subunit. |
| PRP16 protein network | https://string-db.org/network/4932.YKR086W | DEAH-box RNA helicase involved in second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second ste [...] |
| OMA1 protein network | https://string-db.org/network/4932.YKR087C | Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults, preservation of normal mitochondrial function under damage-eliciting con [...] |
| TVP38 protein network | https://string-db.org/network/4932.YKR088C | Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytopla [...] |
| TGL4 protein network | https://string-db.org/network/4932.YKR089C | Lipase 4; Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to P [...] |
| PXL1 protein network | https://string-db.org/network/4932.YKR090W | Paxillin-like protein 1; Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and [...] |
| SRL3 protein network | https://string-db.org/network/4932.YKR091W | Protein SRL3; GTB motif (G1/S transcription factor binding) containing protein; binds SBF-regulated promoters in hydroxyurea-treated cells; when overexpressed, suppresses the lethality of a rad53 [...] |
| SRP40 protein network | https://string-db.org/network/4932.YKR092C | Suppressor protein SRP40; Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunolog [...] |
| PTR2 protein network | https://string-db.org/network/4932.YKR093W | Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway [...] |
| RPL40B protein network | https://string-db.org/network/4932.YKR094C | Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homo [...] |
| MLP1 protein network | https://string-db.org/network/4932.YKR095W | Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; [...] |
| PCC1 protein network | https://string-db.org/network/4932.YKR095W-A | Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; other complex members are Ka [...] |
| ESL2 protein network | https://string-db.org/network/4932.YKR096W | EST/SMG-like protein 2; hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl2p and Esl1p contain a 14-3-3-like domain and a putative PilT N-t [...] |
| PCK1 protein network | https://string-db.org/network/4932.YKR097W | Phosphoenolpyruvate carboxykinase; key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulate [...] |
| UBP11 protein network | https://string-db.org/network/4932.YKR098C | Ubiquitin carboxyl-terminal hydrolase 11; Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication. |
| BAS1 protein network | https://string-db.org/network/4932.YKR099W | Myb-like DNA-binding protein BAS1; Myb-related transcription factor; involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved [...] |
| SKG1 protein network | https://string-db.org/network/4932.YKR100C | Suppressor of lethality of KEX2 GAS1 double null mutant protein 1; Transmembrane protein with a role in cell wall polymer composition; localizes on inner surface of plasma membrane at bud and in [...] |
| SIR1 protein network | https://string-db.org/network/4932.YKR101W | Regulatory protein SIR1; Protein involved in silencing at mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p dom [...] |
| FLO10 protein network | https://string-db.org/network/4932.YKR102W | Flocculation protein FLO10; Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, s [...] |
| NFT1 protein network | https://string-db.org/network/4932.YKR103W | ABC transporter NFT1; Putative transporter of the MRP subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated prote [...] |
| YKR104W protein network | https://string-db.org/network/4932.YKR104W | Putative uncharacterized protein YKR104W; Putative transporter of the MRP subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; [...] |
| VBA5 protein network | https://string-db.org/network/4932.YKR105C | Vacuolar basic amino acid transporter 5; Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that aro [...] |
| GEX2 protein network | https://string-db.org/network/4932.YKR106W | Glutathione exchanger 2; Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; expressed at a very low level; potential role in resistance to oxidative stress and modulat [...] |
| DNM1 protein network | https://string-db.org/network/4932.YLL001W | Dynamin-related protein DNM1; Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochon [...] |
| RTT109 protein network | https://string-db.org/network/4932.YLL002W | Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required [...] |
| SFI1 protein network | https://string-db.org/network/4932.YLL003W | Protein SFI1; Centrin (Cdc31p)-binding protein required for SPB duplication; localizes to the half-bridge of the spindle pole body (SPB); required for progression through G(2)-M transition; phosp [...] |
| ORC3 protein network | https://string-db.org/network/4932.YLL004W | Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; Belongs to the ORC3 family. |
| SPO75 protein network | https://string-db.org/network/4932.YLL005C | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs [...] |
| MMM1 protein network | https://string-db.org/network/4932.YLL006W | Maintenance of mitochondrial morphology protein 1; ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipi [...] |
| YLL006W-A protein network | https://string-db.org/network/4932.YLL006W-A | Uncharacterized protein YLL006W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| LMO1 protein network | https://string-db.org/network/4932.YLL007C | ELMO family protein LMO1; Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a [...] |
| DRS1 protein network | https://string-db.org/network/4932.YLL008W | ATP-dependent RNA helicase DRS1; Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles; [...] |
| COX17 protein network | https://string-db.org/network/4932.YLL009C | Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; interacts with the MICOS complex, and inte [...] |
| PSR1 protein network | https://string-db.org/network/4932.YLL010C | Phosphatase PSR1; Plasma membrane associated protein phosphatase; involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expr [...] |
| SOF1 protein network | https://string-db.org/network/4932.YLL011W | Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene; Belongs to the WD repeat [...] |
| YEH1 protein network | https://string-db.org/network/4932.YLL012W | Sterol esterase 1; Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid [...] |
| PUF3 protein network | https://string-db.org/network/4932.YLL013C | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradatio [...] |
| EMC6 protein network | https://string-db.org/network/4932.YLL014W | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC [...] |
| BPT1 protein network | https://string-db.org/network/4932.YLL015W | Bile pigment transporter 1; ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxificatio [...] |
| DPS1 protein network | https://string-db.org/network/4932.YLL018C | Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase [...] |
| COX19 protein network | https://string-db.org/network/4932.YLL018C-A | Protein required for cytochrome c oxidase assembly; located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; co [...] |
| KNS1 protein network | https://string-db.org/network/4932.YLL019C | Dual specificity protein kinase KNS1; Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ri [...] |
| YLL019W-A protein network | https://string-db.org/network/4932.YLL019W-A | Putative uncharacterized protein YLL019W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| SPA2 protein network | https://string-db.org/network/4932.YLL021W | Protein SPA2; Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; p [...] |
| HIF1 protein network | https://string-db.org/network/4932.YLL022C | HAT1-interacting factor 1; Non-essential component of the HAT-B histone acetyltransferase complex; localized to the nucleus; has a role in telomeric silencing; other members are Hat1p and Hat2p; [...] |
| POM33 protein network | https://string-db.org/network/4932.YLL023C | Pore membrane protein of 33 kDa; Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human T [...] |
| SSA2 protein network | https://string-db.org/network/4932.YLL024C | Heat shock protein SSA2; HSP70 family ATP-binding protein; involved in protein folding, vacuolar import of proteins; required for ubiquitin-dependent degradation of short-lived proteins; associat [...] |
| PAU17 protein network | https://string-db.org/network/4932.YLL025W | Seripauperin-17; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; YLL [...] |
| HSP104 protein network | https://string-db.org/network/4932.YLL026W | Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, e [...] |
| ISA1 protein network | https://string-db.org/network/4932.YLL027W | Iron-sulfur assembly protein 1; Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondri [...] |
| TPO1 protein network | https://string-db.org/network/4932.YLL028W | Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyami [...] |
| FRA1 protein network | https://string-db.org/network/4932.YLL029W | Putative Xaa-Pro aminopeptidase FRA1; Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fail [...] |
| RRT7 protein network | https://string-db.org/network/4932.YLL030C | Regulator of rDNA transcription protein 7; Putative protein of unknown function; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcrip [...] |
| GPI13 protein network | https://string-db.org/network/4932.YLL031C | GPI ethanolamine phosphate transferase 3; ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor pre [...] |
| YLL032C protein network | https://string-db.org/network/4932.YLL032C | KH domain-containing protein YLL032C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to t [...] |
| IRC19 protein network | https://string-db.org/network/4932.YLL033W | Increased recombination centers protein 19; Protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spon [...] |
| RIX7 protein network | https://string-db.org/network/4932.YLL034C | Ribosome biogenesis ATPase RIX7; Putative ATPase of the AAA family; required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nucle [...] |
| GRC3 protein network | https://string-db.org/network/4932.YLL035W | Polynucleotide 5'-hydroxyl-kinase GRC3; Polynucleotide kinase present on rDNA; required for efficient transcription termination by RNA polymerase I; functions with Las1p in a conserved mechanism [...] |
| PRP19 protein network | https://string-db.org/network/4932.YLL036C | Pre-mRNA-processing factor 19; Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; relocalizes to the cytosol in r [...] |
| YLL037W protein network | https://string-db.org/network/4932.YLL037W | Putative uncharacterized protein YLL037W; Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor. |
| ENT4 protein network | https://string-db.org/network/4932.YLL038C | Epsin-4; Protein of unknown function; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome. |
| UBI4 protein network | https://string-db.org/network/4932.YLL039C | Polyubiquitin; Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a [...] |
| VPS13 protein network | https://string-db.org/network/4932.YLL040C | Vacuolar protein sorting-associated protein 13; Protein involved in prospore membrane morphogenesis; peripheral membrane protein that localizes to the prospore membrane and at numerous membrane c [...] |
| SDH2 protein network | https://string-db.org/network/4932.YLL041C | Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial re [...] |
| ATG10 protein network | https://string-db.org/network/4932.YLL042C | Ubiquitin-like-conjugating enzyme ATG10; Conserved E2-like conjugating enzyme; mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy; Belongs to the ATG10 family [...] |
| FPS1 protein network | https://string-db.org/network/4932.YLL043W | Glycerol uptake/efflux facilitator protein; Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid, arsenite, and antimonite; key fact [...] |
| YLL044W protein network | https://string-db.org/network/4932.YLL044W | Putative uncharacterized protein YLL044W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both [...] |
| RPL8B protein network | https://string-db.org/network/4932.YLL045C | Ribosomal 60S subunit protein L8B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Do [...] |
| RNP1 protein network | https://string-db.org/network/4932.YLL046C | Ribonucleoprotein that contains two RNA recognition motifs (RRM); RNP1 has a paralog, SBP1, that arose from the whole genome duplication. |
| YBT1 protein network | https://string-db.org/network/4932.YLL048C | ATP-dependent bile acid permease; Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ st [...] |
| LDB18 protein network | https://string-db.org/network/4932.YLL049W | Protein LDB18; Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for [...] |
| COF1 protein network | https://string-db.org/network/4932.YLL050C | Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo fro [...] |
| FRE6 protein network | https://string-db.org/network/4932.YLL051C | Ferric reductase transmembrane component 6; Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels. |
| AQY2 protein network | https://string-db.org/network/4932.YLL052C | Aquaporin-like protein 2; Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolera [...] |
| YLL053C protein network | https://string-db.org/network/4932.YLL053C | Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin. |
| YLL054C protein network | https://string-db.org/network/4932.YLL054C | Uncharacterized transcriptional regulatory protein YLL054C; Putative protein of unknown function with similarity to Pip2p; an oleate-specific transcriptional activator of peroxisome proliferation [...] |
| YCT1 protein network | https://string-db.org/network/4932.YLL055W | High-affinity cysteine-specific transporter; has similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not [...] |
| YLL056C protein network | https://string-db.org/network/4932.YLL056C | Uncharacterized protein YLL056C; Putative protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resist [...] |
| JLP1 protein network | https://string-db.org/network/4932.YLL057C | Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ [...] |
| YLL058W protein network | https://string-db.org/network/4932.YLL058W | Putative protein of unknown function with similarity to Str2p; Str2p is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene. |
| YLL059C protein network | https://string-db.org/network/4932.YLL059C | Putative uncharacterized protein YLL059C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| GTT2 protein network | https://string-db.org/network/4932.YLL060C | Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress; Belongs to the GST super [...] |
| MMP1 protein network | https://string-db.org/network/4932.YLL061W | High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p; Belongs to the amino acid-poly [...] |
| MHT1 protein network | https://string-db.org/network/4932.YLL062C | Homocysteine S-methyltransferase 1; S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the m [...] |
| AYT1 protein network | https://string-db.org/network/4932.YLL063C | Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis. |
| PAU18 protein network | https://string-db.org/network/4932.YLL064C | Seripauperin-18; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p; Belongs to the SRP1/TIP1 family. Seripauperin [...] |
| YLL065W protein network | https://string-db.org/network/4932.YLL065W | Putative UPF0320 protein YLL065W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps chromosome XII telom [...] |
| YLL066C protein network | https://string-db.org/network/4932.YLL066C | Putative Y' element ATP-dependent helicase; YLL066C is not an essential gene. |
| YLL066W-A protein network | https://string-db.org/network/4932.YLL066W-A | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YLL066C. |
| YLL066W-B protein network | https://string-db.org/network/4932.YLL066W-B | Uncharacterized protein YLL066W-B; Putative protein of unknown function; overexpression causes a cell cycle delay or arrest. |
| YLL067C protein network | https://string-db.org/network/4932.YLL067C | Putative Y' element ATP-dependent helicase. |
| YLL067W-A protein network | https://string-db.org/network/4932.YLL067W-A | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps YLL067C. |
| YLR001C protein network | https://string-db.org/network/4932.YLR001C | FAS1 domain-containing protein YLR001C; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted t [...] |
| NOC3 protein network | https://string-db.org/network/4932.YLR002C | Nucleolar complex-associated protein 3; Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturatio [...] |
| CMS1 protein network | https://string-db.org/network/4932.YLR003C | Protein CMS1; Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA r [...] |
| THI73 protein network | https://string-db.org/network/4932.YLR004C | Thiamine pathway transporter THI73; Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription [...] |
| SSL1 protein network | https://string-db.org/network/4932.YLR005W | Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision re [...] |
| SSK1 protein network | https://string-db.org/network/4932.YLR006C | Osmolarity two-component system protein SSK1; Cytoplasmic phosphorelay intermediate osmosensor and regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorela [...] |
| NSE1 protein network | https://string-db.org/network/4932.YLR007W | Non-structural maintenance of chromosomes element 1; Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromati [...] |
| PAM18 protein network | https://string-db.org/network/4932.YLR008C | Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates [...] |
| RLP24 protein network | https://string-db.org/network/4932.YLR009W | Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p fro [...] |
| TEN1 protein network | https://string-db.org/network/4932.YLR010C | Telomere length regulation protein TEN1; Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telom [...] |
| LOT6 protein network | https://string-db.org/network/4932.YLR011W | FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription f [...] |
| YLR012C protein network | https://string-db.org/network/4932.YLR012C | Putative protein of unknown function; YLR012C is not an essential gene. |
| GAT3 protein network | https://string-db.org/network/4932.YLR013W | Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT4, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative [...] |
| PPR1 protein network | https://string-db.org/network/4932.YLR014C | Pyrimidine pathway regulatory protein 1; Zinc finger transcription factor; contains a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, whi [...] |
| BRE2 protein network | https://string-db.org/network/4932.YLR015W | COMPASS component BRE2; Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain th [...] |
| PML1 protein network | https://string-db.org/network/4932.YLR016C | Pre-mRNA leakage protein 1; Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p. |
| MEU1 protein network | https://string-db.org/network/4932.YLR017W | Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activi [...] |
| POM34 protein network | https://string-db.org/network/4932.YLR018C | Nucleoporin POM34; Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication. |
| PSR2 protein network | https://string-db.org/network/4932.YLR019W | Probable phosphatase PSR2; Plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly throug [...] |
| YEH2 protein network | https://string-db.org/network/4932.YLR020C | Sterol esterase 2; Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome dupl [...] |
| IRC25 protein network | https://string-db.org/network/4932.YLR021W | Proteasome chaperone 3; Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alt [...] |
| SDO1 protein network | https://string-db.org/network/4932.YLR022C | Ribosome maturation protein SDO1; Guanine nucleotide exchange factor (GEF) for Ria1p; essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal s [...] |
| IZH3 protein network | https://string-db.org/network/4932.YLR023C | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevate [...] |
| UBR2 protein network | https://string-db.org/network/4932.YLR024C | Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary [...] |
| SNF7 protein network | https://string-db.org/network/4932.YLR025W | Vacuolar-sorting protein SNF7; One of four subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cyto [...] |
| SED5 protein network | https://string-db.org/network/4932.YLR026C | Integral membrane protein SED5; cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins. |
| AAT2 protein network | https://string-db.org/network/4932.YLR027C | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-pho [...] |
| ADE16 protein network | https://string-db.org/network/4932.YLR028C | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophos [...] |
| RPL15A protein network | https://string-db.org/network/4932.YLR029C | Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplic [...] |
| YLR030W protein network | https://string-db.org/network/4932.YLR030W | Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W. |
| YLR031W protein network | https://string-db.org/network/4932.YLR031W | Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W; YLR031W has a paralog, YMR124W, that arose from the whole genome duplication. |
| RAD5 protein network | https://string-db.org/network/4932.YLR032W | DNA repair protein RAD5; DNA helicase/Ubiquitin ligase; involved in error-free DNA damage tolerance (DDT), replication fork regression during postreplication repair by template switching, error-p [...] |
| RSC58 protein network | https://string-db.org/network/4932.YLR033W | Chromatin structure-remodeling complex protein RSC58; Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and esta [...] |
| SMF3 protein network | https://string-db.org/network/4932.YLR034C | Iron transporter SMF3; Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; pro [...] |
| MLH2 protein network | https://string-db.org/network/4932.YLR035C | Protein involved in mismatch repair and meiotic recombination; only certain frameshift intermediates are mismatch repair substrates; forms a complex with Mlh1p. |
| YLR036C protein network | https://string-db.org/network/4932.YLR036C | Uncharacterized protein YLR036C; Putative protein predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein. |
| PAU23 protein network | https://string-db.org/network/4932.YLR037C | Seripauperin-23; Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anae [...] |
| COX12 protein network | https://string-db.org/network/4932.YLR038C | Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required [...] |
| RIC1 protein network | https://string-db.org/network/4932.YLR039C | Guanine nucleotide exchange factor subunit RIC1; Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; invo [...] |
| AFB1 protein network | https://string-db.org/network/4932.YLR040C | A-factor barrier protein 1; MATalpha-specific a-factor blocker; contributes to mating efficiency under certain conditions; localizes to the cell wall; predicted to be a GPI-attached protein; upre [...] |
| YLR041W protein network | https://string-db.org/network/4932.YLR041W | Putative uncharacterized protein YLR041W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| YLR042C protein network | https://string-db.org/network/4932.YLR042C | Cell wall protein of unknown function; localizes to the cytoplasm; deletion improves xylose fermentation in industrially engineered strains; YLR042C is not an essential gene. |
| TRX1 protein network | https://string-db.org/network/4932.YLR043C | Thioredoxin-1; Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa [...] |
| PDC1 protein network | https://string-db.org/network/4932.YLR044C | Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, an [...] |
| STU2 protein network | https://string-db.org/network/4932.YLR045C | Protein STU2; Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle [...] |
| YLR046C protein network | https://string-db.org/network/4932.YLR046C | Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with ge [...] |
| FRE8 protein network | https://string-db.org/network/4932.YLR047C | Probable ferric reductase transmembrane component 8; Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation gro [...] |
| RPS0B protein network | https://string-db.org/network/4932.YLR048W | Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion o [...] |
| YLR049C protein network | https://string-db.org/network/4932.YLR049C | Uncharacterized protein YLR049C; Putative protein of unknown function. |
| YLR050C protein network | https://string-db.org/network/4932.YLR050C | Uncharacterized membrane protein YLR050C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential [...] |
| FCF2 protein network | https://string-db.org/network/4932.YLR051C | rRNA-processing protein FCF2; Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB re [...] |
| IES3 protein network | https://string-db.org/network/4932.YLR052W | Subunit of the INO80 chromatin remodeling complex. |
| YLR053C protein network | https://string-db.org/network/4932.YLR053C | Putative protein of unknown function. |
| OSW2 protein network | https://string-db.org/network/4932.YLR054C | Outer spore wall protein 2; Protein of unknown function reputedly involved in spore wall assembly. |
| SPT8 protein network | https://string-db.org/network/4932.YLR055C | Transcription factor SPT8; Subunit of the SAGA transcriptional regulatory complex; not present in SAGA-like complex SLIK/SALSA; required for SAGA-mediated inhibition at some promoters. |
| ERG3 protein network | https://string-db.org/network/4932.YLR056W | Delta(7)-sterol 5(6)-desaturase; C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptiona [...] |
| MNL2 protein network | https://string-db.org/network/4932.YLR057W | Putative endoplasmic reticulum mannosidase MNL2; Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin [...] |
| SHM2 protein network | https://string-db.org/network/4932.YLR058C | Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and [...] |
| REX2 protein network | https://string-db.org/network/4932.YLR059C | Oligoribonuclease, mitochondrial; 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null su [...] |
| FRS1 protein network | https://string-db.org/network/4932.YLR060W | Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translatio [...] |
| RPL22A protein network | https://string-db.org/network/4932.YLR061W | Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; required for the oxidative stress response, pseudohyphal and invasive growth; homologou [...] |
| BUD28 protein network | https://string-db.org/network/4932.YLR062C | Putative uncharacterized protein BUD28; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closel [...] |
| BMT6 protein network | https://string-db.org/network/4932.YLR063W | Methyltransferase required for m3U2843 methylation of the 25S rRNA; S-adenosylmethionine-dependent; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an es [...] |
| PER33 protein network | https://string-db.org/network/4932.YLR064W | Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human [...] |
| ENV10 protein network | https://string-db.org/network/4932.YLR065C | Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for [...] |
| SPC3 protein network | https://string-db.org/network/4932.YLR066W | Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of th [...] |
| PET309 protein network | https://string-db.org/network/4932.YLR067C | Pentatricopeptide repeat-containing protein PET309, mitochondrial; Specific translational activator for the COX1 mRNA; binds to the COX1 mRNA; also influences stability of intron-containing COX1 [...] |
| FYV7 protein network | https://string-db.org/network/4932.YLR068W | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin. |
| MEF1 protein network | https://string-db.org/network/4932.YLR069C | Mitochondrial elongation factor involved in translational elongation. |
| XYL2 protein network | https://string-db.org/network/4932.YLR070C | D-xylulose reductase; Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has ce [...] |
| RGR1 protein network | https://string-db.org/network/4932.YLR071C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repressi [...] |
| LAM6 protein network | https://string-db.org/network/4932.YLR072W | Membrane-anchored lipid-binding protein LAM6; Sterol transporter that transfers sterols between membranes; may regulate and coordinate formation of contact sites between organelles; localizes to [...] |
| RFU1 protein network | https://string-db.org/network/4932.YLR073C | Regulator of free ubiquitin chains 1; Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquiti [...] |
| BUD20 protein network | https://string-db.org/network/4932.YLR074C | Bud site selection protein 20; C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cyto [...] |
| RPL10 protein network | https://string-db.org/network/4932.YLR075W | Ribosomal 60S subunit protein L10; homologous to mammalian ribosomal protein L10 and bacterial L16; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to [...] |
| YLR076C protein network | https://string-db.org/network/4932.YLR076C | Putative uncharacterized protein YLR076C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| FMP25 protein network | https://string-db.org/network/4932.YLR077W | Protein FMP25, mitochondrial; Protein required for assembly of respiratory complex III; mitochondrial inner membrane protein; required for an early step in assembly of respiratory complex III (cy [...] |
| BOS1 protein network | https://string-db.org/network/4932.YLR078C | Protein transport protein BOS1; v-SNARE (vesicle specific SNAP receptor); localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; required [...] |
| SIC1 protein network | https://string-db.org/network/4932.YLR079W | Protein SIC1; Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; ph [...] |
| EMP46 protein network | https://string-db.org/network/4932.YLR080W | Protein EMP46; Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; EMP46 has a paralog, EMP47, that arose from the whole genome duplication. |
| GAL2 protein network | https://string-db.org/network/4932.YLR081W | Galactose permease; required for utilization of galactose; also able to transport glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. |
| SRL2 protein network | https://string-db.org/network/4932.YLR082C | Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation. |
| EMP70 protein network | https://string-db.org/network/4932.YLR083C | Transmembrane 9 superfamily member 1; Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of p [...] |
| RAX2 protein network | https://string-db.org/network/4932.YLR084C | Bud site selection protein RAX2; N-glycosylated protein; involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by [...] |
| ARP6 protein network | https://string-db.org/network/4932.YLR085C | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A. |
| SMC4 protein network | https://string-db.org/network/4932.YLR086W | Structural maintenance of chromosomes protein 4; Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hy [...] |
| CSF1 protein network | https://string-db.org/network/4932.YLR087C | Protein required for fermentation at low temperature; plays a role in the maturation of secretory proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-t [...] |
| GAA1 protein network | https://string-db.org/network/4932.YLR088W | Subunit of the GPI:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; human homolog GPAA1 can complement growth [...] |
| ALT1 protein network | https://string-db.org/network/4932.YLR089C | Probable alanine aminotransferase, mitochondrial; Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chron [...] |
| XDJ1 protein network | https://string-db.org/network/4932.YLR090W | DnaJ protein homolog XDJ1; Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-term [...] |
| GEP5 protein network | https://string-db.org/network/4932.YLR091W | Genetic interactor of prohibitin 5, mitochondrial; Protein of unknown function; required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; [...] |
| SUL2 protein network | https://string-db.org/network/4932.YLR092W | High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates; Belongs [...] |
| NYV1 protein network | https://string-db.org/network/4932.YLR093C | v-SNARE component of the vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane. |
| GIS3 protein network | https://string-db.org/network/4932.YLR094C | Protein of unknown function. |
| IOC2 protein network | https://string-db.org/network/4932.YLR095C | ISWI one complex protein 2; Subunit of the Isw1b complex; exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and [...] |
| KIN2 protein network | https://string-db.org/network/4932.YLR096W | Serine/threonine-protein kinase KIN2; Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, tha [...] |
| HRT3 protein network | https://string-db.org/network/4932.YLR097C | F-box protein HRT3; Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in [...] |
| CHA4 protein network | https://string-db.org/network/4932.YLR098C | Activatory protein CHA4; DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6 [...] |
| ICT1 protein network | https://string-db.org/network/4932.YLR099C | 1-acylglycerol-3-phosphate O-acyltransferase ICT1; Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased se [...] |
| MIM2 protein network | https://string-db.org/network/4932.YLR099W-A | Mitochondrial protein required for outer membrane protein import; involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and Fzo [...] |
| ERG27 protein network | https://string-db.org/network/4932.YLR100W | 3-keto sterol reductase; catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs; mutation is fun [...] |
| YLR101C protein network | https://string-db.org/network/4932.YLR101C | Putative uncharacterized protein YLR101C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| APC9 protein network | https://string-db.org/network/4932.YLR102C | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/a [...] |
| CDC45 protein network | https://string-db.org/network/4932.YLR103C | Cell division control protein 45; DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; [...] |
| LCL2 protein network | https://string-db.org/network/4932.YLR104W | Long chronological lifespan protein 2; Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a [...] |
| SEN2 protein network | https://string-db.org/network/4932.YLR105C | Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial s [...] |
| MDN1 protein network | https://string-db.org/network/4932.YLR106C | Midasin; Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive st [...] |
| REX3 protein network | https://string-db.org/network/4932.YLR107W | RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exon [...] |
| YLR108C protein network | https://string-db.org/network/4932.YLR108C | BTB/POZ domain-containing protein YLR108C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundan [...] |
| AHP1 protein network | https://string-db.org/network/4932.YLR109W | Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; Belongs to the peroxiredoxin family. Prx5 subfam [...] |
| CCW12 protein network | https://string-db.org/network/4932.YLR110C | Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog [...] |
| YLR111W protein network | https://string-db.org/network/4932.YLR111W | Uncharacterized protein YLR111W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YLR112W protein network | https://string-db.org/network/4932.YLR112W | Uncharacterized protein YLR112W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| HOG1 protein network | https://string-db.org/network/4932.YLR113W | Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; b [...] |
| AVL9 protein network | https://string-db.org/network/4932.YLR114C | Late secretory pathway protein AVL9; Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfam [...] |
| CFT2 protein network | https://string-db.org/network/4932.YLR115W | Cleavage factor two protein 2; Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with th [...] |
| MSL5 protein network | https://string-db.org/network/4932.YLR116W | Branchpoint-bridging protein; Component of commitment complex; which defines first step in splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the i [...] |
| CLF1 protein network | https://string-db.org/network/4932.YLR117C | Pre-mRNA-splicing factor CLF1; Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; h [...] |
| YLR118C protein network | https://string-db.org/network/4932.YLR118C | Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the D [...] |
| SRN2 protein network | https://string-db.org/network/4932.YLR119W | Protein SRN2; Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from [...] |
| YPS1 protein network | https://string-db.org/network/4932.YLR120C | Aspartic proteinase 3 subunit alpha; Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor [...] |
| YLR120W-A protein network | https://string-db.org/network/4932.YLR120W-A | Putative uncharacterized protein YLR120W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| YPS3 protein network | https://string-db.org/network/4932.YLR121C | Aspartic proteinase yapsin-3; Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidyli [...] |
| YLR123C protein network | https://string-db.org/network/4932.YLR123C | Putative uncharacterized protein YLR123C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| YLR124W protein network | https://string-db.org/network/4932.YLR124W | Putative uncharacterized protein YLR124W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YLR125W protein network | https://string-db.org/network/4932.YLR125W | Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene. |
| YLR126C protein network | https://string-db.org/network/4932.YLR126C | Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cyto [...] |
| APC2 protein network | https://string-db.org/network/4932.YLR127C | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/a [...] |
| DCN1 protein network | https://string-db.org/network/4932.YLR128W | Scaffold-type E3 ligase; required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain i [...] |
| DIP2 protein network | https://string-db.org/network/4932.YLR129W | Nucleolar protein; specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of t [...] |
| ZRT2 protein network | https://string-db.org/network/4932.YLR130C | Zinc-regulated transporter 2; Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor. |
| ACE2 protein network | https://string-db.org/network/4932.YLR131C | Metallothionein expression activator; Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localiza [...] |
| USB1 protein network | https://string-db.org/network/4932.YLR132C | U6 snRNA phosphodiesterase; Putative poly(U)-specific 3'-to-5' RNA exonuclease; involved in 3'-end processing of U6 snRNA removing uridines and generating a terminal 2′,3′ cyclic phos [...] |
| CKI1 protein network | https://string-db.org/network/4932.YLR133W | Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamin [...] |
| PDC5 protein network | https://string-db.org/network/4932.YLR134W | Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involv [...] |
| SLX4 protein network | https://string-db.org/network/4932.YLR135W | Structure-specific endonuclease subunit SLX4; Endonuclease involved in processing DNA; acts during recombination, repair; promotes template switching during break-induced replication (BIR), causi [...] |
| TIS11 protein network | https://string-db.org/network/4932.YLR136C | mRNA decay factor CTH2; mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved [...] |
| RKM5 protein network | https://string-db.org/network/4932.YLR137W | Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among funga [...] |
| NHA1 protein network | https://string-db.org/network/4932.YLR138W | Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH. |
| SLS1 protein network | https://string-db.org/network/4932.YLR139C | Sigma-like sequence protein 1, mitochondrial; Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translatio [...] |
| RRN5 protein network | https://string-db.org/network/4932.YLR141W | Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p. |
| PUT1 protein network | https://string-db.org/network/4932.YLR142W | Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absenc [...] |
| DPH6 protein network | https://string-db.org/network/4932.YLR143W | Diphthine--ammonia ligase; Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhib [...] |
| ACF2 protein network | https://string-db.org/network/4932.YLR144C | Endo-1,3(4)-beta-glucanase 2; Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases [...] |
| RMP1 protein network | https://string-db.org/network/4932.YLR145W | Ribonuclease MRP protein subunit RMP1; Subunit of RNase MRP; RNase MRP processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, [...] |
| SPE4 protein network | https://string-db.org/network/4932.YLR146C | Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid. |
| YLR146W-A protein network | https://string-db.org/network/4932.YLR146W-A | Coiled-coil domain-containing protein YLR146W-A; Putative protein of unknown function. |
| SMD3 protein network | https://string-db.org/network/4932.YLR147C | Small nuclear ribonucleoprotein Sm D3; Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and [...] |
| PEP3 protein network | https://string-db.org/network/4932.YLR148W | Component of CORVET membrane tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar bio [...] |
| YLR149C protein network | https://string-db.org/network/4932.YLR149C | Uncharacterized protein YLR149C; Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149 [...] |
| YLR149C-A protein network | https://string-db.org/network/4932.YLR149C-A | Putative uncharacterized protein YLR149C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| STM1 protein network | https://string-db.org/network/4932.YLR150W | Suppressor protein STM1; Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine mo [...] |
| PCD1 protein network | https://string-db.org/network/4932.YLR151C | Peroxisomal coenzyme A diphosphatase 1, peroxisomal; 8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as perox [...] |
| YLR152C protein network | https://string-db.org/network/4932.YLR152C | Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene. |
| ACS2 protein network | https://string-db.org/network/4932.YLR153C | Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growt [...] |
| RNH203 protein network | https://string-db.org/network/4932.YLR154C | Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome. |
| YLR154C-G protein network | https://string-db.org/network/4932.YLR154C-G | Uncharacterized protein YLR154C-G; Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2. |
| YLR154C-H protein network | https://string-db.org/network/4932.YLR154C-H | Uncharacterized protein YLR157C-C; Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-2; YLR154C-H has a paralog, YLR157C [...] |
| YLR154W-A protein network | https://string-db.org/network/4932.YLR154W-A | Putative uncharacterized protein ART2; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 25S r [...] |
| YLR154W-B protein network | https://string-db.org/network/4932.YLR154W-B | Putative uncharacterized protein YLR154W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the [...] |
| TAR1 protein network | https://string-db.org/network/4932.YLR154W-C | Protein potentially involved in regulation of respiratory metabolism; located in the mitochondria; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on [...] |
| YLR154W-E protein network | https://string-db.org/network/4932.YLR154W-E | Putative uncharacterized protein ART3; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 35S r [...] |
| YLR154W-F protein network | https://string-db.org/network/4932.YLR154W-F | Putative uncharacterized protein YLR154W-F; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the [...] |
| ASP3-1 protein network | https://string-db.org/network/4932.YLR155C | Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; lik [...] |
| YLR156C-A protein network | https://string-db.org/network/4932.YLR156C-A | Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-3; YLR156C-A has a paralog, YLR159C-A, that arose from a segmental duplication. |
| YLR156W protein network | https://string-db.org/network/4932.YLR156W | Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis; YLR156W has a paralog, YLR159W, that arose from a segmental duplication. |
| ASP3-2 protein network | https://string-db.org/network/4932.YLR157C | Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; lik [...] |
| YLR157C-C protein network | https://string-db.org/network/4932.YLR157C-C | Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-4; YLR157C-C has a paralog, YLR154C-H, that arose from a segmental dup [...] |
| YLR157W-E protein network | https://string-db.org/network/4932.YLR157W-E | Putative protein of unknown function identified by gene-trapping; microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element. |
| ASP3-3 protein network | https://string-db.org/network/4932.YLR158C | Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; lik [...] |
| YLR159C-A protein network | https://string-db.org/network/4932.YLR159C-A | Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-5; YLR159C-A has a paralog, YLR156C-A, that arose from a segmental duplication. |
| YLR159W protein network | https://string-db.org/network/4932.YLR159W | Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR159W has a paralog, [...] |
| ASP3-4 protein network | https://string-db.org/network/4932.YLR160C | Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; lik [...] |
| YLR161W protein network | https://string-db.org/network/4932.YLR161W | Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR161W has a paralog, [...] |
| YLR162W protein network | https://string-db.org/network/4932.YLR162W | Protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest, apoptosis, and increased sensitivity to cobalt chloride. |
| RRT15 protein network | https://string-db.org/network/4932.YLR162W-A | Regulator of rDNA transcription protein 15; Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of [...] |
| MAS1 protein network | https://string-db.org/network/4932.YLR163C | Beta subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; Belongs to the pep [...] |
| YLR163W-A protein network | https://string-db.org/network/4932.YLR163W-A | Uncharacterized protein YLR163W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| SHH4 protein network | https://string-db.org/network/4932.YLR164W | Mitochondrial inner membrane protein SHH4; Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can [...] |
| PUS5 protein network | https://string-db.org/network/4932.YLR165C | 21S rRNA pseudouridine(2819) synthase; Pseudouridine synthase; catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability. |
| SEC10 protein network | https://string-db.org/network/4932.YLR166C | Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior [...] |
| RPS31 protein network | https://string-db.org/network/4932.YLR167W | Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B [...] |
| UPS2 protein network | https://string-db.org/network/4932.YLR168C | Mitochondrial intermembrane space protein; involved in phospholipid metabolism; forms complex with Mdm35p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidyle [...] |
| APS1 protein network | https://string-db.org/network/4932.YLR170C | Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex. |
| DPH5 protein network | https://string-db.org/network/4932.YLR172C | Diphthine methyl ester synthase; Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not esse [...] |
| YLR173W protein network | https://string-db.org/network/4932.YLR173W | Putative protein of unknown function. |
| IDP2 protein network | https://string-db.org/network/4932.YLR174W | Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during [...] |
| CBF5 protein network | https://string-db.org/network/4932.YLR175W | H/ACA ribonucleoprotein complex subunit CBF5; Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on large and small rRNAs, on snRNA U2, and on some mRNAs; mutations in human orth [...] |
| RFX1 protein network | https://string-db.org/network/4932.YLR176C | RFX-like DNA-binding protein RFX1; Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication ch [...] |
| YLR177W protein network | https://string-db.org/network/4932.YLR177W | Uncharacterized protein YLR177W; Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gen [...] |
| TFS1 protein network | https://string-db.org/network/4932.YLR178C | Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p); phosphatidylethanolamine-binding protein (PEBP) family member and ortholog of hPEBP1/RKIP, a natural metastasis suppressor; targets t [...] |
| YLR179C protein network | https://string-db.org/network/4932.YLR179C | Uncharacterized protein YLR179C; Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug [...] |
| SAM1 protein network | https://string-db.org/network/4932.YLR180W | S-adenosylmethionine synthase 1; S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the w [...] |
| VTA1 protein network | https://string-db.org/network/4932.YLR181C | Vacuolar protein sorting-associated protein VTA1; Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-ter [...] |
| SWI6 protein network | https://string-db.org/network/4932.YLR182W | Regulatory protein SWI6; Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to re [...] |
| TOS4 protein network | https://string-db.org/network/4932.YLR183C | Protein TOS4; Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes [...] |
| YLR184W protein network | https://string-db.org/network/4932.YLR184W | Putative uncharacterized protein YLR184W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| RPL37A protein network | https://string-db.org/network/4932.YLR185W | Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolo [...] |
| EMG1 protein network | https://string-db.org/network/4932.YLR186W | Ribosomal RNA small subunit methyltransferase NEP1; Methyltransferase for rRNA; methylates pseudouridine 18S rRNA residue 1191; member of the SPOUT methyltransferase family; required for maturati [...] |
| SKG3 protein network | https://string-db.org/network/4932.YLR187W | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalize [...] |
| MDL1 protein network | https://string-db.org/network/4932.YLR188W | ATP-dependent permease MDL1, mitochondrial; Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role [...] |
| ATG26 protein network | https://string-db.org/network/4932.YLR189C | UDP-glucose:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in a [...] |
| MMR1 protein network | https://string-db.org/network/4932.YLR190W | Mitochondrial MYO2 receptor-related protein 1; Phosphorylated protein of the mitochondrial outer membrane; localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial [...] |
| PEX13 protein network | https://string-db.org/network/4932.YLR191W | Peroxisomal membrane protein PAS20; Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interact [...] |
| HCR1 protein network | https://string-db.org/network/4932.YLR192C | eIF3j component of translation initiation factor 3 (eIF3); dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of eIF3; required for 20S pre-rRNA pro [...] |
| UPS1 protein network | https://string-db.org/network/4932.YLR193C | Protein UPS1, mitochondrial; Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; loca [...] |
| NCW2 protein network | https://string-db.org/network/4932.YLR194C | Cell wall biogenesis protein NCW2; Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant [...] |
| NMT1 protein network | https://string-db.org/network/4932.YLR195C | Glycylpeptide N-tetradecanoyltransferase; N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involv [...] |
| PWP1 protein network | https://string-db.org/network/4932.YLR196W | Periodic tryptophan protein 1; Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily; Belongs to [...] |
| NOP56 protein network | https://string-db.org/network/4932.YLR197W | Nucleolar protein 56; Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpressio [...] |
| YLR198C protein network | https://string-db.org/network/4932.YLR198C | Putative uncharacterized protein YLR198C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified [...] |
| PBA1 protein network | https://string-db.org/network/4932.YLR199C | Proteasome chaperone 1; Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the [...] |
| YKE2 protein network | https://string-db.org/network/4932.YLR200W | Prefoldin subunit 6; Subunit of the heterohexameric Gim/prefoldin protein complex; involved in the folding of alpha-tubulin, beta-tubulin, and actin; prefoldin complex also localizes to chromatin [...] |
| COQ9 protein network | https://string-db.org/network/4932.YLR201C | Protein required for ubiquinone biosynthesis and respiratory growth; localizes to matrix face of mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; ubiquinone i [...] |
| MSS51 protein network | https://string-db.org/network/4932.YLR203C | Protein MSS51, mitochondrial; Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole m [...] |
| QRI5 protein network | https://string-db.org/network/4932.YLR204W | Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA. |
| HMX1 protein network | https://string-db.org/network/4932.YLR205C | Heme-binding protein HMX1; ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative str [...] |
| ENT2 protein network | https://string-db.org/network/4932.YLR206W | Epsin-2; Epsin-like protein required for endocytosis and actin patch assembly; functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus; ENT2 has a paralog, ENT1, that aro [...] |
| HRD3 protein network | https://string-db.org/network/4932.YLR207W | ERAD-associated E3 ubiquitin-protein ligase component HRD3; ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation (ERAD) determ [...] |
| SEC13 protein network | https://string-db.org/network/4932.YLR208W | Protein transport protein SEC13; Structural component of 3 complexes; subunit of the Nup84p nuclear pore subcomplex that contributes to nucleocytoplasmic transport and NPC biogenesis; subunit of [...] |
| PNP1 protein network | https://string-db.org/network/4932.YLR209C | Purine nucleoside phosphorylase; specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway; Belongs to the PNP/MTAP phosphorylase family. |
| CLB4 protein network | https://string-db.org/network/4932.YLR210W | G2/mitotic-specific cyclin-4; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulat [...] |
| ATG38 protein network | https://string-db.org/network/4932.YLR211C | Autophagy-related protein 38; Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I; required for the integrity of the active PtdIns-3-kinase complex I by maintaining an association [...] |
| TUB4 protein network | https://string-db.org/network/4932.YLR212C | Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress. |
| CRR1 protein network | https://string-db.org/network/4932.YLR213C | Probable glycosidase CRR1; Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; exp [...] |
| FRE1 protein network | https://string-db.org/network/4932.YLR214W | Ferric/cupric reductase transmembrane component 1; Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by [...] |
| CDC123 protein network | https://string-db.org/network/4932.YLR215C | Cell division cycle protein 123; Assembly factor for the eIF2 translation initiation factor complex; regulates translational initiation; conserved residues of this ATP-Grasp protein that bind to [...] |
| CPR6 protein network | https://string-db.org/network/4932.YLR216C | Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp8 [...] |
| COA4 protein network | https://string-db.org/network/4932.YLR218C | Cytochrome oxidase assembly factor 4; Twin Cx(9)C protein involved in cytochrome c oxidase organization; organization includes assembly or stability; localizes to the mitochondrial intermembrane [...] |
| MSC3 protein network | https://string-db.org/network/4932.YLR219W | Meiotic sister-chromatid recombination protein 3; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in direct [...] |
| CCC1 protein network | https://string-db.org/network/4932.YLR220W | Protein CCC1; Vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relativ [...] |
| RSA3 protein network | https://string-db.org/network/4932.YLR221C | Ribosome assembly protein 3; Protein with a likely role in ribosomal maturation; required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pr [...] |
| UTP13 protein network | https://string-db.org/network/4932.YLR222C | Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA. |
| IFH1 protein network | https://string-db.org/network/4932.YLR223C | Protein IFH1; Coactivator, regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coor [...] |
| UCC1 protein network | https://string-db.org/network/4932.YLR224W | F-box protein and component of SCF ubiquitin ligase complexes; involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; SCF-Ucc1 regulates lev [...] |
| BUR2 protein network | https://string-db.org/network/4932.YLR226W | Protein BUR2; Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise the CDK-cyclin BUR kinase complex which is involved in transcriptional regulation through its phosphorylation o [...] |
| ADY4 protein network | https://string-db.org/network/4932.YLR227C | Accumulates dyads protein 4; Structural component of the meiotic outer plaque; outer plaque is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during [...] |
| ECM22 protein network | https://string-db.org/network/4932.YLR228C | Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes upon sterol depletion, after relocating from intracellular membranes to perinuclear foci; redundant [...] |
| CDC42 protein network | https://string-db.org/network/4932.YLR229C | Cell division control protein 42; Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator [...] |
| YLR230W protein network | https://string-db.org/network/4932.YLR230W | Putative uncharacterized membrane protein YLR230W; Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42/YLR229C gene which encodes a small Rho-li [...] |
| BNA5 protein network | https://string-db.org/network/4932.YLR231C | Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p. |
| YLR232W protein network | https://string-db.org/network/4932.YLR232W | Putative uncharacterized protein YLR232W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| EST1 protein network | https://string-db.org/network/4932.YLR233C | Telomere elongation protein EST1; TLC1 RNA-associated factor involved in telomere length regulation; recruitment subunit of telomerase; has G-quadruplex promoting activity required for telomere e [...] |
| TOP3 protein network | https://string-db.org/network/4932.YLR234W | DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity [...] |
| YLR235C protein network | https://string-db.org/network/4932.YLR235C | Putative uncharacterized protein YLR235C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORFs TOP3/YL [...] |
| YLR236C protein network | https://string-db.org/network/4932.YLR236C | Uncharacterized protein YLR236C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YLR235C. |
| THI7 protein network | https://string-db.org/network/4932.YLR237W | Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); member of the major facilitator su [...] |
| FAR10 protein network | https://string-db.org/network/4932.YLR238W | Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; pote [...] |
| LIP2 protein network | https://string-db.org/network/4932.YLR239C | Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups; Belongs to the LipB family. |
| VPS34 protein network | https://string-db.org/network/4932.YLR240W | Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form [...] |
| CSC1 protein network | https://string-db.org/network/4932.YLR241W | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. |
| ARV1 protein network | https://string-db.org/network/4932.YLR242C | Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates [...] |
| GPN3 protein network | https://string-db.org/network/4932.YLR243W | GPN-loop GTPase 3; Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have [...] |
| MAP1 protein network | https://string-db.org/network/4932.YLR244C | Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; Belongs to the peptidase M [...] |
| CDD1 protein network | https://string-db.org/network/4932.YLR245C | Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm. |
| ERF2 protein network | https://string-db.org/network/4932.YLR246W | Subunit of a palmitoyltransferase; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2 [...] |
| IRC20 protein network | https://string-db.org/network/4932.YLR247C | Uncharacterized ATP-dependent helicase IRC20; E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-jo [...] |
| RCK2 protein network | https://string-db.org/network/4932.YLR248W | Serine/threonine-protein kinase RCK2; Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (ca [...] |
| YEF3 protein network | https://string-db.org/network/4932.YLR249W | Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication; Belongs to the ABC transporter super [...] |
| SSP120 protein network | https://string-db.org/network/4932.YLR250W | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern. |
| SYM1 protein network | https://string-db.org/network/4932.YLR251W | Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17; human homolog MPV17 i [...] |
| YLR252W protein network | https://string-db.org/network/4932.YLR252W | Putative uncharacterized protein YLR252W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| MCP2 protein network | https://string-db.org/network/4932.YLR253W | ABC1 family protein MCP2; Mitochondrial protein of unknown function involved in lipid homeostasis; associates with mitochondrial ribosome; integral membrane protein that localizes to the mitochon [...] |
| NDL1 protein network | https://string-db.org/network/4932.YLR254C | Homolog of nuclear distribution factor NudE; NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends. |
| YLR255C protein network | https://string-db.org/network/4932.YLR255C | Uncharacterized protein YLR255C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| HAP1 protein network | https://string-db.org/network/4932.YLR256W | Zinc finger transcription factor; involved in the complex regulation of gene expression in response to levels of heme and oxygen; localizes to the mitochondrion as well as to the nucleus; the S28 [...] |
| YLR257W protein network | https://string-db.org/network/4932.YLR257W | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. |
| GSY2 protein network | https://string-db.org/network/4932.YLR258W | Glycogen [starch] synthase isoform 2; Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf [...] |
| HSP60 protein network | https://string-db.org/network/4932.YLR259C | Heat shock protein 60, mitochondrial; Tetradecameric mitochondrial chaperonin; required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates [...] |
| LCB5 protein network | https://string-db.org/network/4932.YLR260W | Minor sphingoid long-chain base kinase; possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; LCB5 has a paralog, LCB4, that arose from the whole ge [...] |
| VPS63 protein network | https://string-db.org/network/4932.YLR261C | Uncharacterized protein VPS63; Putative protein of unknown function; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar [...] |
| YPT6 protein network | https://string-db.org/network/4932.YLR262C | GTP-binding protein YPT6; Rab family GTPase; required for endosome-to-Golgii, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; temporarily at the Golgi, dissociating into the cytosol [...] |
| TMA7 protein network | https://string-db.org/network/4932.YLR262C-A | Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundan [...] |
| RED1 protein network | https://string-db.org/network/4932.YLR263W | Protein component of the synaptonemal complex axial elements; involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; pro [...] |
| YLR264C-A protein network | https://string-db.org/network/4932.YLR264C-A | Putative protein of unknown function. |
| RPS28B protein network | https://string-db.org/network/4932.YLR264W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; has an extraribosomal function in autoregulation, in which Rps28Bp bin [...] |
| NEJ1 protein network | https://string-db.org/network/4932.YLR265C | Non-homologous end-joining protein 1; Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regula [...] |
| PDR8 protein network | https://string-db.org/network/4932.YLR266C | Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenom [...] |
| BOP2 protein network | https://string-db.org/network/4932.YLR267W | Protein of unknown function. |
| SEC22 protein network | https://string-db.org/network/4932.YLR268W | R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; syna [...] |
| YLR269C protein network | https://string-db.org/network/4932.YLR269C | Putative uncharacterized protein YLR269C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| DCS1 protein network | https://string-db.org/network/4932.YLR270W | m7GpppX diphosphatase; Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a [...] |
| CMG1 protein network | https://string-db.org/network/4932.YLR271W | Uncharacterized protein YLR271W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the [...] |
| YCS4 protein network | https://string-db.org/network/4932.YLR272C | Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleo [...] |
| PIG1 protein network | https://string-db.org/network/4932.YLR273C | Putative targeting subunit for type-1 protein phosphatase Glc7p; tethers Glc7p to Gsy2p glycogen synthase; PIG1 has a paralog, GAC1, that arose from the whole genome duplication. |
| MCM5 protein network | https://string-db.org/network/4932.YLR274W | Minichromosome maintenance protein 5; Component of the Mcm2-7 hexameric helicase complex; MCM complex is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent [...] |
| SMD2 protein network | https://string-db.org/network/4932.YLR275W | Small nuclear ribonucleoprotein Sm D2; Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and [...] |
| DBP9 protein network | https://string-db.org/network/4932.YLR276C | ATP-dependent RNA helicase DBP9; DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helic [...] |
| YSH1 protein network | https://string-db.org/network/4932.YLR277C | Endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundan [...] |
| YLR278C protein network | https://string-db.org/network/4932.YLR278C | Uncharacterized transcriptional regulatory protein YLR278C; Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain [...] |
| YLR280C protein network | https://string-db.org/network/4932.YLR280C | Putative uncharacterized protein YLR280C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YLR281C protein network | https://string-db.org/network/4932.YLR281C | Uncharacterized peptide chain release factor-like protein YLR281C, mitochondrial; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; Y [...] |
| YLR282C protein network | https://string-db.org/network/4932.YLR282C | Putative uncharacterized protein YLR282C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation con [...] |
| YLR283W protein network | https://string-db.org/network/4932.YLR283W | Uncharacterized protein YLR283W, mitochondrial; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene. |
| ECI1 protein network | https://string-db.org/network/4932.YLR284C | Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; [...] |
| YLR285C-A protein network | https://string-db.org/network/4932.YLR285C-A | Uncharacterized protein YLR285C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| NNT1 protein network | https://string-db.org/network/4932.YLR285W | Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosylmethionine-dependent methyltransferase; novel N-terminal protein methyltransferase that trimethylates the N-terminal glycine resi [...] |
| CTS1 protein network | https://string-db.org/network/4932.YLR286C | Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p. |
| YLR286W-A protein network | https://string-db.org/network/4932.YLR286W-A | Putative uncharacterized protein YLR286W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verifi [...] |
| YLR287C protein network | https://string-db.org/network/4932.YLR287C | Uncharacterized protein YLR287C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene. |
| RPS30A protein network | https://string-db.org/network/4932.YLR287C-A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplica [...] |
| MEC3 protein network | https://string-db.org/network/4932.YLR288C | DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; [...] |
| GUF1 protein network | https://string-db.org/network/4932.YLR289W | Translation factor GUF1, mitochondrial; Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in t [...] |
| COQ11 protein network | https://string-db.org/network/4932.YLR290C | MIOREX complex component 2; Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes; required for synthesis of wild-type levels of Coenzyme Q (ubiquinone); member of the short-chain [...] |
| GCD7 protein network | https://string-db.org/network/4932.YLR291C | Beta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative re [...] |
| SEC72 protein network | https://string-db.org/network/4932.YLR292C | Translocation protein SEC72; Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent pro [...] |
| GSP1 protein network | https://string-db.org/network/4932.YLR293C | GTP-binding nuclear protein GSP1/CNR1; Ran GTPase; GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm [...] |
| YLR294C protein network | https://string-db.org/network/4932.YLR294C | Putative uncharacterized protein YLR294C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| ATP14 protein network | https://string-db.org/network/4932.YLR295C | Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in res [...] |
| YLR296W protein network | https://string-db.org/network/4932.YLR296W | Uncharacterized protein YLR296W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YLR297W protein network | https://string-db.org/network/4932.YLR297W | Uncharacterized vacuolar protein YLR297W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8- [...] |
| YHC1 protein network | https://string-db.org/network/4932.YLR298C | U1 small nuclear ribonucleoprotein C; Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between [...] |
| YLR299C-A protein network | https://string-db.org/network/4932.YLR299C-A | Putative uncharacterized protein YLR299C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verifi [...] |
| ECM38 protein network | https://string-db.org/network/4932.YLR299W | Glutathione hydrolase heavy chain; Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen [...] |
| EXG1 protein network | https://string-db.org/network/4932.YLR300W | Glucan 1,3-beta-glucosidase I/II; Major exo-1,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a par [...] |
| HRI1 protein network | https://string-db.org/network/4932.YLR301W | Protein of unknown function that interacts with Sec72p and Hrr25p; Belongs to the HRI1 family. |
| YLR302C protein network | https://string-db.org/network/4932.YLR302C | Uncharacterized protein YLR302C; Putative protein of unknown function; conserved among S. cerevisiae strains. |
| MET17 protein network | https://string-db.org/network/4932.YLR303W | Homocysteine/cysteine synthase; O-acetyl homoserine-O-acetyl serine sulfhydrylase; required for Methionine and cysteine biosynthesis; Belongs to the trans-sulfuration enzymes family. |
| ACO1 protein network | https://string-db.org/network/4932.YLR304C | Aconitate hydratase, mitochondrial; Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial [...] |
| STT4 protein network | https://string-db.org/network/4932.YLR305C | Phosphatidylinositol-4-kinase; functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization; Belongs to the PI3/ [...] |
| UBC12 protein network | https://string-db.org/network/4932.YLR306W | NEDD8-conjugating enzyme UBC12; Enzyme that mediates the conjugation of Rub1p; a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes. |
| YLR307C-A protein network | https://string-db.org/network/4932.YLR307C-A | Uncharacterized protein YLR307C-A; Putative protein of unknown function. |
| CDA1 protein network | https://string-db.org/network/4932.YLR307W | Chitin deacetylase; together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall. |
| CDA2 protein network | https://string-db.org/network/4932.YLR308W | Chitin deacetylase; together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall. |
| IMH1 protein network | https://string-db.org/network/4932.YLR309C | Golgin IMH1; Protein involved in vesicular transport; mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated [...] |
| CDC25 protein network | https://string-db.org/network/4932.YLR310C | Cell division control protein 25; Membrane bound guanine nucleotide exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p [...] |
| YLR311C protein network | https://string-db.org/network/4932.YLR311C | Putative uncharacterized membrane protein YLR311C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| ATG39 protein network | https://string-db.org/network/4932.YLR312C | Autophagy-related protein 39; Autophagy receptor with a role in degradation of the ER and nucleus; involved specifically in autophagy of perinuclear endoplasmic reticulum in response to nitrogen [...] |
| MRPL15 protein network | https://string-db.org/network/4932.YLR312W-A | Mitochondrial ribosomal protein of the large subunit; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL57 subfamily. |
| SPH1 protein network | https://string-db.org/network/4932.YLR313C | Protein involved in shmoo formation and bipolar bud site selection; localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2 [...] |
| CDC3 protein network | https://string-db.org/network/4932.YLR314C | Cell division control protein 3; Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can [...] |
| NKP2 protein network | https://string-db.org/network/4932.YLR315W | Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2. |
| TAD3 protein network | https://string-db.org/network/4932.YLR316C | Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; Belongs to the cytidine and deoxycytidy [...] |
| YLR317W protein network | https://string-db.org/network/4932.YLR317W | Putative uncharacterized protein YLR317W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; may be part of a bici [...] |
| EST2 protein network | https://string-db.org/network/4932.YLR318W | Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human hom [...] |
| BUD6 protein network | https://string-db.org/network/4932.YLR319C | Bud site selection protein 6; Actin- and formin-interacting protein; participates in actin cable assembly and organization as a nucleation-promoting factor (NPF) for formins Bni1p and Bnr1p; a tr [...] |
| MMS22 protein network | https://string-db.org/network/4932.YLR320W | E3 ubiquitin-protein ligase substrate receptor MMS22; Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the for [...] |
| SFH1 protein network | https://string-db.org/network/4932.YLR321C | Chromatin structure-remodeling complex subunit SFH1; Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosph [...] |
| VPS65 protein network | https://string-db.org/network/4932.YLR322W | Putative uncharacterized protein VPS65; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closel [...] |
| CWC24 protein network | https://string-db.org/network/4932.YLR323C | Pre-mRNA-splicing factor CWC24; General splicing factor; required for stable U2 snRNP binding to primary transcripts; essential for the first step of splicing; component of the pre-catalytic spli [...] |
| PEX30 protein network | https://string-db.org/network/4932.YLR324W | ER-resident protein involved in peroxisomal biogenesis; ER-localized protein that associates with peroxisomes; interacts with Pex29p and reticulons Rtn1p and Yop1p to regulate peroxisome biogenes [...] |
| RPL38 protein network | https://string-db.org/network/4932.YLR325C | Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog; Belongs to the eukaryotic ribosomal protein eL38 family. |
| YLR326W protein network | https://string-db.org/network/4932.YLR326W | Uncharacterized membrane protein YLR326W; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; predicted to be palmitoylated. |
| TMA10 protein network | https://string-db.org/network/4932.YLR327C | Translation machinery-associated protein 10; Protein of unknown function that associates with ribosomes; protein abundance increases in response to DNA replication stress; TMA10 has a paralog, ST [...] |
| NMA1 protein network | https://string-db.org/network/4932.YLR328W | Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, inclu [...] |
| REC102 protein network | https://string-db.org/network/4932.YLR329W | Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination. |
| CHS5 protein network | https://string-db.org/network/4932.YLR330W | Chitin biosynthesis protein CHS5; Component of the exomer complex; the exomer which also contains Csh6p, Bch1p, Bch2p, and Bud7, is involved in the export of select proteins, such as chitin synth [...] |
| JIP3 protein network | https://string-db.org/network/4932.YLR331C | Uncharacterized protein JIP3; Putative protein of unknown function; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified [...] |
| MID2 protein network | https://string-db.org/network/4932.YLR332W | Cell wall integrity sensor MID2; O-glycosylated plasma membrane protein; acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide e [...] |
| RPS25B protein network | https://string-db.org/network/4932.YLR333C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25B has a paralog, RPS25A, that arose from the whole genome duplica [...] |
| YLR334C protein network | https://string-db.org/network/4932.YLR334C | Putative uncharacterized protein YLR334C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps a stand-alon [...] |
| NUP2 protein network | https://string-db.org/network/4932.YLR335W | Nucleoporin involved in nucleocytoplasmic transport; binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin o [...] |
| SGD1 protein network | https://string-db.org/network/4932.YLR336C | Suppressor of glycerol defect protein 1; Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative h [...] |
| VRP1 protein network | https://string-db.org/network/4932.YLR337C | Verprolin, proline-rich actin-associated protein; involved in cytoskeletal organization and cytokinesis; promotes actin nucleation and endocytosis; related to mammalian Wiskott-Aldrich syndrome p [...] |
| OPI9 protein network | https://string-db.org/network/4932.YLR338W | Putative uncharacterized protein OPI9; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the v [...] |
| YLR339C protein network | https://string-db.org/network/4932.YLR339C | Putative uncharacterized protein YLR339C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RPP0 protein network | https://string-db.org/network/4932.YLR340W | Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian rib [...] |
| SPO77 protein network | https://string-db.org/network/4932.YLR341W | Sporulation-specific protein 77; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation and for timely prospore membrane closure along with SPS1; requi [...] |
| FKS1 protein network | https://string-db.org/network/4932.YLR342W | 1,3-beta-glucan synthase component FKS1; Catalytic subunit of 1,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involve [...] |
| YLR342W-A protein network | https://string-db.org/network/4932.YLR342W-A | Uncharacterized protein YLR342W-A; Putative protein of unknown function. |
| GAS2 protein network | https://string-db.org/network/4932.YLR343W | 1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p; Belongs to the glycosyl hydrolase 72 family. |
| RPL26A protein network | https://string-db.org/network/4932.YLR344W | Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosoma [...] |
| YLR345W protein network | https://string-db.org/network/4932.YLR345W | Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W; Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345 [...] |
| CIS1 protein network | https://string-db.org/network/4932.YLR346C | Citrinin resistance protein, mitochondrial; Protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and [...] |
| KAP95 protein network | https://string-db.org/network/4932.YLR347C | Importin subunit beta-1; Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; [...] |
| YLR347W-A protein network | https://string-db.org/network/4932.YLR347W-A | Putative uncharacterized protein YLR347W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verifi [...] |
| DIC1 protein network | https://string-db.org/network/4932.YLR348C | Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into th [...] |
| ORM2 protein network | https://string-db.org/network/4932.YLR350W | Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogen [...] |
| NIT3 protein network | https://string-db.org/network/4932.YLR351C | Omega-amidase NIT3; Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with th [...] |
| YLR352W protein network | https://string-db.org/network/4932.YLR352W | F-box protein YLR352W; Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene. |
| BUD8 protein network | https://string-db.org/network/4932.YLR353W | Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole; BUD8 has a paralog, BUD9, that a [...] |
| TAL1 protein network | https://string-db.org/network/4932.YLR354C | Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate; TAL1 has [...] |
| ILV5 protein network | https://string-db.org/network/4932.YLR355C | Ketol-acid reductoisomerase, mitochondrial; Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondr [...] |
| ATG33 protein network | https://string-db.org/network/4932.YLR356W | Autophagy-related protein 33; Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at post-log phase; not required for other types of selective autophagy or macroaut [...] |
| RSC2 protein network | https://string-db.org/network/4932.YLR357W | Chromatin structure-remodeling complex subunit RSC2; Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere mainte [...] |
| YLR358C protein network | https://string-db.org/network/4932.YLR358C | Uncharacterized protein YLR358C; Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W. |
| ADE13 protein network | https://string-db.org/network/4932.YLR359W | Adenylosuccinate lyase; catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human orthol [...] |
| VPS38 protein network | https://string-db.org/network/4932.YLR360W | Vacuolar protein sorting-associated protein 38; Part of a Vps34p phosphatidylinositol 3-kinase complex; functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote productio [...] |
| DCR2 protein network | https://string-db.org/network/4932.YLR361C | Protein phosphatase; involved in downregulation of the unfolded protein response (UPR), at least in part through dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase [...] |
| YLR361C-A protein network | https://string-db.org/network/4932.YLR361C-A | Uncharacterized protein YLR361C-A; Putative protein of unknown function. |
| STE11 protein network | https://string-db.org/network/4932.YLR362W | Serine/threonine-protein kinase STE11; Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolari [...] |
| NMD4 protein network | https://string-db.org/network/4932.YLR363C | Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress. |
| YLR363W-A protein network | https://string-db.org/network/4932.YLR363W-A | Uncharacterized protein YLR363W-A; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication [...] |
| YLR364C-A protein network | https://string-db.org/network/4932.YLR364C-A | Uncharacterized protein YLR364C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubio [...] |
| GRX8 protein network | https://string-db.org/network/4932.YLR364W | Glutaredoxin-8; Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein locali [...] |
| YLR365W protein network | https://string-db.org/network/4932.YLR365W | Uncharacterized protein YLR365W; Putative protein of unknown function; conserved among S. cerevisiae strains; YLR365W is not an essential gene. |
| YLR366W protein network | https://string-db.org/network/4932.YLR366W | Putative uncharacterized protein YLR366W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RPS22B protein network | https://string-db.org/network/4932.YLR367W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication [...] |
| MDM30 protein network | https://string-db.org/network/4932.YLR368W | Mitochondrial distribution and morphology protein 30; F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fus [...] |
| SSQ1 protein network | https://string-db.org/network/4932.YLR369W | Heat shock protein SSQ1, mitochondrial; Mitochondrial hsp70-type molecular chaperone; required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for matura [...] |
| ARC18 protein network | https://string-db.org/network/4932.YLR370C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches. |
| ROM2 protein network | https://string-db.org/network/4932.YLR371W | Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is depende [...] |
| ELO3 protein network | https://string-db.org/network/4932.YLR372W | Elongation of fatty acids protein 3; Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulat [...] |
| VID22 protein network | https://string-db.org/network/4932.YLR373C | Vacuolar import and degradation protein 22; Glycosylated integral membrane protein localized to plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPa [...] |
| STP3 protein network | https://string-db.org/network/4932.YLR375W | Zinc-finger protein of unknown function; possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids; STP3 has a paralog, STP4, that arose from the whole genome duplication [...] |
| PSY3 protein network | https://string-db.org/network/4932.YLR376C | Platinum sensitivity protein 3; Component of Shu complex (aka PCSS complex); Shu complex also includes Shu1, Csm2, Shu2, and promotes error-free DNA repair; promotes Rad51p filament assembly; Shu [...] |
| FBP1 protein network | https://string-db.org/network/4932.YLR377C | Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation dependin [...] |
| SEC61 protein network | https://string-db.org/network/4932.YLR378C | Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex allows SRP-independen [...] |
| YLR379W protein network | https://string-db.org/network/4932.YLR379W | Putative uncharacterized protein YLR379W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| CSR1 protein network | https://string-db.org/network/4932.YLR380W | Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may h [...] |
| CTF3 protein network | https://string-db.org/network/4932.YLR381W | Inner kinetochore subunit CTF3; Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; required for the spindle assembly checkpoi [...] |
| NAM2 protein network | https://string-db.org/network/4932.YLR382C | Leucine--tRNA ligase, mitochondrial; Mitochondrial leucyl-tRNA synthetase; also has direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome [...] |
| SMC6 protein network | https://string-db.org/network/4932.YLR383W | Structural maintenance of chromosomes protein 6; Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids d [...] |
| IKI3 protein network | https://string-db.org/network/4932.YLR384C | Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause fa [...] |
| SWC7 protein network | https://string-db.org/network/4932.YLR385C | SWR1-complex protein 7; Protein of unknown function; component of the Swr1p complex that incorporates Htz1p into chromatin; Belongs to the SWC7 family. |
| VAC14 protein network | https://string-db.org/network/4932.YLR386W | Vacuole morphology and inheritance protein 14; Enzyme regulator; involved in synthesis of phosphatidylinositol 3,5-bisphosphate, in control of trafficking of some proteins to the vacuole lumen vi [...] |
| REH1 protein network | https://string-db.org/network/4932.YLR387C | Cytoplasmic 60S subunit biogenesis factor; associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2 [...] |
| RPS29A protein network | https://string-db.org/network/4932.YLR388W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication [...] |
| STE23 protein network | https://string-db.org/network/4932.YLR389C | A-factor-processing enzyme; Metalloprotease; involved in N-terminal processing of pro-a-factor to mature form; expressed in both haploids and diploids; one of two yeast homologs of human insulin- [...] |
| ECM19 protein network | https://string-db.org/network/4932.YLR390W | Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| CCW14 protein network | https://string-db.org/network/4932.YLR390W-A | Covalently linked cell wall glycoprotein; present in the inner layer of the cell wall; Belongs to the CCW14 family. |
| ART10 protein network | https://string-db.org/network/4932.YLR392C | Arrestin-related trafficking adapter 10; Protein of unknown function that contains 2 PY motifs; ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP [...] |
| ATP10 protein network | https://string-db.org/network/4932.YLR393W | Mitochondrial ATPase complex subunit ATP10; Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrial inner membrane protein; interacts genetically with ATP6; Belongs to [...] |
| CST9 protein network | https://string-db.org/network/4932.YLR394W | Chromosome stability protein 9; SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; associates with centromeres early in me [...] |
| COX8 protein network | https://string-db.org/network/4932.YLR395C | Subunit VIII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain. |
| VPS33 protein network | https://string-db.org/network/4932.YLR396C | Vacuolar protein sorting-associated protein 33; ATP-binding protein that is a subunit of the HOPS and CORVET complexes; essential for protein sorting, vesicle docking, and fusion at the vacuole; [...] |
| AFG2 protein network | https://string-db.org/network/4932.YLR397C | ATPase family gene 2 protein; ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; re [...] |
| SKI2 protein network | https://string-db.org/network/4932.YLR398C | Antiviral helicase SKI2; Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsR [...] |
| BDF1 protein network | https://string-db.org/network/4932.YLR399C | Bromodomain-containing factor 1; Protein involved in transcription initiation; functions at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodoma [...] |
| YLR399W-A protein network | https://string-db.org/network/4932.YLR399W-A | Putative uncharacterized protein YLR399W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the charac [...] |
| YLR400W protein network | https://string-db.org/network/4932.YLR400W | Putative uncharacterized protein YLR400W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| DUS3 protein network | https://string-db.org/network/4932.YLR401C | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]; Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response [...] |
| YLR402W protein network | https://string-db.org/network/4932.YLR402W | Putative uncharacterized protein YLR402W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| SFP1 protein network | https://string-db.org/network/4932.YLR403W | Transcription factor SFP1; Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage [...] |
| SEI1 protein network | https://string-db.org/network/4932.YLR404W | Seipin involved in lipid droplet (LD) assembly; controls lipid particle morphology, number, and size; promotes initiation of LD formation on the ER; ensures that LDs bud from the ER towards the c [...] |
| DUS4 protein network | https://string-db.org/network/4932.YLR405W | tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]; Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p; Belongs to the Dus family. Dus4 su [...] |
| RPL31B protein network | https://string-db.org/network/4932.YLR406C | Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31 [...] |
| YLR406C-A protein network | https://string-db.org/network/4932.YLR406C-A | Uncharacterized protein YLR406C-A; Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vac [...] |
| YLR407W protein network | https://string-db.org/network/4932.YLR407W | Uncharacterized protein YLR407W; Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus. |
| BLS1 protein network | https://string-db.org/network/4932.YLR408C | Subunit of the BLOC-1 complex involved in endosomal maturation; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene; Belongs to the BLOC1S1 [...] |
| UTP21 protein network | https://string-db.org/network/4932.YLR409C | U3 small nucleolar RNA-associated protein 21; Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; sy [...] |
| VIP1 protein network | https://string-db.org/network/4932.YLR410W | Inositol hexakisphosphate and inositol heptakisphosphate kinase; inositol heptakisphosphate (IP7) production is important for phosphate signaling; involved in cortical actin cytoskeleton function [...] |
| CTR3 protein network | https://string-db.org/network/4932.YLR411W | High-affinity copper transporter of the plasma membrane; acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae. |
| BER1 protein network | https://string-db.org/network/4932.YLR412W | SRR1-like protein BER1; Protein involved in microtubule-related processes; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not a [...] |
| INA1 protein network | https://string-db.org/network/4932.YLR413W | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. |
| PUN1 protein network | https://string-db.org/network/4932.YLR414C | Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell w [...] |
| VPS36 protein network | https://string-db.org/network/4932.YLR417W | Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I a [...] |
| CDC73 protein network | https://string-db.org/network/4932.YLR418C | Cell division control protein 73; Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some h [...] |
| YLR419W protein network | https://string-db.org/network/4932.YLR419W | Putative ATP-dependent RNA helicase YLR419W; Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria [...] |
| URA4 protein network | https://string-db.org/network/4932.YLR420W | Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate. |
| RPN13 protein network | https://string-db.org/network/4932.YLR421C | Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome [...] |
| DCK1 protein network | https://string-db.org/network/4932.YLR422W | DOCK-like protein 1; Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1; upstream component for regulation through the small GTPase Rho5p; may form a complex with Lmo1p that a [...] |
| ATG17 protein network | https://string-db.org/network/4932.YLR423C | Autophagy-related protein 17; Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulate [...] |
| SPP382 protein network | https://string-db.org/network/4932.YLR424W | Pre-mRNA-splicing factor SPP382; Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisub [...] |
| TUS1 protein network | https://string-db.org/network/4932.YLR425W | Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated [...] |
| TDA5 protein network | https://string-db.org/network/4932.YLR426W | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechloreth [...] |
| MAG2 protein network | https://string-db.org/network/4932.YLR427W | RING-finger protein MAG2; Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted [...] |
| CRN1 protein network | https://string-db.org/network/4932.YLR429W | Coronin-like protein; Coronin; cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly. |
| SEN1 protein network | https://string-db.org/network/4932.YLR430W | Helicase SEN1; ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-in [...] |
| ATG23 protein network | https://string-db.org/network/4932.YLR431C | Autophagy-related protein 23; Peripheral membrane protein required for autophagy and CVT; required for cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between th [...] |
| IMD3 protein network | https://string-db.org/network/4932.YLR432W | Inosine-5'-monophosphate dehydrogenase 3; Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, con [...] |
| CNA1 protein network | https://string-db.org/network/4932.YLR433C | Serine/threonine-protein phosphatase 2B catalytic subunit A1; Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphat [...] |
| YLR434C protein network | https://string-db.org/network/4932.YLR434C | Putative uncharacterized protein YLR434C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| TSR2 protein network | https://string-db.org/network/4932.YLR435W | Pre-rRNA-processing protein TSR2; Protein with a potential role in pre-rRNA processing; Belongs to the TSR2 family. |
| ECM30 protein network | https://string-db.org/network/4932.YLR436C | Protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion prot [...] |
| DIF1 protein network | https://string-db.org/network/4932.YLR437C | Damage-regulated import facilitator 1; Protein that regulates nuclear localization of Rnr2p and Rnr4p; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half shows simila [...] |
| LSM3 protein network | https://string-db.org/network/4932.YLR438C-A | U6 snRNA-associated Sm-like protein LSm3; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Ls [...] |
| CAR2 protein network | https://string-db.org/network/4932.YLR438W | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitroge [...] |
| MRPL4 protein network | https://string-db.org/network/4932.YLR439W | Mitochondrial ribosomal protein of the large subunit; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit. |
| SEC39 protein network | https://string-db.org/network/4932.YLR440C | Protein transport protein SEC39; Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; mediates Sey1p-independent homotypic ER fusion; proposed to be i [...] |
| RPS1A protein network | https://string-db.org/network/4932.YLR441C | Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplicati [...] |
| SIR3 protein network | https://string-db.org/network/4932.YLR442C | Regulatory protein SIR3; Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; rec [...] |
| ECM7 protein network | https://string-db.org/network/4932.YLR443W | Protein ECM7; Putative integral membrane protein with a role in calcium uptake; non-essential protein; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under con [...] |
| YLR444C protein network | https://string-db.org/network/4932.YLR444C | Putative uncharacterized protein YLR444C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| GMC2 protein network | https://string-db.org/network/4932.YLR445W | Grand meiotic recombination cluster protein 2; Protein involved in meiotic crossing over; component of the Synaptonemal Complex (SC) along with Ecm11p; required for the efficient loading of the S [...] |
| YLR446W protein network | https://string-db.org/network/4932.YLR446W | Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene; Belongs to the hexokinase family. |
| VMA6 protein network | https://string-db.org/network/4932.YLR447C | Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 i [...] |
| RPL6B protein network | https://string-db.org/network/4932.YLR448W | Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication. |
| FPR4 protein network | https://string-db.org/network/4932.YLR449W | FK506-binding protein 4; Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization [...] |
| HMG2 protein network | https://string-db.org/network/4932.YLR450W | HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuc [...] |
| LEU3 protein network | https://string-db.org/network/4932.YLR451W | Regulatory protein LEU3; Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repress [...] |
| SST2 protein network | https://string-db.org/network/4932.YLR452C | Protein SST2; GTPase-activating protein for Gpa1p; regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of th [...] |
| RIF2 protein network | https://string-db.org/network/4932.YLR453C | Protein that binds to the Rap1p C-terminus; acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation; RIF2 has a [...] |
| FMP27 protein network | https://string-db.org/network/4932.YLR454W | Protein FMP27, mitochondrial; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| PDP3 protein network | https://string-db.org/network/4932.YLR455W | PWWP domain-containing protein YLR455W; Component of the NuA3b histone acetyltransferase complex; regulates interaction between NuA3b and H3K36me3 at the transcribed regions of genes; contains PW [...] |
| YLR456W protein network | https://string-db.org/network/4932.YLR456W | Pyridoxamine 5'-phosphate oxidase YLR456W homolog; Protein of unknown function; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not po [...] |
| NBP1 protein network | https://string-db.org/network/4932.YLR457C | NAP1-binding protein; Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle forma [...] |
| GAB1 protein network | https://string-db.org/network/4932.YLR459W | GPI transamidase subunit; involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI; [...] |
| YLR460C protein network | https://string-db.org/network/4932.YLR460C | Uncharacterized protein YLR460C; Member of the quinone oxidoreductase family; up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine. |
| PAU4 protein network | https://string-db.org/network/4932.YLR461W | Seripauperin-4; Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusi [...] |
| YLR462W protein network | https://string-db.org/network/4932.YLR462W | Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII; Belongs to the helicase family. Yeast subtelomeric Y' repeat [...] |
| YLR463C protein network | https://string-db.org/network/4932.YLR463C | Putative uncharacterized protein YLR463C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharac [...] |
| YLR464W protein network | https://string-db.org/network/4932.YLR464W | Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C. |
| BSC3 protein network | https://string-db.org/network/4932.YLR465C | Putative uncharacterized protein BSC3; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely [...] |
| YLR466C-A protein network | https://string-db.org/network/4932.YLR466C-A | Putative UPF0479 protein YLR466C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the veri [...] |
| YLR466C-B protein network | https://string-db.org/network/4932.YLR466C-B | Putative uncharacterized protein YLR466C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YRF1-4 protein network | https://string-db.org/network/4932.YLR466W | Y' element ATP-dependent helicase protein 1 copy 4; Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially [...] |
| YLR467C-A protein network | https://string-db.org/network/4932.YLR467C-A | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W. |
| YRF1-5 protein network | https://string-db.org/network/4932.YLR467W | Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p. |
| YPT7 protein network | https://string-db.org/network/4932.YML001W | Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; localizes to sites of contact between the vacuo [...] |
| YML002W protein network | https://string-db.org/network/4932.YML002W | UPF0507 protein YML002W; Putative protein of unknown function; expression induced by heat and by calcium shortage; Belongs to the UPF0507 family. |
| YML003W protein network | https://string-db.org/network/4932.YML003W | UPF0507 protein YML003W; Putative protein of unknown function; Belongs to the UPF0507 family. |
| GLO1 protein network | https://string-db.org/network/4932.YML004C | Lactoylglutathione lyase; Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; e [...] |
| TRM12 protein network | https://string-db.org/network/4932.YML005W | tRNA wybutosine-synthesizing protein 2; S-adenosylmethionine-dependent methyltransferase; required for wybutosine formation in phenylalanine-accepting tRNA; member of the seven beta-strand family [...] |
| GIS4 protein network | https://string-db.org/network/4932.YML006C | Protein GIS4; CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway. |
| YML007C-A protein network | https://string-db.org/network/4932.YML007C-A | Uncharacterized protein YML007C-A, mitochondrial; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria. |
| YAP1 protein network | https://string-db.org/network/4932.YML007W | Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to t [...] |
| ERG6 protein network | https://string-db.org/network/4932.YML008C | Delta(24)-sterol C-methyltransferase; converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to lipid particles, the plasma membrane-asso [...] |
| MRPL39 protein network | https://string-db.org/network/4932.YML009C | Mitochondrial ribosomal protein of the large subunit. |
| YML009C-A protein network | https://string-db.org/network/4932.YML009C-A | Putative uncharacterized membrane protein YML009C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps O [...] |
| YML009W-B protein network | https://string-db.org/network/4932.YML009W-B | Putative uncharacterized protein YML009W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation c [...] |
| SPT5 protein network | https://string-db.org/network/4932.YML010W | Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and in concert with RNAP I and II has multiple roles regulating t [...] |
| RAD33 protein network | https://string-db.org/network/4932.YML011C | Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus. |
| YML012C-A protein network | https://string-db.org/network/4932.YML012C-A | Putative uncharacterized protein YML012C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| ERV25 protein network | https://string-db.org/network/4932.YML012W | Endoplasmic reticulum vesicle protein 25; Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1, Erp2p, a [...] |
| UBX2 protein network | https://string-db.org/network/4932.YML013W | UBX domain-containing protein 2; Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p an [...] |
| TRM9 protein network | https://string-db.org/network/4932.YML014W | tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with [...] |
| TAF11 protein network | https://string-db.org/network/4932.YML015C | TFIID subunit (40 kDa); involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors; Belongs to the TAF11 fam [...] |
| PPZ1 protein network | https://string-db.org/network/4932.YML016C | Serine/threonine-protein phosphatase PP-Z1; Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle pr [...] |
| PSP2 protein network | https://string-db.org/network/4932.YML017W | Protein PSP2; Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA poly [...] |
| YML018C protein network | https://string-db.org/network/4932.YML018C | Uncharacterized vacuolar membrane protein YML018C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with [...] |
| OST6 protein network | https://string-db.org/network/4932.YML019W | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6; Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of [...] |
| YML020W protein network | https://string-db.org/network/4932.YML020W | Uncharacterized protein YML020W; Putative protein of unknown function. |
| UNG1 protein network | https://string-db.org/network/4932.YML021C | Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-speci [...] |
| APT1 protein network | https://string-db.org/network/4932.YML022W | Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a par [...] |
| NSE5 protein network | https://string-db.org/network/4932.YML023C | Non-structural maintenance of chromosome element 5; Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatid [...] |
| RPS17A protein network | https://string-db.org/network/4932.YML024W | Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplica [...] |
| YML6 protein network | https://string-db.org/network/4932.YML025C | Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosom [...] |
| RPS18B protein network | https://string-db.org/network/4932.YML026C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication [...] |
| YOX1 protein network | https://string-db.org/network/4932.YML027W | Homeobox protein YOX1; Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression i [...] |
| TSA1 protein network | https://string-db.org/network/4932.YML028W | Peroxiredoxin TSA1; Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stre [...] |
| USA1 protein network | https://string-db.org/network/4932.YML029W | U1 SNP1-associating protein 1; Scaffold subunit of the Hrd1p ubiquitin ligase; also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 sn [...] |
| RCF1 protein network | https://string-db.org/network/4932.YML030W | Respiratory supercomplex factor 1, mitochondrial; Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochr [...] |
| NDC1 protein network | https://string-db.org/network/4932.YML031W | Nucleoporin NDC1; Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to [...] |
| RAD52 protein network | https://string-db.org/network/4932.YML032C | DNA repair and recombination protein RAD52; Protein that stimulates strand exchange; stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single [...] |
| YML034C-A protein network | https://string-db.org/network/4932.YML034C-A | Putative uncharacterized protein YML034C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SRC1/Y [...] |
| SRC1 protein network | https://string-db.org/network/4932.YML034W | Inner nuclear membrane protein; highly enriched at telomeres and subtelomeric regions; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 pro [...] |
| AMD1 protein network | https://string-db.org/network/4932.YML035C | AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleo [...] |
| CGI121 protein network | https://string-db.org/network/4932.YML036W | Component of the EKC/KEOPS complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; Cgi121p is dispensable for tRNA modi [...] |
| YML037C protein network | https://string-db.org/network/4932.YML037C | Uncharacterized protein YML037C; Putative protein of unknown function; has some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-locali [...] |
| YMD8 protein network | https://string-db.org/network/4932.YML038C | Putative nucleotide sugar transporter; has similarity to Vrg4p. |
| VPS71 protein network | https://string-db.org/network/4932.YML041C | Vacuolar protein sorting-associated protein 71; Nucleosome-binding component of the SWR1 complex; SWR1 exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuola [...] |
| CAT2 protein network | https://string-db.org/network/4932.YML042W | Carnitine O-acetyltransferase, mitochondrial; Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitin [...] |
| RRN11 protein network | https://string-db.org/network/4932.YML043C | RNA polymerase I-specific transcription initiation factor RRN11; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA pol [...] |
| PRP39 protein network | https://string-db.org/network/4932.YML046W | Pre-mRNA-processing factor 39; U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats. |
| PRM6 protein network | https://string-db.org/network/4932.YML047C | Pheromone-regulated membrane protein 6; Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated [...] |
| GSF2 protein network | https://string-db.org/network/4932.YML048W | Glucose-signaling factor 2; Endoplasmic reticulum (ER) localized integral membrane protein; may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent re [...] |
| RSE1 protein network | https://string-db.org/network/4932.YML049C | Pre-mRNA-splicing factor RSE1; Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport; Belongs to the RSE1 family. |
| AIM32 protein network | https://string-db.org/network/4932.YML050W | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. |
| GAL80 protein network | https://string-db.org/network/4932.YML051W | Galactose/lactose metabolism regulatory protein GAL80; Transcriptional regulator involved in the repression of GAL genes; involved in the repression of GAL genes in the absence of galactose; inhi [...] |
| SUR7 protein network | https://string-db.org/network/4932.YML052W | Plasma membrane protein, component of eisosomes; long-lived protein that remains stable in eisosomes of mother cells while other eisosome proteins, Pil1p and Lsp1p, turn over; may function to anc [...] |
| YML053C protein network | https://string-db.org/network/4932.YML053C | Uncharacterized protein YML053C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycl [...] |
| CYB2 protein network | https://string-db.org/network/4932.YML054C | Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed [...] |
| YML054C-A protein network | https://string-db.org/network/4932.YML054C-A | Uncharacterized protein YML054C-A; Putative protein of unknown function. |
| SPC2 protein network | https://string-db.org/network/4932.YML055W | Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25; other members of the c [...] |
| IMD4 protein network | https://string-db.org/network/4932.YML056C | Inosine-5'-monophosphate dehydrogenase 4; Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, con [...] |
| YML057C-A protein network | https://string-db.org/network/4932.YML057C-A | Putative uncharacterized membrane protein YML057C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps t [...] |
| CMP2 protein network | https://string-db.org/network/4932.YML057W | Serine/threonine-protein phosphatase 2B catalytic subunit A2; Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphat [...] |
| SML1 protein network | https://string-db.org/network/4932.YML058W | Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome [...] |
| HUG1 protein network | https://string-db.org/network/4932.YML058W-A | MEC1-mediated checkpoint protein HUG1; Ribonucleotide reductase inhibitor; intrinsically disordered protein that binds to and inhibits Rnr2p; involved in the Mec1p-mediated checkpoint pathway; tr [...] |
| NTE1 protein network | https://string-db.org/network/4932.YML059C | Lysophospholipase NTE1; Serine esterase; homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecti [...] |
| OGG1 protein network | https://string-db.org/network/4932.YML060W | DNA-(apurinic or apyrimidinic site) lyase; Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA [...] |
| PIF1 protein network | https://string-db.org/network/4932.YML061C | DNA helicase, potent G-quadruplex DNA binder/unwinder; possesses strand annealing activity; promotes DNA synthesis during break-induced replication; important for crossover recombination; transla [...] |
| MFT1 protein network | https://string-db.org/network/4932.YML062C | Subunit of the THO complex; THO is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere main [...] |
| RPS1B protein network | https://string-db.org/network/4932.YML063W | Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplicati [...] |
| TEM1 protein network | https://string-db.org/network/4932.YML064C | GTP-binding protein of the Ras superfamily; involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis. |
| ORC1 protein network | https://string-db.org/network/4932.YML065W | Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; O [...] |
| SMA2 protein network | https://string-db.org/network/4932.YML066C | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. |
| ERV41 protein network | https://string-db.org/network/4932.YML067C | Protein localized to COPII-coated vesicles; forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein. |
| ITT1 protein network | https://string-db.org/network/4932.YML068W | Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic [...] |
| POB3 protein network | https://string-db.org/network/4932.YML069W | Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and [...] |
| DAK1 protein network | https://string-db.org/network/4932.YML070W | Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation. |
| COG8 protein network | https://string-db.org/network/4932.YML071C | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi com [...] |
| TCB3 protein network | https://string-db.org/network/4932.YML072C | Tricalbin-3; Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate P [...] |
| RPL6A protein network | https://string-db.org/network/4932.YML073C | Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the wh [...] |
| FPR3 protein network | https://string-db.org/network/4932.YML074C | FK506-binding nuclear protein; Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphoryla [...] |
| HMG1 protein network | https://string-db.org/network/4932.YML075C | HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces [...] |
| WAR1 protein network | https://string-db.org/network/4932.YML076C | Weak acid resistance protein 1; Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporte [...] |
| BET5 protein network | https://string-db.org/network/4932.YML077W | Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p, regulating ER-Golgi traffic [...] |
| CPR3 protein network | https://string-db.org/network/4932.YML078W | Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import [...] |
| YML079W protein network | https://string-db.org/network/4932.YML079W | Uncharacterized protein YML079W; Non-essential protein of unknown function; has structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) an [...] |
| DUS1 protein network | https://string-db.org/network/4932.YML080W | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]; Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17; Bel [...] |
| ATP18 protein network | https://string-db.org/network/4932.YML081C-A | Subunit of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspon [...] |
| TDA9 protein network | https://string-db.org/network/4932.YML081W | Transcription factor that regulates acetate production; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; n [...] |
| YML082W protein network | https://string-db.org/network/4932.YML082W | Putative cystathionine gamma-synthase YML082W; Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green [...] |
| YML083C protein network | https://string-db.org/network/4932.YML083C | Putative uncharacterized protein YML083C; Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during [...] |
| YML084W protein network | https://string-db.org/network/4932.YML084W | Putative uncharacterized protein YML084W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| TUB1 protein network | https://string-db.org/network/4932.YML085C | Tubulin alpha-1 chain; Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA [...] |
| ALO1 protein network | https://string-db.org/network/4932.YML086C | D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress. |
| AIM33 protein network | https://string-db.org/network/4932.YML087C | Uncharacterized oxidoreductase AIM33; Protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; A [...] |
| UFO1 protein network | https://string-db.org/network/4932.YML088W | F-box receptor protein; subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitination by SCF and subsequent degr [...] |
| YML089C protein network | https://string-db.org/network/4932.YML089C | Putative uncharacterized protein YML089C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by [...] |
| YML090W protein network | https://string-db.org/network/4932.YML090W | Putative uncharacterized protein YML090W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RPM2 protein network | https://string-db.org/network/4932.YML091C | Protein subunit of mitochondrial RNase P; has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic [...] |
| PRE8 protein network | https://string-db.org/network/4932.YML092C | Alpha 2 subunit of the 20S proteasome; Belongs to the peptidase T1A family. |
| UTP14 protein network | https://string-db.org/network/4932.YML093W | U3 small nucleolar RNA-associated protein 14; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; Belongs [...] |
| YML094C-A protein network | https://string-db.org/network/4932.YML094C-A | Putative uncharacterized protein YML094C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| GIM5 protein network | https://string-db.org/network/4932.YML094W | Prefoldin subunit 5; Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also [...] |
| RAD10 protein network | https://string-db.org/network/4932.YML095C | DNA repair protein RAD10; Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excisi [...] |
| YML096W protein network | https://string-db.org/network/4932.YML096W | Putative protein with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the [...] |
| VPS9 protein network | https://string-db.org/network/4932.YML097C | Vacuolar protein sorting-associated protein 9; Guanine nucleotide exchange factor (GEF) and ubiquitin receptor; involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficki [...] |
| TAF13 protein network | https://string-db.org/network/4932.YML098W | TFIID subunit (19 kDa); involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors. |
| ARG81 protein network | https://string-db.org/network/4932.YML099C | Arginine metabolism regulation protein II; Zinc finger transcription factor involved in arginine-responsive genes; Zn(2)-Cys(6) binuclear cluster domain type; involved in the regulation of argini [...] |
| TSL1 protein network | https://string-db.org/network/4932.YML100W | Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acut [...] |
| YML100W-A protein network | https://string-db.org/network/4932.YML100W-A | Uncharacterized protein YML100W-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| CUE4 protein network | https://string-db.org/network/4932.YML101C | Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication. |
| YML101C-A protein network | https://string-db.org/network/4932.YML101C-A | Putative uncharacterized protein YML101C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| CAC2 protein network | https://string-db.org/network/4932.YML102W | Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; [...] |
| NUP188 protein network | https://string-db.org/network/4932.YML103C | Nucleoporin NUP188; Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188. |
| MDM1 protein network | https://string-db.org/network/4932.YML104C | Structural protein MDM1; PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (P [...] |
| SEC65 protein network | https://string-db.org/network/4932.YML105C | Subunit of the signal recognition particle (SRP); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19. |
| URA5 protein network | https://string-db.org/network/4932.YML106W | Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a pa [...] |
| PML39 protein network | https://string-db.org/network/4932.YML107C | Pre-mRNA leakage protein 39; Protein required for nuclear retention of unspliced pre-mRNAs; required along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with t [...] |
| YML108W protein network | https://string-db.org/network/4932.YML108W | Uncharacterized protein YML108W; Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes t [...] |
| ZDS2 protein network | https://string-db.org/network/4932.YML109W | Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the te [...] |
| COQ5 protein network | https://string-db.org/network/4932.YML110C | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matr [...] |
| BUL2 protein network | https://string-db.org/network/4932.YML111W | Ubiquitin ligase-binding protein BUL2; Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene exp [...] |
| CTK3 protein network | https://string-db.org/network/4932.YML112W | Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal prote [...] |
| DAT1 protein network | https://string-db.org/network/4932.YML113W | DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; relocalizes to the cytosol in respo [...] |
| TAF8 protein network | https://string-db.org/network/4932.YML114C | TFIID subunit (65 kDa); involved in RNA polymerase II transcription initiation. |
| VAN1 protein network | https://string-db.org/network/4932.YML115C | Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant. |
| ATR1 protein network | https://string-db.org/network/4932.YML116W | Aminotriazole resistance protein; Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, t [...] |
| NAB6 protein network | https://string-db.org/network/4932.YML117W | Putative RNA-binding protein; associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; exp [...] |
| NGL3 protein network | https://string-db.org/network/4932.YML118W | 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from [...] |
| YML119W protein network | https://string-db.org/network/4932.YML119W | Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate. |
| NDI1 protein network | https://string-db.org/network/4932.YML120C | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial; NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in [...] |
| GTR1 protein network | https://string-db.org/network/4932.YML121W | GTP-binding protein GTR1; Subunit of a TORC1-stimulating GTPase complex; subunit of the heterodimeric Gtr1-Gtr2 GTPase complex that stimulates TORC1 in response to amino acid stimulation; tethere [...] |
| YML122C protein network | https://string-db.org/network/4932.YML122C | Uncharacterized protein YML122C; Putative protein of unknown function; conserved among S. cerevisiae strains; YML122C is not an essential gene. |
| PHO84 protein network | https://string-db.org/network/4932.YML123C | High-affinity inorganic phosphate (Pi) transporter; also low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturat [...] |
| TUB3 protein network | https://string-db.org/network/4932.YML124C | Tubulin alpha-3 chain; Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, [...] |
| PGA3 protein network | https://string-db.org/network/4932.YML125C | Plasma membrane-associated coenzyme Q6 reductase PGA3; Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Ga [...] |
| ERG13 protein network | https://string-db.org/network/4932.YML126C | 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis. |
| RSC9 protein network | https://string-db.org/network/4932.YML127W | Chromatin structure-remodeling complex subunit RSC9; Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and [...] |
| MSC1 protein network | https://string-db.org/network/4932.YML128C | Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria [...] |
| COX14 protein network | https://string-db.org/network/4932.YML129C | Mitochondrial cytochrome c oxidase (complex IV) assembly factor; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; associates with complex IV [...] |
| ERO1 protein network | https://string-db.org/network/4932.YML130C | Endoplasmic oxidoreductin-1; Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulato [...] |
| YML131W protein network | https://string-db.org/network/4932.YML131W | Uncharacterized membrane protein YML131W; Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agent [...] |
| COS3 protein network | https://string-db.org/network/4932.YML132W | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting [...] |
| YML133C protein network | https://string-db.org/network/4932.YML133C | Putative Y' element ATP-dependent helicase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron. |
| YML133W-A protein network | https://string-db.org/network/4932.YML133W-A | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C. |
| YML133W-B protein network | https://string-db.org/network/4932.YML133W-B | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C. |
| CDC5 protein network | https://string-db.org/network/4932.YMR001C | Cell cycle serine/threonine-protein kinase CDC5/MSD2; Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates S [...] |
| MIX17 protein network | https://string-db.org/network/4932.YMR002W | Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress. |
| AIM34 protein network | https://string-db.org/network/4932.YMR003W | Altered inheritance of mitochondria protein 34, mitochondrial; Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency [...] |
| MVP1 protein network | https://string-db.org/network/4932.YMR004W | Sorting nexin MVP1; Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/o [...] |
| TAF4 protein network | https://string-db.org/network/4932.YMR005W | TFIID subunit (48 kDa); involved in RNA polymerase II transcription initiation; potential Cdc28p substrate. |
| PLB2 protein network | https://string-db.org/network/4932.YMR006C | Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine. |
| YMR007W protein network | https://string-db.org/network/4932.YMR007W | Uncharacterized protein YMR007W; Putative protein of unknown function; conserved among S. cerevisiae strains; YMR007W is not an essential gene. |
| PLB1 protein network | https://string-db.org/network/4932.YMR008C | Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required [...] |
| ADI1 protein network | https://string-db.org/network/4932.YMR009W | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Acireductone dioxygenease involved in methionine salvage pathway; transcribed as polycistronic mRNA with YMR010W and regulated post-transcrip [...] |
| ANY1 protein network | https://string-db.org/network/4932.YMR010W | Scramblase ANY1; Putative protein of unknown function; null allele suppresses the lethality of neo1 and dop1 null alleles, as well as the growth defect of a mon2 null allele, and the cold sensiti [...] |
| HXT2 protein network | https://string-db.org/network/4932.YMR011W | High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose; Belongs to the major facilitator su [...] |
| CLU1 protein network | https://string-db.org/network/4932.YMR012W | Clustered mitochondria protein 1; Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in [...] |
| SEC59 protein network | https://string-db.org/network/4932.YMR013C | Dolichol kinase; catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylatio [...] |
| YMR013C-A protein network | https://string-db.org/network/4932.YMR013C-A | Uncharacterized protein YMR013C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the veri [...] |
| YMR013W-A protein network | https://string-db.org/network/4932.YMR013W-A | Putative uncharacterized protein YMR013W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| BUD22 protein network | https://string-db.org/network/4932.YMR014W | Bud site selection protein 22; Protein required for rRNA maturation and ribosomal subunit biogenesis; required for 18S rRNA maturation; also required for small ribosomal subunit biogenesis; cosed [...] |
| ERG5 protein network | https://string-db.org/network/4932.YMR015C | Cytochrome P450 61; C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target [...] |
| SOK2 protein network | https://string-db.org/network/4932.YMR016C | Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to [...] |
| SPO20 protein network | https://string-db.org/network/4932.YMR017W | Sporulation-specific protein 20; Meiosis-specific subunit of the t-SNARE complex; required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p [...] |
| PEX9 protein network | https://string-db.org/network/4932.YMR018W | Peroxisomal targeting signal receptor 9; Putative protein of unknown function with similarity to human PEX5Rp; transcription increases during colony development similar to genes involved in perox [...] |
| STB4 protein network | https://string-db.org/network/4932.YMR019W | Probable transcriptional regulatory protein STB4; Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests [...] |
| FMS1 protein network | https://string-db.org/network/4932.YMR020W | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Bel [...] |
| MAC1 protein network | https://string-db.org/network/4932.YMR021C | Metal-binding activator 1; Copper-sensing transcription factor; involved in regulation of genes required for high affinity copper transport; required for regulation of yeast copper genes in respo [...] |
| UBC7 protein network | https://string-db.org/network/4932.YMR022W | Ubiquitin-conjugating enzyme E2 7; Ubiquitin conjugating enzyme; involved in the ER-associated protein degradation (ERAD) pathway and in the inner nuclear membrane-associated degradation (INMAD) [...] |
| MSS1 protein network | https://string-db.org/network/4932.YMR023C | tRNA modification GTPase MSS1, mitochondrial; Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in [...] |
| MRPL3 protein network | https://string-db.org/network/4932.YMR024W | Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; [...] |
| CSI1 protein network | https://string-db.org/network/4932.YMR025W | Cop9 signalosome-interactor 1; Subunit of the Cop9 signalosome; which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to [...] |
| PEX12 protein network | https://string-db.org/network/4932.YMR026C | Peroxisome assembly protein 12; C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex wi [...] |
| YMR027W protein network | https://string-db.org/network/4932.YMR027W | Damage-control phosphatase YMR027W; A metal-dependent phosphatase, part of the DUF89 protein family; dephosphorylates fructose-1-phosphate; human ortholog, C6orf211 is involved in response to DNA [...] |
| TAP42 protein network | https://string-db.org/network/4932.YMR028W | Type 2A phosphatase-associated protein 42; Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalyti [...] |
| FAR8 protein network | https://string-db.org/network/4932.YMR029C | Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p. |
| RSF1 protein network | https://string-db.org/network/4932.YMR030W | Respiration factor 1; Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory gr [...] |
| EIS1 protein network | https://string-db.org/network/4932.YMR031C | Eisosome protein 1; Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitoc [...] |
| YMR031W-A protein network | https://string-db.org/network/4932.YMR031W-A | Putative uncharacterized protein YMR031W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant display [...] |
| HOF1 protein network | https://string-db.org/network/4932.YMR032W | Cytokinesis protein 2; Protein that regulates actin cytoskeleton organization; required for cytokinesis, actin cable organization, and secretory vesicle trafficking; localized to bud neck; phosph [...] |
| ARP9 protein network | https://string-db.org/network/4932.YMR033W | Actin-like protein ARP9; Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation. |
| RCH1 protein network | https://string-db.org/network/4932.YMR034C | Solute carrier RCH1; Putative transporter; localizes to the plasma membrane in response to high levels of extracellular calcium; member of the SLC10 carrier family; identified in a transposon mut [...] |
| IMP2-2 protein network | https://string-db.org/network/4932.YMR035W | Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p a [...] |
| MIH1 protein network | https://string-db.org/network/4932.YMR036C | M-phase inducer phosphatase; Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25; Belongs to the MPI phosphatase [...] |
| MSN2 protein network | https://string-db.org/network/4932.YMR037C | Zinc finger protein MSN2; Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress respons [...] |
| CCS1 protein network | https://string-db.org/network/4932.YMR038C | Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within N-terminus is involved in insertion of copper into Sod1p under conditions o [...] |
| SUB1 protein network | https://string-db.org/network/4932.YMR039C | Transcriptional regulator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in nonhomologous end-joining (NHEJ) of ds breaks in plasmi [...] |
| YET2 protein network | https://string-db.org/network/4932.YMR040W | Endoplasmic reticulum transmembrane protein 2; Protein of unknown function that may interact with ribosomes; based on co-purification experiments; homolog of human BAP31 protein; YET2 has a paral [...] |
| ARA2 protein network | https://string-db.org/network/4932.YMR041C | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/ke [...] |
| ARG80 protein network | https://string-db.org/network/4932.YMR042W | Arginine metabolism regulation protein I; Transcription factor involved in regulating arginine-responsive genes; acts with Arg81p and Arg82p. |
| MCM1 protein network | https://string-db.org/network/4932.YMR043W | Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cyto [...] |
| IOC4 protein network | https://string-db.org/network/4932.YMR044W | ISWI one complex protein 4; Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading fra [...] |
| YMR046W-A protein network | https://string-db.org/network/4932.YMR046W-A | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| NUP116 protein network | https://string-db.org/network/4932.YMR047C | FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; f [...] |
| CSM3 protein network | https://string-db.org/network/4932.YMR048W | Chromosome segregation in meiosis protein 3; Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for ac [...] |
| ERB1 protein network | https://string-db.org/network/4932.YMR049C | Ribosome biogenesis protein ERB1; Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for mat [...] |
| YMR052C-A protein network | https://string-db.org/network/4932.YMR052C-A | Putative uncharacterized protein YMR052C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| FAR3 protein network | https://string-db.org/network/4932.YMR052W | Factor arrest protein 3; Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far [...] |
| STB2 protein network | https://string-db.org/network/4932.YMR053C | Protein that interacts with Sin3p in a two-hybrid assay; part of a large protein complex with Sin3p and Stb1p; STB2 has a paralog, STB6, that arose from the whole genome duplication. |
| STV1 protein network | https://string-db.org/network/4932.YMR054W | V-type proton ATPase subunit a, Golgi isoform; Subunit a of the vacuolar-ATPase V0 domain; one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes [...] |
| BUB2 protein network | https://string-db.org/network/4932.YMR055C | Mitotic check point protein BUB2; Mitotic exit network regulator; forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anapha [...] |
| AAC1 protein network | https://string-db.org/network/4932.YMR056C | ADP,ATP carrier protein 1; Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is [...] |
| YMR057C protein network | https://string-db.org/network/4932.YMR057C | Putative uncharacterized protein YMR057C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ve [...] |
| FET3 protein network | https://string-db.org/network/4932.YMR058W | Iron transport multicopper oxidase FET3; Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease F [...] |
| SEN15 protein network | https://string-db.org/network/4932.YMR059W | Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial s [...] |
| SAM37 protein network | https://string-db.org/network/4932.YMR060C | Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; binds precursors of beta-barrel proteins and facilitates th [...] |
| RNA14 protein network | https://string-db.org/network/4932.YMR061W | mRNA 3'-end-processing protein RNA14; Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in c [...] |
| ARG7 protein network | https://string-db.org/network/4932.YMR062C | Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine [...] |
| RIM9 protein network | https://string-db.org/network/4932.YMR063W | pH-response regulator protein palI/RIM9; Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16 [...] |
| AEP1 protein network | https://string-db.org/network/4932.YMR064W | Protein required for expression of the mitochondrial OLI1 gene; mitochondrial OLI1 gene encodes subunit 9 of F1-F0 ATP synthase. |
| KAR5 protein network | https://string-db.org/network/4932.YMR065W | Protein required for nuclear membrane fusion during karyogamy; localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; simila [...] |
| SOV1 protein network | https://string-db.org/network/4932.YMR066W | Mitochondrial protein of unknown function. |
| UBX4 protein network | https://string-db.org/network/4932.YMR067C | UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p A [...] |
| AVO2 protein network | https://string-db.org/network/4932.YMR068W | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth. |
| NAT4 protein network | https://string-db.org/network/4932.YMR069W | N-alpha-acetyltransferase 40; N alpha-acetyl-transferase; involved in acetylation of the N-terminal residues of histones H4 and H2A; Belongs to the acetyltransferase family. NAA40 subfamily. |
| MOT3 protein network | https://string-db.org/network/4932.YMR070W | Transcriptional activator/repressor MOT3; Transcriptional repressor, activator; role in cellular adjustment to osmotic stress including modulation of mating efficiency; involved in repression of [...] |
| TVP18 protein network | https://string-db.org/network/4932.YMR071C | Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments; may have a role in intracellular stero [...] |
| ABF2 protein network | https://string-db.org/network/4932.YMR072W | ARS-binding factor 2, mitochondrial; Mitochondrial DNA-binding protein; involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be reg [...] |
| IRC21 protein network | https://string-db.org/network/4932.YMR073C | Increased recombination centers protein 21; Protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; cont [...] |
| SDD2 protein network | https://string-db.org/network/4932.YMR074C | Uncharacterized protein YMR074C; Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproductio [...] |
| YMR075C-A protein network | https://string-db.org/network/4932.YMR075C-A | Putative uncharacterized protein YMR075C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| RCO1 protein network | https://string-db.org/network/4932.YMR075W | Transcriptional regulatory protein RCO1; Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p. |
| PDS5 protein network | https://string-db.org/network/4932.YMR076C | Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by pr [...] |
| VPS20 protein network | https://string-db.org/network/4932.YMR077C | Vacuolar protein sorting-associated protein 20; Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicu [...] |
| CTF18 protein network | https://string-db.org/network/4932.YMR078C | Chromosome transmission fidelity protein 18; Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping fu [...] |
| SEC14 protein network | https://string-db.org/network/4932.YMR079W | SEC14 cytosolic factor; Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transpo [...] |
| NAM7 protein network | https://string-db.org/network/4932.YMR080C | ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P [...] |
| ISF1 protein network | https://string-db.org/network/4932.YMR081C | Increasing suppression factor 1; Serine-rich, hydrophilic protein; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed wit [...] |
| YMR082C protein network | https://string-db.org/network/4932.YMR082C | Uncharacterized protein YMR082C; Putative protein of unknown function; conserved among S. cerevisiae strains; YMR082C is not an essential gene. |
| ADH3 protein network | https://string-db.org/network/4932.YMR083W | Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production. |
| YMR084W protein network | https://string-db.org/network/4932.YMR084W | Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are par [...] |
| YMR085W protein network | https://string-db.org/network/4932.YMR085W | Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1. |
| SEG1 protein network | https://string-db.org/network/4932.YMR086W | Eisosome protein SEG1; Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation, controls eisosome length and shape; diffusely distributed, form [...] |
| YMR087W protein network | https://string-db.org/network/4932.YMR087W | Probable ADP-ribose 1''-phosphate phosphatase YML087W; Putative ADP-ribose-1''-monophosphatase; converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an [...] |
| VBA1 protein network | https://string-db.org/network/4932.YMR088C | Permease of basic amino acids in the vacuolar membrane; Belongs to the major facilitator superfamily. |
| YTA12 protein network | https://string-db.org/network/4932.YMR089C | Mitochondrial respiratory chain complexes assembly protein YTA12; Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required f [...] |
| YMR090W protein network | https://string-db.org/network/4932.YMR090W | UPF0659 protein YMR090W; Putative protein of unknown function; similar to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide m [...] |
| NPL6 protein network | https://string-db.org/network/4932.YMR091C | Chromatin structure-remodeling complex subunit RSC7; Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range [...] |
| AIP1 protein network | https://string-db.org/network/4932.YMR092C | Actin-interacting protein 1; Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to main [...] |
| UTP15 protein network | https://string-db.org/network/4932.YMR093W | Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA. |
| CTF13 protein network | https://string-db.org/network/4932.YMR094W | Subunit of the CBF3 complex; CBF3 binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis. |
| SNO1 protein network | https://string-db.org/network/4932.YMR095C | Pyridoxal 5'-phosphate synthase subunit SNO1; Protein of unconfirmed function; involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotr [...] |
| SNZ1 protein network | https://string-db.org/network/4932.YMR096W | Pyridoxal 5'-phosphate synthase subunit SNZ1; Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Y [...] |
| MTG1 protein network | https://string-db.org/network/4932.YMR097C | Mitochondrial GTPase 1; Putative GTPase peripheral to the mitochondrial inner membrane; essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homo [...] |
| ATP25 protein network | https://string-db.org/network/4932.YMR098C | ATPase synthesis protein 25, mitochondrial; Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA; also required for the Oli1p ring formation; YMR098C is not an essential gene. |
| YMR099C protein network | https://string-db.org/network/4932.YMR099C | Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in respo [...] |
| MUB1 protein network | https://string-db.org/network/4932.YMR100W | MYND-type zinc finger protein MUB1; MYND domain-containing protein; component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex, required for ubiquitination and degradation of Rpn4p; interacts wi [...] |
| SRT1 protein network | https://string-db.org/network/4932.YMR101C | Forms the dehydrodolichyl diphosphate syntase (DDS) complex with NUS1; involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dol [...] |
| YMR102C protein network | https://string-db.org/network/4932.YMR102C | WD repeat-containing protein YMR102C; Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance [...] |
| YMR103C protein network | https://string-db.org/network/4932.YMR103C | Uncharacterized protein YMR103C; Putative protein of unknown function; conserved among S. cerevisiae strains; YMR103C is not an essential gene. |
| YPK2 protein network | https://string-db.org/network/4932.YMR104C | Serine/threonine-protein kinase YPK2/YKR2; Protein kinase similar to S/T protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required [...] |
| PGM2 protein network | https://string-db.org/network/4932.YMR105C | Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; pro [...] |
| YKU80 protein network | https://string-db.org/network/4932.YMR106C | ATP-dependent DNA helicase II subunit 2; Subunit of telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localizatio [...] |
| SPG4 protein network | https://string-db.org/network/4932.YMR107W | Stationary phase protein 4; Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; Belongs to the SPG4 family. |
| ILV2 protein network | https://string-db.org/network/4932.YMR108W | Acetolactate synthase catalytic subunit, mitochondrial; Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibi [...] |
| MYO5 protein network | https://string-db.org/network/4932.YMR109W | Myosin-5; One of two type I myosin motors; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defe [...] |
| HFD1 protein network | https://string-db.org/network/4932.YMR110C | Fatty aldehyde dehydrogenase HFD1; Dehydrogenase involved in ubiquinone and sphingolipid metabolism; oxidizes 4-hydroxybenzaldehyde into 4-hydroxybenzoic acid in ubiquinone biosynthesis; converts [...] |
| YMR111C protein network | https://string-db.org/network/4932.YMR111C | Transcription factor-like protein EUC1; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci [...] |
| MED11 protein network | https://string-db.org/network/4932.YMR112C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein. |
| FOL3 protein network | https://string-db.org/network/4932.YMR113W | Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from [...] |
| YMR114C protein network | https://string-db.org/network/4932.YMR114C | Abasic site processing protein YMR114C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to [...] |
| MGR3 protein network | https://string-db.org/network/4932.YMR115W | Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; r [...] |
| ASC1 protein network | https://string-db.org/network/4932.YMR116C | G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; required to prevent frameshi [...] |
| SPC24 protein network | https://string-db.org/network/4932.YMR117C | Kinetochore protein SPC24; Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conse [...] |
| SHH3 protein network | https://string-db.org/network/4932.YMR118C | Putative mitochondrial inner membrane protein of unknown function; although similar to paralogous Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 tr [...] |
| ASI1 protein network | https://string-db.org/network/4932.YMR119W | Protein ASI1; Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) path [...] |
| ADE17 protein network | https://string-db.org/network/4932.YMR120C | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophos [...] |
| RPL15B protein network | https://string-db.org/network/4932.YMR121C | Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplic [...] |
| YMR122W-A protein network | https://string-db.org/network/4932.YMR122W-A | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum. |
| PKR1 protein network | https://string-db.org/network/4932.YMR123W | V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replic [...] |
| EPO1 protein network | https://string-db.org/network/4932.YMR124W | Uncharacterized protein YMR124W; Protein involved in septin-ER tethering; interacts with ER membrane protein, Scs2p, and Shs1p, a septin ring component, at bud neck to create ER diffusion barrier [...] |
| STO1 protein network | https://string-db.org/network/4932.YMR125W | Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance [...] |
| DLT1 protein network | https://string-db.org/network/4932.YMR126C | Defect at low temperature protein 1; Protein of unknown function; mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA); Belongs to the DLT1 family. |
| SAS2 protein network | https://string-db.org/network/4932.YMR127C | Histone acetyltransferase (HAT) catalytic subunit of the SAS complex; acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; [...] |
| ECM16 protein network | https://string-db.org/network/4932.YMR128W | Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis. |
| POM152 protein network | https://string-db.org/network/4932.YMR129W | Nucleoporin POM152; Glycoprotein subunit of transmembrane ring of nuclear pore complex; contributes to nucleocytoplasmic transport, nuclear pore complex (NPC) biogenesis and spindle pole body dup [...] |
| YMR130W protein network | https://string-db.org/network/4932.YMR130W | Putative protein of unknown function; YMR130W is not an essential gene; Belongs to the HAD-like hydrolase superfamily. |
| RRB1 protein network | https://string-db.org/network/4932.YMR131C | Ribosome assembly protein RRB1; Specific chaperone for ribosomal protein Rpl3p; binds to nascent Rpl3p during translation; essential gene. |
| JLP2 protein network | https://string-db.org/network/4932.YMR132C | Protein of unknown function; contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein); Belongs to the CCDC25 family. |
| REC114 protein network | https://string-db.org/network/4932.YMR133W | Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic [...] |
| ERG29 protein network | https://string-db.org/network/4932.YMR134W | Uncharacterized protein YMR134W; Protein of unknown function involved in ergosterol biosynthesis; conditional mutants produce less ergosterol, display impaired oxygen consumption, respiratory gro [...] |
| GID8 protein network | https://string-db.org/network/4932.YMR135C | Glucose-induced degradation protein 8; Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6- [...] |
| GAT2 protein network | https://string-db.org/network/4932.YMR136W | Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine. |
| PSO2 protein network | https://string-db.org/network/4932.YMR137C | DNA cross-link repair protein PSO2/SNM1; Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-link [...] |
| CIN4 protein network | https://string-db.org/network/4932.YMR138W | GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the [...] |
| RIM11 protein network | https://string-db.org/network/4932.YMR139W | Serine/threonine-protein kinase RIM11/MSD1; Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p [...] |
| SIP5 protein network | https://string-db.org/network/4932.YMR140W | Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress; Belongs to the SIP5 family. |
| YMR141C protein network | https://string-db.org/network/4932.YMR141C | Uncharacterized protein YMR141C; Putative protein of unknown function; conserved among S. cerevisiae strains; YMR141C is not an essential gene. |
| RPL13B protein network | https://string-db.org/network/4932.YMR142C | Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genom [...] |
| RPS16A protein network | https://string-db.org/network/4932.YMR143W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication. |
| FDO1 protein network | https://string-db.org/network/4932.YMR144W | Uncharacterized protein YMR144W; Protein involved in directionality of mating type switching; acts with Fkh1p to control which donor mating-type locus is inserted into MAT locus during mating typ [...] |
| NDE1 protein network | https://string-db.org/network/4932.YMR145C | Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respi [...] |
| TIF34 protein network | https://string-db.org/network/4932.YMR146C | eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; stimulates rate of ribosomal scanning during translation re [...] |
| YMR147W protein network | https://string-db.org/network/4932.YMR147W | Uncharacterized protein YMR147W; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery. |
| OSW5 protein network | https://string-db.org/network/4932.YMR148W | Outer spore wall protein 5; Protein of unknown function with possible role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increas [...] |
| SWP1 protein network | https://string-db.org/network/4932.YMR149W | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1; Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation o [...] |
| IMP1 protein network | https://string-db.org/network/4932.YMR150C | Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p a [...] |
| YIM2 protein network | https://string-db.org/network/4932.YMR151W | Putative uncharacterized protein YIM2; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely [...] |
| YIM1 protein network | https://string-db.org/network/4932.YMR152W | Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; may have a role in lipid metabolism, based on localization to lipid droplets; the authentic, non-tagged prote [...] |
| NUP53 protein network | https://string-db.org/network/4932.YMR153W | FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcr [...] |
| RIM13 protein network | https://string-db.org/network/4932.YMR154C | Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarit [...] |
| YMR155W protein network | https://string-db.org/network/4932.YMR155W | Uncharacterized membrane protein YMR155W; Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen. |
| TPP1 protein network | https://string-db.org/network/4932.YMR156C | DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase s [...] |
| AIM36 protein network | https://string-db.org/network/4932.YMR157C | Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitocho [...] |
| YMR158C-A protein network | https://string-db.org/network/4932.YMR158C-A | Uncharacterized protein YMR158C-A; Putative protein of unknown function; may contain a lipid attachment site; YMR158C-A is not an essential gene. |
| MRPS8 protein network | https://string-db.org/network/4932.YMR158W | Mitochondrial ribosomal protein of the small subunit. |
| YMR158W-B protein network | https://string-db.org/network/4932.YMR158W-B | Putative uncharacterized protein YMR158W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verifi [...] |
| ATG16 protein network | https://string-db.org/network/4932.YMR159C | Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which binds to membranes and localizes to the pre-autophagosomal structure a [...] |
| YMR160W protein network | https://string-db.org/network/4932.YMR160W | Uncharacterized protein YMR160W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpre [...] |
| HLJ1 protein network | https://string-db.org/network/4932.YMR161W | Protein HLJ1; Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli Dn [...] |
| DNF3 protein network | https://string-db.org/network/4932.YMR162C | Probable phospholipid-transporting ATPase DNF3; Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the mai [...] |
| INP2 protein network | https://string-db.org/network/4932.YMR163C | Inheritance of peroxisomes protein 2; Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physi [...] |
| MSS11 protein network | https://string-db.org/network/4932.YMR164C | Transcription activator MSS11; Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals [...] |
| PAH1 protein network | https://string-db.org/network/4932.YMR165C | Phosphatidic acid phosphohydrolase 1; Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; regulates phospholipid synthesis, nuclear/ER membrane growth, lip [...] |
| MME1 protein network | https://string-db.org/network/4932.YMR166C | Mitochondrial magnesium exporter 1; Transporter of the mitochondrial inner membrane that exports magnesium; involved in mitochondrial Mg2+ homeostasis; has similarity to human mitochondrial ATP-M [...] |
| MLH1 protein network | https://string-db.org/network/4932.YMR167W | Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is as [...] |
| CEP3 protein network | https://string-db.org/network/4932.YMR168C | Essential kinetochore protein; component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, an [...] |
| ALD3 protein network | https://string-db.org/network/4932.YMR169C | Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose. |
| ALD2 protein network | https://string-db.org/network/4932.YMR170C | Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very simi [...] |
| EAR1 protein network | https://string-db.org/network/4932.YMR171C | Protein EAR1; Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the [...] |
| HOT1 protein network | https://string-db.org/network/4932.YMR172W | High-osmolarity-induced transcription protein 1; Transcription factor for glycerol biosynthetic genes; required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in respons [...] |
| DDR48 protein network | https://string-db.org/network/4932.YMR173W | Stress protein DDR48; DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid s [...] |
| YMR173W-A protein network | https://string-db.org/network/4932.YMR173W-A | Putative uncharacterized membrane protein YMR173W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps t [...] |
| PAI3 protein network | https://string-db.org/network/4932.YMR174C | Cytoplasmic proteinase A (Pep4p) inhibitor; dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of p [...] |
| SIP18 protein network | https://string-db.org/network/4932.YMR175W | Protein SIP18; Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress; SIP18 has a paralog, GRE1, that arose from the who [...] |
| ECM5 protein network | https://string-db.org/network/4932.YMR176W | Protein ECM5; Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently [...] |
| MMT1 protein network | https://string-db.org/network/4932.YMR177W | Putative metal transporter involved in mitochondrial iron accumulation; MMT1 has a paralog, MMT2, that arose from the whole genome duplication. |
| YMR178W protein network | https://string-db.org/network/4932.YMR178W | Uncharacterized protein YMR178W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein [...] |
| SPT21 protein network | https://string-db.org/network/4932.YMR179W | Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally rel [...] |
| CTL1 protein network | https://string-db.org/network/4932.YMR180C | RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm; CTL1 has a paralog, CET1, that arose from the whole genome duplication; Belongs to the fungal TPase family. |
| YMR181C protein network | https://string-db.org/network/4932.YMR181C | Uncharacterized protein YMR181C; Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by no [...] |
| RGM1 protein network | https://string-db.org/network/4932.YMR182C | Probable transcription repressor protein RGM1; Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction [...] |
| YMR182W-A protein network | https://string-db.org/network/4932.YMR182W-A | Uncharacterized protein YMR182W-A; Putative protein of unknown function. |
| SSO2 protein network | https://string-db.org/network/4932.YMR183C | Protein SSO2; Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p; SSO2 has a paralog, SSO1, that [...] |
| ADD37 protein network | https://string-db.org/network/4932.YMR184W | Alpha1-proteinase inhibitor-degradation deficient protein 37; Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes [...] |
| RTP1 protein network | https://string-db.org/network/4932.YMR185W | RNA polymerase II assembly factor RTP1; Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviabl [...] |
| HSC82 protein network | https://string-db.org/network/4932.YMR186W | ATP-dependent molecular chaperone HSC82; Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and togethe [...] |
| YMR187C protein network | https://string-db.org/network/4932.YMR187C | Putative protein of unknown function; YMR187C is not an essential gene. |
| MRPS17 protein network | https://string-db.org/network/4932.YMR188C | Mitochondrial ribosomal protein of the small subunit. |
| GCV2 protein network | https://string-db.org/network/4932.YMR189W | P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-meth [...] |
| SGS1 protein network | https://string-db.org/network/4932.YMR190C | ATP-dependent helicase SGS1; RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3 [...] |
| SPG5 protein network | https://string-db.org/network/4932.YMR191W | Stationary phase protein 5; Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stat [...] |
| GYL1 protein network | https://string-db.org/network/4932.YMR192W | Probable GTPase-activating protein GYL1; Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized g [...] |
| MRPL24 protein network | https://string-db.org/network/4932.YMR193W | Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene. |
| YMR194C-A protein network | https://string-db.org/network/4932.YMR194C-A | Putative uncharacterized protein YMR194C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| CMC4 protein network | https://string-db.org/network/4932.YMR194C-B | Cx9C motif-containing protein 4, mitochondrial; Protein that localizes to the mitochondrial intermembrane space; localizes via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs [...] |
| RPL36A protein network | https://string-db.org/network/4932.YMR194W | Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose fro [...] |
| ICY1 protein network | https://string-db.org/network/4932.YMR195W | Interacting with cytoskeleton protein 1; Protein of unknown function; required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongate [...] |
| YMR196W protein network | https://string-db.org/network/4932.YMR196W | Uncharacterized protein YMR196W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene. |
| VTI1 protein network | https://string-db.org/network/4932.YMR197C | t-SNARE VTI1; Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways; human homolog VTI1A can [...] |
| CIK1 protein network | https://string-db.org/network/4932.YMR198W | Spindle pole body-associated protein CIK1; Kinesin-associated protein; required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function [...] |
| CLN1 protein network | https://string-db.org/network/4932.YMR199W | G1/S-specific cyclin CLN1; G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcriptio [...] |
| ROT1 protein network | https://string-db.org/network/4932.YMR200W | Protein ROT1; Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically [...] |
| RAD14 protein network | https://string-db.org/network/4932.YMR201C | Protein that recognizes and binds damaged DNA during NER; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein; NER stands for nucleotid [...] |
| ERG2 protein network | https://string-db.org/network/4932.YMR202W | C-8 sterol isomerase; catalyzes isomerization of delta-8 double bond to delta-7 position at an intermediate step in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in [...] |
| TOM40 protein network | https://string-db.org/network/4932.YMR203W | Mitochondrial import receptor subunit TOM40; Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed pr [...] |
| INP1 protein network | https://string-db.org/network/4932.YMR204C | Peripheral membrane protein of peroxisomes; involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane. |
| PFK2 protein network | https://string-db.org/network/4932.YMR205C | Beta subunit of heterooctameric phosphofructokinase; involved in glycolysis; indispensable for anaerobic growth; activated by fructose-2,6-bisphosphate and AMP; mutation inhibits glucose inductio [...] |
| YMR206W protein network | https://string-db.org/network/4932.YMR206W | Uncharacterized protein YMR206W; Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication. |
| HFA1 protein network | https://string-db.org/network/4932.YMR207C | Acetyl-CoA carboxylase, mitochondrial; Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to [...] |
| ERG12 protein network | https://string-db.org/network/4932.YMR208W | Mevalonate kinase; acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; human MVK functionally complements the lethality of the erg12 null mutation. |
| YMR209C protein network | https://string-db.org/network/4932.YMR209C | Uncharacterized protein YMR209C; Putative S-adenosylmethionine-dependent methyltransferase; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YM [...] |
| MGL2 protein network | https://string-db.org/network/4932.YMR210W | Putative esterase YMR210W; Monoacylglycerol lipase; palmitoyl monoacylglycerol is the preferred substrate; role in triacylglycerol catabolism; minor role in medium-chain fatty acid ethyl ester bi [...] |
| DML1 protein network | https://string-db.org/network/4932.YMR211W | Essential protein involved in mtDNA inheritance; may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of [...] |
| EFR3 protein network | https://string-db.org/network/4932.YMR212C | Protein required for Stt4-containing PI kinase complex localization; required for Stt4-containing phosphoinositide (PI) kinase patch assembly at the plasma membrane; recruited to the plasma membr [...] |
| CEF1 protein network | https://string-db.org/network/4932.YMR213W | Pre-mRNA-splicing factor CEF1; Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19 [...] |
| SCJ1 protein network | https://string-db.org/network/4932.YMR214W | DnaJ-related protein SCJ1; One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins. |
| GAS3 protein network | https://string-db.org/network/4932.YMR215W | Probable 1,3-beta-glucanosyltransferase GAS3; Putative 1,3-beta-glucanosyltransferase; has similarity go other GAS family members; low abundance, possibly inactive member of the GAS family of GPI [...] |
| SKY1 protein network | https://string-db.org/network/4932.YMR216C | Serine/threonine-protein kinase SKY1; SR protein kinase (SRPK); involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1. |
| GUA1 protein network | https://string-db.org/network/4932.YMR217W | GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negat [...] |
| TRS130 protein network | https://string-db.org/network/4932.YMR218C | Trafficking protein particle complex II-specific subunit 130; Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase [...] |
| ESC1 protein network | https://string-db.org/network/4932.YMR219W | Silent chromatin protein ESC1; Protein involved in telomeric silencing; required for quiescent cell telomere hypercluster localization at nuclear membrane vicinity; interacts with PAD4-domain of [...] |
| ERG8 protein network | https://string-db.org/network/4932.YMR220W | Phosphomevalonate kinase; an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate. |
| FMP42 protein network | https://string-db.org/network/4932.YMR221C | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possibl [...] |
| FSH2 protein network | https://string-db.org/network/4932.YMR222C | Family of serine hydrolases 2; Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2. |
| UBP8 protein network | https://string-db.org/network/4932.YMR223W | Ubiquitin carboxyl-terminal hydrolase 8; Ubiquitin-specific protease component of the SAGA acetylation complex; required for SAGA (Spt-Ada-Gcn5-Acetyltransferase)-mediated deubiquitination of his [...] |
| MRE11 protein network | https://string-db.org/network/4932.YMR224C | Double-strand break repair protein MRE11; Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p asso [...] |
| MRPL44 protein network | https://string-db.org/network/4932.YMR225C | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress. |
| YMR226C protein network | https://string-db.org/network/4932.YMR226C | NADP-dependent 3-hydroxy acid dehydrogenase; NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein [...] |
| TAF7 protein network | https://string-db.org/network/4932.YMR227C | TFIID subunit (67 kDa); involved in RNA polymerase II transcription initiation. |
| MTF1 protein network | https://string-db.org/network/4932.YMR228W | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interac [...] |
| RRP5 protein network | https://string-db.org/network/4932.YMR229C | rRNA biogenesis protein RRP5; RNA binding protein involved in synthesis of 18S and 5.8S rRNAs; component of ribosomal small subunit (SSU) processome and 90S preribosome; required for pre-rRNA pac [...] |
| RPS10B protein network | https://string-db.org/network/4932.YMR230W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplica [...] |
| YMR230W-A protein network | https://string-db.org/network/4932.YMR230W-A | Uncharacterized protein YMR230W-A; Putative protein of unknown function. |
| PEP5 protein network | https://string-db.org/network/4932.YMR231W | Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in [...] |
| FUS2 protein network | https://string-db.org/network/4932.YMR232W | Cell fusion regulator; cytoplasmic protein localized to shmoo tip; required for alignment of parental nuclei before nuclear fusion during mating; contains a Dbl-homology domain; binds specificall [...] |
| TRI1 protein network | https://string-db.org/network/4932.YMR233W | Protein TRI1; Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the [...] |
| RNH1 protein network | https://string-db.org/network/4932.YMR234W | Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I. |
| RNA1 protein network | https://string-db.org/network/4932.YMR235C | GTPase activating protein (GAP) for Gsp1p; involved in nuclear transport; Belongs to the RNA1 family. |
| TAF9 protein network | https://string-db.org/network/4932.YMR236W | Subunit (17 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3. |
| BCH1 protein network | https://string-db.org/network/4932.YMR237W | Protein BCH1; Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export [...] |
| DFG5 protein network | https://string-db.org/network/4932.YMR238W | Mannan endo-1,6-alpha-mannosidase DFG5; Putative mannosidase; essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved i [...] |
| RNT1 protein network | https://string-db.org/network/4932.YMR239C | Ribonuclease 3; Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end o [...] |
| CUS1 protein network | https://string-db.org/network/4932.YMR240C | Cold sensitive U2 snRNA suppressor 1; Protein required for assembly of U2 snRNP into the spliceosome; forms a complex with Hsh49p and Hsh155p. |
| YHM2 protein network | https://string-db.org/network/4932.YMR241W | Citrate and oxoglutarate carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids [...] |
| RPL20A protein network | https://string-db.org/network/4932.YMR242C | Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication. |
| YMR242W-A protein network | https://string-db.org/network/4932.YMR242W-A | Uncharacterized protein YMR242W-A; Putative protein of unknown function. |
| ZRC1 protein network | https://string-db.org/network/4932.YMR243C | Zinc/cadmium resistance protein; Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of [...] |
| COA6 protein network | https://string-db.org/network/4932.YMR244C-A | Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Comp [...] |
| YMR244W protein network | https://string-db.org/network/4932.YMR244W | Uncharacterized protein YMR244W; Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuo [...] |
| YMR245W protein network | https://string-db.org/network/4932.YMR245W | Putative uncharacterized protein YMR245W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| FAA4 protein network | https://string-db.org/network/4932.YMR246W | Long-chain-fatty-acid--CoA ligase 4; Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatt [...] |
| RKR1 protein network | https://string-db.org/network/4932.YMR247C | RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins and translationally stalled ER membrane proteins; component of ribosome-bound RQC (ribosome qualit [...] |
| YMR247W-A protein network | https://string-db.org/network/4932.YMR247W-A | Uncharacterized protein YMR247W-A; Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vac [...] |
| GAD1 protein network | https://string-db.org/network/4932.YMR250W | Glutamate decarboxylase; converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress. |
| GTO3 protein network | https://string-db.org/network/4932.YMR251W | Glutathione S-transferase omega-like 3; Omega class glutathione transferase; putative cytosolic localization. |
| HOR7 protein network | https://string-db.org/network/4932.YMR251W-A | Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperos [...] |
| YMR253C protein network | https://string-db.org/network/4932.YMR253C | Uncharacterized membrane protein YMR253C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an [...] |
| YMR254C protein network | https://string-db.org/network/4932.YMR254C | Uncharacterized protein YMR254C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| GFD1 protein network | https://string-db.org/network/4932.YMR255W | mRNA transport factor GFD1; Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress. |
| COX7 protein network | https://string-db.org/network/4932.YMR256C | Subunit VII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain. |
| PET111 protein network | https://string-db.org/network/4932.YMR257C | Protein PET111, mitochondrial; Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane. |
| ROY1 protein network | https://string-db.org/network/4932.YMR258C | GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts w [...] |
| TRM732 protein network | https://string-db.org/network/4932.YMR259C | tRNA (cytidine(32)-2'-O)-methyltransferase non-catalytic subunit TRM732; Protein involved in 2'-O-methylation of C32 of substrate tRNAs; interacts with 2'-O-ribose methyltransferase Trm7p; green [...] |
| TIF11 protein network | https://string-db.org/network/4932.YMR260C | Translation initiation factor eIF1A; essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B [...] |
| TPS3 protein network | https://string-db.org/network/4932.YMR261C | Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP [...] |
| YMR262W protein network | https://string-db.org/network/4932.YMR262W | Uncharacterized deoxyribonuclease YMR262W; Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene. |
| SAP30 protein network | https://string-db.org/network/4932.YMR263W | Transcriptional regulatory protein SAP30; Component of Rpd3L histone deacetylase complex; involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance; [...] |
| CUE1 protein network | https://string-db.org/network/4932.YMR264W | Coupling of ubiquitin conjugation to ER degradation protein 1; Ubiquitin-binding protein; ER membrane protein that recruits and integrates the ubiquitin-conjugating enzyme Ubc7p into ER membrane- [...] |
| YMR265C protein network | https://string-db.org/network/4932.YMR265C | Uncharacterized protein YMR265C; Putative protein of unknown function. |
| RSN1 protein network | https://string-db.org/network/4932.YMR266W | Uncharacterized protein RSN1; Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma mem [...] |
| PPA2 protein network | https://string-db.org/network/4932.YMR267W | Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; human ortholog, PPA2, functionally complement [...] |
| PRP24 protein network | https://string-db.org/network/4932.YMR268C | U4/U6 snRNA-associated-splicing factor PRP24; Splicing factor that reanneals snRNPs during spliceosome recycling; reanneals U4 and U6 snRNPs. |
| TMA23 protein network | https://string-db.org/network/4932.YMR269W | Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan. |
| RRN9 protein network | https://string-db.org/network/4932.YMR270C | RNA polymerase I-specific transcription initiation factor RRN9; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I. |
| URA10 protein network | https://string-db.org/network/4932.YMR271C | Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has [...] |
| SCS7 protein network | https://string-db.org/network/4932.YMR272C | Ceramide very long chain fatty acid hydroxylase SCS7; Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochr [...] |
| YMR272W-A protein network | https://string-db.org/network/4932.YMR272W-A | Uncharacterized protein YMR272W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene S [...] |
| YMR272W-B protein network | https://string-db.org/network/4932.YMR272W-B | Uncharacterized protein YMR272W-B; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP fusion protein loca [...] |
| ZDS1 protein network | https://string-db.org/network/4932.YMR273C | Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regula [...] |
| RCE1 protein network | https://string-db.org/network/4932.YMR274C | Type II CAAX prenyl protease; involved in the proteolysis and maturation of Ras and the a-factor mating pheromone; Belongs to the peptidase U48 family. |
| BUL1 protein network | https://string-db.org/network/4932.YMR275C | Ubiquitin ligase-binding protein BUL1; Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of am [...] |
| DSK2 protein network | https://string-db.org/network/4932.YMR276W | Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; [...] |
| FCP1 protein network | https://string-db.org/network/4932.YMR277W | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in respons [...] |
| PRM15 protein network | https://string-db.org/network/4932.YMR278W | Phosphoribomutase; catalyzes interconversion of ribose-1-phosphate and ribose-5-phosphate; has some phosphoglucomutase activity but primary activity in vivo is phosphoribomutase; contributes to r [...] |
| YMR279C protein network | https://string-db.org/network/4932.YMR279C | Uncharacterized transporter YMR279C; Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified a [...] |
| CAT8 protein network | https://string-db.org/network/4932.YMR280C | Regulatory protein CAT8; Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbo [...] |
| GPI12 protein network | https://string-db.org/network/4932.YMR281W | N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; ER membrane protein involved in the second step of GPI anchor assembly; the second step is the de-N-acetylation of the N-acetylglucosamin [...] |
| AEP2 protein network | https://string-db.org/network/4932.YMR282C | ATPase expression protein 2, mitochondrial; Mitochondrial protein; likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated l [...] |
| RIT1 protein network | https://string-db.org/network/4932.YMR283C | tRNA A64-2'-O-ribosylphosphate transferase; Initiator methionine 2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methion [...] |
| YKU70 protein network | https://string-db.org/network/4932.YMR284W | ATP-dependent DNA helicase II subunit 1; Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localiz [...] |
| NGL2 protein network | https://string-db.org/network/4932.YMR285C | RNA exonuclease NGL2; Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that aro [...] |
| MRPL33 protein network | https://string-db.org/network/4932.YMR286W | Mitochondrial ribosomal protein of the large subunit. |
| DSS1 protein network | https://string-db.org/network/4932.YMR287C | 3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant o [...] |
| HSH155 protein network | https://string-db.org/network/4932.YMR288W | U2-snRNP associated splicing factor; forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated [...] |
| ABZ2 protein network | https://string-db.org/network/4932.YMR289W | Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase); catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis. |
| HAS1 protein network | https://string-db.org/network/4932.YMR290C | ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; [...] |
| YMR290W-A protein network | https://string-db.org/network/4932.YMR290W-A | Putative uncharacterized membrane protein YMR290W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5 [...] |
| TDA1 protein network | https://string-db.org/network/4932.YMR291W | Serine/threonine-protein kinase TDA1; Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to e [...] |
| GOT1 protein network | https://string-db.org/network/4932.YMR292W | Homodimeric protein that is packaged into COPII vesicles; cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may [...] |
| HER2 protein network | https://string-db.org/network/4932.YMR293C | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER cau [...] |
| JNM1 protein network | https://string-db.org/network/4932.YMR294W | Nuclear migration protein JNM1; Component of the yeast dynactin complex; consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic ana [...] |
| YMR295C protein network | https://string-db.org/network/4932.YMR295C | Uncharacterized protein YMR295C; Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; not an essenti [...] |
| LCB1 protein network | https://string-db.org/network/4932.YMR296C | Component of serine palmitoyltransferase; responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ket [...] |
| PRC1 protein network | https://string-db.org/network/4932.YMR297W | Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase famil [...] |
| LIP1 protein network | https://string-db.org/network/4932.YMR298W | Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in cera [...] |
| DYN3 protein network | https://string-db.org/network/4932.YMR299C | Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration; Belongs to the dynein light intermediate chain DYN3 family. |
| ADE4 protein network | https://string-db.org/network/4932.YMR300C | Amidophosphoribosyltransferase; Phosphoribosylpyrophosphate amidotransferase (PRPPAT); catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway; also known as amidophosphoribo [...] |
| ATM1 protein network | https://string-db.org/network/4932.YMR301C | Iron-sulfur clusters transporter ATM1, mitochondrial; Mitochondrial inner membrane ATP-binding cassette (ABC) transporter; exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clu [...] |
| YME2 protein network | https://string-db.org/network/4932.YMR302C | Integral inner mitochondrial membrane protein; role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence [...] |
| ADH2 protein network | https://string-db.org/network/4932.YMR303C | Glucose-repressible alcohol dehydrogenase II; catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1. |
| YMR304C-A protein network | https://string-db.org/network/4932.YMR304C-A | Putative uncharacterized membrane protein YMR304C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially [...] |
| UBP15 protein network | https://string-db.org/network/4932.YMR304W | Ubiquitin carboxyl-terminal hydrolase 15; Ubiquitin-specific protease involved in protein deubiquitination; forms a complex with AAA peroxins Pex1p and Pex6p; deubiquitinates mono- and polyubiqui [...] |
| SCW10 protein network | https://string-db.org/network/4932.YMR305C | Probable family 17 glucosidase SCW10; Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p; SWC10 h [...] |
| FKS3 protein network | https://string-db.org/network/4932.YMR306W | 1,3-beta-glucan synthase component FKS3; Protein involved in spore wall assembly; has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protei [...] |
| YMR307C-A protein network | https://string-db.org/network/4932.YMR307C-A | Putative uncharacterized protein YMR307C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| GAS1 protein network | https://string-db.org/network/4932.YMR307W | 1,3-beta-glucanosyltransferase GAS1; Beta-1,3-glucanosyltransferase; required for cell wall assembly and also has a role in transcriptional silencing; localizes to cell surface via a glycosylphos [...] |
| PSE1 protein network | https://string-db.org/network/4932.YMR308C | Importin subunit beta-3; Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p. |
| NIP1 protein network | https://string-db.org/network/4932.YMR309C | eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3); involved in the assembly of preinitiation complex and start codon selection; eIF3 is also involved in programmed stop codon [...] |
| YMR310C protein network | https://string-db.org/network/4932.YMR310C | Putative methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; not an essential gene; YMR310C has a paralog, [...] |
| GLC8 protein network | https://string-db.org/network/4932.YMR311C | Protein GLC8; Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; o [...] |
| ELP6 protein network | https://string-db.org/network/4932.YMR312W | Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity. |
| TGL3 protein network | https://string-db.org/network/4932.YMR313C | Lipase 3; Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol (TAG) lipase; catalyzes acylation of lysophosphatidylethanolamine (LPE), a fu [...] |
| PRE5 protein network | https://string-db.org/network/4932.YMR314W | Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family. |
| YMR315W protein network | https://string-db.org/network/4932.YMR315W | Uncharacterized protein YMR315W; Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative [...] |
| YMR315W-A protein network | https://string-db.org/network/4932.YMR315W-A | Uncharacterized protein YMR315W-A; Putative protein of unknown function. |
| YMR316C-B protein network | https://string-db.org/network/4932.YMR316C-B | Putative uncharacterized membrane protein YMR316C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost com [...] |
| DIA1 protein network | https://string-db.org/network/4932.YMR316W | Protein of unknown function; involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern. |
| YMR317W protein network | https://string-db.org/network/4932.YMR317W | Uncharacterized protein YMR317W; Putative protein of unknown function; has some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene. |
| ADH6 protein network | https://string-db.org/network/4932.YMR318C | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in alde [...] |
| FET4 protein network | https://string-db.org/network/4932.YMR319C | Low-affinity Fe(II) transporter of the plasma membrane; Belongs to the FET4 family. |
| YMR320W protein network | https://string-db.org/network/4932.YMR320W | Uncharacterized protein YMR320W; Putative protein of unknown function; conserved among S. cerevisiae strains; YMR320W is not an essential gene. |
| YMR321C protein network | https://string-db.org/network/4932.YMR321C | Putative protein of unknown function; proposed to be a palmitoylated membrane protein; YMR321C has a paralog, SAM4, that arose from a single-locus duplication. |
| SNO4 protein network | https://string-db.org/network/4932.YMR322C | Probable glutathione-independent glyoxalase SNO4; Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phas [...] |
| ERR3 protein network | https://string-db.org/network/4932.YMR323W | Enolase-related protein 3; Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant [...] |
| YMR324C protein network | https://string-db.org/network/4932.YMR324C | Putative UPF0377 protein YMR324C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription is AZF1 depende [...] |
| PAU19 protein network | https://string-db.org/network/4932.YMR325W | Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions. |
| YMR326C protein network | https://string-db.org/network/4932.YMR326C | Putative UPF0320 protein YMR326C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the telomere on the [...] |
| DOM34 protein network | https://string-db.org/network/4932.YNL001W | Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stall [...] |
| RLP7 protein network | https://string-db.org/network/4932.YNL002C | Ribosome biogenesis protein RLP7; Nucleolar protein similar to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors [...] |
| PET8 protein network | https://string-db.org/network/4932.YNL003C | Putative mitochondrial carrier protein PET8; S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and [...] |
| HRB1 protein network | https://string-db.org/network/4932.YNL004W | Protein HRB1; Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to [...] |
| MRP7 protein network | https://string-db.org/network/4932.YNL005C | Mitochondrial ribosomal protein of the large subunit. |
| LST8 protein network | https://string-db.org/network/4932.YNL006W | Target of rapamycin complex subunit LST8; Protein required for the transport of Gap1p; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the [...] |
| SIS1 protein network | https://string-db.org/network/4932.YNL007C | Protein SIS1; Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradatio [...] |
| ASI3 protein network | https://string-db.org/network/4932.YNL008C | Protein ASI3; Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway [...] |
| IDP3 protein network | https://string-db.org/network/4932.YNL009W | Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 [...] |
| YNL010W protein network | https://string-db.org/network/4932.YNL010W | Uncharacterized phosphatase YNL010W; Putative protein of unknown function; similar to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nuc [...] |
| YNL011C protein network | https://string-db.org/network/4932.YNL011C | Putative protein of unknown function; YNL011C is not an essential gene. |
| SPO1 protein network | https://string-db.org/network/4932.YNL012W | Putative meiotic phospholipase SPO1; Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper p [...] |
| YNL013C protein network | https://string-db.org/network/4932.YNL013C | Putative uncharacterized protein YNL013C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| HEF3 protein network | https://string-db.org/network/4932.YNL014W | Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 ha [...] |
| PBI2 protein network | https://string-db.org/network/4932.YNL015W | Cytosolic inhibitor of vacuolar proteinase B (PRB1); required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes [...] |
| PUB1 protein network | https://string-db.org/network/4932.YNL016W | Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1; Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; compon [...] |
| YNL017C protein network | https://string-db.org/network/4932.YNL017C | Putative uncharacterized protein YNL017C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps t [...] |
| YNL018C protein network | https://string-db.org/network/4932.YNL018C | Putative protein of unknown function; YNL018C has a paralog, YNL034W, that arose from a segmental duplication; To yeast YNL034w. |
| YNL019C protein network | https://string-db.org/network/4932.YNL019C | Uncharacterized membrane protein YNL019C; Putative protein of unknown function; expression induced during heat stress; YNL019C has a paralog, YNL033W, that arose from a segmental duplication. |
| ARK1 protein network | https://string-db.org/network/4932.YNL020C | Actin-regulating kinase 1; Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose fro [...] |
| HDA1 protein network | https://string-db.org/network/4932.YNL021W | Histone deacetylase HDA1; Putative catalytic subunit of a class II histone deacetylase complex; role in azole resistance via Hsp90p, and in the heat shock response; Hda1p interacts with the Hda2p [...] |
| RCM1 protein network | https://string-db.org/network/4932.YNL022C | rRNA m5C methyltransferase; methylates cytosine at position 2278 of 25S rRNA while Nop2p methylates cytosine at position 2870; contains seven beta-strand methyltransferase motif; localized to the [...] |
| FAP1 protein network | https://string-db.org/network/4932.YNL023C | Protein that binds to Fpr1p; confers rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. me [...] |
| EFM6 protein network | https://string-db.org/network/4932.YNL024C | Protein-lysine N-methyltransferase EFM6; Putative S-adenosylmethionine-dependent lysine methyltransferase; responsible for modifying Lys-390 in translational elongation factor EF-1 alpha (eEF1A); [...] |
| KSH1 protein network | https://string-db.org/network/4932.YNL024C-A | Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; SWAT-GFP and mCherry fusion proteins localize to the e [...] |
| SSN8 protein network | https://string-db.org/network/4932.YNL025C | Cyclin-like component of the RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; forms a kinase-cyclin pair in the RNAPII holoenzyme with Ssn3p; [...] |
| SAM50 protein network | https://string-db.org/network/4932.YNL026W | Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and fa [...] |
| CRZ1 protein network | https://string-db.org/network/4932.YNL027W | Transcriptional regulator CRZ1; Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rap [...] |
| YNL028W protein network | https://string-db.org/network/4932.YNL028W | Putative uncharacterized protein YNL028W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| KTR5 protein network | https://string-db.org/network/4932.YNL029C | Probable mannosyltransferase KTR5; Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR5 has a paralog, KTR7, that arose from th [...] |
| HHF2 protein network | https://string-db.org/network/4932.YNL030W | Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal dom [...] |
| HHT2 protein network | https://string-db.org/network/4932.YNL031C | Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by ac [...] |
| SIW14 protein network | https://string-db.org/network/4932.YNL032W | Inositol phosphatase SIW14; Tyrosine phosphatase involved in actin organization and endocytosis; localized to the cytoplasm. |
| YNL033W protein network | https://string-db.org/network/4932.YNL033W | Putative protein of unknown function; YNL033W has a paralog, YNL019C, that arose from a segmental duplication; To yeast YNL019c. |
| YNL034W protein network | https://string-db.org/network/4932.YNL034W | Uncharacterized protein YNL034W; Putative protein of unknown function; not an essential gene; YNL034W has a paralog, YNL018C, that arose from a segmental duplication; To yeast YNL018c. |
| YNL035C protein network | https://string-db.org/network/4932.YNL035C | Uncharacterized WD repeat-containing protein YNL035C; Nuclear protein of unknown function; relocalizes to the cytosol in response to hypoxia; contains WD-40 domains; not an essential gene; protei [...] |
| NCE103 protein network | https://string-db.org/network/4932.YNL036W | Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a [...] |
| IDH1 protein network | https://string-db.org/network/4932.YNL037C | Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; Belongs to the isocitrate and isopropylm [...] |
| GPI15 protein network | https://string-db.org/network/4932.YNL038W | Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15; Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylino [...] |
| BDP1 protein network | https://string-db.org/network/4932.YNL039W | Essential subunit of RNA polymerase III transcription factor (TFIIIB); TFIIIB is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs. |
| YNL040W protein network | https://string-db.org/network/4932.YNL040W | Putative alanyl-tRNA editing protein alaX; Protein of unknown function; has strong similarity to alanyl-tRNA synthases from Eubacteria; null mutant displays decreased translation rate and increas [...] |
| COG6 protein network | https://string-db.org/network/4932.YNL041C | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi com [...] |
| BOP3 protein network | https://string-db.org/network/4932.YNL042W | Protein of unknown function; potential Cdc28p substrate; overproduction confers resistance to methylmercury. |
| YNL042W-B protein network | https://string-db.org/network/4932.YNL042W-B | Uncharacterized protein YNL042W-B; Putative protein of unknown function. |
| YNL043C protein network | https://string-db.org/network/4932.YNL043C | Putative uncharacterized protein YNL043C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| YIP3 protein network | https://string-db.org/network/4932.YNL044W | Prenylated Rab acceptor 1; Protein localized to COPII vesicles; proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rt [...] |
| LAP2 protein network | https://string-db.org/network/4932.YNL045W | Leucine aminopeptidase 2; Leucyl aminopeptidase yscIV with epoxide hydrolase activity; metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cyto [...] |
| YNL046W protein network | https://string-db.org/network/4932.YNL046W | Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phe [...] |
| SLM2 protein network | https://string-db.org/network/4932.YNL047C | Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2; Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskel [...] |
| ALG11 protein network | https://string-db.org/network/4932.YNL048W | Alpha-1,2-mannosyltransferase; catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in t [...] |
| SFB2 protein network | https://string-db.org/network/4932.YNL049C | SED5-binding protein 2; Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; S [...] |
| YNL050C protein network | https://string-db.org/network/4932.YNL050C | Putative protein of unknown function; YNL050c is not an essential gene. |
| COG5 protein network | https://string-db.org/network/4932.YNL051W | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi com [...] |
| COX5A protein network | https://string-db.org/network/4932.YNL052W | Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic grow [...] |
| MSG5 protein network | https://string-db.org/network/4932.YNL053W | Tyrosine-protein phosphatase MSG5; Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive re [...] |
| VAC7 protein network | https://string-db.org/network/4932.YNL054W | Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock. |
| POR1 protein network | https://string-db.org/network/4932.YNL055C | Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; couples the glut [...] |
| OCA2 protein network | https://string-db.org/network/4932.YNL056W | Tyrosine-protein phosphatase-like protein OCA2; Protein of unknown function; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes [...] |
| YNL058C protein network | https://string-db.org/network/4932.YNL058C | Vacuolar membrane protein YNL058C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to vacuole; not an essential gene; YNL058C has a paralog, PRM5, t [...] |
| ARP5 protein network | https://string-db.org/network/4932.YNL059C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction; Belongs to the actin famil [...] |
| NOP2 protein network | https://string-db.org/network/4932.YNL061W | rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA; has an essential function independent of rRNA methylation; contains seven beta-strand methyltransferase motif; essent [...] |
| GCD10 protein network | https://string-db.org/network/4932.YNL062C | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 5 [...] |
| MTQ1 protein network | https://string-db.org/network/4932.YNL063W | Mitochondrial MRF1 N(5)-glutamine methyltransferase MTQ1; S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essent [...] |
| YDJ1 protein network | https://string-db.org/network/4932.YNL064C | Mitochondrial protein import protein MAS5; Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; acts as an adaptor that helps Rsp5p recognize cytosolic misfolded protei [...] |
| AQR1 protein network | https://string-db.org/network/4932.YNL065W | Probable transporter AQR1; Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarbo [...] |
| SUN4 protein network | https://string-db.org/network/4932.YNL066W | Probable secreted beta-glucosidase SUN4; Cell wall protein related to glucanases; possibly involved in cell wall septation; member of the SUN family; SUN4 has a paralog, SIM1, that arose from the [...] |
| RPL9B protein network | https://string-db.org/network/4932.YNL067W | Ribosomal 60S subunit protein L9B; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9B has a paralog, RPL9A, that arose from a single-locus duplication. |
| YNL067W-A protein network | https://string-db.org/network/4932.YNL067W-A | Putative uncharacterized protein YNL067W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YNL067W-B protein network | https://string-db.org/network/4932.YNL067W-B | Uncharacterized protein YNL067W-B; Putative protein of unknown function. |
| FKH2 protein network | https://string-db.org/network/4932.YNL068C | Fork head protein homolog 2; Forkhead family transcription factor; rate-limiting activator of replication origins; evolutionarily conserved regulator of lifespan; binds multiple chromosomal eleme [...] |
| RPL16B protein network | https://string-db.org/network/4932.YNL069C | Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a [...] |
| TOM7 protein network | https://string-db.org/network/4932.YNL070W | Mitochondrial import receptor subunit TOM7; Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed pro [...] |
| LAT1 protein network | https://string-db.org/network/4932.YNL071W | Dihydrolipoamide acetyltransferase component (E2) of the PDC; the pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA. |
| RNH201 protein network | https://string-db.org/network/4932.YNL072W | Ribonuclease H2 catalytic subunit; removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; role in ribonucleotide excision repair; [...] |
| MSK1 protein network | https://string-db.org/network/4932.YNL073W | Lysine--tRNA ligase, mitochondrial; Mitochondrial lysine-tRNA synthetase; required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of m [...] |
| MLF3 protein network | https://string-db.org/network/4932.YNL074C | Serine-rich protein of unknown function; predicted to be palmitoylated; overproduction suppresses growth inhibition caused by exposure to immunosuppressant leflunomide; MLF3 has a paralog, VHS2, [...] |
| IMP4 protein network | https://string-db.org/network/4932.YNL075W | U3 small nucleolar ribonucleoprotein protein IMP4; Component of the SSU processome; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of prote [...] |
| MKS1 protein network | https://string-db.org/network/4932.YNL076W | Pleiotropic negative transcriptional regulator; involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling. |
| APJ1 protein network | https://string-db.org/network/4932.YNL077W | J domain-containing protein APJ1; Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagati [...] |
| NIS1 protein network | https://string-db.org/network/4932.YNL078W | Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network. |
| TPM1 protein network | https://string-db.org/network/4932.YNL079C | Tropomyosin-1; Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the N [...] |
| EOS1 protein network | https://string-db.org/network/4932.YNL080C | Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C [...] |
| SWS2 protein network | https://string-db.org/network/4932.YNL081C | Putative mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency; localizes to vacuole in respons [...] |
| PMS1 protein network | https://string-db.org/network/4932.YNL082W | ATP-binding protein required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain, si [...] |
| SAL1 protein network | https://string-db.org/network/4932.YNL083W | Truncated non-functional calcium-binding mitochondrial carrier SAL1-1; ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport acti [...] |
| END3 protein network | https://string-db.org/network/4932.YNL084C | Actin cytoskeleton-regulatory complex protein END3; EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p a [...] |
| MKT1 protein network | https://string-db.org/network/4932.YNL085W | Protein similar to nucleases that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variati [...] |
| SNN1 protein network | https://string-db.org/network/4932.YNL086W | Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to endosomes. |
| TCB2 protein network | https://string-db.org/network/4932.YNL087W | Tricalbin-2; ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PM phosphatidy [...] |
| TOP2 protein network | https://string-db.org/network/4932.YNL088W | DNA topoisomerase 2; Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary [...] |
| YNL089C protein network | https://string-db.org/network/4932.YNL089C | Putative uncharacterized protein YNL089C; Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac s [...] |
| RHO2 protein network | https://string-db.org/network/4932.YNL090W | GTP-binding protein RHO2; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly. |
| NST1 protein network | https://string-db.org/network/4932.YNL091W | Stress response protein NST1; Protein of unknown function; mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 [...] |
| YNL092W protein network | https://string-db.org/network/4932.YNL092W | Carnosine N-methyltransferase; S-adenosylmethionine-dependent protein methyltransferase; capable of automethylation; member of the seven beta-strand family; YNL092W is not an essential gene; Belo [...] |
| YPT53 protein network | https://string-db.org/network/4932.YNL093W | GTP-binding protein YPT53; Stress-induced Rab family GTPase; required for vacuolar protein sorting and endocytosis; involved in ionic stress tolerance; similar to Vps21p and Ypt52p; functional ho [...] |
| APP1 protein network | https://string-db.org/network/4932.YNL094W | Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin pat [...] |
| YNL095C protein network | https://string-db.org/network/4932.YNL095C | Uncharacterized transporter YNL095C; Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the who [...] |
| RPS7B protein network | https://string-db.org/network/4932.YNL096C | Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS [...] |
| PHO23 protein network | https://string-db.org/network/4932.YNL097C | Transcriptional regulatory protein PHO23; Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable t [...] |
| YNL097C-B protein network | https://string-db.org/network/4932.YNL097C-B | Uncharacterized protein YNL097C-B; Putative protein of unknown function. |
| YNL097W-A protein network | https://string-db.org/network/4932.YNL097W-A | Putative uncharacterized protein YNL097W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| RAS2 protein network | https://string-db.org/network/4932.YNL098C | Ras-like protein 2; GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to pl [...] |
| OCA1 protein network | https://string-db.org/network/4932.YNL099C | Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA. |
| MIC27 protein network | https://string-db.org/network/4932.YNL100W | Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista jun [...] |
| AVT4 protein network | https://string-db.org/network/4932.YNL101W | Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; localizes to sit [...] |
| POL1 protein network | https://string-db.org/network/4932.YNL102W | Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis. |
| MET4 protein network | https://string-db.org/network/4932.YNL103W | Leucine-zipper transcriptional activator; responsible for regulation of sulfur amino acid pathway; requires different combinations of auxiliary factors Cbf1p, Met28p, Met31p and Met32p; feedforwa [...] |
| YNL103W-A protein network | https://string-db.org/network/4932.YNL103W-A | Putative uncharacterized protein YNL103W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| LEU4 protein network | https://string-db.org/network/4932.YNL104C | Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the who [...] |
| RRT16 protein network | https://string-db.org/network/4932.YNL105W | Putative regulator of rDNA transcription protein 16; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially [...] |
| INP52 protein network | https://string-db.org/network/4932.YNL106C | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Polyphosphatidylinositol phosphatase; dephosphorylates a number of phosphatidylinositol phosphates (PtdInsPs, PIPs) to PI; involved in endocyt [...] |
| YAF9 protein network | https://string-db.org/network/4932.YNL107W | Protein AF-9 homolog; Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human le [...] |
| YNL108C protein network | https://string-db.org/network/4932.YNL108C | Uncharacterized protein YNL108C; Protein phosphatase; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cyto [...] |
| NOP15 protein network | https://string-db.org/network/4932.YNL110C | Ribosome biogenesis protein 15; Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm. |
| CYB5 protein network | https://string-db.org/network/4932.YNL111C | Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation. |
| DBP2 protein network | https://string-db.org/network/4932.YNL112W | ATP-dependent RNA helicase of the DEAD-box protein family; has strong preference for dsRNA; interacts with YRA1; required for assembly of Yra1p, Nab2p and Mex67p onto mRNA and formation of nuclea [...] |
| RPC19 protein network | https://string-db.org/network/4932.YNL113W | RNA polymerase subunit AC19; common to RNA polymerases I and III. |
| YNL114C protein network | https://string-db.org/network/4932.YNL114C | Putative uncharacterized protein YNL114C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps t [...] |
| YNL115C protein network | https://string-db.org/network/4932.YNL115C | Uncharacterized vacuolar membrane protein YNL115C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene [...] |
| DMA2 protein network | https://string-db.org/network/4932.YNL116W | Ubiquitin-protein ligase (E3); controls septin dynamics and spindle position checkpoint (SPOC) with ligase Dma1p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit G [...] |
| MLS1 protein network | https://string-db.org/network/4932.YNL117W | Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during [...] |
| DCP2 protein network | https://string-db.org/network/4932.YNL118C | m7GpppN-mRNA hydrolase; Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex; removes 5' cap structure from mRNAs prior to their degradation; also enters nucleus and positively regulates tra [...] |
| NCS2 protein network | https://string-db.org/network/4932.YNL119W | Cytoplasmic tRNA 2-thiolation protein 2; Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs; required for the thiolation of uridine at the wobble position of Lys(UUU) and Glu( [...] |
| TOM70 protein network | https://string-db.org/network/4932.YNL121C | Mitochondrial import receptor subunit TOM70; Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed pr [...] |
| YNL122C protein network | https://string-db.org/network/4932.YNL122C | Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L35 and human MRPL35 ribosomal proteins. |
| NMA111 protein network | https://string-db.org/network/4932.YNL123W | Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA [...] |
| NAF1 protein network | https://string-db.org/network/4932.YNL124W | H/ACA ribonucleoprotein complex non-core subunit NAF1; RNA-binding protein required for the assembly of box H/ACA snoRNPs; thus required for pre-rRNA processing; forms a complex with Shq1p and in [...] |
| ESBP6 protein network | https://string-db.org/network/4932.YNL125C | Uncharacterized transporter ESBP6; Protein with similarity to monocarboxylate permeases; appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across th [...] |
| SPC98 protein network | https://string-db.org/network/4932.YNL126W | Spindle pole body component SPC98; Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the [...] |
| FAR11 protein network | https://string-db.org/network/4932.YNL127W | Factor arrest protein 11; Protein involved in recovery from cell cycle arrest; acts in response to pheromone; also involved in regulation of intra-S DNA damage checkpoint and autophagy; is essent [...] |
| TEP1 protein network | https://string-db.org/network/4932.YNL128W | Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1; PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human t [...] |
| NRK1 protein network | https://string-db.org/network/4932.YNL129W | Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis. |
| CPT1 protein network | https://string-db.org/network/4932.YNL130C | Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome du [...] |
| DGR1 protein network | https://string-db.org/network/4932.YNL130C-A | 2-deoxy-glucose resistant protein 1, mitochondrial; Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose. |
| TOM22 protein network | https://string-db.org/network/4932.YNL131W | Mitochondrial import receptor subunit TOM22; Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interactio [...] |
| KRE33 protein network | https://string-db.org/network/4932.YNL132W | RNA cytidine acetyltransferase; Protein required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; essential gene; NAT10, [...] |
| FYV6 protein network | https://string-db.org/network/4932.YNL133C | Protein of unknown function; required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining. |
| YNL134C protein network | https://string-db.org/network/4932.YNL134C | Uncharacterized protein YNL134C; NADH-dependent aldehyde reductase, involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, whi [...] |
| FPR1 protein network | https://string-db.org/network/4932.YNL135C | FK506-binding protein 1; Peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its as [...] |
| EAF7 protein network | https://string-db.org/network/4932.YNL136W | Chromatin modification-related protein EAF7; Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A; Belongs to the EAF7 family. |
| NAM9 protein network | https://string-db.org/network/4932.YNL137C | 37S ribosomal protein NAM9, mitochondrial; Mitochondrial ribosomal component of the small subunit; Belongs to the universal ribosomal protein uS4 family. |
| SRV2 protein network | https://string-db.org/network/4932.YNL138W | CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cof [...] |
| YSF3 protein network | https://string-db.org/network/4932.YNL138W-A | RDS3 complex subunit 10; Component of the SF3b subcomplex of the U2 snRNP; essential protein required for splicing and for assembly of SF3b. |
| THO2 protein network | https://string-db.org/network/4932.YNL139C | Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certa [...] |
| YNL140C protein network | https://string-db.org/network/4932.YNL140C | Uncharacterized protein YNL140C; Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C. |
| AAH1 protein network | https://string-db.org/network/4932.YNL141W | Adenine deaminase (adenine aminohydrolase); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entr [...] |
| MEP2 protein network | https://string-db.org/network/4932.YNL142W | Ammonium transporter MEP2; Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); ex [...] |
| YNL143C protein network | https://string-db.org/network/4932.YNL143C | Uncharacterized membrane protein YNL143C; Protein of unknown function; expressed at both mRNA and protein levels. |
| YNL144C protein network | https://string-db.org/network/4932.YNL144C | Uncharacterized protein YNL144C; Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds ph [...] |
| YNL144W-A protein network | https://string-db.org/network/4932.YNL144W-A | Putative uncharacterized protein YNL144W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| MFA2 protein network | https://string-db.org/network/4932.YNL145W | Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal p [...] |
| YNL146W protein network | https://string-db.org/network/4932.YNL146W | Uncharacterized protein YNL146W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene. |
| LSM7 protein network | https://string-db.org/network/4932.YNL147W | U6 snRNA-associated Sm-like protein LSm7; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Ls [...] |
| ALF1 protein network | https://string-db.org/network/4932.YNL148C | Tubulin-specific chaperone B; Alpha-tubulin folding protein; similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may pl [...] |
| PGA2 protein network | https://string-db.org/network/4932.YNL149C | Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; nu [...] |
| YNL150W protein network | https://string-db.org/network/4932.YNL150W | Putative uncharacterized protein YNL150W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; extensive overlap wit [...] |
| RPC31 protein network | https://string-db.org/network/4932.YNL151C | RNA polymerase III subunit C31; Belongs to the eukaryotic RPC7 RNA polymerase subunit family. |
| INN1 protein network | https://string-db.org/network/4932.YNL152W | Ingression protein 1; Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membran [...] |
| GIM3 protein network | https://string-db.org/network/4932.YNL153C | Prefoldin subunit 4; Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also [...] |
| YCK2 protein network | https://string-db.org/network/4932.YNL154C | Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stab [...] |
| CUZ1 protein network | https://string-db.org/network/4932.YNL155W | CDC48-associated ubiquitin-like/zinc finger protein 1; Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein, Cdc48p and the proteasomal regulatory particl [...] |
| NSG2 protein network | https://string-db.org/network/4932.YNL156C | Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammali [...] |
| IGO1 protein network | https://string-db.org/network/4932.YNL157W | mRNA stability protein IGO1; Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protei [...] |
| PGA1 protein network | https://string-db.org/network/4932.YNL158W | GPI mannosyltransferase 2 subunit PGA1; Essential component of GPI-mannosyltransferase II; complex is responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required fo [...] |
| ASI2 protein network | https://string-db.org/network/4932.YNL159C | Protein ASI2; Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) path [...] |
| YGP1 protein network | https://string-db.org/network/4932.YNL160W | Protein YGP1; Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stati [...] |
| CBK1 protein network | https://string-db.org/network/4932.YNL161W | Serine/threonine-protein kinase CBK1; Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular [...] |
| RPL42A protein network | https://string-db.org/network/4932.YNL162W | Ribosomal 60S subunit protein L42A; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42A has a paralog, RPL42B, that arose from the whole genome duplication. |
| YNL162W-A protein network | https://string-db.org/network/4932.YNL162W-A | Uncharacterized protein YNL162W-A; Putative protein of unknown function; identified by homology. |
| RIA1 protein network | https://string-db.org/network/4932.YNL163C | Ribosome assembly protein 1; Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, a guanine nucleotide exchange factor (GEF), promotes release of Tif6p from 60S ribos [...] |
| IBD2 protein network | https://string-db.org/network/4932.YNL164C | Protein IBD2; Component of the BUB2-dependent spindle checkpoint pathway; interacts with Bfa1p and functions upstream of Bub2p and Bfa1p. |
| BNI5 protein network | https://string-db.org/network/4932.YNL166C | Bud neck protein 5; Linker protein responsible for recruitment of myosin to the bud neck; interacts with the C-terminal extensions of septins Cdc11p and Shs1p and binds Myo1p to promote cytokines [...] |
| SKO1 protein network | https://string-db.org/network/4932.YNL167C | CRE-binding bZIP protein SKO1; Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuc [...] |
| FMP41 protein network | https://string-db.org/network/4932.YNL168C | Uncharacterized mitochondrial hydrolase FMP41; Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is [...] |
| PSD1 protein network | https://string-db.org/network/4932.YNL169C | Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology by affecting lipid mix [...] |
| YNL170W protein network | https://string-db.org/network/4932.YNL170W | Putative uncharacterized protein YNL170W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YNL171C protein network | https://string-db.org/network/4932.YNL171C | Putative uncharacterized protein YNL171C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| APC1 protein network | https://string-db.org/network/4932.YNL172W | Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/a [...] |
| MDG1 protein network | https://string-db.org/network/4932.YNL173C | Signal transduction protein MDG1; Plasma membrane protein; involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; MDG1 has a paralog, CRP1, that aro [...] |
| NOP13 protein network | https://string-db.org/network/4932.YNL175C | Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress. |
| TDA7 protein network | https://string-db.org/network/4932.YNL176C | Topoisomerase I damage affected protein 7; Cell cycle-regulated gene of unknown function; promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele; TDA7 has a para [...] |
| MRPL22 protein network | https://string-db.org/network/4932.YNL177C | Mitochondrial ribosomal protein of the large subunit. |
| RPS3 protein network | https://string-db.org/network/4932.YNL178W | Protein component of the small (40S) ribosomal subunit; has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; nascent Rps3p is bound by specific chaperone Yar1p during tr [...] |
| YNL179C protein network | https://string-db.org/network/4932.YNL179C | Putative uncharacterized protein YNL179C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| RHO5 protein network | https://string-db.org/network/4932.YNL180C | GTP-binding protein RHO5; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; RAC1 ortholog; regulated by phosphorylation and ubiquitination; likely involved in protein kinase [...] |
| PBR1 protein network | https://string-db.org/network/4932.YNL181W | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| IPI3 protein network | https://string-db.org/network/4932.YNL182C | Pre-rRNA-processing protein IPI3; Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribo [...] |
| NPR1 protein network | https://string-db.org/network/4932.YNL183C | Nitrogen permease reactivator protein; Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negat [...] |
| YNL184C protein network | https://string-db.org/network/4932.YNL184C | Uncharacterized protein YNL184C; Protein of unknown function; expressed at both mRNA and protein levels. |
| MRPL19 protein network | https://string-db.org/network/4932.YNL185C | Mitochondrial ribosomal protein of the large subunit. |
| UBP10 protein network | https://string-db.org/network/4932.YNL186W | Ubiquitin carboxyl-terminal hydrolase 10; Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis via it [...] |
| SWT21 protein network | https://string-db.org/network/4932.YNL187W | Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; co [...] |
| KAR1 protein network | https://string-db.org/network/4932.YNL188W | Cell division control protein KAR1; Protein involved in karyogamy and spindle pole body duplication; involved in karyogamy during mating; involved in spindle pole body duplication during mitosis; [...] |
| SRP1 protein network | https://string-db.org/network/4932.YNL189W | Importin subunit alpha; Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during [...] |
| YNL190W protein network | https://string-db.org/network/4932.YNL190W | Hydrophilin essential in desiccation-rehydration process; cell wall protein; contains a putative GPI-attachment site; Belongs to the PGA14 family. |
| DUG3 protein network | https://string-db.org/network/4932.YNL191W | Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degr [...] |
| CHS1 protein network | https://string-db.org/network/4932.YNL192W | Chitin synthase I; requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis [...] |
| YNL193W protein network | https://string-db.org/network/4932.YNL193W | Uncharacterized protein YNL193W; Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis. |
| YNL194C protein network | https://string-db.org/network/4932.YNL194C | Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion [...] |
| YNL195C protein network | https://string-db.org/network/4932.YNL195C | Uncharacterized protein YNL195C; Protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput stud [...] |
| SLZ1 protein network | https://string-db.org/network/4932.YNL196C | Sporulation-specific protein with a leucine zipper motif; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation. |
| WHI3 protein network | https://string-db.org/network/4932.YNL197C | RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; regulates genes involved in the cell cycle, sister chromatid cohesion, and stress response; acts as a cytoplasmic retention fact [...] |
| YNL198C protein network | https://string-db.org/network/4932.YNL198C | Uncharacterized protein YNL198C, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| GCR2 protein network | https://string-db.org/network/4932.YNL199C | Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p. |
| NNR1 protein network | https://string-db.org/network/4932.YNL200C | NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and arc [...] |
| PSY2 protein network | https://string-db.org/network/4932.YNL201C | Subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form the active complex, Psy4p may provide additional substrate specificity; regulates recovery from the DNA damage checkpoint, the gen [...] |
| SPS19 protein network | https://string-db.org/network/4932.YNL202W | Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during la [...] |
| YNL203C protein network | https://string-db.org/network/4932.YNL203C | Putative uncharacterized protein YNL203C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| SPS18 protein network | https://string-db.org/network/4932.YNL204C | Sporulation protein SPS18; Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation; SPS18 has a paralog, GCS1, that arose from the whole genome duplicat [...] |
| RTT106 protein network | https://string-db.org/network/4932.YNL206C | Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transpos [...] |
| RIO2 protein network | https://string-db.org/network/4932.YNL207W | Serine/threonine-protein kinase RIO2; Essential serine kinase involved in the processing of 20S pre-rRNA; involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Ri [...] |
| YNL208W protein network | https://string-db.org/network/4932.YNL208W | Uncharacterized protein YNL208W; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria [...] |
| SSB2 protein network | https://string-db.org/network/4932.YNL209W | Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the [...] |
| MER1 protein network | https://string-db.org/network/4932.YNL210W | Meiotic recombination 1 protein; mRNA-binding protein required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential [...] |
| VID27 protein network | https://string-db.org/network/4932.YNL212W | Vacuolar import and degradation protein 27; Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fruct [...] |
| RRG9 protein network | https://string-db.org/network/4932.YNL213C | Required for respiratory growth protein 9, mitochondrial; Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detect [...] |
| PEX17 protein network | https://string-db.org/network/4932.YNL214W | Membrane peroxin of the peroxisomal importomer complex; complex facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis. |
| IES2 protein network | https://string-db.org/network/4932.YNL215W | Ino eighty subunit 2; Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic condit [...] |
| RAP1 protein network | https://string-db.org/network/4932.YNL216W | DNA-binding protein RAP1; Essential DNA-binding transcription regulator that binds many loci; involved in transcription activation, repression, chromatin silencing, telomere length maintenance; r [...] |
| YNL217W protein network | https://string-db.org/network/4932.YNL217W | Putative metallophosphoesterase YNL217W; Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; n [...] |
| MGS1 protein network | https://string-db.org/network/4932.YNL218W | Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting [...] |
| ALG9 protein network | https://string-db.org/network/4932.YNL219C | Alpha-1,2-mannosyltransferase ALG9; Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of both the seventh mannose residue on B-arm and ninth mannose residue on the C [...] |
| ADE12 protein network | https://string-db.org/network/4932.YNL220W | Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded [...] |
| POP1 protein network | https://string-db.org/network/4932.YNL221C | Ribonucleases P/MRP protein subunit POP1; Subunit of RNase MRP, nuclear RNase P and telomerase complexes; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' [...] |
| SSU72 protein network | https://string-db.org/network/4932.YNL222W | RNA polymerase II subunit A C-terminal domain phosphatase SSU72; Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits pho [...] |
| ATG4 protein network | https://string-db.org/network/4932.YNL223W | Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation. |
| SQS1 protein network | https://string-db.org/network/4932.YNL224C | Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by [...] |
| CNM67 protein network | https://string-db.org/network/4932.YNL225C | Chaotic nuclear migration protein 67; Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from t [...] |
| JJJ1 protein network | https://string-db.org/network/4932.YNL227C | J protein JJJ1; Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-dom [...] |
| URE2 protein network | https://string-db.org/network/4932.YNL229C | Nitrogen catabolite repression transcriptional regulator; inhibits GLN3 transcription in good nitrogen source; role in sequestering Gln3p and Gat1p to the cytoplasm; has glutathione peroxidase ac [...] |
| ELA1 protein network | https://string-db.org/network/4932.YNL230C | Elongin-A; Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin- [...] |
| PDR16 protein network | https://string-db.org/network/4932.YNL231C | Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regul [...] |
| CSL4 protein network | https://string-db.org/network/4932.YNL232W | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; human homolog EXOSC1 p [...] |
| BNI4 protein network | https://string-db.org/network/4932.YNL233W | Protein BNI4; Targeting subunit for Glc7p protein phosphatase; localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase [...] |
| YNL234W protein network | https://string-db.org/network/4932.YNL234W | Uncharacterized globin-like protein YNL234W; Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced b [...] |
| SIN4 protein network | https://string-db.org/network/4932.YNL236W | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regu [...] |
| YTP1 protein network | https://string-db.org/network/4932.YNL237W | Protein YTP1; Probable type-III integral membrane protein of unknown function; has regions of similarity to mitochondrial electron transport proteins. |
| KEX2 protein network | https://string-db.org/network/4932.YNL238W | Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway; Belongs to the peptidase S8 fami [...] |
| LAP3 protein network | https://string-db.org/network/4932.YNL239W | Cysteine proteinase 1, mitochondrial; Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; tr [...] |
| NAR1 protein network | https://string-db.org/network/4932.YNL240C | Cytosolic Fe-S cluster assembly factor NAR1; Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal re [...] |
| ZWF1 protein network | https://string-db.org/network/4932.YNL241C | Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidative stress; protein abundance increases in response to DNA repli [...] |
| ATG2 protein network | https://string-db.org/network/4932.YNL242W | Autophagy-related protein 2; Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cv [...] |
| SLA2 protein network | https://string-db.org/network/4932.YNL243W | Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer [...] |
| SUI1 protein network | https://string-db.org/network/4932.YNL244C | Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase; Belongs to the SUI1 family. |
| CWC25 protein network | https://string-db.org/network/4932.YNL245C | Pre-mRNA-splicing factor CWC25; Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. po [...] |
| VPS75 protein network | https://string-db.org/network/4932.YNL246W | Vacuolar protein sorting-associated protein 75; NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity [...] |
| YNL247W protein network | https://string-db.org/network/4932.YNL247W | Cysteine--tRNA ligase; Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulati [...] |
| RPA49 protein network | https://string-db.org/network/4932.YNL248C | RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p. |
| MPA43 protein network | https://string-db.org/network/4932.YNL249C | Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| RAD50 protein network | https://string-db.org/network/4932.YNL250W | DNA repair protein RAD50; Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere mainte [...] |
| NRD1 protein network | https://string-db.org/network/4932.YNL251C | Protein NRD1; RNA-binding subunit of Nrd1 complex; complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with CTD of RNA pol II large subu [...] |
| MRPL17 protein network | https://string-db.org/network/4932.YNL252C | Mitochondrial ribosomal protein of the large subunit. |
| TEX1 protein network | https://string-db.org/network/4932.YNL253W | Protein involved in mRNA export; component of the transcription export (TREX) complex. |
| RTC4 protein network | https://string-db.org/network/4932.YNL254C | Restriction of telomere capping protein 4; Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucl [...] |
| GIS2 protein network | https://string-db.org/network/4932.YNL255C | Zinc finger protein GIS2; Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodi [...] |
| FOL1 protein network | https://string-db.org/network/4932.YNL256W | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Multifunctional enzyme of the folic acid biosynthesis pathway; has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase [...] |
| SIP3 protein network | https://string-db.org/network/4932.YNL257C | Membrane-anchored lipid-binding protein SIP3; Putative sterol transfer protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; co-localizes to puncta i [...] |
| DSL1 protein network | https://string-db.org/network/4932.YNL258C | Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms Dsl1 tethering complex with Sec39p and Tip20p that forms a stable comp [...] |
| ATX1 protein network | https://string-db.org/network/4932.YNL259C | Metal homeostasis factor ATX1; Cytosolic copper metallochaperone; transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxi [...] |
| LTO1 protein network | https://string-db.org/network/4932.YNL260C | Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented [...] |
| ORC5 protein network | https://string-db.org/network/4932.YNL261W | Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing. |
| POL2 protein network | https://string-db.org/network/4932.YNL262W | Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthes [...] |
| YIF1 protein network | https://string-db.org/network/4932.YNL263C | Integral membrane protein; required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homol [...] |
| PDR17 protein network | https://string-db.org/network/4932.YNL264C | Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE level [...] |
| IST1 protein network | https://string-db.org/network/4932.YNL265C | Vacuolar protein sorting-associated protein IST1; Protein with positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is medi [...] |
| YNL266W protein network | https://string-db.org/network/4932.YNL266W | Putative uncharacterized protein YNL266W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| PIK1 protein network | https://string-db.org/network/4932.YNL267W | Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; may control nonselective a [...] |
| LYP1 protein network | https://string-db.org/network/4932.YNL268W | Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids. |
| BSC4 protein network | https://string-db.org/network/4932.YNL269W | Bypass of stop codon protein 4; Protein of unknown function; protein-coding gene that evolved de novo via a series of point mutations in noncoding sequence; ORF exhibits genomic organization comp [...] |
| ALP1 protein network | https://string-db.org/network/4932.YNL270C | Basic amino-acid permease; Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from t [...] |
| BNI1 protein network | https://string-db.org/network/4932.YNL271C | Protein BNI1; Formin; polarisome component; nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formati [...] |
| SEC2 protein network | https://string-db.org/network/4932.YNL272C | Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretor [...] |
| TOF1 protein network | https://string-db.org/network/4932.YNL273W | Topoisomerase 1-associated factor 1; Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA dam [...] |
| GOR1 protein network | https://string-db.org/network/4932.YNL274C | Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; pro [...] |
| BOR1 protein network | https://string-db.org/network/4932.YNL275W | Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1. |
| YNL276C protein network | https://string-db.org/network/4932.YNL276C | Putative uncharacterized protein YNL276C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified [...] |
| MET2 protein network | https://string-db.org/network/4932.YNL277W | L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; Belongs to the AB hydrolase superfa [...] |
| YNL277W-A protein network | https://string-db.org/network/4932.YNL277W-A | Uncharacterized protein YNL277W-A; Putative protein of unknown function. |
| CAF120 protein network | https://string-db.org/network/4932.YNL278W | Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; contains a PH-like domain; CAF120 has a paralog, SKG3, that arose fr [...] |
| PRM1 protein network | https://string-db.org/network/4932.YNL279W | Plasma membrane fusion protein PRM1; Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil do [...] |
| ERG24 protein network | https://string-db.org/network/4932.YNL280C | C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on r [...] |
| HCH1 protein network | https://string-db.org/network/4932.YNL281W | Hsp90 co-chaperone HCH1; Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutati [...] |
| POP3 protein network | https://string-db.org/network/4932.YNL282W | Ribonucleases P/MRP protein subunit POP3; Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and f [...] |
| WSC2 protein network | https://string-db.org/network/4932.YNL283C | Cell wall integrity and stress response component 2; Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat s [...] |
| MRPL10 protein network | https://string-db.org/network/4932.YNL284C | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels. |
| CUS2 protein network | https://string-db.org/network/4932.YNL286W | Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRM [...] |
| SEC21 protein network | https://string-db.org/network/4932.YNL287W | Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo. |
| CAF40 protein network | https://string-db.org/network/4932.YNL288W | Protein CAF40; Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p. |
| PCL1 protein network | https://string-db.org/network/4932.YNL289W | PHO85 cyclin-1; Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression throug [...] |
| RFC3 protein network | https://string-db.org/network/4932.YNL290W | Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor [...] |
| MID1 protein network | https://string-db.org/network/4932.YNL291C | Stretch-activated cation channel MID1; N-glycosylated integral membrane protein of the ER and plasma membrane; functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ inf [...] |
| PUS4 protein network | https://string-db.org/network/4932.YNL292W | Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil m [...] |
| MSB3 protein network | https://string-db.org/network/4932.YNL293W | Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to [...] |
| RIM21 protein network | https://string-db.org/network/4932.YNL294C | pH-response regulator protein palH/RIM21; pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; i [...] |
| MRX6 protein network | https://string-db.org/network/4932.YNL295W | MIOREX complex component 6; Protein that associates with mitochondrial ribosome. |
| YNL296W protein network | https://string-db.org/network/4932.YNL296W | Putative uncharacterized protein YNL296W; Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype [...] |
| MON2 protein network | https://string-db.org/network/4932.YNL297C | Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of prot [...] |
| CLA4 protein network | https://string-db.org/network/4932.YNL298W | Serine/threonine-protein kinase CLA4; Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, v [...] |
| TRF5 protein network | https://string-db.org/network/4932.YNL299W | Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlap [...] |
| TOS6 protein network | https://string-db.org/network/4932.YNL300W | Protein TOS6; Glycosylphosphatidylinositol-dependent cell wall protein; expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion i [...] |
| RPL18B protein network | https://string-db.org/network/4932.YNL301C | Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication. |
| RPS19B protein network | https://string-db.org/network/4932.YNL302C | Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations [...] |
| YPT11 protein network | https://string-db.org/network/4932.YNL304W | GTP-binding protein YPT11; Rab GTPase; Myo2p-binding protein implicated in mother-to-bud transport of cortical endoplasmic reticulum (ER), late Golgi, and mitochondria during cell division; funct [...] |
| BXI1 protein network | https://string-db.org/network/4932.YNL305C | Bax inhibitor 1; Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under som [...] |
| MRPS18 protein network | https://string-db.org/network/4932.YNL306W | Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins. |
| MCK1 protein network | https://string-db.org/network/4932.YNL307C | Protein kinase MCK1; Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p a [...] |
| KRI1 protein network | https://string-db.org/network/4932.YNL308C | Protein KRI1; Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p; Belongs to the KRI1 family. |
| STB1 protein network | https://string-db.org/network/4932.YNL309W | Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; exp [...] |
| ZIM17 protein network | https://string-db.org/network/4932.YNL310C | Protein co-chaperone with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in [...] |
| SKP2 protein network | https://string-db.org/network/4932.YNL311C | F-box protein of unknown function; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, base [...] |
| RFA2 protein network | https://string-db.org/network/4932.YNL312W | Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against i [...] |
| EMW1 protein network | https://string-db.org/network/4932.YNL313C | Essential for maintenance of the cell wall protein 1; Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-termin [...] |
| DAL82 protein network | https://string-db.org/network/4932.YNL314W | Protein DAL82; Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transc [...] |
| ATP11 protein network | https://string-db.org/network/4932.YNL315C | Protein ATP11, mitochondrial; Molecular chaperone; required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; N-terminally propionylated in vivo. |
| PHA2 protein network | https://string-db.org/network/4932.YNL316C | Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway. |
| PFS2 protein network | https://string-db.org/network/4932.YNL317W | Polyadenylation factor subunit 2; Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging [...] |
| HXT14 protein network | https://string-db.org/network/4932.YNL318C | Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified [...] |
| YNL319W protein network | https://string-db.org/network/4932.YNL319W | Putative uncharacterized protein YNL319W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| YNL320W protein network | https://string-db.org/network/4932.YNL320W | Uncharacterized membrane protein YNL320W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; To S.pomb [...] |
| VNX1 protein network | https://string-db.org/network/4932.YNL321W | Low affinity vacuolar monovalent cation/H(+) antiporter; Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p subs [...] |
| KRE1 protein network | https://string-db.org/network/4932.YNL322C | Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor. |
| LEM3 protein network | https://string-db.org/network/4932.YNL323W | Alkylphosphocholine resistance protein LEM3; Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translo [...] |
| YNL324W protein network | https://string-db.org/network/4932.YNL324W | Putative uncharacterized protein YNL324W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| FIG4 protein network | https://string-db.org/network/4932.YNL325C | Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1- [...] |
| PFA3 protein network | https://string-db.org/network/4932.YNL326C | Palmitoyltransferase for Vac8p; required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress cond [...] |
| EGT2 protein network | https://string-db.org/network/4932.YNL327W | Protein EGT2; Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase; required for proper cell separation after cytokinesis; expression is activated by Swi5p and tightly regulated in [...] |
| MDJ2 protein network | https://string-db.org/network/4932.YNL328C | Mitochondrial DnaJ homolog 2; Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of [...] |
| PEX6 protein network | https://string-db.org/network/4932.YNL329C | Peroxisomal ATPase PEX6; AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; [...] |
| RPD3 protein network | https://string-db.org/network/4932.YNL330C | Histone deacetylase, component of both the Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two dif [...] |
| AAD14 protein network | https://string-db.org/network/4932.YNL331C | Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise [...] |
| THI12 protein network | https://string-db.org/network/4932.YNL332W | 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI12; Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12 [...] |
| SNZ2 protein network | https://string-db.org/network/4932.YNL333W | Probable pyridoxal 5'-phosphate synthase subunit SNZ2; Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiami [...] |
| SNO2 protein network | https://string-db.org/network/4932.YNL334C | Probable pyridoxal 5'-phosphate synthase subunit SNO2; Protein of unknown function; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin; B [...] |
| DDI3 protein network | https://string-db.org/network/4932.YNL335W | Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as M [...] |
| COS1 protein network | https://string-db.org/network/4932.YNL336W | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting [...] |
| YNL337W protein network | https://string-db.org/network/4932.YNL337W | Putative UPF0320 protein YNL337W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YNL338W protein network | https://string-db.org/network/4932.YNL338W | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is a telomeric X element c [...] |
| YRF1-6 protein network | https://string-db.org/network/4932.YNL339C | Y' element ATP-dependent helicase protein 1 copy 6; Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially [...] |
| YNL339W-A protein network | https://string-db.org/network/4932.YNL339W-A | Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YNL339W-B protein network | https://string-db.org/network/4932.YNL339W-B | Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| CIT1 protein network | https://string-db.org/network/4932.YNR001C | Citrate synthase, mitochondrial; Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mit [...] |
| YNR001W-A protein network | https://string-db.org/network/4932.YNR001W-A | Putative uncharacterized protein YNR001W-A; Dubious open reading frame unlikely to encode a functional protein; identified by homology. |
| ATO2 protein network | https://string-db.org/network/4932.YNR002C | Ammonia transport outward protein 2; Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mit [...] |
| RPC34 protein network | https://string-db.org/network/4932.YNR003C | RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit [...] |
| YNR003W-A protein network | https://string-db.org/network/4932.YNR003W-A | Putative uncharacterized protein YNR003W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| SWM2 protein network | https://string-db.org/network/4932.YNR004W | Nucleolar protein SWM2; Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRN [...] |
| VPS27 protein network | https://string-db.org/network/4932.YNR006W | Vacuolar protein sorting-associated protein 27; Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated prote [...] |
| ATG3 protein network | https://string-db.org/network/4932.YNR007C | Autophagy-related protein 3; E2-like enzyme; involved in autophagy and cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which [...] |
| LRO1 protein network | https://string-db.org/network/4932.YNR008W | Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; Lro1p and Dga1p can O-acylate ceramides; putative homolog [...] |
| NRM1 protein network | https://string-db.org/network/4932.YNR009W | Transcription factor NRM1; Transcriptional co-repressor of MBF-regulated gene expression; Nrm1p associates stably with promoters via MCB binding factor (MBF) to repress transcription upon exit fr [...] |
| CSE2 protein network | https://string-db.org/network/4932.YNR010W | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regu [...] |
| PRP2 protein network | https://string-db.org/network/4932.YNR011C | Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2; RNA-dependent DExD/H-box ATPase; required for activation of spliceosome before first transesterification step in RNA splicin [...] |
| URK1 protein network | https://string-db.org/network/4932.YNR012W | Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pa [...] |
| PHO91 protein network | https://string-db.org/network/4932.YNR013C | Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of t [...] |
| YNR014W protein network | https://string-db.org/network/4932.YNR014W | Uncharacterized protein YNR014W; Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the [...] |
| SMM1 protein network | https://string-db.org/network/4932.YNR015W | tRNA-dihydrouridine(20) synthase [NAD(P)+]; Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position [...] |
| ACC1 protein network | https://string-db.org/network/4932.YNR016C | Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA [...] |
| TIM23 protein network | https://string-db.org/network/4932.YNR017W | Essential component of the TIM23 complex; involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel; TIM [...] |
| RCF2 protein network | https://string-db.org/network/4932.YNR018W | Respiratory supercomplex factor 2, mitochondrial; Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for l [...] |
| ARE2 protein network | https://string-db.org/network/4932.YNR019W | Sterol O-acyltransferase 2; Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, [...] |
| ATP23 protein network | https://string-db.org/network/4932.YNR020C | Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of [...] |
| YNR021W protein network | https://string-db.org/network/4932.YNR021W | UPF0674 endoplasmic reticulum membrane protein YNR021W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not [...] |
| MRPL50 protein network | https://string-db.org/network/4932.YNR022C | Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation. |
| SNF12 protein network | https://string-db.org/network/4932.YNR023W | Transcription regulatory protein SNF12; 73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; dele [...] |
| MPP6 protein network | https://string-db.org/network/4932.YNR024W | M-phase phosphoprotein 6 homolog; Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copu [...] |
| YNR025C protein network | https://string-db.org/network/4932.YNR025C | Putative uncharacterized protein YNR025C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expr [...] |
| SEC12 protein network | https://string-db.org/network/4932.YNR026C | Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated [...] |
| BUD17 protein network | https://string-db.org/network/4932.YNR027W | Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 [...] |
| CPR8 protein network | https://string-db.org/network/4932.YNR028W | Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; CPR8 has a paral [...] |
| YNR029C protein network | https://string-db.org/network/4932.YNR029C | Uncharacterized protein YNR029C; Putative protein of unknown function; deletion confers reduced fitness in saline. |
| ALG12 protein network | https://string-db.org/network/4932.YNR030W | Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog AL [...] |
| SSK2 protein network | https://string-db.org/network/4932.YNR031C | MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin [...] |
| HUB1 protein network | https://string-db.org/network/4932.YNR032C-A | Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally co [...] |
| PPG1 protein network | https://string-db.org/network/4932.YNR032W | Serine/threonine-protein phosphatase PP2A-like PPG1; Putative serine/threonine protein phosphatase; putative phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation [...] |
| ABZ1 protein network | https://string-db.org/network/4932.YNR033W | Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for [...] |
| SOL1 protein network | https://string-db.org/network/4932.YNR034W | 6-phosphogluconolactonase-like protein 1; Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic acti [...] |
| EGO4 protein network | https://string-db.org/network/4932.YNR034W-A | Uncharacterized protein YNR034W-A; Protein of unknown function; expression is regulated by Msn2p/Msn4p; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication. |
| ARC35 protein network | https://string-db.org/network/4932.YNR035C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin. |
| MRPS12 protein network | https://string-db.org/network/4932.YNR036C | 37S ribosomal protein S12, mitochondrial; Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal protein [...] |
| RSM19 protein network | https://string-db.org/network/4932.YNR037C | Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S19 ribosomal protein. |
| DBP6 protein network | https://string-db.org/network/4932.YNR038W | ATP-dependent RNA helicase DBP6; Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family; human homolog DDX51 complements yeast dbp6 [...] |
| ZRG17 protein network | https://string-db.org/network/4932.YNR039C | Protein ZRG17; Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilita [...] |
| YNR040W protein network | https://string-db.org/network/4932.YNR040W | Uncharacterized protein YNR040W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| COQ2 protein network | https://string-db.org/network/4932.YNR041C | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in wh [...] |
| MVD1 protein network | https://string-db.org/network/4932.YNR043W | Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer; Belongs to the diphosphomevalonate dec [...] |
| AGA1 protein network | https://string-db.org/network/4932.YNR044W | Anchorage subunit of a-agglutinin of a-cells; highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subu [...] |
| PET494 protein network | https://string-db.org/network/4932.YNR045W | Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane. |
| TRM112 protein network | https://string-db.org/network/4932.YNR046W | Multifunctional methyltransferase subunit TRM112; Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase ( [...] |
| FPK1 protein network | https://string-db.org/network/4932.YNR047W | Flippase kinase 1; Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry; phosphorylates and in [...] |
| YNR048W protein network | https://string-db.org/network/4932.YNR048W | Potential noncatalytic subunit for phospholipid translocase Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication. |
| MSO1 protein network | https://string-db.org/network/4932.YNR049C | Protein MSO1; Lipid-interacting protein in SNARE complex assembly machinery; acts at late step in secretion; interacts with membranes through two distinct binding sites; shows genetic and physica [...] |
| LYS9 protein network | https://string-db.org/network/4932.YNR050C | Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits [...] |
| BRE5 protein network | https://string-db.org/network/4932.YNR051C | UBP3-associated protein BRE5; Ubiquitin protease cofactor; forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Go [...] |
| POP2 protein network | https://string-db.org/network/4932.YNR052C | Poly(A) ribonuclease POP2; RNase of the DEDD superfamily; subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation. |
| NOG2 protein network | https://string-db.org/network/4932.YNR053C | Nucleolar GTP-binding protein 2; Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; recruited by ribosomal prote [...] |
| ESF2 protein network | https://string-db.org/network/4932.YNR054C | Pre-rRNA-processing protein ESF2; Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit ( [...] |
| HOL1 protein network | https://string-db.org/network/4932.YNR055C | Protein HOL1; Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histid [...] |
| BIO5 protein network | https://string-db.org/network/4932.YNR056C | 7-keto 8-aminopelargonic acid transporter; Putative transmembrane protein involved in the biotin biosynthesis; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 g [...] |
| BIO4 protein network | https://string-db.org/network/4932.YNR057C | Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acqu [...] |
| BIO3 protein network | https://string-db.org/network/4932.YNR058W | 7,8-diamino-pelargonic acid aminotransferase (DAPA); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synth [...] |
| MNT4 protein network | https://string-db.org/network/4932.YNR059W | Probable alpha-1,3-mannosyltransferase MNT4; Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic ret [...] |
| FRE4 protein network | https://string-db.org/network/4932.YNR060W | Ferric reductase transmembrane component 4; Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels. |
| YNR061C protein network | https://string-db.org/network/4932.YNR061C | Uncharacterized vacuolar membrane protein YNR061C; Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress. |
| YNR062C protein network | https://string-db.org/network/4932.YNR062C | Putative membrane protein of unknown function. |
| YNR063W protein network | https://string-db.org/network/4932.YNR063W | Uncharacterized transcriptional regulatory protein YNR063W; Putative zinc-cluster protein of unknown function. |
| YNR064C protein network | https://string-db.org/network/4932.YNR064C | Uncharacterized hydrolase YNR064C; Epoxide hydrolase; member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides; Belongs to the DmpD/TodF/XylF esterase family. |
| YNR065C protein network | https://string-db.org/network/4932.YNR065C | Uncharacterized membrane glycoprotein YNR065C; Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene. |
| YNR066C protein network | https://string-db.org/network/4932.YNR066C | Uncharacterized membrane glycoprotein YNR066C; Putative membrane-localized protein of unknown function. |
| DSE4 protein network | https://string-db.org/network/4932.YNR067C | Endo-1,3(4)-beta-glucanase 1; Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother. |
| YNR068C protein network | https://string-db.org/network/4932.YNR068C | Uncharacterized protein YNR068C; Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed [...] |
| BSC5 protein network | https://string-db.org/network/4932.YNR069C | Bypass of stop codon protein 5; Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent m [...] |
| PDR18 protein network | https://string-db.org/network/4932.YNR070W | Putative transporter of the ATP-binding cassette (ABC) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and c [...] |
| YNR071C protein network | https://string-db.org/network/4932.YNR071C | Uncharacterized isomerase YNR071C; Putative aldose 1-epimerase; Belongs to the aldose epimerase family. |
| HXT17 protein network | https://string-db.org/network/4932.YNR072W | Hexose transporter HXT17; Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexos [...] |
| MAN2 protein network | https://string-db.org/network/4932.YNR073C | Mannitol dehydrogenase; MAN2 has a paralog, DSF1, that arose from a segmental duplication. |
| AIF1 protein network | https://string-db.org/network/4932.YNR074C | Apoptosis-inducing factor 1; Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase; B [...] |
| YNR075C-A protein network | https://string-db.org/network/4932.YNR075C-A | Putative UPF0377 protein YNR075C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; Belongs to the UPF0377 fami [...] |
| COS10 protein network | https://string-db.org/network/4932.YNR075W | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting [...] |
| PAU6 protein network | https://string-db.org/network/4932.YNR076W | Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to [...] |
| YNR077C protein network | https://string-db.org/network/4932.YNR077C | UPF0320 protein YNR077C; Protein of unknown function, abundance changes with carbon source. |
| PHO80 protein network | https://string-db.org/network/4932.YOL001W | PHO85 cyclin PHO80; Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation a [...] |
| IZH2 protein network | https://string-db.org/network/4932.YOL002C | ADIPOR-like receptor IZH2; Plasma membrane receptor for plant antifungal osmotin; involved in zinc ion homeostasis, apoptosis; negatively regulates ZRT1 and other functionally divergent genes thr [...] |
| PFA4 protein network | https://string-db.org/network/4932.YOL003C | Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the D [...] |
| SIN3 protein network | https://string-db.org/network/4932.YOL004W | Transcriptional regulatory protein SIN3; Component of both the Rpd3S and Rpd3L histone deacetylase complexes; involved in transcriptional repression and activation of diverse processes, including [...] |
| RPB11 protein network | https://string-db.org/network/4932.YOL005C | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. |
| TOP1 protein network | https://string-db.org/network/4932.YOL006C | DNA topoisomerase 1; Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoil [...] |
| CSI2 protein network | https://string-db.org/network/4932.YOL007C | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not a [...] |
| COQ10 protein network | https://string-db.org/network/4932.YOL008W | Coenzyme Q-binding protein COQ10, mitochondrial; Coenzyme Q (ubiquinone) binding protein; functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respirati [...] |
| MDM12 protein network | https://string-db.org/network/4932.YOL009C | Mitochondrial distribution and morphology protein 12; Mitochondrial outer membrane protein, ERMES complex subunit; required for transmission of mitochondria to daughter cells; required for mitoph [...] |
| RCL1 protein network | https://string-db.org/network/4932.YOL010W | RNA 3'-terminal phosphate cyclase-like protein; Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in smal [...] |
| PLB3 protein network | https://string-db.org/network/4932.YOL011W | Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, tha [...] |
| HTZ1 protein network | https://string-db.org/network/4932.YOL012C | Histone variant H2AZ; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; Htz1p-contai [...] |
| HRD1 protein network | https://string-db.org/network/4932.YOL013C | ERAD-associated E3 ubiquitin-protein ligase HRD1; Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation [...] |
| YOL014W protein network | https://string-db.org/network/4932.YOL014W | Putative protein of unknown function; mCherry fusion protein localizes to the cytosol and nucleus. |
| IRC10 protein network | https://string-db.org/network/4932.YOL015W | Uncharacterized protein IRC10; Protein of unknown function; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the pr [...] |
| CMK2 protein network | https://string-db.org/network/4932.YOL016C | Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian [...] |
| ESC8 protein network | https://string-db.org/network/4932.YOL017W | Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IO [...] |
| TLG2 protein network | https://string-db.org/network/4932.YOL018C | t-SNARE affecting a late Golgi compartment protein 2; Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; required al [...] |
| YOL019W protein network | https://string-db.org/network/4932.YOL019W | Uncharacterized membrane protein YOL019W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, tha [...] |
| YOL019W-A protein network | https://string-db.org/network/4932.YOL019W-A | Uncharacterized protein YOL019W-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| TAT2 protein network | https://string-db.org/network/4932.YOL020W | High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance. |
| DIS3 protein network | https://string-db.org/network/4932.YOL021C | Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degra [...] |
| TSR4 protein network | https://string-db.org/network/4932.YOL022C | 20S rRNA accumulation protein 4; Cytoplasmic protein required for correct processing of 20S pre-rRNA; protein required for processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; es [...] |
| IFM1 protein network | https://string-db.org/network/4932.YOL023W | Mitochondrial translation initiation factor 2. |
| YOL024W protein network | https://string-db.org/network/4932.YOL024W | Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication. |
| LAG2 protein network | https://string-db.org/network/4932.YOL025W | Cullin-associated NEDD8-dissociated protein 1 homolog; Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit [...] |
| MIM1 protein network | https://string-db.org/network/4932.YOL026C | Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom2 [...] |
| MDM38 protein network | https://string-db.org/network/4932.YOL027C | Mitochondrial distribution and morphology protein 38; Mitochondrial protein; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in [...] |
| YAP7 protein network | https://string-db.org/network/4932.YOL028C | Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication. |
| YOL029C protein network | https://string-db.org/network/4932.YOL029C | Uncharacterized protein YOL029C; Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens. |
| GAS5 protein network | https://string-db.org/network/4932.YOL030W | 1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall; Belongs to the glycosyl hydrolase 72 family. |
| SIL1 protein network | https://string-db.org/network/4932.YOL031C | Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein [...] |
| OPI10 protein network | https://string-db.org/network/4932.YOL032W | Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to [...] |
| MSE1 protein network | https://string-db.org/network/4932.YOL033W | Glutamate--tRNA ligase, mitochondrial; Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated; Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type [...] |
| SMC5 protein network | https://string-db.org/network/4932.YOL034W | Structural maintenance of chromosomes protein 5; Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chrom [...] |
| YOL036W protein network | https://string-db.org/network/4932.YOL036W | Uncharacterized protein YOL036W; Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication. |
| YOL038C-A protein network | https://string-db.org/network/4932.YOL038C-A | Uncharacterized protein YOL038C-A; Putative protein of unknown function; identified by SAGE analysis. |
| PRE6 protein network | https://string-db.org/network/4932.YOL038W | Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mi [...] |
| RPP2A protein network | https://string-db.org/network/4932.YOL039W | 60S acidic ribosomal protein P2-alpha; Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the riboso [...] |
| RPS15 protein network | https://string-db.org/network/4932.YOL040C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19. |
| NOP12 protein network | https://string-db.org/network/4932.YOL041C | Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Ns [...] |
| NGL1 protein network | https://string-db.org/network/4932.YOL042W | RNA exonuclease NGL1; Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly pu [...] |
| NTG2 protein network | https://string-db.org/network/4932.YOL043C | Endonuclease III homolog 2; DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose fr [...] |
| PEX15 protein network | https://string-db.org/network/4932.YOL044W | Tail-anchored type II integral peroxisomal membrane protein; required for peroxisome biogenesis; cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol; overexpression results in [...] |
| PSK2 protein network | https://string-db.org/network/4932.YOL045W | Serine/threonine-protein kinase PSK2; PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and [...] |
| LDS2 protein network | https://string-db.org/network/4932.YOL047C | Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds1p and Rrt8p, and a strain mutant for all 3 genes exhi [...] |
| RRT8 protein network | https://string-db.org/network/4932.YOL048C | Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identi [...] |
| GSH2 protein network | https://string-db.org/network/4932.YOL049W | Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock. |
| GAL11 protein network | https://string-db.org/network/4932.YOL051W | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and r [...] |
| SPE2 protein network | https://string-db.org/network/4932.YOL052C | S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when [...] |
| DDR2 protein network | https://string-db.org/network/4932.YOL052C-A | Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the w [...] |
| AIM39 protein network | https://string-db.org/network/4932.YOL053W | Protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss; Belongs to the AIM39 family. |
| PSH1 protein network | https://string-db.org/network/4932.YOL054W | RING finger protein PSH1; E3 ubiquitin ligase targeting centromere-binding protein Cse4p; mediates polyubiquitination and degradation of histone H3 variant Cse4p, preventing its mislocalization t [...] |
| THI20 protein network | https://string-db.org/network/4932.YOL055C | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20; Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP- [...] |
| GPM3 protein network | https://string-db.org/network/4932.YOL056W | Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM3 has a paralog, GPM2, that arose from the whole genome duplic [...] |
| YOL057W protein network | https://string-db.org/network/4932.YOL057W | Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for so [...] |
| ARG1 protein network | https://string-db.org/network/4932.YOL058W | Argininosuccinate synthase; Arginosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p subst [...] |
| GPD2 protein network | https://string-db.org/network/4932.YOL059W | Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial; NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to reg [...] |
| MAM3 protein network | https://string-db.org/network/4932.YOL060C | Protein required for normal mitochondrial morphology; has similarity to hemolysins. |
| PRS5 protein network | https://string-db.org/network/4932.YOL061W | Ribose-phosphate pyrophosphokinase 5; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five [...] |
| APM4 protein network | https://string-db.org/network/4932.YOL062C | Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required f [...] |
| CRT10 protein network | https://string-db.org/network/4932.YOL063C | Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region h [...] |
| MET22 protein network | https://string-db.org/network/4932.YOL064C | Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of t [...] |
| INP54 protein network | https://string-db.org/network/4932.YOL065C | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; role in secretion; localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the [...] |
| RIB2 protein network | https://string-db.org/network/4932.YOL066C | Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in [...] |
| RTG1 protein network | https://string-db.org/network/4932.YOL067C | Retrograde regulation protein 1; Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p [...] |
| HST1 protein network | https://string-db.org/network/4932.YOL068C | NAD-dependent protein deacetylase HST1; NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-e [...] |
| NUF2 protein network | https://string-db.org/network/4932.YOL069W | Kinetochore protein NUF2; Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conser [...] |
| NBA1 protein network | https://string-db.org/network/4932.YOL070C | Protein of unknown function; localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate. |
| SDH5 protein network | https://string-db.org/network/4932.YOL071W | Succinate dehydrogenase assembly factor 2, mitochondrial; Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydr [...] |
| THP1 protein network | https://string-db.org/network/4932.YOL072W | Nuclear mRNA export protein THP1; Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; in [...] |
| DSC2 protein network | https://string-db.org/network/4932.YOL073C | Multi-transmembrane subunit of the DSC ubiquitin ligase complex; similar in sequence to rhomboid pseudoproteases Der1p and UBAC2 that function in ERAD; ortholog of fission yeast dsc2. |
| YOL075C protein network | https://string-db.org/network/4932.YOL075C | Uncharacterized ABC transporter ATP-binding protein/permease YOL075C; Putative ABC transporter; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. |
| MDM20 protein network | https://string-db.org/network/4932.YOL076W | Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assemb [...] |
| BRX1 protein network | https://string-db.org/network/4932.YOL077C | Ribosome biogenesis protein BRX1; Nucleolar protein; constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subun [...] |
| ATP19 protein network | https://string-db.org/network/4932.YOL077W-A | Subunit k of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP sy [...] |
| AVO1 protein network | https://string-db.org/network/4932.YOL078W | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell grow [...] |
| YOL079W protein network | https://string-db.org/network/4932.YOL079W | Putative uncharacterized membrane protein YOL079W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| REX4 protein network | https://string-db.org/network/4932.YOL080C | Putative RNA exonuclease; possibly involved in pre-rRNA processing and ribosome assembly. |
| IRA2 protein network | https://string-db.org/network/4932.YOL081W | Inhibitory regulator protein IRA2; GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutri [...] |
| ATG19 protein network | https://string-db.org/network/4932.YOL082W | Autophagy-related protein 19; Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagopho [...] |
| YOL083C-A protein network | https://string-db.org/network/4932.YOL083C-A | Uncharacterized protein YOL083C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression pro [...] |
| ATG34 protein network | https://string-db.org/network/4932.YOL083W | Autophagy-related protein 34; Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog [...] |
| PHM7 protein network | https://string-db.org/network/4932.YOL084W | Phosphate metabolism protein 7; Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuol [...] |
| YOL085C protein network | https://string-db.org/network/4932.YOL085C | Uncharacterized protein YOL085C; Putative protein of unknown function; conserved among S. cerevisiae strains; YOL085C is not an essential gene; partially overlaps dubious ORF YOL085W-A. |
| ADH1 protein network | https://string-db.org/network/4932.YOL086C | Alcohol dehydrogenase; fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; ADH1 has a paralog, [...] |
| MHF1 protein network | https://string-db.org/network/4932.YOL086W-A | Inner kinetochore subunit MHF1; Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complement [...] |
| DUF1 protein network | https://string-db.org/network/4932.YOL087C | DUB-associated factor 1; Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplas [...] |
| MPD2 protein network | https://string-db.org/network/4932.YOL088C | Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; underg [...] |
| HAL9 protein network | https://string-db.org/network/4932.YOL089C | Halotolerance protein 9; Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene whi [...] |
| MSH2 protein network | https://string-db.org/network/4932.YOL090W | Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for [...] |
| SPO21 protein network | https://string-db.org/network/4932.YOL091W | Sporulation-specific protein 21; Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formati [...] |
| YPQ1 protein network | https://string-db.org/network/4932.YOL092W | Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, wit [...] |
| TRM10 protein network | https://string-db.org/network/4932.YOL093W | tRNA methyltransferase; methylates the N-1 position of guanine at position 9 in tRNAs; protein abundance increases in response to DNA replication stress; member of the SPOUT (SpoU-TrmD) methyltra [...] |
| RFC4 protein network | https://string-db.org/network/4932.YOL094C | Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor [...] |
| HMI1 protein network | https://string-db.org/network/4932.YOL095C | Mitochondrial inner membrane localized ATP-dependent DNA helicase; required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli [...] |
| COQ3 protein network | https://string-db.org/network/4932.YOL096C | O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein; Belongs to [...] |
| WRS1 protein network | https://string-db.org/network/4932.YOL097C | Tryptophan--tRNA ligase, cytoplasmic; Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant; Belongs to the class-I aminoa [...] |
| YOL097W-A protein network | https://string-db.org/network/4932.YOL097W-A | Uncharacterized protein YOL097W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| SDD3 protein network | https://string-db.org/network/4932.YOL098C | Uncharacterized protein YOL098C; Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. |
| PKH2 protein network | https://string-db.org/network/4932.YOL100W | Serine/threonine-protein kinase PKH2; Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of sign [...] |
| IZH4 protein network | https://string-db.org/network/4932.YOL101C | ADIPOR-like receptor IZH4; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces se [...] |
| TPT1 protein network | https://string-db.org/network/4932.YOL102C | tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide. |
| ITR2 protein network | https://string-db.org/network/4932.YOL103W | Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication; Belongs to the major facil [...] |
| NDJ1 protein network | https://string-db.org/network/4932.YOL104C | Non-disjunction protein 1; Protein that regulates meiotic SPB cohesion and telomere clustering; localizes to both spindle pole bodies (SPBs) and telomeres; required for bouquet formation, effecti [...] |
| WSC3 protein network | https://string-db.org/network/4932.YOL105C | Cell wall integrity and stress response component 3; Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to [...] |
| YOL107W protein network | https://string-db.org/network/4932.YOL107W | Transmembrane protein 115 homolog; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the e [...] |
| INO4 protein network | https://string-db.org/network/4932.YOL108C | Protein INO4; Transcription factor involved in phospholipid synthesis; required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2 [...] |
| ZEO1 protein network | https://string-db.org/network/4932.YOL109W | Protein ZEO1; Peripheral membrane protein of the plasma membrane; interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a ph [...] |
| SHR5 protein network | https://string-db.org/network/4932.YOL110W | Ras modification protein ERF4; Palmitoyltransferase subunit; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoy [...] |
| MDY2 protein network | https://string-db.org/network/4932.YOL111C | Ubiquitin-like protein MDY2; Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuc [...] |
| MSB4 protein network | https://string-db.org/network/4932.YOL112W | GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; sim [...] |
| SKM1 protein network | https://string-db.org/network/4932.YOL113W | Serine/threonine-protein kinase SKM1; Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream ef [...] |
| PTH4 protein network | https://string-db.org/network/4932.YOL114C | Putative uncharacterized protein YOL114C; Protein similar to the human peptidyl-tRNA hydrolase gene ICT1; associates with mitochondrial large subunit; may function in translation termination; YOL [...] |
| PAP2 protein network | https://string-db.org/network/4932.YOL115W | Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA s [...] |
| MSN1 protein network | https://string-db.org/network/4932.YOL116W | Protein MSN1; Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and [...] |
| RRI2 protein network | https://string-db.org/network/4932.YOL117W | Subunit of the COP9 signalosome (CSN) complex; this complex cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response. |
| YOL118C protein network | https://string-db.org/network/4932.YOL118C | Uncharacterized protein YOL118C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| MCH4 protein network | https://string-db.org/network/4932.YOL119C | Probable transporter MCH4; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane b [...] |
| RPL18A protein network | https://string-db.org/network/4932.YOL120C | Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18 [...] |
| RPS19A protein network | https://string-db.org/network/4932.YOL121C | Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations [...] |
| SMF1 protein network | https://string-db.org/network/4932.YOL122C | Manganese transporter SMF1; Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp fami [...] |
| HRP1 protein network | https://string-db.org/network/4932.YOL123W | Nuclear polyadenylated RNA-binding protein 4; Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-cont [...] |
| TRM11 protein network | https://string-db.org/network/4932.YOL124C | Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methy [...] |
| TRM13 protein network | https://string-db.org/network/4932.YOL125W | tRNA:m(4)X modification enzyme TRM13; 2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyl [...] |
| MDH2 protein network | https://string-db.org/network/4932.YOL126C | Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon [...] |
| RPL25 protein network | https://string-db.org/network/4932.YOL127W | Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosom [...] |
| YGK3 protein network | https://string-db.org/network/4932.YOL128C | Glycogen synthase kinase-3 homolog YGK3; Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-depende [...] |
| VPS68 protein network | https://string-db.org/network/4932.YOL129W | Vacuolar membrane protein of unknown function; involved in vacuolar protein sorting; also detected in the mitochondria; Belongs to the UPF0220 family. |
| ALR1 protein network | https://string-db.org/network/4932.YOL130W | Magnesium transporter ALR1; Plasma membrane Mg(2+) transporter; expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions [...] |
| YOL131W protein network | https://string-db.org/network/4932.YOL131W | Putative protein of unknown function; YOL131W has a paralog, STB1, that arose from the whole genome duplication. |
| GAS4 protein network | https://string-db.org/network/4932.YOL132W | 1,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall. |
| HRT1 protein network | https://string-db.org/network/4932.YOL133W | RING-box protein HRT1; RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is [...] |
| YOL134C protein network | https://string-db.org/network/4932.YOL134C | Putative uncharacterized protein YOL134C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps HR [...] |
| MED7 protein network | https://string-db.org/network/4932.YOL135C | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation. |
| PFK27 protein network | https://string-db.org/network/4932.YOL136C | 6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptiona [...] |
| BSC6 protein network | https://string-db.org/network/4932.YOL137W | Bypass of stop codon protein 6; Protein of unknown function with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of [...] |
| RTC1 protein network | https://string-db.org/network/4932.YOL138C | Restriction of telomere capping protein 1; Subunit of SEACAT, a subcomplex of the SEA complex; Rtc1p, along with Mtc5p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT [...] |
| CDC33 protein network | https://string-db.org/network/4932.YOL139C | mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation fa [...] |
| ARG8 protein network | https://string-db.org/network/4932.YOL140W | Acetylornithine aminotransferase, mitochondrial; Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; Belongs to the class-III pyri [...] |
| PPM2 protein network | https://string-db.org/network/4932.YOL141W | tRNA wybutosine-synthesizing protein 4; AdoMet-dependent tRNA methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found a [...] |
| RRP40 protein network | https://string-db.org/network/4932.YOL142W | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; mutations in [...] |
| RIB4 protein network | https://string-db.org/network/4932.YOL143C | Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase. |
| NOP8 protein network | https://string-db.org/network/4932.YOL144W | Nucleolar protein required for 60S ribosomal subunit biogenesis. |
| CTR9 protein network | https://string-db.org/network/4932.YOL145C | RNA polymerase-associated protein CTR9; Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expressi [...] |
| PSF3 protein network | https://string-db.org/network/4932.YOL146W | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery. |
| PEX11 protein network | https://string-db.org/network/4932.YOL147C | Peroxisomal protein required for medium-chain fatty acid oxidation; also required for peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; [...] |
| SPT20 protein network | https://string-db.org/network/4932.YOL148C | Transcription factor SPT20; Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G [...] |
| DCP1 protein network | https://string-db.org/network/4932.YOL149W | Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regula [...] |
| GRE2 protein network | https://string-db.org/network/4932.YOL151W | 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance t [...] |
| FRE7 protein network | https://string-db.org/network/4932.YOL152W | Ferric/cupric reductase transmembrane component 7; Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels. |
| ZPS1 protein network | https://string-db.org/network/4932.YOL154W | Protein ZPS1; Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH; Belongs to the ZPS1 family. |
| HPF1 protein network | https://string-db.org/network/4932.YOL155C | Haze-protective mannoprotein; reduces the particle size of aggregated proteins in white wines. |
| YOL155W-A protein network | https://string-db.org/network/4932.YOL155W-A | Uncharacterized protein YOL155W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| HXT11 protein network | https://string-db.org/network/4932.YOL156W | Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol w [...] |
| IMA2 protein network | https://string-db.org/network/4932.YOL157C | Oligo-1,6-glucosidase IMA2; Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 gl [...] |
| ENB1 protein network | https://string-db.org/network/4932.YOL158C | Siderophore iron transporter ENB1; Endosomal ferric enterobactin transporter; expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated [...] |
| CSS3 protein network | https://string-db.org/network/4932.YOL159C | Protein of unknown function, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extra [...] |
| YOL159C-A protein network | https://string-db.org/network/4932.YOL159C-A | Uncharacterized protein YOL159C-A; Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species. |
| YOL160W protein network | https://string-db.org/network/4932.YOL160W | Uncharacterized protein YOL160W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| PAU20 protein network | https://string-db.org/network/4932.YOL161C | Seripauperin-20; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; exp [...] |
| YOL162W protein network | https://string-db.org/network/4932.YOL162W | Putative uncharacterized transporter YOL162W; Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family. |
| YOL163W protein network | https://string-db.org/network/4932.YOL163W | Putative uncharacterized transporter YOL163W; Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family. |
| BDS1 protein network | https://string-db.org/network/4932.YOL164W | Alkyl/aryl-sulfatase BDS1; Bacterially-derived sulfatase; required for use of alkyl- and aryl-sulfates as sulfur sources; Belongs to the metallo-beta-lactamase superfamily. |
| YOL164W-A protein network | https://string-db.org/network/4932.YOL164W-A | Uncharacterized protein YOL164W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| AAD15 protein network | https://string-db.org/network/4932.YOL165C | Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD15 has a paralog, AAD3, that arose f [...] |
| YOL166C protein network | https://string-db.org/network/4932.YOL166C | Putative uncharacterized protein YOL166C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YOL166W-A protein network | https://string-db.org/network/4932.YOL166W-A | UPF0320 protein YOL166W-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; Belongs to the UPF0320 family. |
| RRP6 protein network | https://string-db.org/network/4932.YOR001W | Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in [...] |
| ALG6 protein network | https://string-db.org/network/4932.YOR002W | Alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; C998T transition in h [...] |
| YSP3 protein network | https://string-db.org/network/4932.YOR003W | Putative precursor of the subtilisin-like protease III; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YSP3 has a paralog, PRB1, that arose from the whole genome dupl [...] |
| UTP23 protein network | https://string-db.org/network/4932.YOR004W | rRNA-processing protein UTP23; Component of the small subunit processome; involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large p [...] |
| DNL4 protein network | https://string-db.org/network/4932.YOR005C | DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mu [...] |
| TSR3 protein network | https://string-db.org/network/4932.YOR006C | Ribosome biogenesis protein TSR3; Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-f [...] |
| SGT2 protein network | https://string-db.org/network/4932.YOR007C | Small glutamine-rich tetratricopeptide repeat-containing protein 2; Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that [...] |
| SLG1 protein network | https://string-db.org/network/4932.YOR008C | Protein SLG1; Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cyt [...] |
| YOR008W-B protein network | https://string-db.org/network/4932.YOR008W-B | Putative uncharacterized protein YOR008W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| TIR4 protein network | https://string-db.org/network/4932.YOR009W | Cell wall mannoprotein; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; member of the Srp1p/Tip1p family of serine-alanine-ric [...] |
| TIR2 protein network | https://string-db.org/network/4932.YOR010C | Cold shock-induced protein TIR2; Putative cell wall mannoprotein; member of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis; TIR2 h [...] |
| AUS1 protein network | https://string-db.org/network/4932.YOR011W | ATP-dependent permease AUS1; Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the p [...] |
| YOR011W-A protein network | https://string-db.org/network/4932.YOR011W-A | Uncharacterized protein YOR011W-A; Putative protein of unknown function. |
| YOR012W protein network | https://string-db.org/network/4932.YOR012W | Uncharacterized protein YOR012W; Putative protein of unknown function. |
| IRC11 protein network | https://string-db.org/network/4932.YOR013W | Putative increased recombination centers protein 11; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially [...] |
| RTS1 protein network | https://string-db.org/network/4932.YOR014W | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits f [...] |
| YOR015W protein network | https://string-db.org/network/4932.YOR015W | Uncharacterized protein YOR015W; Putative protein of unknown function; conserved among S. cerevisiae strains; YOR015W is not an essential gene. |
| ERP4 protein network | https://string-db.org/network/4932.YOR016C | Protein ERP4; Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; ERP4 has a paralog, ERP2, that arose from the whole genome duplication; Belongs to the EMP2 [...] |
| PET127 protein network | https://string-db.org/network/4932.YOR017W | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. |
| ROD1 protein network | https://string-db.org/network/4932.YOR018W | Protein ROD1; Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is requir [...] |
| YOR019W protein network | https://string-db.org/network/4932.YOR019W | Uncharacterized protein YOR019W; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YOR019W has a paralog, JIP4, that arose from the whole genome dupl [...] |
| HSP10 protein network | https://string-db.org/network/4932.YOR020C | 10 kDa heat shock protein, mitochondrial; Mitochondrial matrix co-chaperonin; inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mi [...] |
| YOR020W-A protein network | https://string-db.org/network/4932.YOR020W-A | Uncharacterized protein YOR020W-A; Putative protein of unknown function; conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput [...] |
| SFM1 protein network | https://string-db.org/network/4932.YOR021C | Protein arginine N-methyltransferase SFM1; SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and rib [...] |
| DDL1 protein network | https://string-db.org/network/4932.YOR022C | DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipi [...] |
| AHC1 protein network | https://string-db.org/network/4932.YOR023C | Protein AHC1; Subunit of the Ada histone acetyltransferase complex; required for structural integrity of the complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related [...] |
| YOR024W protein network | https://string-db.org/network/4932.YOR024W | Putative uncharacterized protein YOR024W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| HST3 protein network | https://string-db.org/network/4932.YOR025W | NAD-dependent histone deacetylase HST3; Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation res [...] |
| BUB3 protein network | https://string-db.org/network/4932.YOR026W | Cell cycle arrest protein BUB3; Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; fo [...] |
| STI1 protein network | https://string-db.org/network/4932.YOR027W | Heat shock protein STI1; Hsp90 cochaperone; regulates spatial organization of amyloid-like proteins in the cytosol, thereby buffering the proteotoxicity caused by amyloid-like proteins; interacts [...] |
| CIN5 protein network | https://string-db.org/network/4932.YOR028C | Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and s [...] |
| YOR029W protein network | https://string-db.org/network/4932.YOR029W | Uncharacterized protein YOR029W; Putative protein of unknown function; conserved among S. cerevisiae strains; YOR029W is not an essential gene. |
| DFG16 protein network | https://string-db.org/network/4932.YOR030W | Protein DFG16; Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p an [...] |
| HMS1 protein network | https://string-db.org/network/4932.YOR032C | bHLH protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozy [...] |
| YOR032W-A protein network | https://string-db.org/network/4932.YOR032W-A | Uncharacterized protein YOR032W-A; Protein of unknown function; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum; identified by gene-trapping, microarray-based expr [...] |
| EXO1 protein network | https://string-db.org/network/4932.YOR033C | Exodeoxyribonuclease 1; 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismat [...] |
| AKR2 protein network | https://string-db.org/network/4932.YOR034C | Probable palmitoyltransferase AKR2; Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly [...] |
| YOR034C-A protein network | https://string-db.org/network/4932.YOR034C-A | Uncharacterized membrane protein YOR034C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| SHE4 protein network | https://string-db.org/network/4932.YOR035C | SWI5-dependent HO expression protein 4; Protein containing a UCS (UNC-45/CRO1/SHE4) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the [...] |
| PEP12 protein network | https://string-db.org/network/4932.YOR036W | Syntaxin PEP12; Target membrane receptor (t-SNARE); for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde tr [...] |
| CYC2 protein network | https://string-db.org/network/4932.YOR037W | Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme [...] |
| HIR2 protein network | https://string-db.org/network/4932.YOR038C | Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene [...] |
| CKB2 protein network | https://string-db.org/network/4932.YOR039W | Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including [...] |
| GLO4 protein network | https://string-db.org/network/4932.YOR040W | Hydroxyacylglutathione hydrolase, mitochondrial; Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that aro [...] |
| YOR041C protein network | https://string-db.org/network/4932.YOR041C | Putative uncharacterized protein YOR041C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| CUE5 protein network | https://string-db.org/network/4932.YOR042W | Ubiquitin-binding protein; functions as ubiquitin-Atg8p adaptor in ubiquitin-dependent autophagy; serves as proteaphagy receptor for inactivated 26S proteasomes; contains CUE domain that binds ub [...] |
| WHI2 protein network | https://string-db.org/network/4932.YOR043W | Growth regulation protein; Protein required for full activation of the general stress response; required with binding partner Psr1p, possibly through Msn2p dephosphorylation; regulates growth dur [...] |
| IRC23 protein network | https://string-db.org/network/4932.YOR044W | Increased recombination centers protein 23; Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p fo [...] |
| TOM6 protein network | https://string-db.org/network/4932.YOR045W | Mitochondrial import receptor subunit TOM6; Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed pro [...] |
| DBP5 protein network | https://string-db.org/network/4932.YOR046C | Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus, remodeling messenger ribonucleoprotein particles (mRNPs), with ATPase activity stimulated [...] |
| STD1 protein network | https://string-db.org/network/4932.YOR047C | Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; inter [...] |
| RAT1 protein network | https://string-db.org/network/4932.YOR048C | 5'-3' exoribonuclease 2; Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism, including rRNA and snoRNA processing, as well as poly (A+) dependent and independent mRNA tr [...] |
| RSB1 protein network | https://string-db.org/network/4932.YOR049C | Putative sphingoid long-chain base (LCB) efflux transporter; integral membrane transporter that localizes to the plasma membrane and may transport long chain bases (LCBs) from the cytoplasmic sid [...] |
| YOR050C protein network | https://string-db.org/network/4932.YOR050C | Putative uncharacterized protein YOR050C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant is viable [...] |
| ETT1 protein network | https://string-db.org/network/4932.YOR051C | Enhancer of translation termination 1; Nuclear protein that inhibits replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in [...] |
| TMC1 protein network | https://string-db.org/network/4932.YOR052C | AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived [...] |
| YOR053W protein network | https://string-db.org/network/4932.YOR053W | Putative uncharacterized protein YOR053W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| VHS3 protein network | https://string-db.org/network/4932.YOR054C | Phosphopantothenoylcysteine decarboxylase subunit VHS3; Negative regulatory subunit of protein phosphatase 1 Ppz1p; involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine [...] |
| YOR055W protein network | https://string-db.org/network/4932.YOR055W | Putative uncharacterized protein YOR055W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| NOB1 protein network | https://string-db.org/network/4932.YOR056C | 20S-pre-rRNA D-site endonuclease NOB1; Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is [...] |
| SGT1 protein network | https://string-db.org/network/4932.YOR057W | Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as [...] |
| ASE1 protein network | https://string-db.org/network/4932.YOR058C | Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulat [...] |
| LPL1 protein network | https://string-db.org/network/4932.YOR059C | Lipid droplet phospholipase 1; Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in [...] |
| SLD7 protein network | https://string-db.org/network/4932.YOR060C | Mitochondrial morphogenesis protein SLD7; Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria. |
| CKA2 protein network | https://string-db.org/network/4932.YOR061W | Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates in [...] |
| YOR062C protein network | https://string-db.org/network/4932.YOR062C | Uncharacterized protein YOR062C; Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; [...] |
| RPL3 protein network | https://string-db.org/network/4932.YOR063W | Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3' end processing of 18S rRNA in conte [...] |
| YNG1 protein network | https://string-db.org/network/4932.YOR064C | Protein YNG1; Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; shares significant s [...] |
| CYT1 protein network | https://string-db.org/network/4932.YOR065W | Cytochrome c1, heme protein, mitochondrial; Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT- [...] |
| MSA1 protein network | https://string-db.org/network/4932.YOR066W | Activator of G1-specific transcription factors MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent [...] |
| ALG8 protein network | https://string-db.org/network/4932.YOR067C | Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Glucosyl transferase; involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior [...] |
| VAM10 protein network | https://string-db.org/network/4932.YOR068C | Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering. |
| VPS5 protein network | https://string-db.org/network/4932.YOR069W | Nexin-1 homolog; required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to late Golgi; structural component of retromer membrane coat complex; forms a retrom [...] |
| GYP1 protein network | https://string-db.org/network/4932.YOR070C | Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion. |
| NRT1 protein network | https://string-db.org/network/4932.YOR071C | High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine) uptake; share [...] |
| YOR072W protein network | https://string-db.org/network/4932.YOR072W | Uncharacterized protein YOR072W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious [...] |
| YOR072W-B protein network | https://string-db.org/network/4932.YOR072W-B | Uncharacterized protein YOR072W-B; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| SGO1 protein network | https://string-db.org/network/4932.YOR073W | Shugoshin; Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation [...] |
| YOR073W-A protein network | https://string-db.org/network/4932.YOR073W-A | Putative uncharacterized protein YOR073W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completel [...] |
| CDC21 protein network | https://string-db.org/network/4932.YOR074C | Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; human homolog TYMSOS can complement yeast cdc21 temperature-sensitive mu [...] |
| UFE1 protein network | https://string-db.org/network/4932.YOR075W | Syntaxin UFE1; t-SNARE protein required for retrograde vesicular traffic; involved in Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex w [...] |
| SKI7 protein network | https://string-db.org/network/4932.YOR076C | Superkiller protein 7; GTP-binding protein that couples the Ski complex and exosome; putative pseudo-translational GTPase involved in 3'-to-5' mRNA decay pathway; interacts with both the cytoplas [...] |
| RTS2 protein network | https://string-db.org/network/4932.YOR077W | Basic zinc-finger protein; similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication. |
| BUD21 protein network | https://string-db.org/network/4932.YOR078W | Bud site selection protein 21; Component of small ribosomal subunit (SSU) processosome; this complex contains U3 snoRNA; required at post-transcriptional step for efficient retrotransposition; ab [...] |
| ATX2 protein network | https://string-db.org/network/4932.YOR079C | Metal homeostasis factor ATX2; Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation. |
| DIA2 protein network | https://string-db.org/network/4932.YOR080W | Protein DIA2; Origin-binding F-box protein; forms SCF ubiquitin ligase complex with Skp1p and Cdc53p; functions in ubiquitination of silent chromatin structural protein Sir4p; required to target [...] |
| TGL5 protein network | https://string-db.org/network/4932.YOR081C | Lipase 5; Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol (TAG) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysop [...] |
| YOR082C protein network | https://string-db.org/network/4932.YOR082C | Putative uncharacterized protein YOR082C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| WHI5 protein network | https://string-db.org/network/4932.YOR083W | G1-specific transcriptional repressor WHI5; Repressor of G1 transcription; binds to SCB binding factor (SBF) at SCB target promoters in early G1; dilution of Whi5p concentration during cell growt [...] |
| LPX1 protein network | https://string-db.org/network/4932.YOR084W | Peroxisomal membrane protein LPX1; Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxi [...] |
| OST3 protein network | https://string-db.org/network/4932.YOR085W | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3; Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation [...] |
| TCB1 protein network | https://string-db.org/network/4932.YOR086C | Tricalbin-1; Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane and regulate PI4P [...] |
| YVC1 protein network | https://string-db.org/network/4932.YOR087W | Calcium channel YVC1; Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock. |
| VPS21 protein network | https://string-db.org/network/4932.YOR089C | Vacuolar protein sorting-associated protein 21; Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET [...] |
| PTC5 protein network | https://string-db.org/network/4932.YOR090C | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Mitochondrial type 2C protein phosphatase (PP2C); involved in regulation of pyruvate dehydrogenase activity by dephosp [...] |
| TMA46 protein network | https://string-db.org/network/4932.YOR091W | Translation machinery-associated protein 46; Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p. |
| ECM3 protein network | https://string-db.org/network/4932.YOR092W | Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocal [...] |
| CMR2 protein network | https://string-db.org/network/4932.YOR093C | Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents. |
| ARF3 protein network | https://string-db.org/network/4932.YOR094W | Glucose-repressible ADP-ribosylation factor; GTPase of Ras superfamily involved in regulating cell polarity and invasive growth; localizes to dynamic spots at plasma membrane and modulates PtdIns [...] |
| RKI1 protein network | https://string-db.org/network/4932.YOR095C | Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis. |
| RPS7A protein network | https://string-db.org/network/4932.YOR096W | Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS [...] |
| YOR097C protein network | https://string-db.org/network/4932.YOR097C | Uncharacterized protein YOR097C; Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene. |
| NUP1 protein network | https://string-db.org/network/4932.YOR098C | FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of thenuclear pore complex (NPC) permeability barrier; po [...] |
| KTR1 protein network | https://string-db.org/network/4932.YOR099W | Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytopla [...] |
| CRC1 protein network | https://string-db.org/network/4932.YOR100C | Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25 [...] |
| RAS1 protein network | https://string-db.org/network/4932.YOR101W | Ras-like protein 1; GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-on [...] |
| OST2 protein network | https://string-db.org/network/4932.YOR103C | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Epsilon subunit of the oligosaccharyltransferase complex; located in the ER lumen; catalyzes asparagine-linked glycosy [...] |
| PIN2 protein network | https://string-db.org/network/4932.YOR104W | [PSI+] induction protein 2; Exomer-dependent cargo protein; induces appearance of [PIN+] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predic [...] |
| YOR105W protein network | https://string-db.org/network/4932.YOR105W | Uncharacterized protein YOR105W; Protein of unknown function; expressed at both mRNA and protein levels. |
| VAM3 protein network | https://string-db.org/network/4932.YOR106W | Syntaxin-like vacuolar t-SNARE; functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting si [...] |
| RGS2 protein network | https://string-db.org/network/4932.YOR107W | Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p. |
| LEU9 protein network | https://string-db.org/network/4932.YOR108W | Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity d [...] |
| INP53 protein network | https://string-db.org/network/4932.YOR109W | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endo [...] |
| TFC7 protein network | https://string-db.org/network/4932.YOR110W | RNA pol III transcription initiation factor complex (TFIIIC) subunit; part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; TFC7 has a pa [...] |
| YOR111W protein network | https://string-db.org/network/4932.YOR111W | dTTP/UTP pyrophosphatase; Putative protein of unknown function. |
| CEX1 protein network | https://string-db.org/network/4932.YOR112W | Cytoplasmic export protein 1; Component of nuclear aminoacylation-dependent tRNA export pathway; cytoplasmic; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors [...] |
| AZF1 protein network | https://string-db.org/network/4932.YOR113W | Asparagine-rich zinc finger protein AZF1; Zinc-finger transcription factor; involved in diauxic shift; in the presence of glucose, activates transcription of genes involved in growth and carbon m [...] |
| YOR114W protein network | https://string-db.org/network/4932.YOR114W | Uncharacterized protein YOR114W; Putative protein of unknown function; null mutant is viable. |
| TRS33 protein network | https://string-db.org/network/4932.YOR115C | Core component of TRAPP complexes I, II and IV; transport protein particle (TRAPP) complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi tr [...] |
| RPO31 protein network | https://string-db.org/network/4932.YOR116C | RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21; Belongs to the RNA polymerase beta' chain family. |
| RPT5 protein network | https://string-db.org/network/4932.YOR117W | ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promo [...] |
| RTC5 protein network | https://string-db.org/network/4932.YOR118W | Restriction of telomere capping protein 5; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sen [...] |
| RIO1 protein network | https://string-db.org/network/4932.YOR119C | Serine/threonine-protein kinase RIO1; Serine kinase involved in cell cycle regulation and rDNA integrity; associated with late pre-40S particles via its conserved C-terminal domain and participat [...] |
| GCY1 protein network | https://string-db.org/network/4932.YOR120W | Glycerol 2-dehydrogenase (NADP(+)); Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member o [...] |
| YOR121C protein network | https://string-db.org/network/4932.YOR121C | Putative uncharacterized protein YOR121C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame ov [...] |
| PFY1 protein network | https://string-db.org/network/4932.YOR122C | Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to the [...] |
| LEO1 protein network | https://string-db.org/network/4932.YOR123C | RNA polymerase-associated protein LEO1; Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition [...] |
| UBP2 protein network | https://string-db.org/network/4932.YOR124C | Ubiquitin carboxyl-terminal hydrolase 2; Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; controls K63 homeostasis during oxidative stress; deubiquitinates Rsp5p and is [...] |
| CAT5 protein network | https://string-db.org/network/4932.YOR125C | 5-demethoxyubiquinone hydroxylase, mitochondrial; Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex wi [...] |
| IAH1 protein network | https://string-db.org/network/4932.YOR126C | Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; Belongs t [...] |
| RGA1 protein network | https://string-db.org/network/4932.YOR127W | GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cy [...] |
| ADE2 protein network | https://string-db.org/network/4932.YOR128C | Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine. |
| AFI1 protein network | https://string-db.org/network/4932.YOR129C | ARF3-interacting protein 1; Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and mai [...] |
| ORT1 protein network | https://string-db.org/network/4932.YOR130C | Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; functionally complemented by human ortholog, SLC25A15, which is as [...] |
| YOR131C protein network | https://string-db.org/network/4932.YOR131C | Uncharacterized hydrolase YOR131C; Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response t [...] |
| VPS17 protein network | https://string-db.org/network/4932.YOR132W | Vacuolar protein sorting-associated protein 17; Subunit of the membrane-associated retromer complex; essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that [...] |
| EFT1 protein network | https://string-db.org/network/4932.YOR133W | Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue speci [...] |
| BAG7 protein network | https://string-db.org/network/4932.YOR134W | Rho-GTPase-activating protein BAG7; Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organizati [...] |
| IRC14 protein network | https://string-db.org/network/4932.YOR135C | Putative increased recombination centers protein 14; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially [...] |
| IDH2 protein network | https://string-db.org/network/4932.YOR136W | Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated; Belongs to the isocitrat [...] |
| SIA1 protein network | https://string-db.org/network/4932.YOR137C | Protein of unassigned function; involved in activation of the Pma1p plasma membrane H+-ATPase by glucose; contains peptide signal for membrane localization. |
| RUP1 protein network | https://string-db.org/network/4932.YOR138C | UBA domain-containing protein RUP1; Protein that regulates ubiquitination of Rsp5p; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains a [...] |
| SFL1 protein network | https://string-db.org/network/4932.YOR140W | Flocculation suppression protein; Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; has direct role in INO1 [...] |
| ARP8 protein network | https://string-db.org/network/4932.YOR141C | Actin-like protein ARP8; Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity. |
| LSC1 protein network | https://string-db.org/network/4932.YOR142W | Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylate [...] |
| THI80 protein network | https://string-db.org/network/4932.YOR143C | Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate). |
| ELG1 protein network | https://string-db.org/network/4932.YOR144C | Telomere length regulation protein ELG1; Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in [...] |
| PNO1 protein network | https://string-db.org/network/4932.YOR145C | Pre-rRNA-processing protein PNO1; Essential nucleolar protein required for pre-18S rRNA processing; interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved i [...] |
| YOR146W protein network | https://string-db.org/network/4932.YOR146W | Putative uncharacterized protein YOR146W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame ov [...] |
| MDM32 protein network | https://string-db.org/network/4932.YOR147W | Mitochondrial distribution and morphology protein 32; Mitochondrial inner membrane protein with similarity to Mdm31p; required for normal mitochondrial morphology and inheritance; interacts genet [...] |
| SPP2 protein network | https://string-db.org/network/4932.YOR148C | Pre-mRNA-splicing factor SPP2; Essential protein that promotes the first step of splicing; required for the final stages of spliceosome maturation and activation; interacts with Prp2p, which may [...] |
| SMP3 protein network | https://string-db.org/network/4932.YOR149C | GPI mannosyltransferase 4; Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI cor [...] |
| MRPL23 protein network | https://string-db.org/network/4932.YOR150W | Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2. |
| RPB2 protein network | https://string-db.org/network/4932.YOR151C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. |
| ATG40 protein network | https://string-db.org/network/4932.YOR152C | Autophagy-related protein 40; Autophagy receptor with a role in endoplasmic reticulum degradation; involved specifically in autophagy of cortical and cytoplasmic ER in response to nitrogen starva [...] |
| PDR5 protein network | https://string-db.org/network/4932.YOR153W | Pleiotropic ABC efflux transporter of multiple drugs; Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport [...] |
| SLP1 protein network | https://string-db.org/network/4932.YOR154W | Uncharacterized protein SLP1; Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins [...] |
| ISN1 protein network | https://string-db.org/network/4932.YOR155C | IMP-specific 5'-nucleotidase 1; Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase; catalyzes the breakdown of IMP to inosine; responsible for production of nicotinamide riboside and nicotin [...] |
| NFI1 protein network | https://string-db.org/network/4932.YOR156C | SUMO E3 ligase; catalyzes sumoylation of Yku70p/80p and Sir4p promoting telomere anchoring to the nuclear envelope and regulating telomerase activity; DNA-bound form catalyzes a DNA-damaged trigg [...] |
| PUP1 protein network | https://string-db.org/network/4932.YOR157C | Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly i [...] |
| PET123 protein network | https://string-db.org/network/4932.YOR158W | Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator. |
| SME1 protein network | https://string-db.org/network/4932.YOR159C | Small nuclear ribonucleoprotein E; Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 s [...] |
| MTR10 protein network | https://string-db.org/network/4932.YOR160W | mRNA transport regulator MTR10; Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm m [...] |
| PNS1 protein network | https://string-db.org/network/4932.YOR161C | Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport; Bel [...] |
| YOR161C-C protein network | https://string-db.org/network/4932.YOR161C-C | Uncharacterized protein YOR161C-C; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YOR161W-A protein network | https://string-db.org/network/4932.YOR161W-A | Putative uncharacterized protein YOR161W-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YRR1 protein network | https://string-db.org/network/4932.YOR162C | Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose f [...] |
| DDP1 protein network | https://string-db.org/network/4932.YOR163W | Diphosphoinositol polyphosphate phosphohydrolase DDP1; Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenos [...] |
| GET4 protein network | https://string-db.org/network/4932.YOR164C | Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20. |
| SEY1 protein network | https://string-db.org/network/4932.YOR165W | Protein SEY1; Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlas [...] |
| SWT1 protein network | https://string-db.org/network/4932.YOR166C | Transcriptional protein SWT1; RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; [...] |
| RPS28A protein network | https://string-db.org/network/4932.YOR167C | Protein component of the small (40S) ribosomal subunit; has an extraribosomal function in regulation of RPS28B, in which Rps28Ap binds to a decapping complex via Edc3p, which then binds to RPS28B [...] |
| GLN4 protein network | https://string-db.org/network/4932.YOR168W | Glutamine--tRNA ligase; Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Gln); N-terminal domain proposed to be involved in enzyme- [...] |
| YOR169C protein network | https://string-db.org/network/4932.YOR169C | Putative uncharacterized protein YOR169C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame ov [...] |
| LCB4 protein network | https://string-db.org/network/4932.YOR171C | Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, [...] |
| YRM1 protein network | https://string-db.org/network/4932.YOR172W | Zinc finger transcription factor involved in multidrug resistance; Zn(2)-Cys(6) zinc finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an [...] |
| DCS2 protein network | https://string-db.org/network/4932.YOR173W | Inactive diphosphatase DCS2; m(7)GpppX pyrophosphatase regulator; non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2 [...] |
| MED4 protein network | https://string-db.org/network/4932.YOR174W | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation. |
| ALE1 protein network | https://string-db.org/network/4932.YOR175C | Broad-specificity lysophospholipid acyltransferase; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position [...] |
| HEM15 protein network | https://string-db.org/network/4932.YOR176W | Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH [...] |
| MPC54 protein network | https://string-db.org/network/4932.YOR177C | Component of the meiotic outer plaque; a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospor [...] |
| GAC1 protein network | https://string-db.org/network/4932.YOR178C | Regulatory subunit for Glc7p type-1 protein phosphatase (PP1); tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated [...] |
| SYC1 protein network | https://string-db.org/network/4932.YOR179C | Protein SYC1; Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH [...] |
| DCI1 protein network | https://string-db.org/network/4932.YOR180C | Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed; DCI1 has a paralog, ECI1, that arose from the whole genome dupl [...] |
| LAS17 protein network | https://string-db.org/network/4932.YOR181W | Proline-rich protein LAS17; Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments ind [...] |
| RPS30B protein network | https://string-db.org/network/4932.YOR182C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30B has a paralog, RPS30A, that arose from the whole genome duplica [...] |
| FYV12 protein network | https://string-db.org/network/4932.YOR183W | Protein of unknown function; required for survival upon exposure to K1 killer toxin. |
| SER1 protein network | https://string-db.org/network/4932.YOR184W | 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino a [...] |
| GSP2 protein network | https://string-db.org/network/4932.YOR185C | GTP-binding nuclear protein GSP2/CNR2; GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap [...] |
| YOR186C-A protein network | https://string-db.org/network/4932.YOR186C-A | Putative uncharacterized protein YOR186C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YOR186W protein network | https://string-db.org/network/4932.YOR186W | Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; mCherry fusion protein localizes to the vacuole; YOR186W has a paralog, YLR297W [...] |
| TUF1 protein network | https://string-db.org/network/4932.YOR187W | Mitochondrial translation elongation factor Tu (EF-Tu); involved in fundamental pathway of mtDNA homeostasis; comprises both GTPase and guanine nucleotide exchange factor activities, while these [...] |
| MSB1 protein network | https://string-db.org/network/4932.YOR188W | Morphogenesis-related protein MSB1; Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperatur [...] |
| IES4 protein network | https://string-db.org/network/4932.YOR189W | Ino eighty subunit 4; Component of the INO80 chromatiin remodeling complex; target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint [...] |
| SPR1 protein network | https://string-db.org/network/4932.YOR190W | Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance; SPR1 has a paralog, EXG1, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 5 [...] |
| ULS1 protein network | https://string-db.org/network/4932.YOR191W | ATP-dependent helicase ULS1; Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL); required for maintenance of NHEJ inhibition at telomeres; functions at telomeres to translocate [...] |
| THI72 protein network | https://string-db.org/network/4932.YOR192C | Transporter of thiamine or related compound; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); shares sequence similarity with Thi7p. |
| PEX27 protein network | https://string-db.org/network/4932.YOR193W | Peripheral peroxisomal membrane protein; involved in controlling peroxisome size and number, interacts with Pex25p; PEX27 has a paralog, PEX25, that arose from the whole genome duplication. |
| TOA1 protein network | https://string-db.org/network/4932.YOR194C | TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa2p, for ribosomal protein gene transcription in vivo; homologous to l [...] |
| SLK19 protein network | https://string-db.org/network/4932.YOR195W | Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regula [...] |
| LIP5 protein network | https://string-db.org/network/4932.YOR196C | Lipoyl synthase, mitochondrial; Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase; Belongs to the radical SAM superfamily. Lipoyl syntha [...] |
| MCA1 protein network | https://string-db.org/network/4932.YOR197W | Metacaspase-1; Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein ag [...] |
| BFR1 protein network | https://string-db.org/network/4932.YOR198C | Nuclear segregation protein BFR1; Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multic [...] |
| YOR200W protein network | https://string-db.org/network/4932.YOR200W | Putative uncharacterized protein YOR200W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| MRM1 protein network | https://string-db.org/network/4932.YOR201C | rRNA methyltransferase 1, mitochondrial; Ribose methyltransferase; modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA; Belongs to the class IV-like SAM-binding methy [...] |
| HIS3 protein network | https://string-db.org/network/4932.YOR202W | Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulat [...] |
| YOR203W protein network | https://string-db.org/network/4932.YOR203W | Putative uncharacterized protein YOR203W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of es [...] |
| DED1 protein network | https://string-db.org/network/4932.YOR204W | ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase; required for translation initiation of all yeast mRNAs; binds to mRNA cap-associated factors, and binding stimulates Ded1p RNA-dependent ATP [...] |
| GEP3 protein network | https://string-db.org/network/4932.YOR205C | Genetic interactor of prohibitins 3, mitochondrial; Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; pr [...] |
| NOC2 protein network | https://string-db.org/network/4932.YOR206W | Nucleolar complex protein 2; Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds [...] |
| RET1 protein network | https://string-db.org/network/4932.YOR207C | Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs. |
| PTP2 protein network | https://string-db.org/network/4932.YOR208W | Tyrosine-protein phosphatase 2; Nuclear phosphotyrosine-specific phosphatase involved in osmosensing; involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sen [...] |
| NPT1 protein network | https://string-db.org/network/4932.YOR209C | Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to [...] |
| RPB10 protein network | https://string-db.org/network/4932.YOR210W | RNA polymerase subunit ABC10-beta; common to RNA polymerases I, II, and III. |
| MGM1 protein network | https://string-db.org/network/4932.YOR211C | Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; promotes membrane bending; exists as long and short form with [...] |
| STE4 protein network | https://string-db.org/network/4932.YOR212W | G protein beta subunit; forms a dimer with Ste18p to activate mating signaling pathway, forms heterotrimer with Gpa1p and Ste18p to dampen signaling; pheromone-induced phosphorylation plays criti [...] |
| SAS5 protein network | https://string-db.org/network/4932.YOR213C | Something about silencing protein 5; Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activ [...] |
| SPR2 protein network | https://string-db.org/network/4932.YOR214C | Putative spore wall protein; expression increases during sporulation; not an essential gene; YOR214C has a paralog, SPO19, that arose from the whole genome duplication. |
| AIM41 protein network | https://string-db.org/network/4932.YOR215C | Altered inheritance of mitochondria protein 41, mitochondrial; Protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null muta [...] |
| RUD3 protein network | https://string-db.org/network/4932.YOR216C | GRIP domain-containing protein RUD3; Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1. |
| RFC1 protein network | https://string-db.org/network/4932.YOR217W | Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor [...] |
| YOR218C protein network | https://string-db.org/network/4932.YOR218C | Putative uncharacterized protein YOR218C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame ov [...] |
| STE13 protein network | https://string-db.org/network/4932.YOR219C | Dipeptidyl aminopeptidase; Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a [...] |
| RCN2 protein network | https://string-db.org/network/4932.YOR220W | Regulator of calcineurin 2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance i [...] |
| MCT1 protein network | https://string-db.org/network/4932.YOR221C | Malonyl CoA-acyl carrier protein transacylase, mitochondrial; Predicted malonyl-CoA:ACP transferase; putative component of a type-II mitochondrial fatty acid synthase that produces intermediates [...] |
| ODC2 protein network | https://string-db.org/network/4932.YOR222W | Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate bios [...] |
| DSC3 protein network | https://string-db.org/network/4932.YOR223W | Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeas [...] |
| RPB8 protein network | https://string-db.org/network/4932.YOR224C | RNA polymerase subunit ABC14.5; common to RNA polymerases I, II, and III. |
| ISU2 protein network | https://string-db.org/network/4932.YOR226C | Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosoli [...] |
| HER1 protein network | https://string-db.org/network/4932.YOR227W | HMG2-induced ER-remodeling protein 1; Protein of unknown function; required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based [...] |
| MCP1 protein network | https://string-db.org/network/4932.YOR228C | MDM10-complementing protein 1; Mitochondrial protein of unknown function involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial outer membrane; involved in m [...] |
| WTM2 protein network | https://string-db.org/network/4932.YOR229W | Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats; relocalizes to the cytosol i [...] |
| WTM1 protein network | https://string-db.org/network/4932.YOR230W | Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr [...] |
| YOR231C-A protein network | https://string-db.org/network/4932.YOR231C-A | Putative uncharacterized protein YOR231C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| MKK1 protein network | https://string-db.org/network/4932.YOR231W | MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2 [...] |
| MGE1 protein network | https://string-db.org/network/4932.YOR232W | GrpE protein homolog, mitochondrial; Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of F [...] |
| KIN4 protein network | https://string-db.org/network/4932.YOR233W | Serine/threonine-protein kinase KIN4; Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mothe [...] |
| RPL33B protein network | https://string-db.org/network/4932.YOR234C | Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homo [...] |
| IRC13 protein network | https://string-db.org/network/4932.YOR235W | Increased recombination centers protein 13; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant display [...] |
| DFR1 protein network | https://string-db.org/network/4932.YOR236W | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR. |
| HES1 protein network | https://string-db.org/network/4932.YOR237W | Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol [...] |
| YOR238W protein network | https://string-db.org/network/4932.YOR238W | Uncharacterized protein YOR238W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. |
| ABP140 protein network | https://string-db.org/network/4932.YOR239W | tRNA(Thr) (cytosine(32)-N(3))-methyltransferase; AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 3 [...] |
| MET7 protein network | https://string-db.org/network/4932.YOR241W | Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance i [...] |
| SSP2 protein network | https://string-db.org/network/4932.YOR242C | Sporulation-specific protein 2; Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; expression con [...] |
| PUS7 protein network | https://string-db.org/network/4932.YOR243C | Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); also pseudourid [...] |
| ESA1 protein network | https://string-db.org/network/4932.YOR244W | Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cell [...] |
| DGA1 protein network | https://string-db.org/network/4932.YOR245C | Diacylglycerol O-acyltransferase 1; Diacylglycerol acyltransferase; catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor; Lro1p [...] |
| ENV9 protein network | https://string-db.org/network/4932.YOR246C | Probable oxidoreductase ENV9; Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, f [...] |
| SRL1 protein network | https://string-db.org/network/4932.YOR247W | Cell wall protein SRL1; Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threoni [...] |
| YOR248W protein network | https://string-db.org/network/4932.YOR248W | Putative uncharacterized protein YOR248W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| APC5 protein network | https://string-db.org/network/4932.YOR249C | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/a [...] |
| CLP1 protein network | https://string-db.org/network/4932.YOR250C | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' [...] |
| TUM1 protein network | https://string-db.org/network/4932.YOR251C | Thiosulfate sulfurtransferase TUM1; Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNA [...] |
| TMA16 protein network | https://string-db.org/network/4932.YOR252W | Translation machinery-associated protein 16; Protein of unknown function that associates with ribosomes; Belongs to the UPF0534 family. |
| NAT5 protein network | https://string-db.org/network/4932.YOR253W | N-alpha-acetyltransferase NAT5; Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins, which influences multipl [...] |
| SEC63 protein network | https://string-db.org/network/4932.YOR254C | Protein translocation protein SEC63; Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent [...] |
| OSW1 protein network | https://string-db.org/network/4932.YOR255W | Outer spore wall protein 1; Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p. |
| TRE2 protein network | https://string-db.org/network/4932.YOR256C | Putative zinc metalloprotease TRE2; Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitination and vacuolar degradation of the metal transporter Smf1p; inviability of null [...] |
| CDC31 protein network | https://string-db.org/network/4932.YOR257W | Cell division control protein 31; Calcium-binding component of the spindle pole body (SPB) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds [...] |
| HNT3 protein network | https://string-db.org/network/4932.YOR258W | Aprataxin-like protein; DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein t [...] |
| RPT4 protein network | https://string-db.org/network/4932.YOR259C | 26S proteasome subunit RPT4; ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contr [...] |
| GCD1 protein network | https://string-db.org/network/4932.YOR260W | Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative r [...] |
| RPN8 protein network | https://string-db.org/network/4932.YOR261C | Essential non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p; Belongs to the peptidas [...] |
| GPN2 protein network | https://string-db.org/network/4932.YOR262W | GPN-loop GTPase 2; Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains [...] |
| DSE3 protein network | https://string-db.org/network/4932.YOR264W | Protein DSE3; Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress. |
| RBL2 protein network | https://string-db.org/network/4932.YOR265W | Tubulin-specific chaperone A; Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to [...] |
| PNT1 protein network | https://string-db.org/network/4932.YOR266W | Pentamidine resistance factor, mitochondrial; Mitochondrial integral inner membrane protein; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18 [...] |
| HRK1 protein network | https://string-db.org/network/4932.YOR267C | Serine/threonine-protein kinase HRK1; Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein [...] |
| YOR268C protein network | https://string-db.org/network/4932.YOR268C | Uncharacterized protein YOR268C; Putative protein of unknown function; sporulation is abnormal in homozygous diploid; SWAT-GFP fusion protein localizes to the nucleus; YOR268C is not an essential [...] |
| PAC1 protein network | https://string-db.org/network/4932.YOR269W | Nuclear distribution protein PAC1; Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud [...] |
| VPH1 protein network | https://string-db.org/network/4932.YOR270C | Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and [...] |
| FSF1 protein network | https://string-db.org/network/4932.YOR271C | Sideroflexin FSF1; Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochond [...] |
| YTM1 protein network | https://string-db.org/network/4932.YOR272W | Ribosome biogenesis protein YTM1; Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-term [...] |
| TPO4 protein network | https://string-db.org/network/4932.YOR273C | Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma mem [...] |
| MOD5 protein network | https://string-db.org/network/4932.YOR274W | Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; also has a role in tRNA gene-mediated sil [...] |
| RIM20 protein network | https://string-db.org/network/4932.YOR275C | pH-response regulator protein palA/RIM20; Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subu [...] |
| CAF20 protein network | https://string-db.org/network/4932.YOR276W | Cap-associated protein CAF20; Phosphoprotein of the mRNA cap-binding complex; involved in translational control; repressor of cap-dependent translation initiation; competes with eIF4G for binding [...] |
| HEM4 protein network | https://string-db.org/network/4932.YOR278W | Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the dis [...] |
| RFM1 protein network | https://string-db.org/network/4932.YOR279C | Repression factor of MSEs protein 1; Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcription [...] |
| FSH3 protein network | https://string-db.org/network/4932.YOR280C | Family of serine hydrolases 3; Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candida [...] |
| PLP2 protein network | https://string-db.org/network/4932.YOR281C | Phosducin-like protein 2; Protein that interacts with the CCT complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like prote [...] |
| YOR282W protein network | https://string-db.org/network/4932.YOR282W | Putative uncharacterized protein YOR282W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps es [...] |
| YOR283W protein network | https://string-db.org/network/4932.YOR283W | Broad-specificity phosphatase YOR283W; Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene; Belongs to [...] |
| HUA2 protein network | https://string-db.org/network/4932.YOR284W | Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly. |
| RDL1 protein network | https://string-db.org/network/4932.YOR285W | Thiosulfate sulfurtransferase; contains a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress; similar to the h [...] |
| RDL2 protein network | https://string-db.org/network/4932.YOR286W | Thiosulfate sulfurtransferase RDL2, mitochondrial; Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle [...] |
| RRP36 protein network | https://string-db.org/network/4932.YOR287C | rRNA biogenesis protein RRP36; Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit; Belongs to the RRP36 family. |
| MPD1 protein network | https://string-db.org/network/4932.YOR288C | Protein disulfide-isomerase MPD1; Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant su [...] |
| YOR289W protein network | https://string-db.org/network/4932.YOR289W | Uncharacterized protein YOR289W; Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the [...] |
| SNF2 protein network | https://string-db.org/network/4932.YOR290C | Transcription regulatory protein SNF2; Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions in [...] |
| YPK9 protein network | https://string-db.org/network/4932.YOR291W | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), m [...] |
| YOR292C protein network | https://string-db.org/network/4932.YOR292C | Vacuolar membrane protein YOR292C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene; Belongs to the [...] |
| YOR293C-A protein network | https://string-db.org/network/4932.YOR293C-A | Uncharacterized protein YOR293C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| RPS10A protein network | https://string-db.org/network/4932.YOR293W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplica [...] |
| RRS1 protein network | https://string-db.org/network/4932.YOR294W | Regulator of ribosome biosynthesis; Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the n [...] |
| UAF30 protein network | https://string-db.org/network/4932.YOR295W | Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting f [...] |
| YOR296W protein network | https://string-db.org/network/4932.YOR296W | Uncharacterized protein YOR296W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is no [...] |
| TIM18 protein network | https://string-db.org/network/4932.YOR297C | Mitochondrial import inner membrane translocase subunit TIM18; Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; may mediate assem [...] |
| MBF1 protein network | https://string-db.org/network/4932.YOR298C-A | Multiprotein-bridging factor 1; Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increas [...] |
| MUM3 protein network | https://string-db.org/network/4932.YOR298W | Protein of unknown function involved in outer spore wall organization; has similarity to the tafazzins superfamily of acyltransferases. |
| BUD7 protein network | https://string-db.org/network/4932.YOR299W | Bud site selection protein 7; Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p t [...] |
| YOR300W protein network | https://string-db.org/network/4932.YOR300W | Putative uncharacterized protein YOR300W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps with verifie [...] |
| RAX1 protein network | https://string-db.org/network/4932.YOR301W | Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily. |
| YOR302W protein network | https://string-db.org/network/4932.YOR302W | CPA1 uORF; Arginine attenuator peptide, regulates translation of the CPA1 mRNA. |
| CPA1 protein network | https://string-db.org/network/4932.YOR303W | Carbamoyl-phosphate synthase arginine-specific small chain; Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arg [...] |
| BIL1 protein network | https://string-db.org/network/4932.YOR304C-A | Uncharacterized protein YOR304C-A; Protein that binds Bud6p and has a role in actin cable assembly; involved in the Bnr1p-dependent pathway of cable assembly; localizes to bud tip and bud neck. |
| ISW2 protein network | https://string-db.org/network/4932.YOR304W | ISWI chromatin-remodeling complex ATPase ISW2; ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-spec [...] |
| RRG7 protein network | https://string-db.org/network/4932.YOR305W | Required for respiratory growth protein 7, mitochondrial; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity [...] |
| MCH5 protein network | https://string-db.org/network/4932.YOR306C | Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are [...] |
| SLY41 protein network | https://string-db.org/network/4932.YOR307C | Uncharacterized transporter SLY41; Protein involved in ER-to-Golgi transport. |
| SNU66 protein network | https://string-db.org/network/4932.YOR308C | 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component; Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may [...] |
| YOR309C protein network | https://string-db.org/network/4932.YOR309C | Putative uncharacterized protein YOR309C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| NOP58 protein network | https://string-db.org/network/4932.YOR310C | Nucleolar protein 58; Protein involved in producing mature rRNAs and snoRNAs; involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome [...] |
| DGK1 protein network | https://string-db.org/network/4932.YOR311C | Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contain [...] |
| RPL20B protein network | https://string-db.org/network/4932.YOR312C | Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication. |
| SPS4 protein network | https://string-db.org/network/4932.YOR313C | Sporulation-specific protein 4; Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA d [...] |
| YOR314W protein network | https://string-db.org/network/4932.YOR314W | Uncharacterized protein YOR314W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YOR314W-A protein network | https://string-db.org/network/4932.YOR314W-A | Putative uncharacterized protein YOR314W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| SFG1 protein network | https://string-db.org/network/4932.YOR315W | Nuclear protein putative transcription factor; required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together [...] |
| COT1 protein network | https://string-db.org/network/4932.YOR316C | Cobalt uptake protein COT1; Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to [...] |
| FAA1 protein network | https://string-db.org/network/4932.YOR317W | Long-chain-fatty-acid--CoA ligase 1; Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatt [...] |
| YOR318C protein network | https://string-db.org/network/4932.YOR318C | Putative uncharacterized protein YOR318C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcript is predict [...] |
| HSH49 protein network | https://string-db.org/network/4932.YOR319W | Protein HSH49; U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p [...] |
| GNT1 protein network | https://string-db.org/network/4932.YOR320C | Glucose N-acetyltransferase 1; N-acetylglucosaminyltransferase; capable of modification of N-linked glycans in the Golgi apparatus; Belongs to the GNT1 family. |
| PMT3 protein network | https://string-db.org/network/4932.YOR321W | Dolichyl-phosphate-mannose--protein mannosyltransferase 3; Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts i [...] |
| LDB19 protein network | https://string-db.org/network/4932.YOR322C | Protein LDB19; Alpha-arrestin involved in ubiquitin-dependent endocytosis; regulates endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its targets; involved in t [...] |
| PRO2 protein network | https://string-db.org/network/4932.YOR323C | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. |
| FRT1 protein network | https://string-db.org/network/4932.YOR324C | Protein HPH1; Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly vi [...] |
| MYO2 protein network | https://string-db.org/network/4932.YOR326W | Myosin-2; Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitoti [...] |
| SNC2 protein network | https://string-db.org/network/4932.YOR327C | Synaptobrevin homolog 2; Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; Snc2p levels regulated by Vps45p; m [...] |
| PDR10 protein network | https://string-db.org/network/4932.YOR328W | ATP-dependent permease PDR10; ATP-binding cassette (ABC) transporter; multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p; Belongs to the ABC t [...] |
| SCD5 protein network | https://string-db.org/network/4932.YOR329C | Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of [...] |
| YOR329W-A protein network | https://string-db.org/network/4932.YOR329W-A | Putative uncharacterized protein YOR329W-A; Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR. |
| MIP1 protein network | https://string-db.org/network/4932.YOR330C | Mitochondrial DNA polymerase gamma; single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in yeast, petites occ [...] |
| YOR331C protein network | https://string-db.org/network/4932.YOR331C | Putative uncharacterized membrane protein YOR331C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading [...] |
| VMA4 protein network | https://string-db.org/network/4932.YOR332W | Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V [...] |
| YOR333C protein network | https://string-db.org/network/4932.YOR333C | Putative uncharacterized protein YOR333C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of MR [...] |
| MRS2 protein network | https://string-db.org/network/4932.YOR334W | Magnesium transporter MRS2, mitochondrial; Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splici [...] |
| ALA1 protein network | https://string-db.org/network/4932.YOR335C | Alanine--tRNA ligase, mitochondrial; Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethalit [...] |
| YOR335W-A protein network | https://string-db.org/network/4932.YOR335W-A | Putative uncharacterized protein YOR335W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps [...] |
| KRE5 protein network | https://string-db.org/network/4932.YOR336W | Killer toxin-resistance protein 5; Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects. |
| TEA1 protein network | https://string-db.org/network/4932.YOR337W | Ty1 enhancer activator involved in Ty enhancer-mediated transcription; required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein. |
| YOR338W protein network | https://string-db.org/network/4932.YOR338W | Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporu [...] |
| UBC11 protein network | https://string-db.org/network/4932.YOR339C | Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of [...] |
| RPA43 protein network | https://string-db.org/network/4932.YOR340C | RNA polymerase I subunit A43; Belongs to the eukaryotic RPA43 RNA polymerase subunit family. |
| RPA190 protein network | https://string-db.org/network/4932.YOR341W | RNA polymerase I largest subunit A190; Belongs to the RNA polymerase beta' chain family. |
| YOR342C protein network | https://string-db.org/network/4932.YOR342C | Uncharacterized protein YOR342C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon [...] |
| YOR343C protein network | https://string-db.org/network/4932.YOR343C | Uncharacterized protein YOR343C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| TYE7 protein network | https://string-db.org/network/4932.YOR344C | Serine-rich protein that contains a bHLH DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene [...] |
| YOR345C protein network | https://string-db.org/network/4932.YOR345C | Putative uncharacterized protein YOR345C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified [...] |
| REV1 protein network | https://string-db.org/network/4932.YOR346W | DNA repair protein REV1; Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA [...] |
| PYK2 protein network | https://string-db.org/network/4932.YOR347C | Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the [...] |
| PUT4 protein network | https://string-db.org/network/4932.YOR348C | Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells. |
| CIN1 protein network | https://string-db.org/network/4932.YOR349W | Chromosome instability protein 1; Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl. |
| MNE1 protein network | https://string-db.org/network/4932.YOR350C | Protein involved in splicing Group I aI5-beta intron from COX1 mRNA; mitochondrial matrix protein. |
| MEK1 protein network | https://string-db.org/network/4932.YOR351C | Meiosis-specific serine/threonine protein kinase; functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister c [...] |
| TFB6 protein network | https://string-db.org/network/4932.YOR352W | Uncharacterized protein YOR352W; Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion [...] |
| SOG2 protein network | https://string-db.org/network/4932.YOR353C | Leucine-rich repeat-containing protein SOG2; Key component of the RAM signaling network; required for proper cell morphogenesis and cell separation after mitosis. |
| MSC6 protein network | https://string-db.org/network/4932.YOR354C | Multicopy suppressor of HER2 involved in mitochondrial translation; mutant is defective in directing meiotic recombination events to homologous chromatids. |
| GDS1 protein network | https://string-db.org/network/4932.YOR355W | Protein of unknown function; required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. |
| CIR2 protein network | https://string-db.org/network/4932.YOR356W | Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenase [...] |
| SNX3 protein network | https://string-db.org/network/4932.YOR357C | Sorting nexin for late-Golgi enzymes; required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and s [...] |
| HAP5 protein network | https://string-db.org/network/4932.YOR358W | Transcriptional activator HAP5; Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose repressed; complex is a transcriptional activator and global regulator o [...] |
| VTS1 protein network | https://string-db.org/network/4932.YOR359W | Protein VTS1; Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) fami [...] |
| PDE2 protein network | https://string-db.org/network/4932.YOR360C | 3',5'-cyclic-nucleotide phosphodiesterase 2; High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP [...] |
| PRT1 protein network | https://string-db.org/network/4932.YOR361C | eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates bi [...] |
| PRE10 protein network | https://string-db.org/network/4932.YOR362C | Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress. |
| PIP2 protein network | https://string-db.org/network/4932.YOR363C | Peroxisome proliferation transcriptional regulator; Autoregulatory, oleate-activated transcription factor; subunit of a heterodimeric complex with Oaf1p, which binds to oleate-response elements ( [...] |
| YOR364W protein network | https://string-db.org/network/4932.YOR364W | Putative uncharacterized protein YOR364W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| YOR365C protein network | https://string-db.org/network/4932.YOR365C | Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication. |
| SCP1 protein network | https://string-db.org/network/4932.YOR367W | Transgelin; Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1 [...] |
| RAD17 protein network | https://string-db.org/network/4932.YOR368W | Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human an [...] |
| RPS12 protein network | https://string-db.org/network/4932.YOR369C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog. |
| MRS6 protein network | https://string-db.org/network/4932.YOR370C | Rab proteins geranylgeranyltransferase component A; Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgerany [...] |
| GPB1 protein network | https://string-db.org/network/4932.YOR371C | Guanine nucleotide-binding protein subunit beta 1; Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-de [...] |
| NDD1 protein network | https://string-db.org/network/4932.YOR372C | Nuclear division defective protein 1; Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a s [...] |
| NUD1 protein network | https://string-db.org/network/4932.YOR373W | Protein NUD1; Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance. |
| ALD4 protein network | https://string-db.org/network/4932.YOR374W | Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzym [...] |
| GDH1 protein network | https://string-db.org/network/4932.YOR375C | NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen [...] |
| YOR376W protein network | https://string-db.org/network/4932.YOR376W | Uncharacterized membrane protein YOR376W; Putative protein of unknown function; conserved among S. cerevisiae strains; YOR376W is not an essential gene. |
| YOR376W-A protein network | https://string-db.org/network/4932.YOR376W-A | Uncharacterized protein YOR376W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| ATF1 protein network | https://string-db.org/network/4932.YOR377W | Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthes [...] |
| AMF1 protein network | https://string-db.org/network/4932.YOR378W | Low affinity NH4+ transporter; member of the DHA2 family of drug:H+ anti porters; putative paralog of ATR1; but not required for boron tolerance; non-essential gene; Belongs to the major facilita [...] |
| YOR379C protein network | https://string-db.org/network/4932.YOR379C | Putative uncharacterized protein YOR379C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RDR1 protein network | https://string-db.org/network/4932.YOR380W | Protein RDR1; Transcriptional repressor involved in regulating multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins. |
| FRE3 protein network | https://string-db.org/network/4932.YOR381W | Ferric reductase transmembrane component 3; Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; Belongs to the ferric reductas [...] |
| YOR381W-A protein network | https://string-db.org/network/4932.YOR381W-A | Uncharacterized protein YOR381W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| FIT2 protein network | https://string-db.org/network/4932.YOR382W | Facilitator of iron transport 2; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron [...] |
| FIT3 protein network | https://string-db.org/network/4932.YOR383C | Facilitator of iron transport 3; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron [...] |
| FRE5 protein network | https://string-db.org/network/4932.YOR384W | Ferric reductase transmembrane component 5; Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly puri [...] |
| YOR385W protein network | https://string-db.org/network/4932.YOR385W | Uncharacterized protein YOR385W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene. |
| PHR1 protein network | https://string-db.org/network/4932.YOR386W | Deoxyribodipyrimidine photo-lyase, mitochondrial; DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by tra [...] |
| YOR387C protein network | https://string-db.org/network/4932.YOR387C | VEL1-related protein YOR387C; Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the so [...] |
| FDH1 protein network | https://string-db.org/network/4932.YOR388C | NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. |
| YOR389W protein network | https://string-db.org/network/4932.YOR389W | Uncharacterized protein YOR389W; Putative protein of unknown function; expression regulated by copper levels. |
| FEX1 protein network | https://string-db.org/network/4932.YOR390W | Protein involved in fluoride export; nearly identical to FEX2, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX [...] |
| HSP33 protein network | https://string-db.org/network/4932.YOR391C | Probable glutathione-independent glyoxalase HSP33; Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary pha [...] |
| YOR392W protein network | https://string-db.org/network/4932.YOR392W | Putative uncharacterized protein YOR392W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; gene expression induc [...] |
| ERR1 protein network | https://string-db.org/network/4932.YOR393W | Enolase-related protein 1; Putative phosphopyruvate hydratase. |
| YOR394C-A protein network | https://string-db.org/network/4932.YOR394C-A | Uncharacterized protein YOR394C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| PAU21 protein network | https://string-db.org/network/4932.YOR394W | Seripauperin-21; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to th [...] |
| YOR396C-A protein network | https://string-db.org/network/4932.YOR396C-A | Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YRF1-8 protein network | https://string-db.org/network/4932.YOR396W | One of several telomeric Y' element-encoded DNA helicases; known as Y'-Help1 (Y'-HELicase Protein 1). |
| HAT1 protein network | https://string-db.org/network/4932.YPL001W | Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing a [...] |
| SNF8 protein network | https://string-db.org/network/4932.YPL002C | Vacuolar-sorting protein SNF8; Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; in [...] |
| ULA1 protein network | https://string-db.org/network/4932.YPL003W | NEDD8-activating enzyme E1 regulatory subunit; Protein that activates Rub1p (NEDD8) before neddylation; acts together with Uba3p; may play a role in protein degradation; Belongs to the ubiquitin- [...] |
| LSP1 protein network | https://string-db.org/network/4932.YPL004C | Sphingolipid long chain base-responsive protein LSP1; Eisosome core component; eisosomes are large immobile patch structures at the cell cortex associated with endocytosis; phosphorylated on Thr2 [...] |
| AEP3 protein network | https://string-db.org/network/4932.YPL005W | ATPase expression protein 3; Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1- [...] |
| NCR1 protein network | https://string-db.org/network/4932.YPL006W | NPC intracellular sterol transporter 1-related protein 1; Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells [...] |
| TFC8 protein network | https://string-db.org/network/4932.YPL007C | Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that [...] |
| CHL1 protein network | https://string-db.org/network/4932.YPL008W | Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recomb [...] |
| RQC2 protein network | https://string-db.org/network/4932.YPL009C | Ribosome quality control complex subunit 2; Component of RQC, which mediates nascent chain degradation; RQC (ribosome quality control complex) is a ribosome-bound complex required for degradation [...] |
| RET3 protein network | https://string-db.org/network/4932.YPL010W | Zeta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER. |
| TAF3 protein network | https://string-db.org/network/4932.YPL011C | TFIID subunit (47 kDa); involved in promoter binding and RNA polymerase II transcription initiation; Belongs to the TAF3 family. |
| RRP12 protein network | https://string-db.org/network/4932.YPL012W | Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the ce [...] |
| MRPS16 protein network | https://string-db.org/network/4932.YPL013C | Mitochondrial ribosomal protein of the small subunit. |
| CIP1 protein network | https://string-db.org/network/4932.YPL014W | Uncharacterized protein YPL014W; Cyclin-dependent kinase inhibitor; interacts with and inhibits the Cdc28p/Cln2p, G1/S phase cyclin-dependent kinase complex but not S-phase, or M-phase complexes; [...] |
| HST2 protein network | https://string-db.org/network/4932.YPL015C | Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent prote [...] |
| SWI1 protein network | https://string-db.org/network/4932.YPL016W | Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; self [...] |
| IRC15 protein network | https://string-db.org/network/4932.YPL017C | Increased recombination centers protein 15; Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded [...] |
| CTF19 protein network | https://string-db.org/network/4932.YPL018W | Inner kinetochore subunit CTF19; Outer kinetochore protein, needed for accurate chromosome segregation; component of kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as [...] |
| VTC3 protein network | https://string-db.org/network/4932.YPL019C | Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; V [...] |
| ULP1 protein network | https://string-db.org/network/4932.YPL020C | Ubiquitin-like-specific protease 1; Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rin [...] |
| ECM23 protein network | https://string-db.org/network/4932.YPL021W | Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p. |
| RAD1 protein network | https://string-db.org/network/4932.YPL022W | Single-stranded DNA endonuclease (with Rad10p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1) [...] |
| MET12 protein network | https://string-db.org/network/4932.YPL023C | Methylenetetrahydrofolate reductase 1; Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofol [...] |
| RMI1 protein network | https://string-db.org/network/4932.YPL024W | RecQ-mediated genome instability protein 1; Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing, DNA catenation/decatenation and ssDNA binding activities of T [...] |
| YPL025C protein network | https://string-db.org/network/4932.YPL025C | Putative uncharacterized protein YPL025C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| SKS1 protein network | https://string-db.org/network/4932.YPL026C | Serine/threonine-protein kinase SKS1; Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a p [...] |
| SMA1 protein network | https://string-db.org/network/4932.YPL027W | Protein of unknown function involved in prospore membrane assembly; involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p. |
| ERG10 protein network | https://string-db.org/network/4932.YPL028W | Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first [...] |
| SUV3 protein network | https://string-db.org/network/4932.YPL029W | ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during spl [...] |
| TRM44 protein network | https://string-db.org/network/4932.YPL030W | tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog [...] |
| PHO85 protein network | https://string-db.org/network/4932.YPL031C | Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissen [...] |
| SVL3 protein network | https://string-db.org/network/4932.YPL032C | Styryl dye vacuolar localization protein 3; Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes [...] |
| SRL4 protein network | https://string-db.org/network/4932.YPL033C | Oxidoreductase-like protein SRL4; Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced b [...] |
| YPL034W protein network | https://string-db.org/network/4932.YPL034W | Putative protein of unknown function; YPL034W is not essential gene. |
| PMA2 protein network | https://string-db.org/network/4932.YPL036W | Plasma membrane H+-ATPase; isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential; Belongs to the cation transport ATPase (P-type [...] |
| EGD1 protein network | https://string-db.org/network/4932.YPL037C | Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of hu [...] |
| MET31 protein network | https://string-db.org/network/4932.YPL038W | Transcriptional regulator MET31; Zinc-finger DNA-binding transcription factor; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; involved in transcriptional r [...] |
| ISM1 protein network | https://string-db.org/network/4932.YPL040C | Isoleucine--tRNA ligase, mitochondrial; Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can part [...] |
| MRX11 protein network | https://string-db.org/network/4932.YPL041C | MIOREX complex component 11; Protein that associates with mitochondrial ribosome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; involved in maintenance of telomere length. |
| SSN3 protein network | https://string-db.org/network/4932.YPL042C | Meiotic mRNA stability protein kinase SSN3; Cyclin-dependent protein kinase; component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; inv [...] |
| NOP4 protein network | https://string-db.org/network/4932.YPL043W | Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs [...] |
| VPS16 protein network | https://string-db.org/network/4932.YPL045W | Vacuolar protein sorting-associated protein 16; Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and en [...] |
| ELC1 protein network | https://string-db.org/network/4932.YPL046C | Elongin-C; Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic [...] |
| SGF11 protein network | https://string-db.org/network/4932.YPL047W | SAGA-associated factor 11; Integral subunit of SAGA histone acetyltransferase complex; regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA an [...] |
| CAM1 protein network | https://string-db.org/network/4932.YPL048W | Elongation factor 1-gamma 1; One of two isoforms of the gamma subunit of eEF1B; stimulates the release of GDP from eEF1A (Tef1p/Tef2p) post association with the ribosomal complex with eEF1Balpha [...] |
| DIG1 protein network | https://string-db.org/network/4932.YPL049C | Down-regulator of invasive growth 1; MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; relat [...] |
| MNN9 protein network | https://string-db.org/network/4932.YPL050C | Mannan polymerase complexes subunit MNN9; Subunit of Golgi mannosyltransferase complex; this complex mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p [...] |
| ARL3 protein network | https://string-db.org/network/4932.YPL051W | ADP-ribosylation factor-like protein 3; ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-cat [...] |
| OAZ1 protein network | https://string-db.org/network/4932.YPL052W | Regulator of ornithine decarboxylase Spe1p; antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translatio [...] |
| KTR6 protein network | https://string-db.org/network/4932.YPL053C | Mannosyltransferase KTR6; Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase [...] |
| LEE1 protein network | https://string-db.org/network/4932.YPL054W | Zinc-finger protein of unknown function. |
| LGE1 protein network | https://string-db.org/network/4932.YPL055C | Transcriptional regulatory protein LGE1; Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and re [...] |
| LCL1 protein network | https://string-db.org/network/4932.YPL056C | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. |
| SUR1 protein network | https://string-db.org/network/4932.YPL057C | Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 [...] |
| PDR12 protein network | https://string-db.org/network/4932.YPL058C | ATP-dependent permease PDR12; Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and b [...] |
| GRX5 protein network | https://string-db.org/network/4932.YPL059W | Monothiol glutaredoxin-5, mitochondrial; Glutathione-dependent oxidoreductase; mitochondrial matrix protein involved at an early step in the biogenesis of iron-sulfur centers along with Bol1p; hy [...] |
| MFM1 protein network | https://string-db.org/network/4932.YPL060W | Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; func [...] |
| ALD6 protein network | https://string-db.org/network/4932.YPL061W | Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mito [...] |
| YPL062W protein network | https://string-db.org/network/4932.YPL062W | Uncharacterized protein YPL062W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YPL062W is not an essential ge [...] |
| TIM50 protein network | https://string-db.org/network/4932.YPL063W | Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control th [...] |
| CWC27 protein network | https://string-db.org/network/4932.YPL064C | Peptidyl-prolyl isomerase CWC27; Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to D [...] |
| VPS28 protein network | https://string-db.org/network/4932.YPL065W | Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain int [...] |
| RGL1 protein network | https://string-db.org/network/4932.YPL066W | RHO1 GEF localizing protein 1; Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion pro [...] |
| YPL067C protein network | https://string-db.org/network/4932.YPL067C | Uncharacterized protein YPL067C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene. |
| YPL068C protein network | https://string-db.org/network/4932.YPL068C | Uncharacterized protein YPL068C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS. |
| BTS1 protein network | https://string-db.org/network/4932.YPL069C | Geranylgeranyl diphosphate synthase (GGPS); increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-bind [...] |
| MUK1 protein network | https://string-db.org/network/4932.YPL070W | Protein MUK1; Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); sp [...] |
| UBP16 protein network | https://string-db.org/network/4932.YPL072W | Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning, but may perform a mor [...] |
| YTA6 protein network | https://string-db.org/network/4932.YPL074W | Probable 26S proteasome subunit YTA6; Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma [...] |
| GCR1 protein network | https://string-db.org/network/4932.YPL075W | Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p. |
| GPI2 protein network | https://string-db.org/network/4932.YPL076W | Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit; Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinos [...] |
| YPL077C protein network | https://string-db.org/network/4932.YPL077C | Uncharacterized protein YPL077C; Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essenti [...] |
| ATP4 protein network | https://string-db.org/network/4932.YPL078C | Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization o [...] |
| RPL21B protein network | https://string-db.org/network/4932.YPL079W | Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication. |
| RPS9A protein network | https://string-db.org/network/4932.YPL081W | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication. |
| MOT1 protein network | https://string-db.org/network/4932.YPL082C | TATA-binding protein-associated factor MOT1; Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity; may have a role in ensuri [...] |
| SEN54 protein network | https://string-db.org/network/4932.YPL083C | Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial s [...] |
| BRO1 protein network | https://string-db.org/network/4932.YPL084W | Vacuolar-sorting protein BRO1; Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes. |
| SEC16 protein network | https://string-db.org/network/4932.YPL085W | COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound [...] |
| ELP3 protein network | https://string-db.org/network/4932.YPL086C | Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption [...] |
| YDC1 protein network | https://string-db.org/network/4932.YPL087W | Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a pa [...] |
| YPL088W protein network | https://string-db.org/network/4932.YPL088W | Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; Belongs to the aldo/keto red [...] |
| RLM1 protein network | https://string-db.org/network/4932.YPL089C | MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; R [...] |
| RPS6A protein network | https://string-db.org/network/4932.YPL090C | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S23 [...] |
| GLR1 protein network | https://string-db.org/network/4932.YPL091W | Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitocho [...] |
| SSU1 protein network | https://string-db.org/network/4932.YPL092W | Plasma membrane sulfite pump involved in sulfite metabolism; required for efficient sulfite efflux; major facilitator superfamily protein; Belongs to the tellurite-resistance/dicarboxylate transp [...] |
| NOG1 protein network | https://string-db.org/network/4932.YPL093W | Nucleolar GTP-binding protein 1; Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosom [...] |
| SEC62 protein network | https://string-db.org/network/4932.YPL094C | Translocation protein SEC62; Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein [...] |
| EEB1 protein network | https://string-db.org/network/4932.YPL095C | Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be i [...] |
| ERI1 protein network | https://string-db.org/network/4932.YPL096C-A | Phosphatidylinositol N-acetylglucosaminyltransferase ERI1 subunit; Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic r [...] |
| PNG1 protein network | https://string-db.org/network/4932.YPL096W | Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Conserved peptide N-glycanase; deglycosylating enzyme that cleaves N-glycans that are attached to misfolded ERAD substrate glycoprotei [...] |
| MSY1 protein network | https://string-db.org/network/4932.YPL097W | Tyrosine--tRNA ligase, mitochondrial; Mitochondrial tyrosyl-tRNA synthetase. |
| MGR2 protein network | https://string-db.org/network/4932.YPL098C | Protein MGR2; Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; provides quality control for insertion of membrane proteins by regulating their rele [...] |
| INA17 protein network | https://string-db.org/network/4932.YPL099C | Inner membrane assembly complex subunit 17; F1F0 ATPase synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) [...] |
| ATG21 protein network | https://string-db.org/network/4932.YPL100W | Autophagy-related protein 21; Phosphoinositide binding protein; required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosph [...] |
| ELP4 protein network | https://string-db.org/network/4932.YPL101W | Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; null mutation is [...] |
| YPL102C protein network | https://string-db.org/network/4932.YPL102C | Putative uncharacterized protein YPL102C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in clos [...] |
| FMP30 protein network | https://string-db.org/network/4932.YPL103C | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial; Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mi [...] |
| MSD1 protein network | https://string-db.org/network/4932.YPL104W | Aspartate--tRNA ligase, mitochondrial; Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases con [...] |
| SYH1 protein network | https://string-db.org/network/4932.YPL105C | SMY2 homolog 2; Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chron [...] |
| SSE1 protein network | https://string-db.org/network/4932.YPL106C | ATPase component of heat shock protein Hsp90 chaperone complex; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; plays a role in prion propagation and dete [...] |
| YPL107W protein network | https://string-db.org/network/4932.YPL107W | UPF0651 protein YPL107W, mitochondrial; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene; Belongs t [...] |
| YPL108W protein network | https://string-db.org/network/4932.YPL108W | Uncharacterized protein YPL108W; Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced [...] |
| YPL109C protein network | https://string-db.org/network/4932.YPL109C | UbiB family protein; contains transmembrane domain and mitochondrial targeting sequence; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; [...] |
| GDE1 protein network | https://string-db.org/network/4932.YPL110C | Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact [...] |
| CAR1 protein network | https://string-db.org/network/4932.YPL111W | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl car [...] |
| PEX25 protein network | https://string-db.org/network/4932.YPL112C | Peripheral peroxisomal membrane peroxin; required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with Pex27p; PEX25 has [...] |
| YPL113C protein network | https://string-db.org/network/4932.YPL113C | Putative 2-hydroxyacid dehydrogenase YPL113C; Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene; Belongs to the D-isomer specific 2-hydroxy [...] |
| BEM3 protein network | https://string-db.org/network/4932.YPL115C | GTPase-activating protein BEM3; Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment [...] |
| HOS3 protein network | https://string-db.org/network/4932.YPL116W | Histone deacetylase HOS3; Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; del [...] |
| IDI1 protein network | https://string-db.org/network/4932.YPL117C | Isopentenyl-diphosphate Delta-isomerase; Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for v [...] |
| MRP51 protein network | https://string-db.org/network/4932.YPL118W | Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences. |
| DBP1 protein network | https://string-db.org/network/4932.YPL119C | Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundanc [...] |
| YPL119C-A protein network | https://string-db.org/network/4932.YPL119C-A | Uncharacterized protein YPL119C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. |
| VPS30 protein network | https://string-db.org/network/4932.YPL120W | Vacuolar protein sorting-associated protein 30; Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar prot [...] |
| MEI5 protein network | https://string-db.org/network/4932.YPL121C | Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p; Belongs to [...] |
| TFB2 protein network | https://string-db.org/network/4932.YPL122C | Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH. |
| RNY1 protein network | https://string-db.org/network/4932.YPL123C | Ribonuclease T2-like; Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; required for tRNA-specific translational paus [...] |
| SPC29 protein network | https://string-db.org/network/4932.YPL124W | Inner plaque spindle pole body (SPB) component; links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication. |
| KAP120 protein network | https://string-db.org/network/4932.YPL125W | Importin beta-like protein KAP120; Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor; Belongs to the importin beta family. |
| NAN1 protein network | https://string-db.org/network/4932.YPL126W | NET1-associated nuclear protein 1; U3 snoRNP protein; component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA. |
| HHO1 protein network | https://string-db.org/network/4932.YPL127C | Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spo [...] |
| TBF1 protein network | https://string-db.org/network/4932.YPL128C | Protein TBF1; Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRN [...] |
| TAF14 protein network | https://string-db.org/network/4932.YPL129W | Transcription initiation factor TFIID subunit 14; Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification [...] |
| SPO19 protein network | https://string-db.org/network/4932.YPL130W | Sporulation-specific protein 19; Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a we [...] |
| RPL5 protein network | https://string-db.org/network/4932.YPL131W | Ribosomal 60S subunit protein L5; nascent Rpl5p is bound by specific chaperone Syo1p during translation; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is requi [...] |
| COX11 protein network | https://string-db.org/network/4932.YPL132W | Cytochrome c oxidase assembly protein COX11, mitochondrial; Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; association with mitochondrial ribosomes sugges [...] |
| RDS2 protein network | https://string-db.org/network/4932.YPL133C | Regulator of drug sensitivity 2; Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of prote [...] |
| ODC1 protein network | https://string-db.org/network/4932.YPL134C | Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesi [...] |
| YPL135C-A protein network | https://string-db.org/network/4932.YPL135C-A | Putative uncharacterized protein YPL135C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| ISU1 protein network | https://string-db.org/network/4932.YPL135W | Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has [...] |
| YPL136W protein network | https://string-db.org/network/4932.YPL136W | Putative uncharacterized protein YPL136W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps t [...] |
| GIP3 protein network | https://string-db.org/network/4932.YPL137C | GLC7-interacting protein 3; Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact wit [...] |
| SPP1 protein network | https://string-db.org/network/4932.YPL138C | COMPASS component SPP1; Subunit of COMPASS (Set1C); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; promotes meiotic DSB formation by int [...] |
| UME1 protein network | https://string-db.org/network/4932.YPL139C | Transcriptional regulatory protein UME1; Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes d [...] |
| MKK2 protein network | https://string-db.org/network/4932.YPL140C | MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1 [...] |
| FRK1 protein network | https://string-db.org/network/4932.YPL141C | Fatty acyl-CoA synthetase and RNA processing-associated kinase 1; Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts wit [...] |
| YPL142C protein network | https://string-db.org/network/4932.YPL142C | Putative uncharacterized protein YPL142C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps t [...] |
| RPL33A protein network | https://string-db.org/network/4932.YPL143W | Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein [...] |
| POC4 protein network | https://string-db.org/network/4932.YPL144W | Proteasome chaperone 4; Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alt [...] |
| KES1 protein network | https://string-db.org/network/4932.YPL145C | Oxysterol-binding protein homolog 4; One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, per [...] |
| NOP53 protein network | https://string-db.org/network/4932.YPL146C | Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant [...] |
| PXA1 protein network | https://string-db.org/network/4932.YPL147W | Peroxisomal long-chain fatty acid import protein 2; Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar [...] |
| PPT2 protein network | https://string-db.org/network/4932.YPL148C | Mitochondrial holo-[acyl-carrier-protein] synthase; Phosphopantetheine:protein transferase (PPTase); activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation; Belongs to t [...] |
| ATG5 protein network | https://string-db.org/network/4932.YPL149W | Autophagy protein 5; Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances [...] |
| YPL150W protein network | https://string-db.org/network/4932.YPL150W | Putative serine/threonine-protein kinase YPL150W; Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study. |
| PRP46 protein network | https://string-db.org/network/4932.YPL151C | Pre-mRNA-splicing factor PRP46; Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs. |
| RRD2 protein network | https://string-db.org/network/4932.YPL152W | Serine/threonine-protein phosphatase 2A activator 2; Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 pha [...] |
| YPL152W-A protein network | https://string-db.org/network/4932.YPL152W-A | Uncharacterized protein YPL152W-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| RAD53 protein network | https://string-db.org/network/4932.YPL153C | Serine/threonine-protein kinase RAD53; DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to co [...] |
| PEP4 protein network | https://string-db.org/network/4932.YPL154C | Saccharopepsin; Vacuolar aspartyl protease (proteinase A); required for posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; play [...] |
| KIP2 protein network | https://string-db.org/network/4932.YPL155C | Kinesin-like protein KIP2; Kinesin-related motor protein involved in mitotic spindle positioning; stabilizes microtubules by targeting Bik1p to the plus end; functions as a microtubule polymerase [...] |
| PRM4 protein network | https://string-db.org/network/4932.YPL156C | Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift [...] |
| TGS1 protein network | https://string-db.org/network/4932.YPL157W | Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assemb [...] |
| AIM44 protein network | https://string-db.org/network/4932.YPL158C | Altered inheritance of mitochondria protein 44; Protein that regulates Cdc42p and Rho1p; functions in the late steps of cytokinesis and cell separation; sustains Rho1p at the cell division site a [...] |
| PET20 protein network | https://string-db.org/network/4932.YPL159C | Mitochondrial protein; required for respiratory growth under some conditions and for stability of the mitochondrial genome. |
| CDC60 protein network | https://string-db.org/network/4932.YPL160W | Leucine--tRNA ligase, cytoplasmic; Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; human homolog LARS can complement yeast temperature-sensitive mutant at restrictive t [...] |
| BEM4 protein network | https://string-db.org/network/4932.YPL161C | Bud emergence protein 4; Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in [...] |
| YPL162C protein network | https://string-db.org/network/4932.YPL162C | Vacuolar membrane protein YPL162C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology. |
| SVS1 protein network | https://string-db.org/network/4932.YPL163C | Protein SVS1; Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication. |
| MLH3 protein network | https://string-db.org/network/4932.YPL164C | Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian mi [...] |
| SET6 protein network | https://string-db.org/network/4932.YPL165C | Potential protein lysine methyltransferase SET6; SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in co [...] |
| ATG29 protein network | https://string-db.org/network/4932.YPL166W | Autophagy-related protein 29; Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a [...] |
| REV3 protein network | https://string-db.org/network/4932.YPL167C | Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; [...] |
| MRX4 protein network | https://string-db.org/network/4932.YPL168W | MIOREX complex component 4; Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regula [...] |
| MEX67 protein network | https://string-db.org/network/4932.YPL169C | mRNA export factor MEX67; Poly(A)RNA binding protein involved in nuclear mRNA export; component of the nuclear pore; ortholog of human TAP; Belongs to the NXF family. |
| DAP1 protein network | https://string-db.org/network/4932.YPL170W | Damage response protein 1; Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations [...] |
| OYE3 protein network | https://string-db.org/network/4932.YPL171C | NADPH dehydrogenase 3; Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in ox [...] |
| COX10 protein network | https://string-db.org/network/4932.YPL172C | Protoheme IX farnesyltransferase, mitochondrial; Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; [...] |
| MRPL40 protein network | https://string-db.org/network/4932.YPL173W | Mitochondrial ribosomal protein of the large subunit. |
| NIP100 protein network | https://string-db.org/network/4932.YPL174C | Protein NIP100; Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued). |
| SPT14 protein network | https://string-db.org/network/4932.YPL175W | Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit; UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the [...] |
| TRE1 protein network | https://string-db.org/network/4932.YPL176C | Uncharacterized protein TRE1; Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitination and vacuolar degradation of the metal transporter Smf1p; fun [...] |
| CUP9 protein network | https://string-db.org/network/4932.YPL177C | Homeobox protein CUP9; Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent pr [...] |
| CBC2 protein network | https://string-db.org/network/4932.YPL178W | Nuclear cap-binding protein subunit 2; Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a ro [...] |
| PPQ1 protein network | https://string-db.org/network/4932.YPL179W | Serine/threonine-protein phosphatase PPQ; Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threoni [...] |
| TCO89 protein network | https://string-db.org/network/4932.YPL180W | Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of ce [...] |
| CTI6 protein network | https://string-db.org/network/4932.YPL181W | Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contai [...] |
| YPL182C protein network | https://string-db.org/network/4932.YPL182C | Putative uncharacterized protein YPL182C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RTT10 protein network | https://string-db.org/network/4932.YPL183C | Regulator of Ty1 transposition protein 10; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling [...] |
| RTC6 protein network | https://string-db.org/network/4932.YPL183W-A | 54S ribosomal protein RTC6, mitochondrial; Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be [...] |
| MRN1 protein network | https://string-db.org/network/4932.YPL184C | RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome e [...] |
| UIP4 protein network | https://string-db.org/network/4932.YPL186C | ULP1-interacting protein 4; Protein that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondri [...] |
| MF(ALPHA)1 protein network | https://string-db.org/network/4932.YPL187W | Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(A [...] |
| POS5 protein network | https://string-db.org/network/4932.YPL188W | Mitochondrial NADH kinase; phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress. |
| COA2 protein network | https://string-db.org/network/4932.YPL189C-A | Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p an [...] |
| GUP2 protein network | https://string-db.org/network/4932.YPL189W | Glycerol uptake protein 2; Probable membrane protein; possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; homolog of the mammali [...] |
| NAB3 protein network | https://string-db.org/network/4932.YPL190C | RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of [...] |
| YPL191C protein network | https://string-db.org/network/4932.YPL191C | Ubiquitin carboxyl-terminal hydrolase MIY1; Protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytop [...] |
| PRM3 protein network | https://string-db.org/network/4932.YPL192C | Pheromone-regulated membrane protein 3; Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; peripheral protein of the nuclear membrane; interacts with Kar5p at the [...] |
| RSA1 protein network | https://string-db.org/network/4932.YPL193W | Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly. |
| DDC1 protein network | https://string-db.org/network/4932.YPL194W | DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination interm [...] |
| APL5 protein network | https://string-db.org/network/4932.YPL195W | Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase [...] |
| OXR1 protein network | https://string-db.org/network/4932.YPL196W | Oxidation resistance protein 1; Protein of unknown function required for oxidative damage resistance; required for normal levels of resistance to oxidative damage; null mutants are sensitive to h [...] |
| YPL197C protein network | https://string-db.org/network/4932.YPL197C | Putative uncharacterized protein YPL197C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RPL7B protein network | https://string-db.org/network/4932.YPL198W | Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a con [...] |
| YPL199C protein network | https://string-db.org/network/4932.YPL199C | Smr domain-containing protein YPL199C; Putative protein of unknown function; predicted to be palmitoylated. |
| CSM4 protein network | https://string-db.org/network/4932.YPL200W | Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements; functions with meiosis- [...] |
| YIG1 protein network | https://string-db.org/network/4932.YPL201C | Protein that interacts with glycerol 3-phosphatase; plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol. |
| AFT2 protein network | https://string-db.org/network/4932.YPL202C | Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that a [...] |
| TPK2 protein network | https://string-db.org/network/4932.YPL203W | cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-b [...] |
| HRR25 protein network | https://string-db.org/network/4932.YPL204W | Conserved casein kinase; regulates diverse events including: vesicular traffic, DNA repair, the CVT pathway, monopolar attachment of sister kinetochores at meiosis I, and ribosomal subunit biogen [...] |
| PGC1 protein network | https://string-db.org/network/4932.YPL206C | Phosphatidylglycerol phospholipase C; regulates phosphatidylglycerol (PG) accumulation via a phospholipase C-type degradation mechanism; PG levels affect mitochondrial function; contains glycerop [...] |
| TYW1 protein network | https://string-db.org/network/4932.YPL207W | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-posit [...] |
| RKM1 protein network | https://string-db.org/network/4932.YPL208W | SET-domain lysine-N-methyltransferase; catalyzes the formation of dimethyllysine residues on the large ribosomal subunit proteins L23 (Rpl23Ap and Rpl23Bp) and monomethyllysine residues on L18 (R [...] |
| IPL1 protein network | https://string-db.org/network/4932.YPL209C | Spindle assembly checkpoint kinase; Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB [...] |
| SRP72 protein network | https://string-db.org/network/4932.YPL210C | Core component of the signal recognition particle (SRP); the SRP is a ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) memb [...] |
| NIP7 protein network | https://string-db.org/network/4932.YPL211W | Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p. |
| PUS1 protein network | https://string-db.org/network/4932.YPL212C | tRNA:pseudouridine synthase; introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; also acts on U2 snRNA; also pseudouridylates some mRNAs, and pseudouridylation level varies w [...] |
| LEA1 protein network | https://string-db.org/network/4932.YPL213W | U2 small nuclear ribonucleoprotein A; Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein; Belo [...] |
| THI6 protein network | https://string-db.org/network/4932.YPL214C | Thiamine biosynthetic bifunctional enzyme; Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in [...] |
| CBP3 protein network | https://string-db.org/network/4932.YPL215W | Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of [...] |
| YPL216W protein network | https://string-db.org/network/4932.YPL216W | Putative ISWI chromatin-remodeling complex subunit YPL216W; Putative protein of unknown function; not an essential gene; YPL216W has a paralog, ITC1, that arose from the whole genome duplication. |
| BMS1 protein network | https://string-db.org/network/4932.YPL217C | Ribosome biogenesis protein BMS1; GTPase required for ribosomal subunit synthesis and rRNA processing; required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at site [...] |
| SAR1 protein network | https://string-db.org/network/4932.YPL218W | ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes [...] |
| PCL8 protein network | https://string-db.org/network/4932.YPL219W | Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose [...] |
| RPL1A protein network | https://string-db.org/network/4932.YPL220W | Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplicati [...] |
| FLC1 protein network | https://string-db.org/network/4932.YPL221W | Flavin carrier protein 1; Flavin adenine dinucleotide transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose f [...] |
| YPL222C-A protein network | https://string-db.org/network/4932.YPL222C-A | Putative uncharacterized protein YPL222C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| FMP40 protein network | https://string-db.org/network/4932.YPL222W | Protein adenylyltransferase SelO, mitochondrial; Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detect [...] |
| GRE1 protein network | https://string-db.org/network/4932.YPL223C | Protein GRE1; Hydrophilin essential in desiccation-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; GRE1 has a paralog, [...] |
| MMT2 protein network | https://string-db.org/network/4932.YPL224C | Putative metal transporter involved in mitochondrial iron accumulation; MMT2 has a paralog, MMT1, that arose from the whole genome duplication; Belongs to the cation diffusion facilitator (CDF) t [...] |
| YPL225W protein network | https://string-db.org/network/4932.YPL225W | Protein PBDC1 homolog; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; p [...] |
| NEW1 protein network | https://string-db.org/network/4932.YPL226W | [NU+] prion formation protein 1; ATP binding cassette protein; cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] pr [...] |
| ALG5 protein network | https://string-db.org/network/4932.YPL227C | UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant; Belon [...] |
| CET1 protein network | https://string-db.org/network/4932.YPL228W | mRNA-capping enzyme subunit beta; RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of g [...] |
| USV1 protein network | https://string-db.org/network/4932.YPL230W | Nutrient and stress factor 1; Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon source [...] |
| FAS2 protein network | https://string-db.org/network/4932.YPL231W | 3-oxoacyl-[acyl-carrier-protein] reductase; Alpha subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain a [...] |
| SSO1 protein network | https://string-db.org/network/4932.YPL232W | Protein SSO1; Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2 [...] |
| NSL1 protein network | https://string-db.org/network/4932.YPL233W | Kinetochore-associated protein NSL1; Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromos [...] |
| VMA11 protein network | https://string-db.org/network/4932.YPL234C | Vacuolar ATPase V0 domain subunit c'; involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the [...] |
| RVB2 protein network | https://string-db.org/network/4932.YPL235W | RuvB-like protein 2; ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO8 [...] |
| ENV7 protein network | https://string-db.org/network/4932.YPL236C | Serine/threonine-protein kinase ENV7; Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in [...] |
| SUI3 protein network | https://string-db.org/network/4932.YPL237W | Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding. |
| YPL238C protein network | https://string-db.org/network/4932.YPL238C | Putative uncharacterized protein YPL238C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' [...] |
| YAR1 protein network | https://string-db.org/network/4932.YPL239W | Ankyrin repeat-containing protein YAR1; Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with nascent Rps3p during its [...] |
| HSP82 protein network | https://string-db.org/network/4932.YPL240C | ATP-dependent molecular chaperone HSP82; Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial pr [...] |
| CIN2 protein network | https://string-db.org/network/4932.YPL241C | Tubulin-specific chaperone C; GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl s [...] |
| IQG1 protein network | https://string-db.org/network/4932.YPL242C | Ras GTPase-activating-like protein IQG1; Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with S [...] |
| SRP68 protein network | https://string-db.org/network/4932.YPL243W | Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytopla [...] |
| HUT1 protein network | https://string-db.org/network/4932.YPL244C | UDP-galactose transporter homolog 1; Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction w [...] |
| YPL245W protein network | https://string-db.org/network/4932.YPL245W | Uncharacterized protein YPL245W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm. |
| RBD2 protein network | https://string-db.org/network/4932.YPL246C | Rhomboid protein 2; Possible rhomboid protease; has similarity to eukaryotic rhomboid proteases including Pcp1p. |
| YPL247C protein network | https://string-db.org/network/4932.YPL247C | WD repeat-containing protein YPL247C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat [...] |
| GAL4 protein network | https://string-db.org/network/4932.YPL248C | Regulatory protein GAL4; DNA-binding transcription factor required for activating GAL genes; responds to galactose; repressed by Gal80p and activated by Gal3p. |
| GYP5 protein network | https://string-db.org/network/4932.YPL249C | GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts wi [...] |
| RPL36B protein network | https://string-db.org/network/4932.YPL249C-A | Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplic [...] |
| ATG41 protein network | https://string-db.org/network/4932.YPL250C | Autophagy-related protein 41; Protein of unknown function; required for selective and nonselective autophagy, and mitophagy; regulates the rate of autophagosome formation; interacts with Atg9p, a [...] |
| YPL250W-A protein network | https://string-db.org/network/4932.YPL250W-A | Putative uncharacterized protein YPL250W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely o [...] |
| YPL251W protein network | https://string-db.org/network/4932.YPL251W | Putative uncharacterized protein YPL251W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' [...] |
| YAH1 protein network | https://string-db.org/network/4932.YPL252C | Adrenodoxin homolog, mitochondrial; Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; human homolog FDX1L can compl [...] |
| VIK1 protein network | https://string-db.org/network/4932.YPL253C | Spindle pole body-associated protein VIK1; Protein that forms a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor dom [...] |
| HFI1 protein network | https://string-db.org/network/4932.YPL254W | Transcriptional coactivator HFI1/ADA1; Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation [...] |
| BBP1 protein network | https://string-db.org/network/4932.YPL255W | Protein required for the spindle pole body (SPB) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p a [...] |
| CLN2 protein network | https://string-db.org/network/4932.YPL256C | G1/S-specific cyclin CLN2; G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcriptio [...] |
| YPL257W protein network | https://string-db.org/network/4932.YPL257W | Uncharacterized membrane protein YPL257W; Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an [...] |
| THI21 protein network | https://string-db.org/network/4932.YPL258C | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21; Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI [...] |
| APM1 protein network | https://string-db.org/network/4932.YPL259C | Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex. |
| CUB1 protein network | https://string-db.org/network/4932.YPL260W | UPF0662 protein YPL260W; Conserved fungal gene linked to DNA repair and proteasome function; putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion prot [...] |
| YPL261C protein network | https://string-db.org/network/4932.YPL261C | Uncharacterized protein YPL261C; Putative protein of unknown function; conserved among S. cerevisiae strains; YPL261C is not an essential gene; partially overlaps verified ORF YPL260W. |
| FUM1 protein network | https://string-db.org/network/4932.YPL262W | Fumarate hydratase, mitochondrial; Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, prot [...] |
| KEL3 protein network | https://string-db.org/network/4932.YPL263C | Kelch repeat-containing protein 3; Cytoplasmic protein of unknown function. |
| YPL264C protein network | https://string-db.org/network/4932.YPL264C | Probable transport protein YPL264C; Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene. |
| DIP5 protein network | https://string-db.org/network/4932.YPL265W | Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma me [...] |
| DIM1 protein network | https://string-db.org/network/4932.YPL266W | Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolu [...] |
| ACM1 protein network | https://string-db.org/network/4932.YPL267W | APC/C-CDH1 modulator 1; Pseudosubstrate inhibitor of the APC/C; suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated prote [...] |
| PLC1 protein network | https://string-db.org/network/4932.YPL268W | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1; Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphat [...] |
| KAR9 protein network | https://string-db.org/network/4932.YPL269W | Karyogamy protein KAR9; Spindle positioning factor; orients astral microtubules, connecting them to actin cables at the cortex with Bim1p and Myo2, resulting in proper spindle positioning; target [...] |
| MDL2 protein network | https://string-db.org/network/4932.YPL270W | ATP-dependent permease MDL2, mitochondrial; Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response [...] |
| ATP15 protein network | https://string-db.org/network/4932.YPL271W | Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and AT [...] |
| PBI1 protein network | https://string-db.org/network/4932.YPL272C | Uncharacterized protein YPL272C; Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene. |
| SAM4 protein network | https://string-db.org/network/4932.YPL273W | Homocysteine S-methyltransferase 2; S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the [...] |
| SAM3 protein network | https://string-db.org/network/4932.YPL274W | High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p. |
| YPL277C protein network | https://string-db.org/network/4932.YPL277C | Uncharacterized protein YPL277C; Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels. |
| YPL278C protein network | https://string-db.org/network/4932.YPL278C | Putative protein of unknown function; gene expression regulated by copper levels. |
| FEX2 protein network | https://string-db.org/network/4932.YPL279C | Protein involved in fluoride export; nearly identical to FEX1, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX [...] |
| HSP32 protein network | https://string-db.org/network/4932.YPL280W | Probable glutathione-independent glyoxalase HSP32; Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary pha [...] |
| ERR2 protein network | https://string-db.org/network/4932.YPL281C | Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant. |
| PAU22 protein network | https://string-db.org/network/4932.YPL282C | Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while [...] |
| YRF1-7 protein network | https://string-db.org/network/4932.YPL283C | Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p. |
| YPL283W-A protein network | https://string-db.org/network/4932.YPL283W-A | Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YPL283W-B protein network | https://string-db.org/network/4932.YPL283W-B | Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| CIT3 protein network | https://string-db.org/network/4932.YPR001W | Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-m [...] |
| YPR002C-A protein network | https://string-db.org/network/4932.YPR002C-A | Putative uncharacterized protein YPR002C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps [...] |
| PDH1 protein network | https://string-db.org/network/4932.YPR002W | Putative 2-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitr [...] |
| YPR003C protein network | https://string-db.org/network/4932.YPR003C | Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene; Belongs to the SLC26A/SulP trans [...] |
| AIM45 protein network | https://string-db.org/network/4932.YPR004C | Probable electron transfer flavoprotein subunit alpha, mitochondrial; Putative ortholog of mammalian ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochon [...] |
| HAL1 protein network | https://string-db.org/network/4932.YPR005C | Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induc [...] |
| ICL2 protein network | https://string-db.org/network/4932.YPR006C | 2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repres [...] |
| REC8 protein network | https://string-db.org/network/4932.YPR007C | Meiotic recombination protein REC8; Meiosis-specific component of the sister chromatid cohesion complex; alpha-kleisin family member that maintains cohesion between sister chromatids during meios [...] |
| HAA1 protein network | https://string-db.org/network/4932.YPR008W | Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that aros [...] |
| RPA135 protein network | https://string-db.org/network/4932.YPR010C | RNA polymerase I second largest subunit A135. |
| YPR010C-A protein network | https://string-db.org/network/4932.YPR010C-A | UPF0495 protein YPR010C-A; Putative protein of unknown function; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cytosol; conserved among Saccharomyces sensu stricto species. |
| YPR011C protein network | https://string-db.org/network/4932.YPR011C | Uncharacterized mitochondrial carrier YPR011C; Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate (APS) and 3'-phospho-adenosine 5'-phosphosulfate (PAPS); member of the m [...] |
| CMR3 protein network | https://string-db.org/network/4932.YPR013C | Putative zinc finger protein; YPR013C is not an essential gene. |
| YPR014C protein network | https://string-db.org/network/4932.YPR014C | Uncharacterized protein YPR014C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YPR014C is not an essential ge [...] |
| YPR015C protein network | https://string-db.org/network/4932.YPR015C | Putative zinc finger transcription factor; binds DNA in sequence-specific manner; overexpression causes a cell cycle delay or arrest. |
| TIF6 protein network | https://string-db.org/network/4932.YPR016C | Eukaryotic translation initiation factor 6; Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or st [...] |
| DSS4 protein network | https://string-db.org/network/4932.YPR017C | Protein DSS4; Guanine nucleotide dissociation stimulator for Sec4p; functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol; Belongs to the DSS4/MSS4 [...] |
| RLF2 protein network | https://string-db.org/network/4932.YPR018W | Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; main [...] |
| MCM4 protein network | https://string-db.org/network/4932.YPR019W | DNA replication licensing factor MCM4; Essential helicase component of heterohexameric MCM2-7 complexes; MCM2-7 complexes bind pre-replication complexes on DNA and melt DNA prior to replication; [...] |
| ATP20 protein network | https://string-db.org/network/4932.YPR020W | Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex, which in turn determin [...] |
| AGC1 protein network | https://string-db.org/network/4932.YPR021C | Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; human homolog [...] |
| SDD4 protein network | https://string-db.org/network/4932.YPR022C | Zinc finger protein YPR022C; Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [...] |
| EAF3 protein network | https://string-db.org/network/4932.YPR023C | Chromatin modification-related protein EAF3; Component of the Rpd3S histone deacetylase complex; Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous [...] |
| YME1 protein network | https://string-db.org/network/4932.YPR024W | Catalytic subunit of i-AAA protease complex; complex is located in mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as noncon [...] |
| CCL1 protein network | https://string-db.org/network/4932.YPR025C | Cyclin associated with protein kinase Kin28p; Kin28p is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters; human homolo [...] |
| ATH1 protein network | https://string-db.org/network/4932.YPR026W | Acid trehalase required for utilization of extracellular trehalose; involved in intracellular trehalose degradation during growth recovery after saline stress. |
| YPR027C protein network | https://string-db.org/network/4932.YPR027C | Uncharacterized membrane protein YPR027C; Putative protein of unknown function; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum, while the mCherry fusion protein l [...] |
| YOP1 protein network | https://string-db.org/network/4932.YPR028W | Protein YOP1; Reticulon-interacting protein; ER integral membrane protein involved in the generation of tubular ER morphology; promotes membrane curvature; forms tubules in vitro; regulates the E [...] |
| APL4 protein network | https://string-db.org/network/4932.YPR029C | AP-1 complex subunit gamma-1; Gamma-adaptin; large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport. |
| CSR2 protein network | https://string-db.org/network/4932.YPR030W | Transcription factor CSR2; Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction [...] |
| NTO1 protein network | https://string-db.org/network/4932.YPR031W | NuA3 HAT complex component NTO1; Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3. |
| SRO7 protein network | https://string-db.org/network/4932.YPR032W | Lethal(2) giant larvae protein homolog SRO7; Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with [...] |
| HTS1 protein network | https://string-db.org/network/4932.YPR033C | Histidine--tRNA ligase, mitochondrial; Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mu [...] |
| ARP7 protein network | https://string-db.org/network/4932.YPR034W | Actin-related protein 7; Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation. |
| GLN1 protein network | https://string-db.org/network/4932.YPR035W | Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen sour [...] |
| VMA13 protein network | https://string-db.org/network/4932.YPR036W | Subunit H of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the [...] |
| SPO24 protein network | https://string-db.org/network/4932.YPR036W-A | Sporulation protein 24; Small (67 amino acids) protein involved in sporulation; localizes to the prospore membrane; phosphorylated during meiosis; a longer, 5'-extended mRNA is also transcribed b [...] |
| ERV2 protein network | https://string-db.org/network/4932.YPR037C | Flavin-linked sulfhydryl oxidase localized to the ER lumen; involved in disulfide bond formation within the endoplasmic reticulum (ER). |
| TIP41 protein network | https://string-db.org/network/4932.YPR040W | Type 2A phosphatase activator TIP41; Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in respons [...] |
| TIF5 protein network | https://string-db.org/network/4932.YPR041W | Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2; Bel [...] |
| PUF2 protein network | https://string-db.org/network/4932.YPR042C | PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranuc [...] |
| RPL43A protein network | https://string-db.org/network/4932.YPR043W | Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that aro [...] |
| OPI11 protein network | https://string-db.org/network/4932.YPR044C | Putative uncharacterized protein OPI11; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; largely overlaps verifi [...] |
| THP3 protein network | https://string-db.org/network/4932.YPR045C | Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect f [...] |
| MCM16 protein network | https://string-db.org/network/4932.YPR046W | Inner kinetochore subunit MCM16; Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous [...] |
| MSF1 protein network | https://string-db.org/network/4932.YPR047W | Phenylalanine--tRNA ligase, mitochondrial; Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit d [...] |
| TAH18 protein network | https://string-db.org/network/4932.YPR048W | NADPH-dependent diflavin oxidoreductase 1; Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons fro [...] |
| ATG11 protein network | https://string-db.org/network/4932.YPR049C | Autophagy-related protein 11; Adapter protein for pexophagy and the Cvt targeting pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required [...] |
| YPR050C protein network | https://string-db.org/network/4932.YPR050C | Putative uncharacterized membrane protein YPR050C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost compl [...] |
| MAK3 protein network | https://string-db.org/network/4932.YPR051W | N-alpha-acetyltransferase 30; Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT); involved in subcellular targeting of select N-terminally acetylated substrates to the Golgi ap [...] |
| NHP6A protein network | https://string-db.org/network/4932.YPR052C | Non-histone chromosomal protein 6A; High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; fun [...] |
| SMK1 protein network | https://string-db.org/network/4932.YPR054W | Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p. |
| SEC8 protein network | https://string-db.org/network/4932.YPR055W | Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prio [...] |
| TFB4 protein network | https://string-db.org/network/4932.YPR056W | General transcription and DNA repair factor IIH subunit TFB4; Subunit of TFIIH complex; involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p. |
| BRR1 protein network | https://string-db.org/network/4932.YPR057W | Pre-mRNA-splicing factor BRR1; snRNP protein component of spliceosomal snRNPs; required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3' [...] |
| YMC1 protein network | https://string-db.org/network/4932.YPR058W | Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate met [...] |
| ARO7 protein network | https://string-db.org/network/4932.YPR060C | Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis. |
| JID1 protein network | https://string-db.org/network/4932.YPR061C | J domain-containing protein 1; Probable Hsp40p co-chaperone; has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytop [...] |
| FCY1 protein network | https://string-db.org/network/4932.YPR062W | Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) [...] |
| YPR063C protein network | https://string-db.org/network/4932.YPR063C | Uncharacterized protein YPR063C; ER-localized protein of unknown function. |
| YPR064W protein network | https://string-db.org/network/4932.YPR064W | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. |
| ROX1 protein network | https://string-db.org/network/4932.YPR065W | Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occ [...] |
| UBA3 protein network | https://string-db.org/network/4932.YPR066W | NEDD8-activating enzyme E1 catalytic subunit; Protein that activates Rub1p (NEDD8) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localiz [...] |
| ISA2 protein network | https://string-db.org/network/4932.YPR067W | Iron-sulfur assembly protein 2; Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermemb [...] |
| HOS1 protein network | https://string-db.org/network/4932.YPR068C | Class I histone deacetylase (HDAC) family member; deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6 [...] |
| SPE3 protein network | https://string-db.org/network/4932.YPR069C | Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells. |
| MED1 protein network | https://string-db.org/network/4932.YPR070W | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation. |
| YPR071W protein network | https://string-db.org/network/4932.YPR071W | Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog, YIL029C, that arose from a single-locus duplication. |
| NOT5 protein network | https://string-db.org/network/4932.YPR072W | General negative regulator of transcription subunit 5; Component of the CCR4-NOT core complex, involved in mRNA decapping; involved intranscription initiation and elongation and in mRNA degradati [...] |
| LTP1 protein network | https://string-db.org/network/4932.YPR073C | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. |
| TKL1 protein network | https://string-db.org/network/4932.YPR074C | Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthes [...] |
| YPR074W-A protein network | https://string-db.org/network/4932.YPR074W-A | Putative uncharacterized protein YPR074W-A; Hypothetical protein identified by homology. |
| OPY2 protein network | https://string-db.org/network/4932.YPR075C | Protein OPY2; Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamen [...] |
| YPR077C protein network | https://string-db.org/network/4932.YPR077C | Putative uncharacterized protein YPR077C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased [...] |
| YPR078C protein network | https://string-db.org/network/4932.YPR078C | Uncharacterized protein YPR078C; Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible. |
| MRL1 protein network | https://string-db.org/network/4932.YPR079W | Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in respon [...] |
| TEF1 protein network | https://string-db.org/network/4932.YPR080W | Translational elongation factor EF-1 alpha; in the GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; associates wi [...] |
| GRS2 protein network | https://string-db.org/network/4932.YPR081C | Glycine--tRNA ligase 2; Glycine-tRNA synthetase, not expressed under normal growth conditions; expression is induced under heat, oxidative, pH, or ethanol stress conditions; more stable than the [...] |
| DIB1 protein network | https://string-db.org/network/4932.YPR082C | Spliceosomal protein DIB1; 17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing; human ortholog TXNL4A (the human U5-specific 15-kDa protein) complements yeast [...] |
| MDM36 protein network | https://string-db.org/network/4932.YPR083W | Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-ancor (MECA); interacts with Num1p to link the ER and mitochondria at [...] |
| YPR084W protein network | https://string-db.org/network/4932.YPR084W | Uncharacterized protein YPR084W; Putative protein of unknown function. |
| ASA1 protein network | https://string-db.org/network/4932.YPR085C | ASTRA-associated protein 1; Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1. |
| SUA7 protein network | https://string-db.org/network/4932.YPR086W | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. |
| SRP54 protein network | https://string-db.org/network/4932.YPR088C | Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal rec [...] |
| YPR089W protein network | https://string-db.org/network/4932.YPR089W | Dilute domain-containing protein YPR089W; Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p. |
| NVJ2 protein network | https://string-db.org/network/4932.YPR091C | Uncharacterized PH domain-containing protein YPR091C; Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contain [...] |
| ASR1 protein network | https://string-db.org/network/4932.YPR093C | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alc [...] |
| RDS3 protein network | https://string-db.org/network/4932.YPR094W | Pre-mRNA-splicing factor RDS3; Component of the SF3b subcomplex of the U2 snRNP; zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance. |
| SYT1 protein network | https://string-db.org/network/4932.YPR095C | Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; cont [...] |
| YPR096C protein network | https://string-db.org/network/4932.YPR096C | Uncharacterized protein YPR096C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments. |
| YPR097W protein network | https://string-db.org/network/4932.YPR097W | Protein that contains a PX domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; PX stands for Phox homolog [...] |
| YPR098C protein network | https://string-db.org/network/4932.YPR098C | Protein of unknown function; localized to the mitochondrial outer membrane. |
| YPR099C protein network | https://string-db.org/network/4932.YPR099C | Putative uncharacterized protein YPR099C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| MRPL51 protein network | https://string-db.org/network/4932.YPR100W | Mitochondrial ribosomal protein of the large subunit. |
| SNT309 protein network | https://string-db.org/network/4932.YPR101W | Pre-mRNA-splicing factor SNT309; Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; [...] |
| RPL11A protein network | https://string-db.org/network/4932.YPR102C | Ribosomal 60S subunit protein L11A; expressed at twice the level of Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosoma [...] |
| PRE2 protein network | https://string-db.org/network/4932.YPR103W | Beta 5 subunit of the 20S proteasome; responsible for the chymotryptic activity of the proteasome; Belongs to the peptidase T1B family. |
| FHL1 protein network | https://string-db.org/network/4932.YPR104C | Pre-rRNA-processing protein FHL1; Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor C [...] |
| COG4 protein network | https://string-db.org/network/4932.YPR105C | Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to [...] |
| ISR1 protein network | https://string-db.org/network/4932.YPR106W | Serine/threonine-protein kinase ISR1; Predicted protein kinase; overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C. |
| YTH1 protein network | https://string-db.org/network/4932.YPR107C | mRNA 3'-end-processing protein YTH1; Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylatio [...] |
| RPN7 protein network | https://string-db.org/network/4932.YPR108W | Essential non-ATPase regulatory subunit of the 26S proteasome; similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits. |
| YPR108W-A protein network | https://string-db.org/network/4932.YPR108W-A | Uncharacterized protein YPR108W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. |
| YPR109W protein network | https://string-db.org/network/4932.YPR109W | Golgi/endosome-localized DSC protein 1; Predicted membrane protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; diploid deletion strain has high budding index. |
| RPC40 protein network | https://string-db.org/network/4932.YPR110C | RNA polymerase subunit AC40; common to RNA polymerase I and III; predominant determinant targeting Ty1 integration upstream of Pol III-transcribed genes. |
| DBF20 protein network | https://string-db.org/network/4932.YPR111W | Serine/threonine-protein kinase DBF20; Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a r [...] |
| MRD1 protein network | https://string-db.org/network/4932.YPR112C | Multiple RNA-binding domain-containing protein 1; Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and sma [...] |
| PIS1 protein network | https://string-db.org/network/4932.YPR113W | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Phosphatidylinositol synthase; required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingoli [...] |
| YPR114W protein network | https://string-db.org/network/4932.YPR114W | Uncharacterized TLC domain-containing protein YPR114W; Putative protein of unknown function. |
| RGC1 protein network | https://string-db.org/network/4932.YPR115W | Putative regulator of the Fps1p glycerol channel; multiply phosphorylated by Hog1p under osmotic stress; contains a pleckstrin homology domain; forms homodimers and heterodimerizes with paralog A [...] |
| RRG8 protein network | https://string-db.org/network/4932.YPR116W | Protein of unknown function; required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport; Belongs to the RRG8 family. |
| YPR117W protein network | https://string-db.org/network/4932.YPR117W | Uncharacterized protein YPR117W; Putative protein of unknown function. |
| MRI1 protein network | https://string-db.org/network/4932.YPR118W | 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway; Belongs to the eIF- [...] |
| CLB2 protein network | https://string-db.org/network/4932.YPR119W | G2/mitotic-specific cyclin-2; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a des [...] |
| CLB5 protein network | https://string-db.org/network/4932.YPR120C | S-phase entry cyclin-5; B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Cl [...] |
| THI22 protein network | https://string-db.org/network/4932.YPR121W | Thiamine biosynthesis protein THI22; Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis; SW [...] |
| AXL1 protein network | https://string-db.org/network/4932.YPR122W | Putative protease AXL1; Haploid specific endoprotease of a-factor mating pheromone; performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial bud [...] |
| YPR123C protein network | https://string-db.org/network/4932.YPR123C | Putative uncharacterized protein YPR123C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completely [...] |
| CTR1 protein network | https://string-db.org/network/4932.YPR124W | High-affinity copper transporter of plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper leve [...] |
| YLH47 protein network | https://string-db.org/network/4932.YPR125W | LETM1 domain-containing protein YLH47, mitochondrial; Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respirat [...] |
| YPR126C protein network | https://string-db.org/network/4932.YPR126C | Putative uncharacterized protein YPR126C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YPR127W protein network | https://string-db.org/network/4932.YPR127W | Putative pyridoxal reductase; Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluores [...] |
| ANT1 protein network | https://string-db.org/network/4932.YPR128C | Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation; Belongs to the mitochondrial carrier (TC 2.A.29) family. |
| SCD6 protein network | https://string-db.org/network/4932.YPR129W | Protein SCD6; Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA pr [...] |
| NAT3 protein network | https://string-db.org/network/4932.YPR131C | Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some prot [...] |
| RPS23B protein network | https://string-db.org/network/4932.YPR132W | Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23 [...] |
| SPN1 protein network | https://string-db.org/network/4932.YPR133C | Transcription factor SPN1; Protein involved in RNA polymerase II transcription; is constitutively recruited to the CYC1 promoter and is required for recruitment of chromatin remodeling factors fo [...] |
| TOM5 protein network | https://string-db.org/network/4932.YPR133W-A | Mitochondrial import receptor subunit TOM5; Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import of all mitochondrially directed proteins; [...] |
| MSS18 protein network | https://string-db.org/network/4932.YPR134W | Nuclear encoded protein needed for splicing of mitochondrial intron; required for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junct [...] |
| CTF4 protein network | https://string-db.org/network/4932.YPR135W | DNA polymerase alpha-binding protein; Chromatin-associated protein; required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chroma [...] |
| YPR136C protein network | https://string-db.org/network/4932.YPR136C | Putative uncharacterized protein YPR136C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ve [...] |
| RRP9 protein network | https://string-db.org/network/4932.YPR137W | Ribosomal RNA-processing protein 9; Protein involved in pre-rRNA processing; associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protei [...] |
| MEP3 protein network | https://string-db.org/network/4932.YPR138C | Ammonium transporter MEP3; Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is [...] |
| LOA1 protein network | https://string-db.org/network/4932.YPR139C | Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA. |
| TAZ1 protein network | https://string-db.org/network/4932.YPR140W | Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific [...] |
| KAR3 protein network | https://string-db.org/network/4932.YPR141C | Kinesin-like protein KAR3; Minus-end-directed microtubule motor; functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required f [...] |
| YPR142C protein network | https://string-db.org/network/4932.YPR142C | Putative uncharacterized protein YPR142C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| RRP15 protein network | https://string-db.org/network/4932.YPR143W | Nucleolar protein; constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs; Belongs to the RRP15 f [...] |
| NOC4 protein network | https://string-db.org/network/4932.YPR144C | Nucleolar protein; forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; relocalizes to the cytosol in response to hypoxia. |
| ASN1 protein network | https://string-db.org/network/4932.YPR145W | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication. |
| YPR146C protein network | https://string-db.org/network/4932.YPR146C | Putative uncharacterized protein YPR146C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YPR147C protein network | https://string-db.org/network/4932.YPR147C | Uncharacterized protein YPR147C; Protein of unknown function; may have a role in lipid metabolism, based on localization to lipid droplets; green fluorescent protein (GFP)-fusion protein localize [...] |
| YPR148C protein network | https://string-db.org/network/4932.YPR148C | Uncharacterized protein YPR148C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cy [...] |
| NCE102 protein network | https://string-db.org/network/4932.YPR149W | Non-classical export protein 2; Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the det [...] |
| SUE1 protein network | https://string-db.org/network/4932.YPR151C | Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria. |
| URN1 protein network | https://string-db.org/network/4932.YPR152C | Pre-mRNA-splicing factor URN1; Protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase. |
| MAY24 protein network | https://string-db.org/network/4932.YPR153W | Uncharacterized protein YPR153W; Protein of unknown function. |
| PIN3 protein network | https://string-db.org/network/4932.YPR154W | [PSI+] inducibility protein 3; Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-termin [...] |
| NCA2 protein network | https://string-db.org/network/4932.YPR155C | Nuclear control of ATPase protein 2; Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) o [...] |
| TPO3 protein network | https://string-db.org/network/4932.YPR156C | Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, [...] |
| TDA6 protein network | https://string-db.org/network/4932.YPR157W | Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; SWAT-GFP and mCherry fusion [...] |
| CUR1 protein network | https://string-db.org/network/4932.YPR158W | Curing of [URE3] protein 1; Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfol [...] |
| YPR159C-A protein network | https://string-db.org/network/4932.YPR159C-A | Uncharacterized protein YPR159C-A; Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol; identified by gene-trapping, microarray-based expression analysis, an [...] |
| KRE6 protein network | https://string-db.org/network/4932.YPR159W | Beta-glucan synthesis-associated protein KRE6; Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites [...] |
| GPH1 protein network | https://string-db.org/network/4932.YPR160W | Glycogen phosphorylase required for the mobilization of glycogen; non-essential; regulated by cyclic AMP-mediated phosphorylation; phosphorylation by Cdc28p may coordinately regulate carbohydrate [...] |
| YPR160W-A protein network | https://string-db.org/network/4932.YPR160W-A | Uncharacterized protein YPR160W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression pro [...] |
| SGV1 protein network | https://string-db.org/network/4932.YPR161C | Serine/threonine-protein kinase BUR1; Cyclin (Bur2p)-dependent protein kinase; part of the BUR kinase complex which functions in transcriptional regulation; phosphorylates the carboxy-terminal do [...] |
| ORC4 protein network | https://string-db.org/network/4932.YPR162C | Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog, RIF2, that ar [...] |
| TIF3 protein network | https://string-db.org/network/4932.YPR163C | Translation initiation factor eIF-4B; contains an RNA recognition motif and binds to single-stranded RNA; has RNA annealing activity; interacts with Rps20p at the head of the 40S ribosomal subuni [...] |
| MMS1 protein network | https://string-db.org/network/4932.YPR164W | Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preven [...] |
| RHO1 protein network | https://string-db.org/network/4932.YPR165W | GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan [...] |
| MRP2 protein network | https://string-db.org/network/4932.YPR166C | Mitochondrial ribosomal protein of the small subunit. |
| MET16 protein network | https://string-db.org/network/4932.YPR167C | Phosphoadenosine phosphosulfate reductase; 3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosu [...] |
| NUT2 protein network | https://string-db.org/network/4932.YPR168W | Subunit of the RNA polymerase II mediator complex; conserved from yeast to human; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional a [...] |
| JIP5 protein network | https://string-db.org/network/4932.YPR169W | WD repeat-containing protein JIP5; Protein required for biogenesis of the large ribosomal subunit; required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA [...] |
| YPR170C protein network | https://string-db.org/network/4932.YPR170C | Putative uncharacterized membrane protein YPR170C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially ov [...] |
| YPR170W-A protein network | https://string-db.org/network/4932.YPR170W-A | Putative uncharacterized protein YPR170W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expre [...] |
| YPR170W-B protein network | https://string-db.org/network/4932.YPR170W-B | Uncharacterized protein YPR170W-B; Putative protein of unknown function; conserved in fungi; SWAT-GFP fusion protein localizes to the vacuole membrane; partially overlaps the dubious genes YPR169 [...] |
| BSP1 protein network | https://string-db.org/network/4932.YPR171W | Protein BSP1; Adapter that links synaptojanins to the cortical actin cytoskeleton; the synaptojanins are Inp52p and Inp53p. |
| YPR172W protein network | https://string-db.org/network/4932.YPR172W | Pyridoxamine 5'-phosphate oxidase homolog; Protein of unknown function; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess th [...] |
| VPS4 protein network | https://string-db.org/network/4932.YPR173C | AAA-ATPase involved in multivesicular body (MVB) protein sorting; ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by [...] |
| YPR174C protein network | https://string-db.org/network/4932.YPR174C | Nuclear envelope protein YPR174C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylino [...] |
| DPB2 protein network | https://string-db.org/network/4932.YPR175W | Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of t [...] |
| BET2 protein network | https://string-db.org/network/4932.YPR176C | Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt [...] |
| YPR177C protein network | https://string-db.org/network/4932.YPR177C | Putative uncharacterized protein YPR177C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps th [...] |
| PRP4 protein network | https://string-db.org/network/4932.YPR178W | U4/U6 small nuclear ribonucleoprotein PRP4; Splicing factor; component of the U4/U6-U5 snRNP complex. |
| HDA3 protein network | https://string-db.org/network/4932.YPR179C | Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; require [...] |
| AOS1 protein network | https://string-db.org/network/4932.YPR180W | DNA damage tolerance protein RHC31; Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play [...] |
| SEC23 protein network | https://string-db.org/network/4932.YPR181C | GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 [...] |
| SMX3 protein network | https://string-db.org/network/4932.YPR182W | Small nuclear ribonucleoprotein F; Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 s [...] |
| DPM1 protein network | https://string-db.org/network/4932.YPR183W | Dolichol-phosphate mannosyltransferase; Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane; catalyzes formation of Dol-P-Man from Dol-P and GDP-Man; required for biosynthesis of glyco [...] |
| GDB1 protein network | https://string-db.org/network/4932.YPR184W | Amylo-alpha-1,6-glucosidase; Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; [...] |
| ATG13 protein network | https://string-db.org/network/4932.YPR185W | Autophagy-related protein 13; Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole tar [...] |
| PZF1 protein network | https://string-db.org/network/4932.YPR186C | Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserve [...] |
| RPO26 protein network | https://string-db.org/network/4932.YPR187W | RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit; Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subun [...] |
| MLC2 protein network | https://string-db.org/network/4932.YPR188C | Regulatory light chain for the type II myosin Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring. |
| SKI3 protein network | https://string-db.org/network/4932.YPR189W | Superkiller protein 3; Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are [...] |
| RPC82 protein network | https://string-db.org/network/4932.YPR190C | RNA polymerase III subunit C82. |
| QCR2 protein network | https://string-db.org/network/4932.YPR191W | Subunit 2 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by [...] |
| AQY1 protein network | https://string-db.org/network/4932.YPR192W | Aquaporin-1; Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outfl [...] |
| HPA2 protein network | https://string-db.org/network/4932.YPR193C | Tetrameric histone acetyltransferase; has similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; also acetylates polyamines. |
| OPT2 protein network | https://string-db.org/network/4932.YPR194C | Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of li [...] |
| YPR195C protein network | https://string-db.org/network/4932.YPR195C | Uncharacterized protein YPR195C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. |
| YPR196W protein network | https://string-db.org/network/4932.YPR196W | Maltose fermentation regulatory protein YPR196W; Putative maltose-responsive transcription factor; Belongs to the MAL13 family. |
| YPR197C protein network | https://string-db.org/network/4932.YPR197C | Putative uncharacterized protein YPR197C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SGE1/YPR [...] |
| SGE1 protein network | https://string-db.org/network/4932.YPR198W | Protein SGE1; Plasma membrane multidrug transporter; member of the major facilitator superfamily; acts as an extrusion permease; partial multicopy suppressor of gal11 mutations. |
| ARR1 protein network | https://string-db.org/network/4932.YPR199C | AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly [...] |
| ARR2 protein network | https://string-db.org/network/4932.YPR200C | Arsenical-resistance protein 2; Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p. |
| ARR3 protein network | https://string-db.org/network/4932.YPR201W | Arsenical-resistance protein 3; Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resist [...] |
| YPR202W protein network | https://string-db.org/network/4932.YPR202W | Putative protein of unknown function; similar to telomere-encoded helicases; down-regulated at low calcium levels; YPR202W is not an essential gene; transcript is predicted to be spliced but ther [...] |
| YPR203W protein network | https://string-db.org/network/4932.YPR203W | Putative protein of unknown function; Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily. |
| YPR204C-A protein network | https://string-db.org/network/4932.YPR204C-A | Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. |
| YPR204W protein network | https://string-db.org/network/4932.YPR204W | DNA helicase encoded within the telomeric Y' element; Y' -helicase protein 1. |